- Accession Number
Derivatives of BENZOIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxybenzene structure.
Drug Drug Description Aminosalicylic acid An aminosalicylate drug used to induce remission in ulcerative colitis. Diatrizoate An injected contrast agent used in radiology. Aminohippuric acid A hippuric acid derivative injection utilized in the measurement of effective renal plasma flow (ERPF) and functional capacity of the renal excretory system. Nitisinone A hydroxyphenylpyruvate dioxygenase inhibitor used as an adjunct to dietary restrictions for the treatment of hereditary tyrosinemia type 1 (HT-1), which causes intolerance to tyrosine containing foods. Sulpiride Sulpiride is indicated for the treatment of schizophrenia. Remoxipride Remoxipride is an atypical antipsychotic once used for the treatment of schizophrenia. Bentiromide Indicated as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. Cisapride A medication used to treat heartburn associated with GERD. Imatinib A tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. Bacitracin A cyclic polypeptide antibiotic used to prevent wound infections, treat pneumonia and empyema in infants, and to treat skin and eye infections. Trimethobenzamide An antiemetic used to treat postoperative nausea and vomiting and nausea associated with gastroenteritis. Furosemide A loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension. Procaine A local anesthetic used for anesthesia, peripheral nerve block, and spinal nerve block. Mefenamic acid An NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. Proparacaine A topical anesthetic used for ophthalmic practice. Diflunisal An NSAID used to treat mild to moderate pain, inflammation, osteoarthritis, and rheumatoid arthritis. Bumetanide A sulfamyl diuretic used to treat edema in congestive heart failure, hepatic and renal disease, and nephrotic syndrome. Oxybuprocaine A local anesthetic used in ophthalmology. Salicylic acid An acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. Meclofenamic acid An NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis. Balsalazide An aminosalicylate used to treat ulcerative colitis. Procainamide A medication used to treat life threatening ventricular arrhythmias. Benzocaine A topical local anesthetic used for the temporary relief of pain and itching associated with minor burns, sunburn, scrapes and insect bites or minor skin irritations. Chloroprocaine A local anesthetic agent indicated for intrathecal injection in adults for the production of subarachnoid block, or spinal anesthesia. Procarbazine An antineoplastic agent indicated for the treatment of stage III and stage IV Hodgkin's disease in combination with other chemotherapeutic agents. Moclobemide A monoamine oxidase inhibitor used in the treatment of major depressive disorder and bipolar disorder. Metoclopramide An antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying. Iodixanol A contrast agent used during coronary angiography, particularly in patients with renal dysfunction. Olsalazine An anti-inflammatory agent used in the treatment of inflammatory bowel disease and ulcerative colitis. Bismuth subsalicylate An antidiarrheal and anti-inflammatory agent used for symptomatic treatment of nausea, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract. Iohexol A contrast agent for intrathecal administration used in myelography and contrast enhancement for computerized tomography. Bezafibrate A lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder. Magnesium salicylate An NSAID analgesic used in the symptomatic relief of mild to moderate muscular pain. Salsalate A nonsteroidal anti-inflammatory agent used in the symptomatic relief of rheumatoid arthritis, osteoarthritis and related rheumatic disorders. Choline magnesium trisalicylate Choline magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults. Embutramide Not Available Metrizamide Metrizamide is used for lumbar, thoracic, cervical, and total columnar myelography to determine the presence of abnormalities in the spinal column, spinal canal, and central nervous system (CNS) as well... Roflumilast A selective phosphodiesterase 4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) associated with a history of exacerbations and chronic bronchitis. Piclamilast Piclamilast (RP-73,401), is a selective PDE4 inhibitor comparable to other PDE4 inhibitors for its anti-inflammatory effects. It has been