Aza Compounds

Organic chemicals where carbon atoms have been replaced by nitrogen atoms.
DrugDrug NameDrug Description
DB00209TrospiumAn antimuscarinic agent used to treat the symptoms of overactive bladder (OAB).
DB00245BenzatropineAn anticholinergic drug used to treat Parkinson's disease (PD) and extrapyramidal symptoms, except tardive dyskinesia.
DB00332IpratropiumAn anticholinergic drug used in the control of symptoms related to bronchospasm in chronic obstructive pulmonary disease (COPD).
DB00417PhenoxymethylpenicillinA penicillin antibiotic used to prevent and treat mild to moderately severe infections in the respiratory tract, skin, and soft tissues.
DB00424HyoscyamineFor treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis. Also used to treat certain heart conditions, to control the symptoms of Parkinson's disease...
DB00517Anisotropine methylbromideFor use in conjunction with antacids or histamine H2-receptor antagonists in the treatment of peptic ulcer, to reduce further gastric acid secretion and delay gastric emptying.
DB00535CefdinirA third generation cephalosporin used to treat susceptible Gram negative and Gram positive bacterial infections.
DB00567CephalexinA first generation cephalosporin used to treat certain susceptible bacterial infections.
DB00572AtropineA muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs.
DB00725Homatropine methylbromideA muscarinic receptor antagonist used to treat peptic ulcers, gastric ulcers, and duodenal ulcers.
DB00747ScopolamineAn anticholinergic used to treat excessive salivation, colicky abdominal pain, bradycardia, diverticulitis, IBS, and motion sickness.
DB00810BiperidenA muscarinic receptor antagonist used to treat parkinsonism and control extrapyramidal side effects of neuroleptic drugs.
DB00889GranisetronA 5HT3 antagonist used to treat nausea and vomiting in cancer therapy and postoperatively.
DB00907CocaineAn ester local anesthetic used during diagnostic procedures and surgeries in or through the nasal cavities.
DB00928AzacitidineA pyrimidine nucleoside analogue used to treat certain subtypes of myelodysplastic syndrome.
DB01198ZopicloneA nonbenzodiazepine hypnotic used for the short-term management of insomnia.
DB01262DecitabineA chemotherapeutic agent used for the treatment of myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia, and conditions related to refractory anemia.
DB01409TiotropiumA long-acting bronchodilator used in the management of chronic obstructive pulmonary disease (COPD).
DB01515BenzoylecgonineBenzoylecgonine is the major metabolite of cocaine. It is formed by hydrolysis of cocaine in the liver, catalysed by carboxylesterases. It is excreted in the urine of cocaine users after...
DB01525EcgonineNot Available
DB01606TazobactamA beta lactamase inhibitor administered with antibiotics such as piperacillin and ceftolozane to prevent their degradation, resulting in increased efficacy.
DB016678-azaguanine8-azaguanine is one of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids.
DB01874TropinoneNot Available
DB04026PseudotropineNot Available
DB04688MethylecgonineNot Available
DB04947AltropaneInvestigated for use/treatment in attention deficit/hyperactivity disorder (ADHD), parkinson's disease, and pediatric indications.
DB05805NS-2359Investigated for use/treatment in addictions, attention deficit/hyperactivity disorder (ADHD), and depression.
DB08824Ioflupane I-123A radiopharmaceutical used in single photon emission computed tomography (SPECT) brain imaging to help diagnose patients with suspected Parkinsonian syndromes.
DB08897AclidiniumAn inhaled long-acting anticholinergic used as a maintenance bronchodilator in patients with chronic obstructive pulmonary disease (COPD).
DB08978FentoniumFentonium is an atropine derivative.
DB09060AvibactamA non-β-lactam β-lactamase inhibitor used in combination with ceftazidime for the treatment of complicated intra-abdominal infections, complicated urinary tract infections, and hospital or ventilator-acquired pneumonia.
DB09271CimetropiumCimetropium is a semi-synthetic belladonna alkaloid and derivative of scopolamine. It is a potent antimuscarinic and an effective antispasmodic drug. It is also endowed of a direct myolitic action which...
