Aza Compounds

Name
Aza Compounds
Accession Number
DBCAT000572
Description

Organic chemicals where carbon atoms have been replaced by nitrogen atoms.

Drugs
DrugDrug Description
TrospiumAn antimuscarinic agent used to treat the symptoms of overactive bladder (OAB).
BenzatropineAn anticholinergic drug used to treat Parkinson's disease (PD) and extrapyramidal symptoms, except tardive dyskinesia.
IpratropiumAn anticholinergic drug used in the control of symptoms related to bronchospasm in chronic obstructive pulmonary disease (COPD).
PhenoxymethylpenicillinA penicillin antibiotic used to prevent and treat mild to moderately severe infections in the respiratory tract, skin, and soft tissues.
HyoscyamineFor treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis. Also used to treat certain heart conditions, to control the symptoms of Parkinson's disease...
Anisotropine methylbromideFor use in conjunction with antacids or histamine H2-receptor antagonists in the treatment of peptic ulcer, to reduce further gastric acid secretion and delay gastric emptying.
CefdinirA third generation cephalosporin used to treat susceptible Gram negative and Gram positive bacterial infections.
CephalexinA first generation cephalosporin used to treat certain susceptible bacterial infections.
AtropineA muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs.
Homatropine methylbromideA muscarinic receptor antagonist used to treat peptic ulcers, gastric ulcers, and duodenal ulcers.
ScopolamineAn anticholinergic used to treat excessive salivation, colicky abdominal pain, bradycardia, diverticulitis, IBS, and motion sickness.
BiperidenA muscarinic receptor antagonist used to treat parkinsonism and control extrapyramidal side effects of neuroleptic drugs.
GranisetronA 5HT3 antagonist used to treat nausea and vomiting in cancer therapy and postoperatively.
CocaineAn ester local anesthetic used during diagnostic procedures and surgeries in or through the nasal cavities.
AzacitidineA pyrimidine nucleoside analogue used to treat certain subtypes of myelodysplastic syndrome.
ZopicloneA nonbenzodiazepine hypnotic used for the short-term management of insomnia.
DecitabineA chemotherapeutic agent used for the treatment of myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia, and conditions related to refractory anemia.
TiotropiumA long-acting bronchodilator used in the management of chronic obstructive pulmonary disease (COPD).
BenzoylecgonineBenzoylecgonine is the major metabolite of cocaine. It is formed by hydrolysis of cocaine in the liver, catalysed by carboxylesterases. It is excreted in the urine of cocaine users after...
EcgonineNot Available
TazobactamA beta lactamase inhibitor administered with antibiotics such as piperacillin and ceftolozane to prevent their degradation, resulting in increased efficacy.
8-azaguanine8-azaguanine is one of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids.
TropinoneNot Available
PseudotropineNot Available
MethylecgonineNot Available
AltropaneInvestigated for use/treatment in attention deficit/hyperactivity disorder (ADHD), parkinson's disease, and pediatric indications.
NS-2359Investigated for use/treatment in addictions, attention deficit/hyperactivity disorder (ADHD), and depression.
Ioflupane I-123A radiopharmaceutical used in single photon emission computed tomography (SPECT) brain imaging to help diagnose patients with suspected Parkinsonian syndromes.
AclidiniumAn inhaled long-acting anticholinergic used as a maintenance bronchodilator in patients with chronic obstructive pulmonary disease (COPD).
FentoniumFentonium is an atropine derivative.
AvibactamA non-β-lactam β-lactamase inhibitor used in combination with ceftazidime for the treatment of complicated intra-abdominal infections, complicated urinary tract infections, and hospital or ventilator-acquired pneumonia.
CimetropiumCimetropium is a semi-synthetic belladonna alkaloid and derivative of scopolamine. It is a potent antimuscarinic and an effective antispasmodic drug. It is also endowed of a direct myolitic action which...
ButylscopolamineAn antispasmodic and anticholinergic agent used for the symptomatic treatment of abdominal cramping and pain.
HomatropineAn anticholinergic agent used to dilate the pupil, treat inflammation of the uveal tract, and suppress a cough.
MethscopolamineMethscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The...
AZD-1305AZD1305 has been used in trials studying the treatment and basic science of Atrial Flutter, Atrial Fibrillation, and Left Ventricle Function.
GuadecitabineGuadecitabine is under investigation for the treatment of Previously Treated Metastatic Colorectal Cancer.
