Hydroxy Acids

Organic compounds containing both the hydroxyl and carboxyl radicals.
DrugDrug NameDrug Indication
DB00126Ascorbic acidUsed to treat vitamin C deficiency, scurvy, delayed wound and bone healing, urine acidification, and in general as an antioxidant. It has also been suggested to be an effective antiviral agent.
DB00209TrospiumFor the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency, detrusor instability and frequency of micturition.
DB00233Aminosalicylic AcidFor the treatment of tuberculosis
DB00326Calcium glucoheptonateFor treatment of mild hypocalcemia due to neonatal tetany, tetany due to parathyroid deficiency or vitamin D deficiency, and alkalosis, as prophylaxis of hypocalcemia during exchange transfusions, in the treatment of intestinal malabsorption, and to replenish electrolytes.
DB00551Acetohydroxamic acidUsed, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.
DB00558ZanamivirFor the prevention and treatment of influenza A and B.
DB00626BacitracinFor the treatment of infants with pneumonia and empyema caused by staphylococci shown to be susceptible to the drug. Also used in ointment form for topical treatment of a variety of localized skin and eye infections, as well as for the prevention of wound infections. Used against gram positive bacteria. Bacitracin is also used as an inhibitor of proteases and other enzymes. However, specific activity of bactracin's inhibition of protein disulfide isomerase has been called into question.
DB00746DeferoxamineUsed to treat acute iron or aluminum toxicity (an excess of aluminum in the body) in certain patients. Also used in certain patients with anemia who must receive many blood transfusions.
DB00771ClidiniumFor the treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome.
DB00786MarimastatFor the treatment of various cancers
DB00807ProparacaineUsed as a local (ophthalmic) anesthetic.
DB00861DiflunisalFor symptomatic treatment of mild to moderate pain accompanied by inflammation (e.g. musculoskeletal trauma, post-dental extraction, post-episiotomy), osteoarthritis, and rheumatoid arthritis.
DB00903Etacrynic acidFor the treatment of high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure.
DB00936Salicylic acidKey additive in many skin-care products for the treatment of acne, psoriasis, callouses, corns, keratosis pilaris and warts.
DB00945Acetylsalicylic acid**Pain, fever, and inflammation** Acetylsalicylic acid (ASA), in the regular tablet form (immediate-release), is indicated to relieve pain, fever, and inflammation associated with many conditions, including the flu, the common cold, neck and back pain, dysmenorrhea, headache, tooth pain, sprains, fractures, myositis, neuralgia, synovitis, arthritis, bursitis, burns, and various injuries. It is also used for symptomatic pain relief after surgical and dental procedures [FDA label]. The _extra strength_ formulation of acetylsalicylic acid is also indicated for the management migraine pain with photophobia (sensitivity to light) and phonophobia (sensitivity to sound)[FDA label]. **Other indications** ASA is also indicated for various other purposes, due to its ability to inhibit platelet aggregation. These include: Reducing the risk of cardiovascular death in suspected cases of myocardial infarction (MI) [FDA label]. Reducing the risk of a first non-fatal myocardial infarction in patients, and for reducing the risk of morbidity and mortality in cases of unstable angina and in those who have had a prior myocardial infarction [FDA label]. For reducing the risk of transient ischemic attacks (TIA) and to prevent atherothrombotic cerebral infarction (in conjunction with other treatments) [FDA label]. For the prevention of thromboembolism after hip replacement surgery [FDA label]. For decreasing platelet to platelet adhesion following carotid endarterectomy, aiding in the prevention of transient ischemic attacks (TIA) [FDA label]. Used for patients undergoing hemodialysis with a silicone rubber arteriovenous cannula inserted to prevent thrombosis at the insertion site [FDA Label]. **Important note regarding use of the extended-release formulation [F4405]** In the setting of acute myocardial infarction, or before percutaneous interventions, the extended-release form of acetylsalicylic acid should not be used. Use immediate-release formulations in scenarios requiring rapid onset of action [Label, F4405]. The extended-release form is taken to decrease the incidence of mortality and myocardial infarction (MI) for individuals diagnosed with chronic coronary artery disease (CAD), including patients with previous myocardial infarction (MI) or unstable angina or with chronic stable angina. Additionally, the extended-release form is used to decrease the risk of death and recurrent episodes of stroke in patients with a history of stroke or TIA [F4405].
DB01014BalsalazideFor the treatment of mildly to moderately active ulcerative colitis.
DB01062OxybutyninFor the treatment of overactive bladder.
DB01129RabeprazoleFor the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.
DB01157TrimetrexateFor use, with concurrent leucovorin administration (leucovorin protection), as an alternative therapy for the treatment of moderate-to-severe Pneumocystis carinii pneumonia (PCP) in immunocompromised patients, including patients with the acquired immunodeficiency syndrome (AIDS). Also used to treat several types of cancer including colon cancer.
DB01233MetoclopramideFor the treatment of gastroesophageal reflux disease (GERD). It is also used in treating nausea and vomiting, and to increase gastric emptying.
DB01250OlsalazineFor the treatment of Inflammatory Bowel Disease and Ulcerative Colitis.
DB01294Bismuth subsalicylateUsed to treat nausea, heartburn, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract.
DB01397Magnesium salicylateMagnesium salicylate is a common analgesic and non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate muscular pain
DB01399SalsalateFor relief of the signs and symptoms of rheumatoid arthritis, osteoarthritis and related rheumatic disorders.
