Organic compounds having two alkyl or aryl groups bonded to an oxygen atom, as in the formula R1–O–R2.
DrugDrug NameDrug Description
DB13598Diethyl etherNot Annotated
DB00228EnfluraneA halogenated inhalational anesthetic agent used for the induction and maintenance of anesthesia and for analgesia during labor and delivery.
DB00379MexiletineA class 1B antiarrhythmic agent used in the treatment of documented ventricular arrhythmias that warrant treatment.
DB00410MupirocinAn antibacterial ointment used to treat impetigo and secondary skin infections caused by Staphylococcus aureus and Streptococcus pyogenes.
DB00423MethocarbamolA CNS depressant indicated with rest, physical therapy and other treatments to control the discomfort associated with various acute musculoskeletal conditions.
DB00636ClofibrateA fibric acid derivative used to treat hypertriglyceridemia and high cholesterol.
DB00753IsofluraneAn inhaled general anesthetic used in surgery.
DB00793HaloproginUsed to treat fungal (Tinea) skin infections such as athlete's foot, jock itch, ringworm, and tinea versicolor.
DB00807ProparacaineA topical anesthetic used for ophthalmic practice.
DB00874GuaifenesinAn expectorant commonly found in OTC products for the symptomatic relief from congested chests and coughs associated with cold, bronchitis, and/or other breathing illnesses.
DB01028MethoxyfluraneFor use in the induction and maintenance of general anesthesia
DB01039FenofibrateA peroxisome proliferator receptor alpha activator used to lower LDL-C, total-C, triglycerides, and Apo B, while increasing HDL-C in hypercholesterolemia, dyslipidemia, and hypertriglyceridemia.
DB01189DesfluraneA general inhalation anesthetic for inpatient and outpatient surgery in adults.
DB01236SevofluraneA inhalation anaesthetic agent used for induction and maintenance of general anesthesia during surgical procedures.
DB01241GemfibrozilA lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia.
DB01393BezafibrateA lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder.
DB017491,2-DimethoxyethaneNot Available
DB02261Platelet Activating FactorNot Available
DB02795P-Anisic AcidNot Available
DB04905TesmilifeneIntended for the treatment of various forms of cancer.
DB05864PPI-2458Investigated for use/treatment in lymphoma (non-hodgkin's) and solid tumors.
DB06217VernakalantAn antiarrhythmic medication used to treat patients with atrial fibrillation.
DB06313BNC105Investigated for use/treatment in cancer/tumors (unspecified).
DB08604TriclosanAn antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew.
DB08969FlurothylFlurothyl is a convulsant primarily used in experimental animals. It was formerly used to induce convulsions as a alternative to electroshock therapy.
DB08983EtofibrateEtofibrate is a fibrate produced by the combination of clofibrate ester linked to niacin. These components separate in the body slowly allowing for pharmacokinetics similar to controlled-release formulations.
DB09018BromoprideBromopride in indicated in the treatment of nausea and vomiting, including PONV (post-operative nausea and vomiting), gastroesophageal reflux disease (GERD/GORD), as well as endoscopy preparation and radiographic studies of the...
DB09064CiprofibrateNot Annotated
DB09089TrimebutineA spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery.
DB09342PropoxycainePropoxycaine is a local anesthetic medication. It was used beginning in the 1950s during dental procedures . It has been combined with procaine to accelerate its onset of action and...
DB09516MequinolA topical agent used in combination with tretinoin to treat solar lentigines.
DB11324NonivamideNonivamide is used as a topical analgesic and is also used as a flavoring ingredient , , .
DB11359GuaiacolIt is used medicinally as an expectorant, antiseptic, and local anesthetic. Guaiacol is used in traditional dental pulp sedation, and has the property of inducing cell proliferation; guaiacol is a...
DB11706RaxatrigineRaxatrigine has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.
DB11737IcotinibIcotinib hydrochloride is a novel epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitor, exhibits encouraging efficacy and tolerability in patients with advanced non-small-cell lung cancer (NSCLC) who failed previous chemotherapy.
