|DB00126||Ascorbic acid||Used to treat vitamin C deficiency, scurvy, delayed wound and bone healing, urine acidification, and in general as an antioxidant. It has also been suggested to be an effective antiviral agent.|
|DB00209||Trospium||For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency, detrusor instability and frequency of micturition.|
|DB00233||Aminosalicylic Acid||For the treatment of tuberculosis|
|DB00326||Calcium glucoheptonate||For treatment of mild hypocalcemia due to neonatal tetany, tetany due to parathyroid deficiency or vitamin D deficiency, and alkalosis, as prophylaxis of hypocalcemia during exchange transfusions, in the treatment of intestinal malabsorption, and to replenish electrolytes.|
|DB00551||Acetohydroxamic acid||Used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.|
|DB00558||Zanamivir||For the prevention and treatment of influenza A and B.|
|DB00626||Bacitracin||For the treatment of infants with pneumonia and empyema caused by staphylococci shown to be susceptible to the drug. Also used in ointment form for topical treatment of a variety of localized skin and eye infections, as well as for the prevention of wound infections. Used against gram positive bacteria. Bacitracin is also used as an inhibitor of proteases and other enzymes.
However, specific activity of bactracin's inhibition of protein disulfide isomerase has been called into question. |
|DB00746||Deferoxamine||Used to treat acute iron or aluminum toxicity (an excess of aluminum in the body) in certain patients. Also used in certain patients with anemia who must receive many blood transfusions.|
|DB00771||Clidinium||For the treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome.|
|DB00786||Marimastat||For the treatment of various cancers|
|DB00807||Proparacaine||Used as a local (ophthalmic) anesthetic.|
|DB00861||Diflunisal||For symptomatic treatment of mild to moderate pain accompanied by inflammation (e.g. musculoskeletal trauma, post-dental extraction, post-episiotomy), osteoarthritis, and rheumatoid arthritis.|
|DB00903||Etacrynic acid||For the treatment of high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure.|
|DB00936||Salicylic acid||Key additive in many skin-care products for the treatment of acne, psoriasis, callouses, corns, keratosis pilaris and warts.|
|DB00945||Acetylsalicylic acid||**Pain, fever, and inflammation**
Acetylsalicylic acid (ASA), in the regular tablet form (immediate-release), is indicated to relieve pain, fever, and inflammation associated with many conditions, including the flu, the common cold, neck and back pain, dysmenorrhea, headache, tooth pain, sprains, fractures, myositis, neuralgia, synovitis, arthritis, bursitis, burns, and various injuries. It is also used for symptomatic pain relief after surgical and dental procedures [FDA label].
The _extra strength_ formulation of acetylsalicylic acid is also indicated for the management migraine pain with photophobia (sensitivity to light) and phonophobia (sensitivity to sound)[FDA label].
ASA is also indicated for various other purposes, due to its ability to inhibit platelet aggregation. These include:
Reducing the risk of cardiovascular death in suspected cases of myocardial infarction (MI) [FDA label].
Reducing the risk of a first non-fatal myocardial infarction in patients, and for reducing the risk of morbidity and mortality in cases of unstable angina and in those who have had a prior myocardial infarction [FDA label].
For reducing the risk of transient ischemic attacks (TIA) and to prevent atherothrombotic cerebral infarction (in conjunction with other treatments) [FDA label].
For the prevention of thromboembolism after hip replacement surgery [FDA label].
For decreasing platelet to platelet adhesion following carotid endarterectomy, aiding in the prevention of transient ischemic attacks (TIA) [FDA label].
Used for patients undergoing hemodialysis with a silicone rubber arteriovenous cannula inserted to prevent thrombosis at the insertion site [FDA Label].