DB09300ButylscopolamineAn antispasmodic and anticholinergic agent used for the symptomatic treatment of abdominal cramping and pain.
DB11181HomatropineAn anticholinergic agent used to dilate the pupil, treat inflammation of the uveal tract, and suppress a cough.
DB11315MethscopolamineMethscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The...
DB11766AZD-1305AZD1305 has been used in trials studying the treatment and basic science of Atrial Flutter, Atrial Fibrillation, and Left Ventricle Function.
DB11918GuadecitabineGuadecitabine is under investigation for the treatment of Previously Treated Metastatic Colorectal Cancer.
DB11973TesevatinibTesevatinib has been used in trials studying the treatment of Cancer, Stomach Cancer, Brain Metastases, Esophageal Cancer, and Leptomeningeal Metastases, among others. Tesevatinib is a potent inhibitor of multiple RTKs...
DB11993PF-03463275Pf 3463275 has been used in trials studying the treatment of Schizophrenia and Cognitive Impairments Associated With Schizophrenia.
DB12013AxelopranAxelopran has been used in trials studying the treatment of OIC and Opioid-induced Constipation.
DB12086OxitropiumOxitropium has been investigated for the treatment of Pulmonary Disease, Chronic Obstructive.
DB12138PF-03715455PF-03715455 has been used in trials studying the treatment of Asthma, Pulmonary Disease, Chronic Obstructive, and Chronic Obstructive Pulmonary Disease (COPD).
DB12365PerzinfotelPerzinfotel has been used in trials studying the treatment of Diabetes Mellitus and Diabetic Neuropathy, Painful.
DB12377RelebactamRelebactam is indicated in combination with imipenem and cilastatin for the treatment of complicated urinary tract infections, including pyelonephritis, and complicated intra-abdominal infections caused by susceptible organisms in adults.[label]
DB12512VerucerfontVerucerfont has been used in trials studying the treatment of Congenital Adrenal Hyperplasia.
DB12527SofiniclineSofinicline has been used in trials studying the treatment of ADHD, Neuralgia, Diabetic, Diabetic Neuropathies, Diabetic Polyneuropathy, and Diabetic Neuropathic Pain, among others.
DB12702VelusetragVelusetrag has been used in trials studying the treatment of Gastroparesis and Alzheimer's Disease. It is a highly selective serotonin receptor agonist effective in patients with chronic constipation. It is...
DB12782SCH-486757Sch 486757 has been used in trials studying the treatment of Cough.
DB12981XL-888XL888 has been used in trials studying the treatment of Cancer and Melanoma.
DB13093TAK-593TAK-593 has been used in trials studying the treatment of Solid Tumors.
DB13468EtybenzatropineNot Annotated
DB13833MethylatropineNot Annotated
DB13935AC-262536A selective androgen receptor modulator.
DB14813PF-232798PF-232798 is under investigation in clinical trial NCT01140425 (Study To Evaluate The Effect Of A Multiple Oral Dose Of PF-00232798 On QT Intervals In Healthy Subjects).
DB15419NanatinostatNanatinostat is under investigation in clinical trial NCT00697879 (Safety Study of the Histone Deacetylase Inhibitor, CHR-3996, in Patients With Advanced Solid Tumours).
DB09050CeftolozaneA cephalosporin antibiotic used to treat complicated intra-abdominal infections in combination with metronidazole, complicated urinary tract infections, and hospital-acquired pneumonia.
DB12196CP-866087CP-866,087 has been used in trials studying the treatment of Obesity, Alcoholism, and Sexual Dysfunction, Physiological.
DB13090ZidebactamZidebactam is under investigation in clinical trial NCT02674347 (MAD Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Intravenous Zidebactam in Healthy Adults).
DB13466DeptropineNot Annotated
DB14955PF-04634817PF-04634817 is under investigation in clinical trial NCT01140672 (A Multiple Dose Study To Determine Safety, Tolerability, and Pharmacokinetics Of PF-04634817 In Healthy Adult Subjects).