DB12025TriptolideTriptolide has been used in trials studying the treatment of HIV, Crohn's Disease, Intestinal Diseases, Gastrointestinal Diseases, and Digestive System Diseases, among others.
DB12043SepetaprostSepetaprost has been used in trials studying the treatment of Open Angle-glaucoma, Ocular Hypertension, and Mild Open Angle-glaucoma (OAG).
DB12608EmixustatEmixustat has been used in trials studying the treatment of Geographic Atrophy, Age-Related Macular Degeneration, and Dry Age-related Macular Degeneration.
DB12671BeloranibBeloranib has been used in trials studying the treatment of Obesity, Over-weight, Type 2 Diabetes, Craniopharyngioma, and Hypothalamic Injury, among others.
DB12879OmigapilOmigapil has been used in trials studying the treatment of Congenital Muscular Dystrophy.
DB13120DeferitazoleDeferitazole has been used in trials studying the treatment and basic science of Beta-thalassemia, Hepatic Impairment, Impaired Renal Function, Transfusional Iron Overload, and Iron Overload Due to Repeated Red Blood...
DB13265HexobendineHexobendine is a medication used to cause vasodilation, to treat several conditions including angina pectoris. It has not been approved in the United States or the United Kingdom, but has...
DB13278BucetinBucetin is an analgesic and antipyretic medication which was approved for use in Germany but was withdrawn from the market in 1986 due to renal toxicity caused by the medication...
DB13339EtoglucidNot Annotated
DB13433SimfibrateNot Annotated
DB13849ClofibrideNot Annotated
DB13853Anethole trithioneA medication used to treat dry mouth associated with medication or radiotherapy of the head and neck.
DB13873Fenofibric acidA fibrate used to treat severe hypertriglyceridemia, primary hypercholesterolemia, or mixed dyslipidemia.
DB13918Diclofop-methylHerbicide for control of wild oat & foxtails in cereal crops.
DB13690Vinyl etherNot Annotated
DB14083Bisphenol A diglycidyl etherNot Annotated
DB13735Potassium GuaiacolsulfonateGuaiacolsulfonate is an aromatic sulfonic acid. Potassium guaiacolsulfonate salt is an expectorant that thins the mucus in the lungs and reduces chest congestion.
DB14557EthylhexylglycerinAn emollient solvent with antimicrobial activity.
DB02130Vanillic acidA flavoring agent. It is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (J Biotechnol 1996;50(2-3):107-13).
DB02935DiglymeNot Available
DB03176KB-141An anticholesteremic agent.
DB036462,3-di-O-phytanyl-sn-glycerolNot Available
DB09026AliskirenA direct renin inhibitor used to manage hypertension.
DB15348AmpreloxetineAmpreloxetine is under investigation in clinical trial NCT03750552 (Clinical Effect of TD-9855 for Treating snOH in Subjects With Primary Autonomic Failure).
DB08711Methyl vanillateNot Available
DB14856PF-05089771PF-05089771 is under investigation in clinical trial NCT01529671 (A Safety And Tolerability Study Of PF-05089771 In Healthy Subjects And In Subjects With Otseoarthritis Of The Knee).
DB15589ZingeroneZingerone is a pungent component of ginger.