**Important note regarding use of the extended-release formulation [F4405]**
In the setting of acute myocardial infarction, or before percutaneous interventions, the extended-release form of acetylsalicylic acid should not be used. Use immediate-release formulations in scenarios requiring rapid onset of action [Label, F4405]. The extended-release form is taken to decrease the incidence of mortality and myocardial infarction (MI) for individuals diagnosed with chronic coronary artery disease (CAD), including patients with previous myocardial infarction (MI) or unstable angina or with chronic stable angina. Additionally, the extended-release form is used to decrease the risk of death and recurrent episodes of stroke in patients with a history of stroke or TIA [F4405].
|DB01014||Balsalazide||For the treatment of mildly to moderately active ulcerative colitis.|
|DB01062||Oxybutynin||For the treatment of overactive bladder.|
|DB01129||Rabeprazole||For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.|
|DB01157||Trimetrexate||For use, with concurrent leucovorin administration (leucovorin protection), as an alternative therapy for the treatment of moderate-to-severe Pneumocystis carinii pneumonia (PCP) in immunocompromised patients, including patients with the acquired immunodeficiency syndrome (AIDS). Also used to treat several types of cancer including colon cancer.|
|DB01233||Metoclopramide||For the treatment of gastroesophageal reflux disease (GERD). It is also used in treating nausea and vomiting, and to increase gastric emptying.|
|DB01250||Olsalazine||For the treatment of Inflammatory Bowel Disease and Ulcerative Colitis.|
|DB01294||Bismuth subsalicylate||Used to treat nausea, heartburn, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract.|
|DB01397||Magnesium salicylate||Magnesium salicylate is a common analgesic and non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate muscular pain|
|DB01399||Salsalate||For relief of the signs and symptoms of rheumatoid arthritis, osteoarthritis and related rheumatic disorders.|
|DB01401||Choline magnesium trisalicylate||Choline magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults.|
|DB01440||gamma-Hydroxybutyric acid||Used as a general anesthetic, to treat conditions such as insomnia, clinical depression, narcolepsy, and alcoholism, and to improve athletic performance. |
|DB01924||Benzhydroxamic Acid||Not Available|
|DB02076||6-phospho-D-gluconic acid||Not Available|
|DB02279||Benzoylformic Acid||Not Available|
|DB02546||Vorinostat||For the treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma who have progressive, persistent or recurrent disease on or following two systemic therapies.|
|DB02795||P-Anisic Acid||Not Available|
|DB02839||2,4-Dihydroxybenzoic Acid||Not Available|
|DB03066||D-Lactic acid||Not Available|
|DB03085||Glycolic acid||Not Available|
|DB03548||3-deoxy-α-D-manno-oct-2-ulopyranosonic acid||Not Available|
|DB03644||3-hydroxyanthranilic acid||Not Available|
|DB03868||3-Dehydroquinic Acid||Not Available|
|DB03946||3,4-Dihydroxybenzoic Acid||Not Available|
|DB04398||Lactic Acid||For use as an alkalinizing agent.|
|DB04496||4-Phospho-D-Erythronohydroxamic Acid||Not Available|
|DB04831||Tienilic acid||For the treatment of hypertension.|
|DB04838||Cyclandelate||Used in the treatment of various blood vessel diseases (e.g., claudication, arteriosclerosis and Raynaud's disease) and nighttime leg cramps.|
|DB04843||Mepenzolate||For use as adjunctive therapy in the treatment of peptic ulcer. It has not been
shown to be effective in contributing to the healing of peptic ulcer, decreasing the rate of recurrence, or preventing complications.