DB01401Choline magnesium trisalicylateCholine magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults.
DB01440gamma-Hydroxybutyric acidUsed as a general anesthetic, to treat conditions such as insomnia, clinical depression, narcolepsy, and alcoholism, and to improve athletic performance.
DB01461DimenoxadolNot Available
DB01630SC-74020Not Available
DB01747CoprogenNot Available
DB01819PhosphoenolpyruvateNot Available
DB01924Benzhydroxamic AcidNot Available
DB02071WAY-151693Not Available
DB020766-phospho-D-gluconic acidNot Available
DB02279Benzoylformic AcidNot Available
DB02546VorinostatFor the treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma who have progressive, persistent or recurrent disease on or following two systemic therapies.
DB02795P-Anisic AcidNot Available
DB028392,4-Dihydroxybenzoic AcidNot Available
DB03066D-Lactic acidNot Available
DB03085Glycolic acidNot Available
DB03436GallichromeNot Available
DB034892-Keto-3-DeoxygluconateNot Available
DB035483-deoxy-α-D-manno-oct-2-ulopyranosonic acidNot Available
DB036443-hydroxyanthranilic acidNot Available
DB03734XylarohydroxamateNot Available
DB038683-Dehydroquinic AcidNot Available
DB039463,4-Dihydroxybenzoic AcidNot Available
DB04098BalanolNot Available
DB04328Shikimate-3-PhosphateNot Available
DB043473-DehydroshikimateNot Available
DB04368Bb-3497Not Available
DB04398Lactic AcidFor use as an alkalinizing agent.
DB044964-Phospho-D-Erythronohydroxamic AcidNot Available
DB04564GluconolactoneNot Available
DB04831Tienilic acidFor the treatment of hypertension.
DB04838CyclandelateUsed in the treatment of various blood vessel diseases (e.g., claudication, arteriosclerosis and Raynaud's disease) and nighttime leg cramps.
DB04843MepenzolateFor use as adjunctive therapy in the treatment of peptic ulcer. It has not been shown to be effective in contributing to the healing of peptic ulcer, decreasing the rate of recurrence, or preventing complications.
DB05015BelinostatBelinostat is indicated for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma (PTCL) with manageable safety profile. It is a potential alternative therapy for patients who did not experience adequate response to first-line drugs for PTCL. It can be used in patients with baseline thrombocytopenia [A19161].
DB05630Sodium stibogluconateFor the treatment of various types of a protozoal infection called leishmaniasis, which may result from sandfly bites in tropical and temperate parts of the world. Also investigated for use/treatment in cancer/tumors (unspecified) and solid tumors.
DB06251DersalazineInvestigated for use/treatment in inflammatory bowel disease.
DB06603PanobinostatPanobinostat is indicated in the treatment of multiple myeloma in combination with dexamethasone and bortezomib in patients who have received 2 previous treatment regimens including bortezomib and an immunomodulatory agent. This indication is approved by accelerated approval based on progression free survival as of February 23, 2015.
DB06799MethenamineFor prophylactic or suppressive treatment of frequently recurring urinary tract infections when long-term therapy is considered necessary. This drug is not used to treat infection and should only be used after appropriate eradication of infection with antimicrobial agents.
DB06807Phenyl aminosalicylateNot Available
DB08814TriflusalTriflusal is indicated as prophylaxis of thromboembolic disorders.[L1185] It has been registered in Spain and in other countries of Europe, South America and South Korea for the prevention of Stroke and myocardial infarction.[T93]
DB08830Dehydroascorbic acidThere is no approved indication for dehydroascorbic acid, but it has potential therapeutic use in patients with certain viruses and ischemic stroke.
DB08880TeriflunomideUsed in the treatment of relapsing forms of multiple sclerosis (MS).
DB08925AdrafinilUsed to relieve excessive sleepiness and inattention in elderly patients.
DB08955IbuproxamNot Available
DB09006ClinofibrateNot Available
DB09018BromoprideBromopride in indicated in the treatment of nausea and vomiting, including PONV (post-operative nausea and vomiting), gastroesophageal reflux disease (GERD/GORD), as well as endoscopy preparation and radiographic studies of the GI tract.
DB09023BenactyzineNot Available
DB09072Sodium oxybateFor the treatment of cataplexy in narcolepsy and excessive daytime sleepiness (EDS) in narcolepsy.
DB09089TrimebutineIndicated for symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery.
DB09146Iron saccharateIron sucrose is elemental iron as an injection. It replenishes body iron stores in patients with iron deficiency.
DB09247IproclozideFor the treatment of depression.
DB09276Sodium aurothiomalateAs anti-inflammatory agent for the treatment of arthritis. Disease-modifying antirheumatic drug, DMARD.
DB09342PropoxycainePropoxycaine is a local anesthetic medication. It was used beginning in the 1950s during dental procedures [L1591]. It has been combined with procaine to accelerate its onset of action and provide longer-lasting anesthetic effect [L1592]. It was produced for use when amide local anesthetics were contraindicated due to allergy or when several amide anesthetics were unsuccessful [L1592].
DB09459L-tartaric acidTartaric Acid is primarily indicated in conditions like Antiscorbutic, Antiseptic.
DB09543Methyl salicylateOintments or liniments containing methyl salicylate are applied topically as counter irritant for relief of acute pain associated with lumbago,sciatica and rheumatic conditions. Local analgesics for human and veterinary medicine.