DrugDrug NameTargetType
DB00228EnfluraneCalcium-transporting ATPase type 2C member 1target
DB00228EnfluraneGlycine receptor (alpha-1/beta)target
DB00228EnfluraneGlutamate receptor 1target
DB00228EnfluranePotassium voltage-gated channel subfamily A member 1target
DB00228EnfluraneATP synthase subunit delta, mitochondrialtarget
DB00228EnfluraneIntermediate conductance calcium-activated potassium channel protein 4target
DB00228EnfluraneCytochrome P450 2E1enzyme
DB00228EnfluraneSerum albumincarrier
DB00228EnfluraneGABA-A receptor (anion channel)target
DB00379MexiletineSodium channel protein type 5 subunit alphatarget
DB00379MexiletineCytochrome P450 1A2enzyme
DB00379MexiletineCytochrome P450 2D6enzyme
DB00379MexiletineCytochrome P450 2B6enzyme
DB00379MexiletineCytochrome P450 2E1enzyme
DB00379MexiletineCytochrome P450 3A4enzyme
DB00379MexiletineAryl hydrocarbon receptortarget
DB00410MupirocinIsoleucine--tRNA ligasetarget
DB00423MethocarbamolCarbonic anhydrase 1target
DB00636ClofibratePeroxisome proliferator-activated receptor alphatarget
DB00636ClofibrateCytochrome P450 3A4enzyme
DB00636ClofibrateGlutathione S-transferase A2enzyme
DB00636ClofibrateCytochrome P450 2E1enzyme
DB00636ClofibrateCytochrome P450 1A1enzyme
DB00636ClofibrateCytochrome P450 4A11enzyme
DB00636ClofibrateThyroxine-binding globulincarrier
DB00753IsofluraneCalcium-transporting ATPase type 2C member 1target
DB00753IsofluraneATP synthase subunit delta, mitochondrialtarget
DB00753IsofluraneGamma-aminobutyric acid receptor subunit alpha-1target
DB00753IsofluranePotassium voltage-gated channel subfamily A member 1target
DB00753IsofluraneGlutamate receptor 1target
DB00753IsofluraneGlycine receptor subunit alpha-1target
DB00753IsofluraneCytochrome P450 2E1enzyme
DB00753IsofluraneSerum albumincarrier
DB00753IsofluraneCytochrome P450 2B6enzyme
DB00753IsofluraneNADH-ubiquinone oxidoreductase chain 1enzyme
DB00753IsofluraneGABA-A receptor (anion channel)target
DB00753IsofluraneNeuronal acetylcholine receptor subunit alpha-4target
DB00753IsofluraneNeuronal acetylcholine receptor subunit beta-2target
DB00807ProparacaineSodium channel protein type 10 subunit alphatarget
DB00874GuaifenesinNMDA receptortarget
DB01028MethoxyfluraneCalcium-transporting ATPase type 2C member 1target
DB01028MethoxyfluraneATP synthase subunit delta, mitochondrialtarget
DB01028MethoxyfluraneNADH-ubiquinone oxidoreductase chain 1target
DB01028MethoxyfluraneGamma-aminobutyric acid receptor subunit alpha-1target
DB01028MethoxyfluranePotassium voltage-gated channel subfamily A member 1target
DB01028MethoxyfluraneGlutamate receptor 1target
DB01028MethoxyfluraneGlycine receptor subunit alpha-1target
DB01028MethoxyfluraneCytochrome P450 2E1enzyme
DB01028MethoxyfluraneCytochrome P450 1A2enzyme
DB01028MethoxyfluraneCytochrome P450 2A6enzyme
DB01028MethoxyfluraneCytochrome P450 2B6enzyme
DB01028MethoxyfluraneCytochrome P450 2C9enzyme
DB01028MethoxyfluraneCytochrome P450 2D6enzyme
DB01028MethoxyfluraneCytochrome P450 3A4enzyme
DB01028MethoxyfluraneGABA-A receptor (anion channel)target
DB01039FenofibratePeroxisome proliferator-activated receptor alphatarget
DB01039FenofibrateMatrix metalloproteinase-25target
DB01039FenofibrateCytochrome P450 2C8enzyme
DB01039FenofibrateCytochrome P450 2C9enzyme
DB01039FenofibrateNuclear receptor subfamily 1 group I member 2target