investigated for its applications to the treatment of conditions such as... Benzhydroxamic Acid Not Available Flufenamic acid An anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically. (From Martindale, The Extra Pharmacopoeia, 30th... Aminobenzoic acid A member of the vitamin B complex. It used to be common in sunscreening agents until found to also be a sensitizer. The potassium salt is used therapeutically in fibrotic... Compound 18 Not Available P-Anisic Acid Not Available 2,4-Dihydroxybenzoic Acid Not Available 3-Methoxybenzamide Not Available Mant-Adp Not Available 4-Fluorobenzylamine Not Available 3-hydroxyanthranilic acid An oxidation product of tryptophan metabolism. It may be a free radical scavenger and a carcinogen. p-Chlorobenzoic acid Not Available Benzoic acid An antimicrobial food additive. 3,4-Dihydroxybenzoic Acid Not Available Balanol Not Available Anthranilic acid Not Available 1-(4-Amidinophenyl)-3-(4-Chlorophenyl)Urea Not Available Acedoben Not Available Niflumic acid Used in the treatment of rheumatoid arthritis. Iodipamide A contrast agent used in cholangiography and cholecystography. Renzapride For the treatment of constipation-predominant irritable bowel syndrome (IBS-C). Itopride Investigated for use/treatment in gastrointestinal diseases and disorders (miscellaneous). ADL5859 Investigated for use/treatment in pain (acute or chronic). INCB3284 Investigated for use/treatment in inflammatory disorders (unspecified). APD791 For the treatment and prophylaxis of arterial thrombosis. VX-765 Investigated for use/treatment in inflammatory disorders (unspecified) and psoriasis and psoriatic disorders. Naronapride Investigated for use/treatment in gastroesophageal reflux disease (GERD) and gastroparesis. SLx-4090 Investigated for use/treatment in hyperlipidemia. SNX-5422 Investigated for use/treatment in cancer/tumors (unspecified). Ispinesib Investigated for use/treatment in breast cancer, lung cancer, solid tumors, renal cell carcinoma, pediatric indications, ovarian cancer, and head and neck cancer. Dersalazine Investigated for use/treatment in inflammatory bowel disease. Amisulpride Investigated for use/treatment in schizophrenia and schizoaffective disorders, mania in bipolar disorder, and depression. Onalespib Investigated for use/treatment in cancer/tumors (unspecified). Tucidinostat Investigated for use/treatment in cancer/tumors (unspecified). Declopramide Investigated for use/treatment in colorectal cancer and inflammatory bowel disease. FK-960 Investigated for use/treatment in dementia, alzheimer's disease, schizophrenia and schizoaffective disorders, and memory loss. Tonabersat Investigated for use/treatment in migraine and cluster headaches. Saredutant Investigated for use/treatment in depression and anxiety disorders. Lixivaptan Investigated for use/treatment in hyponatremia and congestive heart failure. Methenamine A urinary tract antiseptic and antibacterial drug used for the prophylaxis and treatment of frequently recurring urinary tract infections requiring a long-term therapy. Phenyl aminosalicylate Not Annotated m-Hydroxyhippuric acid Not Available Tranilast For the treatment of bronchial asthma, keloid and hypertrophic scar, and allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. Platensimycin Not Available 4-(ACETYLAMINO)-3-HYDROXY-5-NITROBENZOIC ACID Not Available 4-(Dimethylamino)benzoic acid Not Available Salicylamide Salicylamide is the common name for the substance o-hydroxybenzamide, or amide of salicyl. Salicylamide is a non-prescription drug with analgesic and antipyretic properties. It has similar medicinal uses to aspirin.... Cinitapride It is indicated to treat gastrointestinal disorders associated with motility disturbances like gastroesophageal reflux disease (GERD), non-ulcer dyspepsia and delayed gastric emptying. Triflusal Triflusal is indicated as prophylaxis of thromboembolic disorders. It has been registered in Spain and in other countries of Europe, South America and South Korea for the prevention of Stroke... Iotroxic acid Iotroxic acid is a contrast medium molecule. Iopamidol A diagnostic imaging agent used for angiography throughout the cardiovascular system. Iodamide Iodamide is a contrast medium molecule that is no longer marketed in the United States. Indoramin Indoramin is a discontinued piperidine antiadrenergic drug with the trade names Baratol and Doralese. It is a selective alpha-1 adrenergic