DB11062OctisalateIngredient in sunscreens for protection against damage effects of sun light, provides protection from sunburns, aging and skin cancer.
DB11064HomosalateAs ingredient in many sunscreen for protection against sunburn, skin aging and skin cancer.
DB11071Phenyl salicylatePain and fever [L2468].
DB11079Trolamine salicylateIndicated for the temporary relief of aches, and pains of muscles and joints associated with backache, lumbago, strains, bruises, sprains and arthritic or rheumatic pain, pain of tendons and ligaments [L1791].
DB11126Calcium gluconateOral calcium salts are used as dietary supplemental therapy for person who may not get enough calcium in their regular diet. Calcium gluconate is used as a cardioprotective agent in high blood potassium. Calcium gluconate is the antidote for magnesium sulfate toxicity.
DB11141Manganese gluconateManganese gluconate is currently only available in combination products. It is indicated for the prophylactic or nutritional supplementation of [DB06757] [FDA Label].
DB11246Copper gluconateNot Available
DB11248Zinc gluconateZinc gluconate is mainly indicated in conditions like zinc deficiency, and can also be administered in adjunctive therapy as an alternative drug of choice in diarrhea [L2088].
DB11323Glycol salicylateThis drug is only recommended for topical usages for the relief of muscular and rheumatic pain in human and animals [L2687].
DB11324Nonivamide Nonivamide is used as a topical analgesic and is also used as a flavoring ingredient [L2641], [A32884], [L2642].
DB11335Ascorbyl glucosideNot Available
DB11781TosedostatNot Available
DB11888Laninamivir octanoateNot Available
DB11912LanopepdenNot Available
DB12174CUDC-101Not Available
DB12259CG-200745Not Available
DB12278PropiverineIndicated for symptomatic treatment of urinary incontinence and/or increased urinary frequency and urgency in patients with overactive bladder (OAB) [L2315]. Propiverine may also be used in patients with neurogenic bladder as a result of spinal cord injury [A32581].
DB12376RicolinostatNot Available
DB12382R-306465Not Available
DB12392ResminostatNot Available
DB12445NitroaspirinNot Available
DB12448LifibrolNot Available
DB12450Propyl GallateNot Available
DB12565AbexinostatNot Available
DB12681SalirasibNot Available
DB12751Malic AcidNot Available
DB12791LaninamivirNot Available
DB12847PyroxamideNot Available
DB12948DidoxNot Available
DB12985QuisinostatNot Available
DB13180Gluconic AcidFor use as part of electrolyte supplementation in total parenteral nutrition [FDA Label].
DB13231Calcium lactateIndicated for use as the nutritional supplement.
DB13346BufexamacIndicated for the treatment of various skin conditions, such as atopic eczema and other inflammatory dermatoses.
DB13372Calcium alginateNot Available
DB13509AloxiprinNot Available
DB13518Alginic acidIndicated for the management of gastric reflux, reflux oesophagitis, hiatus hernia, heartburn (including heartburn of pregnancy) and similar gastric distress [F46].
DB13538GuacetisalNot Available
DB13612Carbaspirin calciumNot Available
DB13615MifamurtideIndicated in children, adolescents and young adults for the treatment of high-grade, resectable, non-metastatic osteosarcoma after macroscopically complete surgical resection, typically in combination with post-operative multi-agent chemotherapy [L1203].
DB13628Ethyl hydroxybenzoateNot Available
DB13657BenorilateNot Available
DB13707Sodium tartrate It acts as an emulsifier and pH control agent in food products [L2590], [L2598]. In the laboratory, it is used while performing the Karl Fischer equation, which is used to determine the water content of various substances [F18], [L2590].
DB13749Magnesium gluconateMagnesium gluconate is a mineral supplement which is used to prevent and treat low levels of magnesium. Magnesium is very important for the normal physiologic functioning of cells, nerves, muscles, bones, and the heart. Generally, a well-balanced diet provides the necessary amounts of magnesium for homeostasis. However, certain conditions causing chronic magnesium deficiency may decrease levels of magnesium. These conditions include treatment with diuretics, a poor diet, alcoholism, or other medical conditions (e.g., severe diarrhea/vomiting, stomach/intestinal absorption problems, poorly controlled diabetes) [L2600].
DB13864Hemoglobin crosfumarilNot Available
DB13909Bismuth subgallateThe most common medical purpose for which bismuth subgallate is currently and formally indicated for is the use as a non-prescription internal deodorant product for the purpose of deodorizing flatulence and stools [L2309, L2312, A32566]. Additionally, there are also various non-prescription (over the counter) bismuth subgallate based wound healing products as well as ongoing studies into whether or not the substance can be utilized as a legitimate hemostatic agent - usually for soft tissue surgery in otorhinolaryngology and/or dermatologic settings [A32567, A32568, A32569, A32570]. Moreover, in the past bismuth subgallate may have seen some use as a treatment for Helicobacter pylori infection [A32571]. In contrast, contemporary first-line therapies generally involve proton pump inhibitor and antibiotic combination therapies that generally achieve high rates of pathogen eradication, ease of administration, and patient compliance.
DB13962Calcium saccharateNot Available
DB14006Choline salicylateThe oral gel is indicated for the relief of pain and discomfort of common mouth ulcers, cold sores, denture sore spots, infant teething and mouth ulcers, and sore spots due to orthodontic devices in children [L2135].