TesevatinibTesevatinib has been used in trials studying the treatment of Cancer, Stomach Cancer, Brain Metastases, Esophageal Cancer, and Leptomeningeal Metastases, among others. Tesevatinib is a potent inhibitor of multiple RTKs...
PF-03463275PF-03463275 has been used in trials studying the treatment of Schizophrenia and Cognitive Impairments Associated With Schizophrenia.
AxelopranAxelopran has been used in trials studying the treatment of OIC and Opioid-induced Constipation.
OxitropiumOxitropium has been investigated for the treatment of Pulmonary Disease, Chronic Obstructive.
PF-03715455PF-03715455 has been used in trials studying the treatment of Asthma, Pulmonary Disease, Chronic Obstructive, and Chronic Obstructive Pulmonary Disease (COPD).
PerzinfotelPerzinfotel has been used in trials studying the treatment of Diabetes Mellitus and Diabetic Neuropathy, Painful.
RelebactamA beta-lactamase inhibitor used to prevent hydrolysis of beta-lactam antibiotics, leading to increased effectiveness.
VerucerfontVerucerfont has been used in trials studying the treatment of Congenital Adrenal Hyperplasia.
SofiniclineSofinicline has been used in trials studying the treatment of ADHD, Neuralgia, Diabetic, Diabetic Neuropathies, Diabetic Polyneuropathy, and Diabetic Neuropathic Pain, among others.
VelusetragVelusetrag has been used in trials studying the treatment of Gastroparesis and Alzheimer's Disease. It is a highly selective serotonin receptor agonist effective in patients with chronic constipation. It is...
SCH-486757Sch 486757 has been used in trials studying the treatment of Cough.
XL-888XL888 has been used in trials studying the treatment of Cancer and Melanoma.
TAK-593TAK-593 has been used in trials studying the treatment of Solid Tumors.
EtybenzatropineNot Annotated
MethylatropineNot Annotated
AC-262536A selective androgen receptor modulator.
PF-232798PF-232798 is under investigation in clinical trial NCT01140425 (Study To Evaluate The Effect Of A Multiple Oral Dose Of PF-00232798 On QT Intervals In Healthy Subjects).
NanatinostatNanatinostat is under investigation in clinical trial NCT00697879 (Safety Study of the Histone Deacetylase Inhibitor, CHR-3996, in Patients With Advanced Solid Tumours).
CeftolozaneA cephalosporin antibiotic used to treat complicated intra-abdominal infections in combination with metronidazole, complicated urinary tract infections, and hospital-acquired pneumonia.
CP-866087CP-866,087 has been used in trials studying the treatment of Obesity, Alcoholism, and Sexual Dysfunction, Physiological.
ZidebactamZidebactam is under investigation in clinical trial NCT02674347 (MAD Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Intravenous Zidebactam in Healthy Adults).
DeptropineNot Annotated
PF-04634817PF-04634817 is under investigation in clinical trial NCT01140672 (A Multiple Dose Study To Determine Safety, Tolerability, and Pharmacokinetics Of PF-04634817 In Healthy Adult Subjects).
AcebilustatAcebilustat is under investigation in clinical trial NCT01748838 (Phase 1 Study Assessing the Safety and Tolerability of CTX-4430).