DB01039FenofibrateUDP-glucuronosyltransferase 1-9enzyme
DB01039FenofibrateBile salt export pumptransporter
DB01039FenofibrateSerum albumincarrier
DB01039FenofibrateCytochrome P450 2C19enzyme
DB01039FenofibrateCytochrome P450 2A6enzyme
DB01039FenofibrateLiver carboxylesterase 1enzyme
DB01039FenofibrateCarbonyl reductase [NADPH] 1enzyme
DB01039FenofibrateAldo-keto reductase family 1 member C1enzyme
DB01039FenofibrateAldo-keto reductase family 1 member C2enzyme
DB01039FenofibrateAldo-keto reductase family 1 member C3enzyme
DB01039FenofibrateAldose reductaseenzyme
DB01189DesfluraneCalcium-transporting ATPase type 2C member 1target
DB01189DesfluraneNADH-ubiquinone oxidoreductase chain 1target
DB01189DesfluraneGlycine receptor subunit alpha-1target
DB01189DesfluraneGlutamate receptor 1target
DB01189DesfluraneGABA-A receptor (anion channel)target
DB01189DesfluranePotassium voltage-gated channel subfamily A member 1target
DB01189DesfluraneATP synthase subunit delta, mitochondrialtarget
DB01189DesfluraneSerum albumincarrier
DB01236SevofluraneCalcium-transporting ATPase type 2C member 1target
DB01236SevofluraneNADH-ubiquinone oxidoreductase chain 1target
DB01236SevofluraneGlycine receptor subunit alpha-1target
DB01236SevofluraneGlutamate receptor 1target
DB01236SevofluraneGamma-aminobutyric acid receptor subunit alpha-1target
DB01236SevofluranePotassium voltage-gated channel subfamily A member 1target
DB01236SevofluraneATP synthase subunit delta, mitochondrialtarget
DB01236SevofluraneCytochrome P450 2E1enzyme
DB01236SevofluraneSerum albumincarrier
DB01236SevofluraneCytochrome P450 2A6enzyme
DB01236SevofluraneCytochrome P450 2B6enzyme
DB01236SevofluraneCytochrome P450 3A4enzyme
DB01236SevofluraneGABA-A receptor (anion channel)target
DB01241GemfibrozilPeroxisome proliferator-activated receptor alphatarget
DB01241GemfibrozilCytochrome P450 2C9enzyme
DB01241GemfibrozilCytochrome P450 2C8enzyme
DB01241GemfibrozilCytochrome P450 1A2enzyme
DB01241GemfibrozilCytochrome P450 2C19enzyme
DB01241GemfibrozilUDP-glucuronosyltransferase 1-1enzyme
DB01241GemfibrozilCytochrome P450 3A4enzyme
DB01241GemfibrozilUDP-glucuronosyltransferase 1-3enzyme
DB01241GemfibrozilSolute carrier organic anion transporter family member 1B1target
DB01241GemfibrozilUDP-glucuronosyltransferase 2B7enzyme
DB01241GemfibrozilUDP-glucuronosyltransferase 1-9enzyme
DB01241GemfibrozilUDP-glucuronosyltransferase 2B4enzyme
DB01241GemfibrozilUDP-glucuronosyltransferase 2B17enzyme
DB01241GemfibrozilSerum albumincarrier
DB01241GemfibrozilSolute carrier family 22 member 8target
DB01241GemfibrozilSolute carrier organic anion transporter family member 2B1target
DB01241GemfibrozilSolute carrier organic anion transporter family member 1B3target
DB01393BezafibratePeroxisome proliferator-activated receptor alphatarget
DB01393BezafibrateSolute carrier organic anion transporter family member 1B1transporter
DB01393BezafibratePeroxisome proliferator-activated receptor deltatarget
DB01393BezafibratePeroxisome proliferator-activated receptor gammatarget
DB01393BezafibrateCytochrome P450 1A1enzyme
DB01393BezafibrateCytochrome P450 2C8enzyme
DB01393BezafibrateCytochrome P450 3A4enzyme
DB01393BezafibrateNuclear receptor subfamily 1 group I member 2target
DB01393BezafibrateRetinoic acid receptor RXR-alphatarget