|DB05015||Belinostat||Belinostat is indicated for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma (PTCL) with manageable safety profile. It is a potential alternative therapy for patients who did not experience adequate response to first-line drugs for PTCL. It can be used in patients with baseline thrombocytopenia [A19161]. |
|DB05630||Sodium stibogluconate||For the treatment of various types of a protozoal infection called leishmaniasis, which may result from sandfly bites in tropical and temperate parts of the world. Also investigated for use/treatment in cancer/tumors (unspecified) and solid tumors.|
|DB06251||Dersalazine||Investigated for use/treatment in inflammatory bowel disease.|
|DB06603||Panobinostat||Panobinostat is indicated in the treatment of multiple myeloma in combination with dexamethasone and bortezomib in patients who have received 2 previous treatment regimens including bortezomib and an immunomodulatory agent. This indication is approved by accelerated approval based on progression free survival as of February 23, 2015. |
|DB06799||Methenamine||For prophylactic or suppressive treatment of frequently recurring urinary tract infections when long-term therapy is considered necessary. This drug is not used to treat infection and should only be used after appropriate eradication of infection with antimicrobial agents.|
|DB06807||Phenyl aminosalicylate||Not Available|
|DB08814||Triflusal||Triflusal is indicated as prophylaxis of thromboembolic disorders.[L1185] It has been registered in Spain and in other countries of Europe, South America and South Korea for the prevention of Stroke and myocardial infarction.[T93]|
|DB08830||Dehydroascorbic acid||There is no approved indication for dehydroascorbic acid, but it has potential therapeutic use in patients with certain viruses and ischemic stroke.|
|DB08880||Teriflunomide||Used in the treatment of relapsing forms of multiple sclerosis (MS).|
|DB08925||Adrafinil||Used to relieve excessive sleepiness and inattention in elderly patients.|
|DB09018||Bromopride||Bromopride in indicated in the treatment of nausea and vomiting, including PONV (post-operative nausea and vomiting), gastroesophageal reflux disease (GERD/GORD), as well as endoscopy preparation and radiographic studies of the GI tract. |
|DB09072||Sodium oxybate||For the treatment of cataplexy in narcolepsy and excessive daytime sleepiness (EDS) in narcolepsy.|
|DB09089||Trimebutine||Indicated for symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery. |
|DB09146||Iron saccharate||Iron sucrose is elemental iron as an injection. It replenishes body iron stores in patients with iron deficiency.|
|DB09247||Iproclozide||For the treatment of depression.|
|DB09276||Sodium aurothiomalate||As anti-inflammatory agent for the treatment of arthritis. Disease-modifying antirheumatic drug, DMARD.|
|DB09342||Propoxycaine||Propoxycaine is a local anesthetic medication. It was used beginning in the 1950s during dental procedures [L1591]. It has been combined with procaine to accelerate its onset of action and provide longer-lasting anesthetic effect [L1592].
It was produced for use when amide local anesthetics were contraindicated due to allergy or when several amide anesthetics were unsuccessful [L1592].|
|DB09459||L-tartaric acid||Tartaric Acid is primarily indicated in conditions like Antiscorbutic, Antiseptic.|
|DB09543||Methyl salicylate||Ointments or liniments containing methyl salicylate are applied topically as counter irritant for relief of acute pain associated with lumbago,sciatica and rheumatic conditions. Local analgesics for human and veterinary medicine.|
|DB11062||Octisalate||Ingredient in sunscreens for protection against damage effects of sun light, provides protection from sunburns, aging and skin cancer. |
|DB11064||Homosalate||As ingredient in many sunscreen for protection against sunburn, skin aging and skin cancer. |
|DB11071||Phenyl salicylate||Pain and fever [L2468].|
|DB11079||Trolamine salicylate||Indicated for the temporary relief of aches, and pains of muscles and joints associated with backache, lumbago, strains, bruises, sprains and arthritic or rheumatic pain, pain of tendons and ligaments [L1791].|
|DB11126||Calcium gluconate||Oral calcium salts are used as dietary supplemental therapy for person who may not get enough calcium in their regular diet. Calcium gluconate is used as a cardioprotective agent in high blood potassium. Calcium gluconate is the antidote for magnesium sulfate toxicity.|
|DB11141||Manganese gluconate||Manganese gluconate is currently only available in combination products. It is indicated for the prophylactic or nutritional supplementation of [DB06757] [FDA Label].|
|DB11246||Copper gluconate||Not Available|
|DB11248||Zinc gluconate||Zinc gluconate is mainly indicated in conditions like zinc deficiency, and can also be administered in adjunctive therapy as an alternative drug of choice in diarrhea [L2088].|
|DB11323||Glycol salicylate||This drug is only recommended for topical usages for the relief of muscular and rheumatic pain in human and animals [L2687].|
|DB11324||Nonivamide|| Nonivamide is used as a topical analgesic and is also used as a flavoring ingredient [L2641], [A32884], [L2642]. |
|DB11335||Ascorbyl glucoside||Not Available|
|DB11888||Laninamivir octanoate||Not Available|
|DB12278||Propiverine||Indicated for symptomatic treatment of urinary incontinence and/or increased urinary frequency and urgency in patients with overactive bladder (OAB) [L2315]. Propiverine may also be used in patients with neurogenic bladder as a result of spinal cord injury [A32581].|
|DB12450||Propyl Gallate||Not Available|
|DB12751||Malic Acid||Not Available|
|DB13180||Gluconic Acid||For use as part of electrolyte supplementation in total parenteral nutrition [FDA Label].|
|DB13231||Calcium lactate||Indicated for use as the nutritional supplement. |
|DB13346||Bufexamac||Indicated for the treatment of various skin conditions, such as atopic eczema and other inflammatory dermatoses. |
|DB13372||Calcium alginate||Not Available|
|DB13518||Alginic acid||Indicated for the management of gastric reflux, reflux oesophagitis, hiatus hernia, heartburn (including heartburn of pregnancy) and similar gastric distress [F46].|
|DB13612||Carbaspirin calcium||Not Available|
|DB13615||Mifamurtide||Indicated in children, adolescents and young adults for the treatment of high-grade, resectable, non-metastatic osteosarcoma after macroscopically complete surgical resection, typically in combination with post-operative multi-agent chemotherapy [L1203].|
|DB13628||Ethyl hydroxybenzoate||Not Available|
|DB13707||Sodium tartrate|| It acts as an emulsifier and pH control agent in food products [L2590], [L2598].