DB15385AcebilustatAcebilustat is under investigation in clinical trial NCT01748838 (Phase 1 Study Assessing the Safety and Tolerability of CTX-4430).
DrugDrug NameTargetType
DB00209TrospiumMuscarinic acetylcholine receptor M1target
DB00209TrospiumCytochrome P450 2D6enzyme
DB00245BenzatropineMuscarinic acetylcholine receptor M1target
DB00245BenzatropineSodium-dependent dopamine transportertarget
DB00245BenzatropineHistamine H1 receptortarget
DB00245BenzatropineSerum albumincarrier
DB00245BenzatropineSodium-dependent serotonin transportertarget
DB00245BenzatropineSodium-dependent noradrenaline transportertarget
DB00332IpratropiumMuscarinic acetylcholine receptor M1target
DB00332IpratropiumMuscarinic acetylcholine receptor M2target
DB00332IpratropiumMuscarinic acetylcholine receptor M3target
DB00332IpratropiumSolute carrier family 22 member 5transporter
DB00332IpratropiumSolute carrier family 22 member 4transporter
DB00332IpratropiumSerum albumincarrier
DB00332Ipratropiumalpha1-acid glycoproteincarrier
DB00417PhenoxymethylpenicillinPenicillin-binding protein 1Atarget
DB00417PhenoxymethylpenicillinMecA PBP2' (penicillin binding protein 2')target
DB00417PhenoxymethylpenicillinD-alanyl-D-alanine carboxypeptidase DacBtarget
DB00417PhenoxymethylpenicillinPenicillin acylasetarget
DB00417PhenoxymethylpenicillinSolute carrier family 15 member 1target
DB00424HyoscyamineMuscarinic acetylcholine receptor M1target
DB00424HyoscyamineMuscarinic acetylcholine receptor M2target
DB00424HyoscyamineMuscarinic acetylcholine receptor M3target
DB00424HyoscyamineMuscarinic acetylcholine receptor M4target
DB00517Anisotropine methylbromideMuscarinic acetylcholine receptor M1target
DB00517Anisotropine methylbromideMuscarinic acetylcholine receptor M2target
DB00517Anisotropine methylbromideMuscarinic acetylcholine receptor M3target
DB00535CefdinirMyeloperoxidasetarget
DB00535CefdinirPenicillin-binding protein 2target
DB00535CefdinirPBP3target
DB00535CefdinirSolute carrier family 22 member 5transporter
DB00535CefdinirSolute carrier family 15 member 1transporter
DB00535CefdinirSolute carrier family 15 member 2transporter
DB00535CefdinirSolute carrier family 22 member 6transporter
DB00535CefdinirSolute carrier family 22 member 8transporter
DB00535CefdinirPeptidoglycan transpeptidasetarget
DB00567CephalexinSerum albumincarrier
DB00567CephalexinSolute carrier family 22 member 5transporter
DB00567CephalexinSolute carrier family 15 member 1transporter
DB00567CephalexinSolute carrier family 15 member 2transporter
DB00567CephalexinSolute carrier family 22 member 6transporter
DB00567CephalexinSolute carrier family 22 member 8transporter
DB00567CephalexinMultidrug and toxin extrusion protein 1transporter
DB00567CephalexinPenicillin-binding protein 3target
DB00567CephalexinPenicillin-binding protein 2atarget
DB00567CephalexinPenicillin-binding protein 1btarget
DB00567CephalexinPenicillin-binding protein 1Atarget
DB00567CephalexinPenicillin-binding protein 2Btarget
DB00572AtropineMuscarinic acetylcholine receptor M2target
DB00572AtropineMuscarinic acetylcholine receptor M1target
DB00572AtropineMuscarinic acetylcholine receptor M4target
DB00572AtropineMuscarinic acetylcholine receptor M5target
DB00572AtropineMuscarinic acetylcholine receptor M3target
DB00572AtropineGlycine receptor subunit alpha-1target