DB14026Thiosalicylic acidNot Available
DB14084ButylparabenNot Available
DB14176BenzylparabenBenzylparaben is used in allergenic testing.
DB14177PropylparabenPropylparaben is used in allergenic testing.
DB14212MethylparabenNot Available
DB14475L-Lactic acidNot Available
DB14482Sodium ascorbateNot Available
DB14483Calcium ascorbateNot Available
DB14484Magnesium ascorbateNot Available
DB14490Ferrous ascorbateUsed in preventing and treating iron-deficiency anemia.
DB02130Vanillic acidNot Available
DB031084-phospho-D-erythronic acidNot Available
DB033033-deoxy-D-arabino-hexonic acidNot Available
DB03518Mevalonic acidNot Available
DB03603Glucaric acidNot Available
DB045103-phospho-D-glyceric acidNot Available
DB08490CTS-1027Not Available
DB06768Ammonium lactateFor the treatment of dry, scaly skin (xerosis) and ichthyosis vulgaris and for temporary relief of itching associated with these conditions.
DB06461SqualamineInvestigated for use/treatment in ovarian cancer, lung cancer, and macular degeneration.
DB02446Glutamine hydroxamateNot Available
DB04825PrenylamineNot Available
DrugDrug NameTargetType
DB00126Ascorbic acidProlyl 4-hydroxylase subunit alpha-1target
DB00126Ascorbic acidSolute carrier family 23 member 1target
DB00126Ascorbic acidProcollagen-lysine,2-oxoglutarate 5-dioxygenase 1target
DB00126Ascorbic acidHyaluronate lyasetarget
DB00126Ascorbic acidDNAtarget
DB00126Ascorbic acidXylose isomerasetarget
DB00126Ascorbic acidProcollagen-lysine,2-oxoglutarate 5-dioxygenase 2target
DB00126Ascorbic acidPhytanoyl-CoA dioxygenase, peroxisomaltarget
DB00126Ascorbic acidProcollagen-lysine,2-oxoglutarate 5-dioxygenase 3target
DB00126Ascorbic acidGamma-butyrobetaine dioxygenasetarget
DB00126Ascorbic acidDopamine beta-hydroxylasetarget
DB00126Ascorbic acidPeptidyl-glycine alpha-amidating monooxygenasetarget
DB00126Ascorbic acidProlyl 3-hydroxylase 1target
DB00126Ascorbic acid2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2target
DB00126Ascorbic acidAlpha-ketoglutarate-dependent dioxygenase alkB homolog 2target
DB00126Ascorbic acidProlyl 3-hydroxylase 2target
DB00126Ascorbic acidProlyl 3-hydroxylase 3target
DB00126Ascorbic acid2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1target
DB00126Ascorbic acidEgl nine homolog 2target
DB00126Ascorbic acidAlpha-ketoglutarate-dependent dioxygenase alkB homolog 3target
DB00126Ascorbic acidLysine-specific demethylase 5Dtarget
DB00126Ascorbic acidEgl nine homolog 1target
DB00126Ascorbic acidEgl nine homolog 3target
DB00126Ascorbic acidTrimethyllysine dioxygenase, mitochondrialtarget
DB00126Ascorbic acidTransmembrane prolyl 4-hydroxylasetarget
DB00126Ascorbic acidLactase-phlorizin hydrolasetarget
DB00126Ascorbic acidSolute carrier family 23 member 1transporter
DB00209TrospiumMuscarinic acetylcholine receptor M1target
DB00209TrospiumCytochrome P450 2D6enzyme
DB00233Aminosalicylic Acid2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinasetarget
DB00233Aminosalicylic AcidGroup IIE secretory phospholipase A2target
DB00233Aminosalicylic AcidProstaglandin G/H synthase 2target
DB00233Aminosalicylic AcidArachidonate 5-lipoxygenasetarget
DB00233Aminosalicylic AcidInhibitor of nuclear factor kappa-B kinase subunit alphatarget
DB00233Aminosalicylic AcidMyeloperoxidaseenzyme
DB00551Acetohydroxamic acidUrease subunit alphatarget
DB00551Acetohydroxamic acidMacrophage metalloelastasetarget
DB00626BacitracinInsulin-degrading enzymetarget
DB00626BacitracinC55-isoprenyl pyrophosphatetarget
DB00746DeferoxamineXanthine dehydrogenase/oxidaseenzyme
DB00746DeferoxamineAmyloid beta A4 proteintarget
DB00771ClidiniumMuscarinic acetylcholine receptor M1target
DB00786Marimastat72 kDa type IV collagenasetarget
DB00786MarimastatMatrix metalloproteinase-9target
DB00786MarimastatInterstitial collagenasetarget
DB00786MarimastatNeutrophil collagenasetarget
DB00786MarimastatMacrophage metalloelastasetarget
DB00786MarimastatCollagenase 3target
DB00786MarimastatMatrix metalloproteinase-14target
DB00786MarimastatMatrix metalloproteinase-15target
DB00786MarimastatMatrix metalloproteinase-16target
DB00786MarimastatMatrix metalloproteinase-17target
DB00786MarimastatMatrix metalloproteinase-19target
DB00786MarimastatMatrix metalloproteinase-20target
DB00786MarimastatMatrix metalloproteinase-21target
DB00786MarimastatMatrix metalloproteinase-23target
DB00786MarimastatMatrix metalloproteinase-24target
DB00786MarimastatMatrix metalloproteinase-25target