In the laboratory, it is used while performing the Karl Fischer equation, which is used to determine the water content of various substances [F18], [L2590].|
|DB13749||Magnesium gluconate||Magnesium gluconate is a mineral supplement which is used to prevent and treat low levels of magnesium. Magnesium is very important for the normal physiologic functioning of cells, nerves, muscles, bones, and the heart. Generally, a well-balanced diet provides the necessary amounts of magnesium for homeostasis. However, certain conditions causing chronic magnesium deficiency may decrease levels of magnesium. These conditions include treatment with diuretics, a poor diet, alcoholism, or other medical conditions (e.g., severe diarrhea/vomiting, stomach/intestinal absorption problems, poorly controlled diabetes) [L2600].|
|DB13864||Hemoglobin crosfumaril||Not Available|
|DB13909||Bismuth subgallate||The most common medical purpose for which bismuth subgallate is currently and formally indicated for is the use as a non-prescription internal deodorant product for the purpose of deodorizing flatulence and stools [L2309, L2312, A32566].
Additionally, there are also various non-prescription (over the counter) bismuth subgallate based wound healing products as well as ongoing studies into whether or not the substance can be utilized as a legitimate hemostatic agent - usually for soft tissue surgery in otorhinolaryngology and/or dermatologic settings [A32567, A32568, A32569, A32570].
Moreover, in the past bismuth subgallate may have seen some use as a treatment for Helicobacter pylori infection [A32571]. In contrast, contemporary first-line therapies generally involve proton pump inhibitor and antibiotic combination therapies that generally achieve high rates of pathogen eradication, ease of administration, and patient compliance.|
|DB13962||Calcium saccharate||Not Available|
|DB14006||Choline salicylate||The oral gel is indicated for the relief of pain and discomfort of common mouth ulcers, cold sores, denture sore spots, infant teething and mouth ulcers, and sore spots due to orthodontic devices in children [L2135].
|DB14026||Thiosalicylic acid||Not Available|
|DB14176||Benzylparaben||Benzylparaben is used in allergenic testing.|
|DB14177||Propylparaben||Propylparaben is used in allergenic testing.|
|DB14475||L-Lactic acid||Not Available|
|DB14482||Sodium ascorbate||Not Available|
|DB14483||Calcium ascorbate||Not Available|
|DB14484||Magnesium ascorbate||Not Available|
|DB14490||Ferrous ascorbate||Used in preventing and treating iron-deficiency anemia.|
|DB02130||Vanillic acid||Not Available|
|DB03108||4-phospho-D-erythronic acid||Not Available|
|DB03303||3-deoxy-D-arabino-hexonic acid||Not Available|
|DB03518||Mevalonic acid||Not Available|
|DB03603||Glucaric acid||Not Available|
|DB04510||3-phospho-D-glyceric acid||Not Available|
|DB06768||Ammonium lactate||For the treatment of dry, scaly skin (xerosis) and ichthyosis vulgaris and for temporary relief of itching associated with these conditions.|
|DB06461||Squalamine||Investigated for use/treatment in ovarian cancer, lung cancer, and macular degeneration.|
|DB02446||Glutamine hydroxamate||Not Available|