DB00572AtropineNeuronal acetylcholine receptor subunit alpha-4target
DB00572AtropineNeuronal acetylcholine receptor subunit beta-2target
DB00572AtropineBile salt export pumptransporter
DB00725Homatropine methylbromideMuscarinic acetylcholine receptor M2target
DB00725Homatropine methylbromideMuscarinic acetylcholine receptor M1target
DB00725Homatropine methylbromideMuscarinic acetylcholine receptor M4target
DB00725Homatropine methylbromideMuscarinic acetylcholine receptor M5target
DB00725Homatropine methylbromideMuscarinic acetylcholine receptor M3target
DB00747ScopolamineMuscarinic acetylcholine receptor M1target
DB00747ScopolamineSucrase-isomaltase, intestinaltarget
DB00747ScopolamineMuscarinic acetylcholine receptor M2target
DB00747ScopolamineMuscarinic acetylcholine receptor M3target
DB00747ScopolamineMuscarinic acetylcholine receptor M4target
DB00747ScopolamineMuscarinic acetylcholine receptor M5target
DB00747ScopolamineP-glycoprotein 1transporter
DB00747ScopolamineNeuronal acetylcholine receptor subunit alpha-4target
DB00747ScopolamineNeuronal acetylcholine receptor subunit beta-2target
DB00810BiperidenNeuronal acetylcholine receptor subunit alpha-2target
DB00810BiperidenMuscarinic acetylcholine receptor M1target
DB00810BiperidenCytochrome P450 2D6enzyme
DB00889Granisetron5-hydroxytryptamine receptor 3Atarget
DB00889GranisetronCytochrome P450 3A4enzyme
DB00889GranisetronCytochrome P450 1A1enzyme
DB00907CocaineSodium-dependent noradrenaline transportertarget
DB00907CocaineSodium channel protein type 5 subunit alphatarget
DB00907CocaineSodium channel protein type 11 subunit alphatarget
DB00907CocaineSodium channel protein type 10 subunit alphatarget
DB00907CocaineSodium-dependent serotonin transportertarget
DB00907CocaineSodium-dependent dopamine transportertarget
DB00907CocaineCytochrome P450 3A4enzyme
DB00907CocaineMuscarinic acetylcholine receptor M1target
DB00907CocaineMuscarinic acetylcholine receptor M2target
DB00907CocaineCytochrome P450 3A5enzyme
DB00907CocaineCytochrome P450 3A7enzyme
DB00907CocaineCytochrome P450 2D6enzyme
DB00907CocaineSolute carrier family 22 member 2transporter
DB00907CocaineCytochrome P450 2C8enzyme
DB00907CocaineSigma non-opioid intracellular receptor 1target
DB00907CocaineLiver carboxylesterase 1target
DB00907CocaineCholinesteraseenzyme
DB00928AzacitidineDNA (cytosine-5)-methyltransferase 1target
DB00928AzacitidineCytidine deaminaseenzyme
DB00928AzacitidineDNAtarget
DB00928AzacitidineRNAtarget
DB01198ZopicloneTranslocator proteintarget
DB01198ZopicloneCytochrome P450 2C8enzyme
DB01198ZopicloneCytochrome P450 2C9enzyme
DB01198ZopicloneCytochrome P450 3A4enzyme
DB01198ZopicloneProstaglandin G/H synthase 1enzyme
DB01198ZopicloneGamma-aminobutyric acid receptor subunit alpha-1target
DB01198ZopicloneGamma-aminobutyric acid receptor subunit alpha-2target
DB01198ZopicloneGamma-aminobutyric acid receptor subunit alpha-3target
DB01198ZopicloneGamma-aminobutyric acid receptor subunit alpha-5target
DB01198ZopicloneCytochrome P450 2E1enzyme
DB01262DecitabineDNAtarget
DB01262DecitabineDNA (cytosine-5)-methyltransferase 1target
DB01262DecitabineDeoxycytidine kinaseenzyme
DB01409TiotropiumMuscarinic acetylcholine receptor M3target
DB01409TiotropiumCytochrome P450 2D6enzyme
DB01409TiotropiumCytochrome P450 3A4enzyme