DB00786MarimastatMatrix metalloproteinase-26target
DB00786MarimastatMatrix metalloproteinase-27target
DB00786MarimastatMatrix metalloproteinase-28target
DB00807ProparacaineSodium channel protein type 10 subunit alphatarget
DB00861DiflunisalProstaglandin G/H synthase 1target
DB00861DiflunisalProstaglandin G/H synthase 2target
DB00861DiflunisalSerum albumincarrier
DB00861DiflunisalSolute carrier family 22 member 6transporter
DB00861DiflunisalUDP-glucuronosyltransferase 1-8enzyme
DB00861DiflunisalUDP-glucuronosyltransferase 1-9enzyme
DB00903Etacrynic acidSolute carrier family 12 member 1target
DB00903Etacrynic acidSodium/potassium-transporting ATPase subunit alpha-1target
DB00903Etacrynic acidGlutathione S-transferase A2enzyme
DB00903Etacrynic acidSerum albumincarrier
DB00903Etacrynic acidSolute carrier family 22 member 6transporter
DB00903Etacrynic acidLymphoid enhancer-binding factor 1target
DB00903Etacrynic acidGlutathione S-transferase Ptarget
DB00936Salicylic acidSerum albumincarrier
DB00936Salicylic acidProstaglandin G/H synthase 1target
DB00936Salicylic acidProstaglandin G/H synthase 2target
DB00936Salicylic acidAldo-keto reductase family 1 member C1target
DB00936Salicylic acidSolute carrier family 22 member 6transporter
DB00936Salicylic acidSolute carrier family 22 member 10transporter
DB00936Salicylic acidSolute carrier family 22 member 8transporter
DB00936Salicylic acidSolute carrier family 22 member 11transporter
DB00936Salicylic acidSolute carrier organic anion transporter family member 2B1transporter
DB00936Salicylic acidMonocarboxylate transporter 1transporter
DB00936Salicylic acidSolute carrier family 22 member 7transporter
DB00936Salicylic acidCytochrome P450 2C9enzyme
DB00945Acetylsalicylic acidProstaglandin G/H synthase 1target
DB00945Acetylsalicylic acidProstaglandin G/H synthase 2target
DB00945Acetylsalicylic acidAldo-keto reductase family 1 member C1target
DB00945Acetylsalicylic acidSolute carrier family 22 member 6transporter
DB00945Acetylsalicylic acidMultidrug resistance protein 1transporter
DB00945Acetylsalicylic acidCytochrome P450 2C19enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C9enzyme
DB00945Acetylsalicylic acid5'-AMP-activated protein kinasetarget
DB00945Acetylsalicylic acidEndothelin-1 receptortarget
DB00945Acetylsalicylic acidNuclear factor kappa b beta subunittarget
DB00945Acetylsalicylic acidCellular tumor antigen p53target
DB00945Acetylsalicylic acid78 kDa glucose-regulated proteintarget
DB00945Acetylsalicylic acidRibosomal protein S6 kinase alpha-3target
DB00945Acetylsalicylic acidNF-kappa-B inhibitor alphatarget
DB00945Acetylsalicylic acidTumor necrosis factor-inducible gene 6 proteintarget
DB00945Acetylsalicylic acidCaspase-1target
DB00945Acetylsalicylic acidCaspase-3target
DB00945Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00945Acetylsalicylic acidExtracellular signal-regulated kinase (ERK)target
DB00945Acetylsalicylic acidG1/S-specific cyclin-D1target
DB00945Acetylsalicylic acidMyc proto-oncogene proteintarget
DB00945Acetylsalicylic acidProliferating cell nuclear antigentarget
DB00945Acetylsalicylic acidCyclin Atarget
DB00945Acetylsalicylic acidUDP-glucuronosyltransferase 1-6enzyme
DB00945Acetylsalicylic acidArylamine N-acetyltransferase 2enzyme
DB00945Acetylsalicylic acidSolute carrier family 22 member 8transporter
DB01014BalsalazideProstaglandin G/H synthase 1target
DB01014BalsalazideProstaglandin G/H synthase 2target
DB01014BalsalazideArachidonate 5-lipoxygenasetarget
DB01014BalsalazidePeroxisome proliferator-activated receptor gammatarget
DB01014BalsalazideNADPH azoreductaseenzyme
DB01062OxybutyninMuscarinic acetylcholine receptor M1target
DB01062OxybutyninMuscarinic acetylcholine receptor M2target
DB01062OxybutyninMuscarinic acetylcholine receptor M3target
DB01062OxybutyninCytochrome P450 3A4enzyme
DB01062OxybutyninCytochrome P450 2C8enzyme
DB01062OxybutyninCytochrome P450 2D6enzyme
DB01062OxybutyninCytochrome P450 3A5enzyme
DB01129RabeprazolePotassium-transporting ATPase alpha chain 1target
DB01129RabeprazoleCytochrome P450 3A4enzyme
DB01129RabeprazoleCytochrome P450 2C19enzyme
DB01129RabeprazoleATP-binding cassette sub-family G member 2transporter
DB01129RabeprazoleCytochrome P450 1A1enzyme
DB01129RabeprazoleCytochrome P450 1A2enzyme
DB01129RabeprazoleCytochrome P450 2C9enzyme
DB01129RabeprazoleCytochrome P450 2D6enzyme
DB01129RabeprazoleCytochrome P450 2C8enzyme
DB01157TrimetrexateDihydrofolate reductasetarget
