Hydroxybenzoates

Benzoate derivatives substituted by one or more hydroxy groups in any position on the benzene ring.
DrugDrug NameDrug Indication
DB00122CholineFor nutritional supplementation, also for treating dietary shortage or imbalance
DB00233Aminosalicylic AcidFor the treatment of tuberculosis
DB00244MesalazineFor the treatment of active ulcerative proctitis.
DB00626BacitracinFor the treatment of infants with pneumonia and empyema caused by staphylococci shown to be susceptible to the drug. Also used in ointment form for topical treatment of a variety of localized skin and eye infections, as well as for the prevention of wound infections. Used against gram positive bacteria. Bacitracin is also used as an inhibitor of proteases and other enzymes. However, specific activity of bactracin's inhibition of protein disulfide isomerase has been called into question.
DB00807ProparacaineUsed as a local (ophthalmic) anesthetic.
DB00861DiflunisalFor symptomatic treatment of mild to moderate pain accompanied by inflammation (e.g. musculoskeletal trauma, post-dental extraction, post-episiotomy), osteoarthritis, and rheumatoid arthritis.
DB00936Salicylic acidKey additive in many skin-care products for the treatment of acne, psoriasis, callouses, corns, keratosis pilaris and warts.
DB00945Acetylsalicylic acidFor use in the temporary relief of various forms of pain, inflammation associated with various conditions (including rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, and ankylosing spondylitis), and is also used to reduce the risk of death and/or nonfatal myocardial infarction in patients with a previous infarction or unstable angina pectoris.
DB01014BalsalazideFor the treatment of mildly to moderately active ulcerative colitis.
DB01233MetoclopramideFor the treatment of gastroesophageal reflux disease (GERD). It is also used in treating nausea and vomiting, and to increase gastric emptying.
DB01250OlsalazineFor the treatment of Inflammatory Bowel Disease and Ulcerative Colitis.
DB01294Bismuth SubsalicylateUsed to treat nausea, heartburn, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract.
DB01397Magnesium salicylateMagnesium salicylate is a common analgesic and non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate muscular pain
DB01399SalsalateFor relief of the signs and symptoms of rheumatoid arthritis, osteoarthritis and related rheumatic disorders.
DB01401Choline magnesium trisalicylateCholine magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults.
DB02795P-Anisic AcidNot Available
DB036443-Hydroxyanthranilic AcidNot Available
DB06251DersalazineInvestigated for use/treatment in inflammatory bowel disease.
DB08814TriflusalTriflusal is indicated as prophylaxis of thromboembolic disorders.[L1185] It has been registered in Spain and in other countries of Europe, South America and South Korea for the prevention of Stroke and myocardial infarction.[T93]
DB09018BromoprideBromopride in indicated in the treatment of nausea and vomiting, including PONV (post-operative nausea and vomiting), gastroesophageal reflux disease (GERD/GORD), as well as endoscopy preparation and radiographic studies of the GI tract.
DB09089TrimebutineIndicated for symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery.
DB09342PropoxycaineNot Available
DB09543Methyl salicylateOintments or liniments containing methyl salicylate are applied topically as counter irritant for relief of acute pain associated with lumbago,sciatica and rheumatic conditions. Local analgesics for human and veterinary medicine.
DB11062OctisalateIngredient in sunscreens for protection against damage effects of sun light, provides protection from sunburns, aging and skin cancer.
DB11064HomosalateAs ingredient in many sunscreen for protection against sunburn, skin aging and skin cancer.
DB11071Phenyl salicylateNot Available
DB11079Trolamine salicylateNot Available
DB11323Glycol salicylateNot Available
DB12445NitroaspirinNot Available
DB12450Propyl GallateNot Available
DB12681SalirasibNot Available
DB13509AloxiprinNot Available
DB13612Carbaspirin calciumNot Available
DB13864Hemoglobin crosfumarilNot Available
DB13909Bismuth SubgallateBismuth subgallate is indicated for the treatment of malodorous flatulence.