DB01409TiotropiumMuscarinic acetylcholine receptor M1target
DB01409TiotropiumMuscarinic acetylcholine receptor M2target
DB01409TiotropiumSolute carrier family 22 member 5transporter
DB01409TiotropiumSolute carrier family 22 member 4transporter
DB01409TiotropiumMuscarinic acetylcholine receptor M4target
DB01409TiotropiumMuscarinic acetylcholine receptor M5target
DB01606TazobactamBeta-lactamase TEMtarget
DB01606TazobactamSolute carrier family 22 member 6transporter
DB01606TazobactamSolute carrier family 22 member 8transporter
DB01606TazobactamBeta-lactamase Ohio-1target
DB01606TazobactamBeta-lactamase SHV-1target
DB016678-azaguaninePurine nucleoside phosphorylasetarget
DB016678-azaguanineCytochrome P450 1A2enzyme
DB04688MethylecgonineIg gamma-2 chain C regiontarget
DB04688MethylecgonineIg kappa chain C regiontarget
DB04947AltropaneSodium-dependent dopamine transportertarget
DB08824Ioflupane I-123Sodium-dependent dopamine transportertransporter
DB08897AclidiniumMuscarinic acetylcholine receptor M1target
DB08897AclidiniumMuscarinic acetylcholine receptor M2target
DB08897AclidiniumMuscarinic acetylcholine receptor M3target
DB08897AclidiniumMuscarinic acetylcholine receptor M4target
DB08897AclidiniumMuscarinic acetylcholine receptor M5target
DB08897AclidiniumCholinesteraseenzyme
DB09060AvibactamCanalicular multispecific organic anion transporter 1transporter
DB09060AvibactamSolute carrier family 22 member 8transporter
DB09060AvibactamBeta-lactamase TEMtarget
DB09060AvibactamBeta-lactamase CTX-Mtarget
DB09060AvibactamBeta-lactamasetarget
DB09060AvibactamBeta-lactamase SHV-1target
DB09060AvibactamBeta-lactamase SHV-2target
DB09060AvibactamBeta-lactamase SHV-1target
DB09060AvibactamClass D OXA-48 carbapenemasetarget
DB09060AvibactamCarbapenem-hydrolyzing beta-lactamase KPCtarget
DB09060AvibactamBeta-lactamase CTX-M-15target
DB09060AvibactamExtended-spectrum beta-lactamase PER-1target
DB09300ButylscopolamineMuscarinic acetylcholine receptor M3target
DB09300ButylscopolamineMuscarinic acetylcholine receptor M2target
DB11181HomatropineLiver carboxylesterase 1enzyme
DB11181HomatropineMuscarinic acetylcholine receptor M1target
DB11181HomatropineMuscarinic acetylcholine receptor M2target
DB11181HomatropineMuscarinic acetylcholine receptor M3target
DB11181HomatropineMuscarinic acetylcholine receptor M4target
DB11181HomatropineMuscarinic acetylcholine receptor M5target
DB11973TesevatinibPro-epidermal growth factortarget
DB11973TesevatinibEphrin type-B receptor 4target
DB11973TesevatinibReceptor tyrosine-protein kinase erbB-2target
DB12377RelebactamSolute carrier family 22 member 8transporter
DB12377RelebactamSolute carrier family 22 member 11transporter
DB12377RelebactamMultidrug and toxin extrusion protein 1transporter
DB12377RelebactamMultidrug and toxin extrusion protein 2transporter
DB12377RelebactamBeta-lactamase TEMtarget
DB12377RelebactamBeta-lactamase SHV-1target
DB12377RelebactamBeta-lactamase CTX-Mtarget
DB12377RelebactamBeta-lactamase (KPC-2)target
DB12377RelebactamBeta-lactamasetarget
DB12702Velusetrag5-hydroxytryptamine receptor 4target
DB09050CeftolozanePenicillin-binding protein 1Btarget
DB09050CeftolozanePenicillin-binding protein 3target
DB09050CeftolozanePenicillin-binding proteintarget
DB09050CeftolozanePenicillin-binding protein 1Ctarget
DB09050CeftolozanePenicillin-binding protein 2target