DB01233MetoclopramideMuscarinic acetylcholine receptor M1target
DB01233MetoclopramideD(2) dopamine receptortarget
DB01233MetoclopramideCytochrome P450 2D6enzyme
DB01233Metoclopramide5-hydroxytryptamine receptor 4target
DB01233MetoclopramideCytochrome P450 11B1, mitochondrialenzyme
DB01233MetoclopramideCytochrome P450 11B2, mitochondrialenzyme
DB01233MetoclopramideSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DB01233Metoclopramide5-hydroxytryptamine receptor 3Atarget
DB01250OlsalazineInterferon gammatarget
DB01250OlsalazineThiopurine S-methyltransferasetarget
DB01294Bismuth subsalicylateSerum albumincarrier
DB01294Bismuth subsalicylateSerotransferrincarrier
DB01397Magnesium salicylateSerum albumincarrier
DB01397Magnesium salicylateProstaglandin G/H synthase 1target
DB01397Magnesium salicylateProstaglandin G/H synthase 2target
DB01399SalsalateProstaglandin G/H synthase 1target
DB01399SalsalateProstaglandin G/H synthase 2target
DB01401Choline magnesium trisalicylateProstaglandin G/H synthase 1target
DB01401Choline magnesium trisalicylateProstaglandin G/H synthase 2target
DB01440gamma-Hydroxybutyric acidMonocarboxylate transporter 2transporter
DB01440gamma-Hydroxybutyric acidMonocarboxylate transporter 1transporter
DB01440gamma-Hydroxybutyric acidMonocarboxylate transporter 4transporter
DB01440gamma-Hydroxybutyric acidGamma-hydroxybutyrate (GHB) receptortarget
DB01440gamma-Hydroxybutyric acidGamma-aminobutyric acid receptor subunit beta-1target
DB01630SC-7402072 kDa type IV collagenasetarget
DB01747CoprogenIron(3+)-hydroxamate-binding protein FhuDtarget
DB01819Phosphoenolpyruvate2-dehydro-3-deoxyphosphooctonate aldolasetarget
DB01819PhosphoenolpyruvatePhosphoenolpyruvate carboxykinase, cytosolic [GTP]target
DB01819Phosphoenolpyruvate2-dehydro-3-deoxyphosphooctonate aldolasetarget
DB01819PhosphoenolpyruvatePhospho-2-dehydro-3-deoxyheptonate aldolasetarget
DB01819PhosphoenolpyruvatePhospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitivetarget
DB01819PhosphoenolpyruvateCapsule biosynthesis proteintarget
DB01819PhosphoenolpyruvateSolute carrier organic anion transporter family member 2A1transporter
DB02071WAY-151693Collagenase 3target
DB020766-phospho-D-gluconic acid6-phosphogluconate dehydrogenase, decarboxylatingtarget
DB020766-phospho-D-gluconic acidGlucose-6-phosphate isomerasetarget
DB020766-phospho-D-gluconic acidThermoresistant gluconokinasetarget
DB02279Benzoylformic AcidHydroxyacid oxidase 1target
DB02546VorinostatHistone deacetylase 1target
DB02546VorinostatHistone deacetylase 2target
DB02546VorinostatHistone deacetylase 3target
DB02546VorinostatHistone deacetylase 6target
DB02546VorinostatHistone deacetylase 8target
DB02546VorinostatAcetoin utilization proteintarget
DB02795P-Anisic AcidGroup IIE secretory phospholipase A2target
DB02795P-Anisic AcidPhospholipase A2target
DB028392,4-Dihydroxybenzoic Acidp-hydroxybenzoate hydroxylasetarget
DB028392,4-Dihydroxybenzoic Acidp-hydroxybenzoate hydroxylasetarget
DB03066D-Lactic acid(S)-2-haloacid dehalogenasetarget
DB03066D-Lactic acidMonocarboxylate transporter 2transporter
DB03066D-Lactic acidMonocarboxylate transporter 1transporter
DB03066D-Lactic acidMonocarboxylate transporter 4transporter
DB03085Glycolic acidGlucose-6-phosphate 1-dehydrogenasetarget
DB03085Glycolic acidGlycine oxidasetarget
DB03436GallichromeIron(3+)-hydroxamate-binding protein FhuDtarget
DB034892-Keto-3-Deoxygluconate2-keto-3-deoxy-gluconate kinasetarget
DB035483-deoxy-α-D-manno-oct-2-ulopyranosonic acidFerrichrome-iron receptortarget
DB036443-hydroxyanthranilic acidTrans-2,3-dihydro-3-hydroxyanthranilate isomerasetarget
DB03734XylarohydroxamateGlucarate dehydratasetarget
DB038683-Dehydroquinic Acid3-dehydroquinate dehydratasetarget
DB04098BalanolcAMP-dependent protein kinase catalytic subunit alphatarget
DB04328Shikimate-3-Phosphate3-phosphoshikimate 1-carboxyvinyltransferasetarget
DB04328Shikimate-3-Phosphate3-phosphoshikimate 1-carboxyvinyltransferasetarget
DB043473-Dehydroshikimate3-dehydroquinate dehydratasetarget
DB043473-Dehydroshikimate3-dehydroquinate dehydratasetarget
DB04368Bb-3497Peptide deformylasetarget
DB04368Bb-3497Peptide deformylase, mitochondrialtarget
DB04398Lactic AcidBifunctional protein PutAtarget
DB04398Lactic AcidNimA-related proteintarget
DB04398Lactic AcidMonocarboxylate transporter 2transporter
DB04398Lactic AcidSolute carrier organic anion transporter family member 2B1transporter
DB04398Lactic AcidMonocarboxylate transporter 1transporter