DrugDrug NameTargetType
DB00122CholineCholine-phosphate cytidylyltransferase Btarget
DB00122CholineAcetylcholinesterasetarget
DB00122CholineCholine-phosphate cytidylyltransferase Atarget
DB00122CholinePhospholipase D2target
DB00122CholineCholinesterasetarget
DB00122CholinePhospholipase D1target
DB00122CholinePhosphoethanolamine/phosphocholine phosphatasetarget
DB00122CholineSolute carrier family 22 member 2transporter
DB00122CholineSolute carrier family 22 member 1transporter
DB00122CholineSolute carrier family 22 member 3transporter
DB00122CholineSolute carrier family 22 member 5transporter
DB00122CholineSolute carrier family 22 member 4transporter
DB00122CholineCholine/ethanolaminephosphotransferase 1enzyme
DB00122CholineCholine transporter-like protein 1transporter
DB00122CholineCholine transporter-like protein 4transporter
DB00122CholineCholine transporter-like protein 2transporter
DB00122CholineCholine transporter-like protein 3transporter
DB00122CholineCholine/ethanolamine kinaseenzyme
DB00122CholineCholine O-acetyltransferaseenzyme
DB00122CholineCholine kinase alphaenzyme
DB00122CholineCholine dehydrogenase, mitochondrialenzyme
DB00122CholineHigh affinity choline transporter 1transporter
DB00122CholineNeuronal acetylcholine receptor subunit alpha-7target
DB00233Aminosalicylic Acid2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinasetarget
DB00233Aminosalicylic AcidGroup IIE secretory phospholipase A2target
DB00233Aminosalicylic AcidProstaglandin G/H synthase 2target
DB00233Aminosalicylic AcidArachidonate 5-lipoxygenasetarget
DB00233Aminosalicylic AcidInhibitor of nuclear factor kappa-B kinase subunit alphatarget
DB00233Aminosalicylic AcidMyeloperoxidaseenzyme
DB00244MesalazineProstaglandin G/H synthase 1target
DB00244MesalazineProstaglandin G/H synthase 2target
DB00244MesalazinePeroxisome proliferator-activated receptor gammatarget
DB00244MesalazineInhibitor of nuclear factor kappa-B kinase subunit alphatarget
DB00244MesalazineInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00244MesalazineArachidonate 5-lipoxygenasetarget
DB00244MesalazineMyeloperoxidasetarget
DB00244MesalazineArylamine N-acetyltransferasetarget
DB00626BacitracinAlpha-2-macroglobulintarget
DB00626BacitracinInsulin-degrading enzymetarget
DB00626BacitracinC55-isoprenyl pyrophosphatetarget
DB00807ProparacaineSodium channel protein type 10 subunit alphatarget
DB00861DiflunisalProstaglandin G/H synthase 1target
DB00861DiflunisalProstaglandin G/H synthase 2target
DB00861DiflunisalTransthyretincarrier
DB00861DiflunisalSerum albumincarrier
DB00861DiflunisalSolute carrier family 22 member 6transporter
DB00861DiflunisalUDP-glucuronosyltransferase 1-8enzyme
DB00936Salicylic acidSerum albumincarrier
DB00936Salicylic acidProstaglandin G/H synthase 1target
DB00936Salicylic acidProstaglandin G/H synthase 2target
DB00936Salicylic acidAldo-keto reductase family 1 member C1target
DB00936Salicylic acidSolute carrier family 22 member 6transporter
DB00936Salicylic acidSolute carrier family 22 member 10transporter
DB00936Salicylic acidSolute carrier family 22 member 8transporter
DB00936Salicylic acidSolute carrier family 22 member 11transporter
DB00936Salicylic acidSolute carrier organic anion transporter family member 2B1transporter
DB00936Salicylic acidMultidrug resistance protein 1transporter
DB00936Salicylic acidMonocarboxylate transporter 1transporter
DB00936Salicylic acidSolute carrier family 22 member 7transporter
DB00936Salicylic acidCytochrome P450 2C9enzyme
DB00945Acetylsalicylic acidProstaglandin G/H synthase 1target