Drugs & Drug Targets
DrugTargetType
TrospiumMuscarinic acetylcholine receptor M1target
TrospiumCytochrome P450 2D6enzyme
TrospiumMuscarinic acetylcholine receptor M3target
BenzatropineMuscarinic acetylcholine receptor M1target
BenzatropineSodium-dependent dopamine transportertarget
BenzatropineHistamine H1 receptortarget
BenzatropineSerum albumincarrier
BenzatropineSodium-dependent serotonin transportertarget
BenzatropineSodium-dependent noradrenaline transportertarget
IpratropiumMuscarinic acetylcholine receptor M1target
IpratropiumMuscarinic acetylcholine receptor M2target
IpratropiumMuscarinic acetylcholine receptor M3target
IpratropiumSolute carrier family 22 member 5transporter
IpratropiumSolute carrier family 22 member 4transporter
IpratropiumSerum albumincarrier
Ipratropiumalpha1-acid glycoproteincarrier
PhenoxymethylpenicillinPenicillin-binding protein 1Atarget
PhenoxymethylpenicillinMecA PBP2' (penicillin binding protein 2')target
PhenoxymethylpenicillinD-alanyl-D-alanine carboxypeptidase DacBtarget
PhenoxymethylpenicillinPenicillin acylasetarget
PhenoxymethylpenicillinSolute carrier family 15 member 1target
HyoscyamineMuscarinic acetylcholine receptor M1target
HyoscyamineMuscarinic acetylcholine receptor M2target
HyoscyamineMuscarinic acetylcholine receptor M3target
HyoscyamineMuscarinic acetylcholine receptor M4target
Anisotropine methylbromideMuscarinic acetylcholine receptor M1target
Anisotropine methylbromideMuscarinic acetylcholine receptor M2target
Anisotropine methylbromideMuscarinic acetylcholine receptor M3target
CefdinirMyeloperoxidasetarget
CefdinirPenicillin-binding protein 2target
CefdinirPBP3target
CefdinirSolute carrier family 22 member 5transporter
CefdinirSolute carrier family 15 member 1transporter
CefdinirSolute carrier family 15 member 2transporter
CefdinirSolute carrier family 22 member 6transporter
CefdinirSolute carrier family 22 member 8transporter
CefdinirPeptidoglycan transpeptidasetarget
CephalexinSerum albumincarrier
CephalexinSolute carrier family 22 member 5transporter
CephalexinSolute carrier family 15 member 1transporter
CephalexinSolute carrier family 15 member 2transporter
CephalexinSolute carrier family 22 member 6transporter
CephalexinSolute carrier family 22 member 8transporter
CephalexinMultidrug and toxin extrusion protein 1transporter
CephalexinPenicillin-binding protein 3target
CephalexinPenicillin-binding protein 2atarget
CephalexinPenicillin-binding protein 1btarget
CephalexinPenicillin-binding protein 1Atarget
CephalexinPenicillin-binding protein 2Btarget
AtropineMuscarinic acetylcholine receptor M2target
AtropineMuscarinic acetylcholine receptor M1target
AtropineMuscarinic acetylcholine receptor M4target
AtropineMuscarinic acetylcholine receptor M5target
AtropineMuscarinic acetylcholine receptor M3target
AtropineGlycine receptor subunit alpha-1target
AtropineNeuronal acetylcholine receptor subunit alpha-4target
AtropineNeuronal acetylcholine receptor subunit beta-2target
AtropineBile salt export pumptransporter
Homatropine methylbromideMuscarinic acetylcholine receptor M2target
Homatropine methylbromideMuscarinic acetylcholine receptor M1target
Homatropine methylbromideMuscarinic acetylcholine receptor M4target
Homatropine methylbromideMuscarinic acetylcholine receptor M5target
Homatropine methylbromideMuscarinic acetylcholine receptor M3target
ScopolamineMuscarinic acetylcholine receptor M1target
ScopolamineSucrase-isomaltase, intestinaltarget
ScopolamineMuscarinic acetylcholine receptor M2target
ScopolamineMuscarinic acetylcholine receptor M3target
ScopolamineMuscarinic acetylcholine receptor M4target
ScopolamineMuscarinic acetylcholine receptor M5target
ScopolamineP-glycoprotein 1transporter
ScopolamineNeuronal acetylcholine receptor subunit alpha-4target
ScopolamineNeuronal acetylcholine receptor subunit beta-2target
BiperidenMuscarinic acetylcholine receptor M1target
BiperidenCytochrome P450 2D6enzyme
Granisetron5-hydroxytryptamine receptor 3Atarget
GranisetronCytochrome P450 3A4enzyme
GranisetronCytochrome P450 1A1enzyme
CocaineSodium-dependent noradrenaline transportertarget
CocaineSodium channel proteintarget
CocaineSodium-dependent serotonin transportertarget
CocaineSodium-dependent dopamine transportertarget