DB04398Lactic AcidMonocarboxylate transporter 10transporter
DB04398Lactic AcidSolute carrier organic anion transporter family member 2A1transporter
DB04398Lactic AcidMonocarboxylate transporter 4transporter
DB044964-Phospho-D-Erythronohydroxamic AcidRibose-5-phosphate isomerase Btarget
DB04564GluconolactoneLactase-phlorizin hydrolasetarget
DB04831Tienilic acidCytochrome P450 2C9enzyme
DB04838CyclandelateVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB04838CyclandelateLiver carboxylesterase 1target
DB04838CyclandelateCytochrome P450 3A4enzyme
DB04843MepenzolateMuscarinic acetylcholine receptor M1target
DB04843MepenzolateMuscarinic acetylcholine receptor M3target
DB05015BelinostatHistone deacetylasetarget
DB05015BelinostatCytochrome P450 1A2enzyme
DB05015BelinostatUDP-glucuronosyltransferase 1A1enzyme
DB05015BelinostatCytochrome P450 2C8enzyme
DB05015BelinostatCytochrome P450 2C9enzyme
DB05015BelinostatMultidrug resistance protein 1transporter
DB05630Sodium stibogluconateDNA topoisomerase 1target
DB06603PanobinostatCytochrome P450 2D6enzyme
DB06603PanobinostatCytochrome P450 3A4enzyme
DB06603PanobinostatMultidrug resistance protein 1transporter
DB06603PanobinostatHistone deacetylasetarget
DB08814TriflusalProstaglandin G/H synthase 1target
DB08814TriflusalNuclear factor NF-kappa-B p105 subunittarget
DB08814TriflusalNitric oxide synthase, inducibletarget
DB08814TriflusalcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Atarget
DB08814TriflusalSerum albumincarrier
DB08830Dehydroascorbic acidSolute carrier family 2, facilitated glucose transporter member 1transporter
DB08880TeriflunomideATP-binding cassette sub-family G member 2transporter
DB08880TeriflunomideDihydroorotate dehydrogenase (quinone), mitochondrialtarget
DB08880TeriflunomideCytochrome P450 2C8enzyme
DB08880TeriflunomideSolute carrier organic anion transporter family member 1B1transporter
DB08880TeriflunomideCytochrome P450 1A2enzyme
DB09006ClinofibratePeroxisome proliferator-activated receptor alphatarget
DB09006ClinofibratePeroxisome proliferator-activated receptor gammatarget
DB09006ClinofibratePeroxisome proliferator-activated receptor deltatarget
DB09018BromoprideD(2) dopamine receptortarget
DB09072Sodium oxybateSuccinate-semialdehyde dehydrogenase, mitochondrialenzyme
DB09072Sodium oxybateHydroxyacid-oxoacid transhydrogenase, mitochondrialenzyme
DB09089TrimebutineMu-type opioid receptortarget
DB09089TrimebutineVoltage-dependent L-type calcium channeltarget
DB09089TrimebutineCalcium-activated potassium channeltarget
DB09089TrimebutineVoltage-dependent T-type calcium channeltarget
DB09089TrimebutineMuscarinic acetylcholine receptor M1target
DB09089TrimebutineMuscarinic acetylcholine receptor M2target
DB09089TrimebutineMuscarinic acetylcholine receptor M3target
DB09089TrimebutineMuscarinic acetylcholine receptor M4target
DB09089TrimebutineCytochrome P450 3A4enzyme
DB09146Iron saccharateHemoglobin subunit alphatarget
DB09146Iron saccharateSerotransferrincarrier
DB09276Sodium aurothiomalateUDP-glucuronosyltransferase 1-1enzyme
DB09342PropoxycaineVoltage gated sodium channeltarget
DB09342PropoxycaineLiver carboxylesterase 1enzyme
DB09459L-tartaric acidGalactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1enzyme
DB09459L-tartaric acidHypoxia-inducible factor 1-alpha inhibitorenzyme
DB11064HomosalateProgesterone receptortarget
DB11064HomosalateAndrogen receptortarget
DB11064HomosalateEstrogen receptor alphatarget
DB11071Phenyl salicylateProstaglandin G/H synthase 1target
DB11071Phenyl salicylateProstaglandin G/H synthase 2target
DB11079Trolamine salicylateProstaglandin G/H synthase 1target
DB11079Trolamine salicylateProstaglandin G/H synthase 2target
DB11323Glycol salicylateProstaglandin G/H synthase 1target
DB11323Glycol salicylateProstaglandin G/H synthase 2target
DB11324NonivamideTransient receptor potential cation channel subfamily V member 1target
DB11781TosedostatPuromycin-sensitive aminopeptidasetarget
DB11781TosedostatLeukotriene A-4 hydrolasetarget
DB12278PropiverineMuscarinic acetylcholine receptor M1target
DB12278PropiverineMuscarinic acetylcholine receptor M2target
DB12278PropiverineMuscarinic acetylcholine receptor M3target
DB12278PropiverineMuscarinic acetylcholine receptor M4target
DB12278PropiverineMuscarinic acetylcholine receptor M5target
DB12278PropiverineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB12278PropiverineAlpha-1A adrenergic receptortarget