antagonist with no reflex tachycardia and direct myocardial depression action. Floctafenine An anti-inflammatory analgesic used to manage mild to moderate acute pain. Etofenamate Etofenamate is used to treat muscle and joint paint. It is a non-steroidal anti-inflammatory drug (NSAID). Etamivan Etamivan (INN) or ethamivan (USAN) is marketed under the name Analepticon. Etamvin is a respiratory stimulant drug similar to nikethamide. It is no longer used in the United States. Bromopride Bromopride in indicated in the treatment of nausea and vomiting, including PONV (post-operative nausea and vomiting), gastroesophageal reflux disease (GERD/GORD), as well as endoscopy preparation and radiographic studies of the... Tetracaine A local anaesthetic agent used to induce local analgesia in the eyes and skin during medical procedures. Trimebutine A spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery. Benzoyl peroxide An antibacterial and anti-inflammatory agent used for the symptomatic treatment of mild to moderate acne vulgaris and rosacea. Iothalamic acid A diagnostic contrast agent used in various medical imaging procedures, such as angiography, arthrography, and computed tomographic scans. Ioversol A diagnostic contrast agent used in various medical imaging procedures, such as angiography, urography, and computed tomographic scans. Ioxilan A diagnostic contrast agent used in various medical imaging procedures, such as angiography, urography, and computed tomographic scans. Iopromide An X-ray contrast agent used during various types of imaging tests such as angiography and contrast computed tomography (CT) imaging tests. Tolfenamic acid In the information for tolfenamic acid, it is stated that this drug, being an NSAID, is effective in treating the pain associated with the acute attack of migraines in adults. Morniflumate Morniflumate is indicated for the treatment of inflammatory conditions affecting the airways, ENT system, urogenital tract and bone and joint systems in adults. In Italy, morniflumate is also indicated for... Ioxaglic acid A tri-iodinated benzoate contrast agent used in various radiological procedures including angiography, phlebography, urography, computed tomography (CT), and hysterosalpingography. Procaine benzylpenicillin A local anesthetic and antibiotic combination for intramuscular injection to treat a variety of bacterial infections while reducing pain from a deep intramuscular injection. Propoxycaine Propoxycaine is a local anesthetic medication. It was used beginning in the 1950s during dental procedures . It has been combined with procaine to accelerate its onset of action and... Metrizoic acid For use as a contrast medium . Acetrizoic acid Acetrizoic acid indication was to be used as a contrast agent for X-ray. Some information indicates its nephrotropic property as one of the characteristics for the utilization of acetrizoic acid.... Iotrolan Nonionic, isotonic contrast medium designed for intrathecal use. Methyl salicylate A topical counter-irritant used for the symptomatic relief of acute musculoskeletal pain in the muscles, joints, and tendons. Octisalate Ingredient in sunscreens for protection against damage effects of sun light, provides protection from sunburns, aging and skin cancer. Homosalate As ingredient in many sunscreen for protection against sunburn, skin aging and skin cancer. Phenyl salicylate Pain and fever . Trolamine salicylate A medication used to relieve minor aches and pains of the muscles and joints. Meradimate An ingredient used in sunscreens to absorb UV radiation. Butamben Anesthesia of mucus membranes other than the eyes. Padimate A Padimate A is an ester derivative of PABA and an ingredient in some sunscreens. It absorbs ultraviolet rays thereby preventing sunburn, however, its chemical structure and behaviour is similar to... Diethyltoluamide An insect repellant, also known as DEET. Glycol salicylate A salicylate used to treat mild to moderate muscle pain. Nonivamide Nonivamide is used as a topical analgesic and is also used as a flavoring ingredient , , . Lufenuron Lufenuron is used in veterinary for the control of flea. Zoalene Dinitolmide is a fodder additive for prophylaxis against coccidiosis infections in poultry. Butacaine Not Annotated Tricaine Tricaine (as tricaine methanesulfonate) is white powder used for anesthesia, sedation, or euthanasia of fish. It is also the only anesthetic licensed in the United