CocaineCytochrome P450 3A4enzyme
CocaineMuscarinic acetylcholine receptor M1target
CocaineMuscarinic acetylcholine receptor M2target
CocaineCytochrome P450 2D6enzyme
CocaineSolute carrier family 22 member 2transporter
CocaineCytochrome P450 2C8enzyme
CocaineSigma non-opioid intracellular receptor 1target
CocaineLiver carboxylesterase 1target
CocaineCholinesteraseenzyme
CocaineSodium-dependent dopamine transportertransporter
Cocainealpha1-acid glycoproteincarrier
CocaineLiver carboxylesterase 1enzyme
AzacitidineDNA (cytosine-5)-methyltransferase 1target
AzacitidineCytidine deaminaseenzyme
AzacitidineDNAtarget
AzacitidineRNAtarget
ZopicloneTranslocator proteintarget
ZopicloneCytochrome P450 2C8enzyme
ZopicloneCytochrome P450 2C9enzyme
ZopicloneCytochrome P450 3A4enzyme
ZopicloneProstaglandin G/H synthase 1enzyme
ZopicloneGamma-aminobutyric acid receptor subunit alpha-1target
ZopicloneGamma-aminobutyric acid receptor subunit alpha-2target
ZopicloneGamma-aminobutyric acid receptor subunit alpha-3target
ZopicloneGamma-aminobutyric acid receptor subunit alpha-5target
ZopicloneCytochrome P450 2E1enzyme
DecitabineDNAtarget
DecitabineDNA (cytosine-5)-methyltransferase 1target
DecitabineDeoxycytidine kinaseenzyme
TiotropiumMuscarinic acetylcholine receptor M3target
TiotropiumCytochrome P450 2D6enzyme
TiotropiumCytochrome P450 3A4enzyme
TiotropiumMuscarinic acetylcholine receptor M1target
TiotropiumMuscarinic acetylcholine receptor M2target
TiotropiumSolute carrier family 22 member 5transporter
TiotropiumSolute carrier family 22 member 4transporter
TiotropiumMuscarinic acetylcholine receptor M4target
TiotropiumMuscarinic acetylcholine receptor M5target
TazobactamBeta-lactamase TEMtarget
TazobactamSolute carrier family 22 member 6transporter
TazobactamSolute carrier family 22 member 8transporter
TazobactamBeta-lactamase Ohio-1target
TazobactamBeta-lactamase SHV-1target
8-azaguaninePurine nucleoside phosphorylasetarget
8-azaguanineCytochrome P450 1A2enzyme
MethylecgonineIg gamma-2 chain C regiontarget
MethylecgonineIg kappa chain C regiontarget
AltropaneSodium-dependent dopamine transportertarget
Ioflupane I-123Sodium-dependent dopamine transportertransporter
AclidiniumMuscarinic acetylcholine receptor M1target
AclidiniumMuscarinic acetylcholine receptor M2target
AclidiniumMuscarinic acetylcholine receptor M3target
AclidiniumMuscarinic acetylcholine receptor M4target
AclidiniumMuscarinic acetylcholine receptor M5target
AclidiniumCholinesteraseenzyme
AvibactamCanalicular multispecific organic anion transporter 1transporter
AvibactamSolute carrier family 22 member 8transporter
AvibactamBeta-lactamase TEMtarget
AvibactamBeta-lactamase CTX-Mtarget
AvibactamBeta-lactamasetarget
AvibactamBeta-lactamase SHV-1target
AvibactamBeta-lactamase SHV-2target
AvibactamBeta-lactamase SHV-1target
AvibactamClass D OXA-48 carbapenemasetarget
AvibactamCarbapenem-hydrolyzing beta-lactamase KPCtarget
AvibactamBeta-lactamase CTX-M-15target
AvibactamExtended-spectrum beta-lactamase PER-1target
ButylscopolamineMuscarinic acetylcholine receptor M3target
ButylscopolamineMuscarinic acetylcholine receptor M2target
HomatropineLiver carboxylesterase 1enzyme
HomatropineMuscarinic acetylcholine receptor M1target
HomatropineMuscarinic acetylcholine receptor M2target
HomatropineMuscarinic acetylcholine receptor M3target
HomatropineMuscarinic acetylcholine receptor M4target
HomatropineMuscarinic acetylcholine receptor M5target
TesevatinibPro-epidermal growth factortarget
TesevatinibEphrin type-B receptor 4target
TesevatinibReceptor tyrosine-protein kinase erbB-2target
RelebactamSolute carrier family 22 member 8transporter
RelebactamSolute carrier family 22 member 11transporter
RelebactamMultidrug and toxin extrusion protein 1transporter
RelebactamMultidrug and toxin extrusion protein 2transporter
RelebactamBeta-lactamase TEMtarget
RelebactamBeta-lactamase SHV-1target
RelebactamBeta-lactamase CTX-Mtarget
RelebactamBeta-lactamase (KPC-2)target
RelebactamBeta-lactamasetarget
Velusetrag5-hydroxytryptamine receptor 4target
CeftolozanePenicillin-binding protein 1Btarget
CeftolozanePenicillin-binding protein 3target
CeftolozanePenicillin-binding proteintarget
CeftolozanePenicillin-binding protein 1Ctarget
CeftolozanePenicillin-binding protein 2target