DB12278PropiverineCytochrome P450 3A4enzyme
DB12278PropiverineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB12278PropiverineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB12278PropiverineCYP2B proteinenzyme
DB12445NitroaspirinProstaglandin G/H synthase 1target
DB12450Propyl GallateEstrogen receptor alphatarget
DB12565AbexinostatHistone deacetylase 1target
DB13346BufexamacProstaglandin G/H synthase 1target
DB13346BufexamacProstaglandin G/H synthase 2target
DB13346BufexamacHistone deacetylase 6target
DB13346BufexamacHistone deacetylase 10target
DB13615MifamurtideToll-like receptor 4target
DB13615MifamurtideNucleotide-binding oligomerization domain-containing protein 2target
DB13749Magnesium gluconateHexokinaseenzyme
DB13749Magnesium gluconateCreatine kinase B-typeenzyme
DB13749Magnesium gluconateTyrosine-protein kinase ABL1enzyme
DB13749Magnesium gluconateATP synthase subunit delta, mitochondrialenzyme
DB13749Magnesium gluconateAdenylate cyclase type 1enzyme
DB13749Magnesium gluconateGuanylate cyclase soluble subunit alpha-2enzyme
DB13749Magnesium gluconate6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1enzyme
DB13749Magnesium gluconatePhosphoribosylpyrophosphate synthetaseenzyme
DB13749Magnesium gluconateSodium/potassium-transporting ATPase subunit alpha-1enzyme
DB13909Bismuth subgallateSerum albumincarrier
DB14006Choline salicylateCholine-phosphate cytidylyltransferase Btarget
DB14006Choline salicylateAcetylcholinesterasetarget
DB14006Choline salicylateCholine-phosphate cytidylyltransferase Atarget
DB14006Choline salicylatePhospholipase D2target
DB14006Choline salicylateCholinesterasetarget
DB14006Choline salicylatePhospholipase D1target
DB14006Choline salicylatePhosphoethanolamine/phosphocholine phosphatasetarget
DB14006Choline salicylateSolute carrier family 22 member 2transporter
DB14006Choline salicylateSolute carrier family 22 member 1transporter
DB14006Choline salicylateSolute carrier family 22 member 3transporter
DB14006Choline salicylateSolute carrier family 22 member 5transporter
DB14006Choline salicylateSolute carrier family 22 member 4transporter
DB14006Choline salicylateCholine/ethanolaminephosphotransferase 1enzyme
DB14006Choline salicylateCholine transporter-like protein 1transporter
DB14006Choline salicylateCholine transporter-like protein 4transporter
DB14006Choline salicylateCholine transporter-like protein 2transporter
DB14006Choline salicylateCholine transporter-like protein 3transporter
DB14006Choline salicylateCholine/ethanolamine kinaseenzyme
DB14006Choline salicylateCholine O-acetyltransferaseenzyme
DB14006Choline salicylateCholine kinase alphaenzyme
DB14006Choline salicylateCholine dehydrogenase, mitochondrialenzyme
DB14006Choline salicylateHigh affinity choline transporter 1transporter
DB14006Choline salicylateNeuronal acetylcholine receptor subunit alpha-7target
DB14490Ferrous ascorbateTransferrin receptor protein 1target
DB14490Ferrous ascorbateEgl nine homolog 1target
DB14490Ferrous ascorbateHistone deacetylase 8target
DB14490Ferrous ascorbateAlpha-hemoglobin-stabilizing proteintarget
DB14490Ferrous ascorbateHemoglobin subunit alphatarget
DB14490Ferrous ascorbateFrataxin, mitochondrialtarget
DB14490Ferrous ascorbateFerritin heavy chaintarget
DB14490Ferrous ascorbateFlap endonuclease 1target
DB14490Ferrous ascorbateEndonuclease 8-like 1target
DB14490Ferrous ascorbateEndonuclease 8-like 2target
DB14490Ferrous ascorbateDNA polymerase betatarget
DB14490Ferrous ascorbateCeruloplasmintarget
DB14490Ferrous ascorbateSerotransferrintarget
DB02130Vanillic acidChorismate--pyruvate lyasetarget
DB031084-phospho-D-erythronic acidRibose-5-phosphate isomerase Btarget
DB03518Mevalonic acid3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB03603Glucaric acidGlucarate dehydratasetarget
DB045103-phospho-D-glyceric acidTriosephosphate isomerasetarget
DB045103-phospho-D-glyceric acid2,3-bisphosphoglycerate-independent phosphoglycerate mutasetarget
DB045103-phospho-D-glyceric acidPhosphoglycerate mutase 2target
DB045103-phospho-D-glyceric acidTriosephosphate isomerasetarget
DB045103-phospho-D-glyceric acidPhosphoglycerate kinase 1target
DB045103-phospho-D-glyceric acidBifunctional PGK/TIMtarget
DB08490CTS-1027Collagenase 3target
DB02446Glutamine hydroxamateGlutamine--fructose-6-phosphate aminotransferase [isomerizing]target
DB04825PrenylamineMyosin light chain kinase 2, skeletal/cardiac muscletarget
DB04825PrenylamineCytochrome P450 3A4enzyme