States for use in fin... Padimate O An ingredient used in sunscreens to absorb UV radiation. AZD-4877 AZD4877 has been used in trials studying the treatment of NHL, Tumors, Cancer, Lymphoma, and Neoplasms, among others. Mosapride Mosapride is under investigation for the treatment and prevention of Postoperative Ileus and Gastric Peroral Endoscopic Pyloromyotomy (G-POEM). Mosapride has been investigated for the treatment and diagnostic of Constipation, Type... Acalabrutinib A Bruton tyrosine kinase inhibitor used to treat mantle cell lymphoma, chronic lymphocytic leukemia, and small lymphocytic lymphoma. Iomeprol Iomeprol has been investigated for the diagnostic of Coronary Artery Disease. Navarixin Navarixin has been investigated for the treatment of Asthma. Momelotinib Momelotinib has been used in trials studying the treatment of Polycythemia Vera, Primary Myelofibrosis, Post-Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofibrosis (PMF), among others. Danusertib Danusertib has been used in trials studying the treatment of Leukemia. Danegaptide Danegaptide has been investigated for the treatment of Focus of Study is STEMI. Mocetinostat Mocetinostat has been used in trials studying the treatment of Lymphoma, Urothelial Carcinoma, Relapsed and Refractory, Myelodysplastic Syndrome, and Metastatic Leiomyosarcoma, among others. Entinostat Entinostat is under investigation for the treatment and other of Volunteers, Breast Cancer, Human Volunteers, and Normal Volunteers. Entinostat has been investigated for the treatment of Non-Small Lung Cancer, Epigenetic... Flumatinib Flumatinib has been used in trials studying the treatment of Myelogenous Leukemia, Chronic. Tasisulam Tasisulam has been used in trials studying the treatment and basic science of Melanoma, Lymphoma, Solid Tumors, Breast Cancer, and Ovarian Cancer, among others. Axelopran Axelopran has been used in trials studying the treatment of OIC and Opioid-induced Constipation. CE-224535 CE-224535 has been used in trials studying the treatment of Osteoarthritis. N-6022 N6022 has been used in trials studying the treatment of Asthma and Cystic Fibrosis. Balicatib Balicatib has been used in trials studying the treatment of Osteoporosis and Knee Osteoarthritis. Darexaban Darexaban has been used in trials studying the prevention and basic science of Japanese, Caucasian, Thromboembolism, Pharmacodynamics, and Pharmacokinetics, among others. Bavisant Bavisant has been used in trials studying the basic science and treatment of Alcoholism, Pharmacokinetics, Drug Interactions, Attention Deficit Hyperactivity Disorder, and Attention Deficit Disorders With Hyperactivity. Radotinib Radotinib is indicated for the treatment of different types of cancer, most notably Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) with resistance or intolerance of other Bcr-Abl tyrosine-kinase inhibitors, such... Idasanutlin Idasanutlin has been used in trials studying the treatment of Neoplasms, Non-Hodgkin's Lymphoma, Leukemia, Myeloid, Acute, Recurrent Plasma Cell Myeloma, and Neoplasms, Leukemia, Acute Myeloid Leukemia. LY-2456302 Ly2456302 has been used in trials studying the health services research and basic science of Anxiety Disorders and Alcohol Dependence. Betrixaban A Factor Xa inhibitor used for prophylaxis of venous thromboembolism in hospitalized patients. Iobitridol Iobitridol has been used in trials studying the diagnostic of Diagnostic Imaging, Coronary Artery Disease, Type 2 Diabetes Mellitus, and Coronary Atherosclerosis. CI-1040 CI-1040 has been used in trials studying the treatment of Lung Cancer, Breast Cancer, Breast Neoplasms, Pancreatic Cancer, and Colorectal Cancer, among others. Ioforminol Ioforminol has been used in trials studying the diagnostic of Cardio Renal Safety in High-risk Elderly Subjects Undergoing a Coronary CATH With or Without PCI. Nitroaspirin Nitroaspirin has been investigated for the treatment of Intermittent Claudication. Lifibrol Lifibrol has been used in trials studying the basic science of Hyperlipoproteinemia and Hypercholesterolemia. Propyl Gallate Propyl Gallate is under investigation in clinical trial NCT01450098 (A Study of LY2484595 in Healthy Subjects). Acotiamide Acotiamide has been used in trials studying the treatment of Dyspepsia and Functional Dyspepsia. Raclopride Raclopride has been used in trials studying Parkinson Disease. BI-671800 Bi 671800 has been used in trials studying