DB00945Acetylsalicylic acidProstaglandin G/H synthase 2target
DB00945Acetylsalicylic acidSerum albumincarrier
DB00945Acetylsalicylic acidAldo-keto reductase family 1 member C1target
DB00945Acetylsalicylic acidSolute carrier family 22 member 6transporter
DB00945Acetylsalicylic acidMultidrug resistance protein 1transporter
DB00945Acetylsalicylic acidSolute carrier family 22 member 7transporter
DB00945Acetylsalicylic acidCytochrome P450 2C19enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C8enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C9enzyme
DB00945Acetylsalicylic acid5'-AMP-activated protein kinasetarget
DB00945Acetylsalicylic acidEndothelin-1 receptortarget
DB00945Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00945Acetylsalicylic acidCellular tumor antigen p53target
DB00945Acetylsalicylic acid78 kDa glucose-regulated proteintarget
DB00945Acetylsalicylic acidRibosomal protein S6 kinase alpha-3target
DB00945Acetylsalicylic acidNF-kappa-B inhibitor alphatarget
DB00945Acetylsalicylic acidNuclear factor NF-kappa-Btarget
DB01014BalsalazideProstaglandin G/H synthase 1target
DB01014BalsalazideProstaglandin G/H synthase 2target
DB01014BalsalazideArachidonate 5-lipoxygenasetarget
DB01014BalsalazidePeroxisome proliferator-activated receptor gammatarget
DB01014BalsalazideNADPH azoreductaseenzyme
DB01233MetoclopramideMuscarinic acetylcholine receptor M1target
DB01233MetoclopramideD(2) dopamine receptortarget
DB01233MetoclopramideCytochrome P450 2D6enzyme
DB01233Metoclopramide5-hydroxytryptamine receptor 4target
DB01233MetoclopramideCytochrome P450 11B1, mitochondrialenzyme
DB01233MetoclopramideCytochrome P450 11B2, mitochondrialenzyme
DB01233MetoclopramideSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DB01233Metoclopramide5-hydroxytryptamine receptor 3Atarget
DB01233MetoclopramideAcetylcholinesterasetarget
DB01250OlsalazineInterferon gammatarget
DB01250OlsalazineThiopurine S-methyltransferasetarget
DB01294Bismuth SubsalicylateSerum albumincarrier
DB01294Bismuth SubsalicylateSerotransferrincarrier
DB01397Magnesium salicylateSerum albumincarrier
DB01397Magnesium salicylateProstaglandin G/H synthase 1target
DB01397Magnesium salicylateProstaglandin G/H synthase 2target
DB01399SalsalateProstaglandin G/H synthase 1target
DB01399SalsalateProstaglandin G/H synthase 2target
DB01401Choline magnesium trisalicylateProstaglandin G/H synthase 1target
DB01401Choline magnesium trisalicylateProstaglandin G/H synthase 2target
DB02795P-Anisic AcidGroup IIE secretory phospholipase A2target
DB02795P-Anisic AcidPhospholipase A2target
DB036443-Hydroxyanthranilic AcidTrans-2,3-dihydro-3-hydroxyanthranilate isomerasetarget
DB08814TriflusalProstaglandin G/H synthase 1target
DB08814TriflusalNuclear factor NF-kappa-B p105 subunittarget
DB08814TriflusalNitric oxide synthase, inducibletarget
DB08814TriflusalcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Atarget
DB08814TriflusalSerum albumincarrier
DB09018BromoprideD(2) dopamine receptortarget
DB09089TrimebutineMu-type opioid receptortarget
DB09089TrimebutineVoltage dependent L type calcium channeltarget
DB09089TrimebutineCalcium-activated potassium channeltarget
DB09089TrimebutineVoltage-dependent T-type calcium channeltarget
DB11064HomosalateProgesterone receptortarget
DB11064HomosalateAndrogen receptortarget
DB11064HomosalateEstrogen receptor alphatarget
DB11071Phenyl salicylateEstrogen receptor alphatarget
DB12445NitroaspirinProstaglandin G/H synthase 1target
DB12450Propyl GallateEstrogen receptor alphatarget