DB01393BezafibrateRetinoic acid receptor RXR-betatarget
DB01393BezafibrateRetinoic acid receptor RXR-gammatarget
DB02261Platelet Activating FactorGanglioside GM2 activatortarget
DB02261Platelet Activating FactorP-glycoprotein 1transporter
DB02261Platelet Activating FactorPlatelet-activating factor receptortarget
DB02795P-Anisic AcidGroup IIE secretory phospholipase A2target
DB02795P-Anisic AcidPhospholipase A2target
DB04905TesmilifeneP-glycoprotein 1target
DB04905TesmilifeneHistamine H1 receptortarget
DB04905TesmilifeneCytochrome P450 3A4enzyme
DB04905TesmilifeneCytochrome P450 2D6enzyme
DB04905TesmilifeneCytochrome P450 1A1enzyme
DB05864PPI-2458Methionine aminopeptidase 2target
DB06217VernakalantCytochrome P450 2D6enzyme
DB06217VernakalantSodium channel protein type 5 subunit alphatarget
DB06217VernakalantPotassium voltage-gated channel subfamily A member 5target
DB06217VernakalantPotassium voltage-gated channel subfamily D member 3target
DB06217VernakalantPotassium voltage-gated channel subfamily H member 2target
DB08604TriclosanEnoyl-[acyl-carrier-protein] reductase [NADH] FabItarget
DB08604TriclosanEnoyl-[acyl-carrier-protein] reductase [NADH]target
DB08604TriclosanEnoyl-[acyl-carrier-protein] reductase [NADH] FabItarget
DB08604TriclosanEnoyl-[acyl-carrier-protein] reductase [NADH]target
DB08604TriclosanEnoyl-[acyl-carrier-protein] reductase [NADPH] FabItarget
DB08604TriclosanNuclear receptor subfamily 1 group I member 2target
DB08604TriclosanAndrogen receptortarget
DB08604TriclosanNuclear receptor subfamily 1 group I member 3target
DB08604TriclosanPeroxisome proliferator-activated receptor gammatarget
DB08604TriclosanThyroid peroxidasetarget
DB09018BromoprideDopamine D2 receptortarget
DB09064CiprofibratePeroxisome proliferator-activated receptor alphatarget
DB09089TrimebutineMu-type opioid receptortarget
DB09089TrimebutineVoltage-dependent L-type calcium channeltarget
DB09089TrimebutineCalcium-activated potassium channeltarget
DB09089TrimebutineVoltage-dependent T-type calcium channeltarget
DB09089TrimebutineMuscarinic acetylcholine receptor M1target
DB09089TrimebutineMuscarinic acetylcholine receptor M2target
DB09089TrimebutineMuscarinic acetylcholine receptor M3target
DB09089TrimebutineMuscarinic acetylcholine receptor M4target
DB09089TrimebutineCytochrome P450 3A4enzyme
DB09342PropoxycaineLiver carboxylesterase 1enzyme
DB09342PropoxycaineVoltage-gated sodium channel alpha subunittarget
DB11324NonivamideTransient receptor potential cation channel subfamily V member 1target
DB11359GuaiacolSerum albumintarget
DB11737IcotinibEpidermal growth factor receptortarget
DB11737IcotinibCytochrome P450 3A4enzyme
DB11737IcotinibCytochrome P450 1A2enzyme
DB11737IcotinibCytochrome P450 3A5enzyme
DB13873Fenofibric acidPeroxisome proliferator-activated receptor alphatarget
DB13873Fenofibric acidMatrix metalloproteinase-25target
DB13873Fenofibric acidPeroxisome proliferator-activated receptor gammatarget
DB13873Fenofibric acidPeroxisome proliferator-activated receptor deltatarget
DB13873Fenofibric acidNuclear receptor subfamily 1 group I member 2target
DB02130Vanillic acidChorismate--pyruvate lyasetarget
DB03176KB-141Thyroid hormone receptor betatarget
DB03176KB-141Thyroid hormone receptor alphatarget
DB09026AliskirenCytochrome P450 3A4enzyme
DB08711Methyl vanillateEndo-1,4-beta-xylanase Ytarget