the treatment of Asthma and Rhinitis, Allergic, Perennial. AZD-9056 AZD9056 has been used in trials studying the basic science and treatment of Rheumatoid Arthritis. JNJ-41443532 JNJ-41443532 has been used in trials studying the basic science and treatment of Diabetes Mellitus, Type 2. Salirasib Salirasib has been used in trials studying the diagnostic of Carcinoma, Non-Small-Cell Lung. Relenopride Relenopride has been used in trials studying the treatment of Chronic Idiopathic Constipation. CHF-6001 CHF6001 has been used in trials studying the treatment of Asthma and Chronic Obstructive Pulmonary Disease. Ataciguat Ataciguat has been investigated for the basic science of Aortic Valve Stenosis. DA-6886 DA-6886 has been used in trials studying the treatment of Irritable Bowel Syndrome. Tazemetostat A methyltransferase inhibitor indicated to treat patients 16 years and older with metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. RO-4987655 RO4987655 has been used in trials studying the treatment of Neoplasms. Granotapide Granotapide has been used in trials studying the treatment of Type II Diabetes Mellitus. Tiapride Tiapride is indicated for the treatment of a variety of neurological and psychiatric disorders including dyskinesia, alcohol withdrawal syndrome, negative symptoms of psychosis, and agitation and aggression in the elderly. Aminaphthone Aminaftone has been investigated for the treatment of Cockett Syndrome, May-Thurner Syndrome, and Iliac Vein Obstruction. SCYX-7158 SCYX-7158 has been used in trials studying the treatment of Trypanosomiasis, Parasitic Diseases, Protozoan Infections, and Trypanosomiasis, African. Hexobendine Hexobendine is a medication used to cause vasodilation, to treat several conditions including angina pectoris. It has not been approved in the United States or the United Kingdom, but has... Sultopride Sultopride is used in Japan, Hong Kong, and Europe to treat schizophrenia. It is of the drug class atypical antipsychotics . Iobenzamic acid Not Annotated Ioxitalamic acid A contrast agent used for CT scans of the abdomen and pelvis. Aloxiprin Not Annotated Clebopride Not Annotated Veralipride Not Annotated Guacetisal Not Annotated Iodoxamic acid Radiopaque medium used in the diagnosis of gall bladder & bile duct diseases, usually as meglumine salt. Carbaspirin calcium Not Annotated Ethyl hydroxybenzoate Not Annotated Benorilate Not Annotated Ioglicic acid Not Annotated Ioglycamic acid Not Annotated Iocarmic acid Not Annotated Nifuroxazide Not Annotated Imidazole salicylate Not Annotated Iopentol Iopentol is used as a contrast medium. Hemoglobin crosfumaril Hemoglobin in which the alpha-subunit are cross-linked intramolecularly. Iniparib Not Annotated Bismuth subgallate A medication used to deodorize flatulence and stools as well as hemostasis in soft tissue surgery. Choline salicylate The oral gel is indicated for the relief of pain and discomfort of common mouth ulcers, cold sores, denture sore spots, infant teething and mouth ulcers, and sore spots due... Thiosalicylic acid Not Annotated Butylparaben Not Annotated Benzylparaben Benzylparaben is used in allergenic testing. Propylparaben Propylparaben is used in allergenic testing. Methylparaben Methylparaben is used in allergenic testing. Ticalopride Investigated for use/treatment in gastroesophageal reflux disease (GERD) and gastroparesis. Acifluorfen Acifluorfen is a protoporphyrinogen oxidase inhibitor. Brovanexine Not Annotated Vanillic acid A flavoring agent. It is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (J Biotechnol 1996;50(2-3):107-13). PD-0325901 PD-0325901 has been used in trials studying the treatment and basic science of Melanoma, Solid Tumour, Solid Tumors, Advanced Cancer, and Breast Neoplasms, among others. PH-797804 PH-797804 has been investigated for the treatment of Osteoarthritis. Tecovirimat An antiviral medication used to treat smallpox. Diethyltryptamine Diethyltryptamine (DET) is an orally active hallucinogenic agent and a substituted form of tryptamine. TAS-116 TAS-116 is under investigation in clinical trial NCT02965885 (A Study of TAS-116 in Patients With Solid Tumors). GTX-758 GTX-758 is under investigation in clinical trial NCT01420861 (GTx-758 on Serum Prostate-specific Antigen (PSA) in Men With Castrate Resistant Prostate Cancer). AZD-6482 AZD-6482 is under investigation in clinical trial NCT00688714 (Study to Investigate Safety and Tolerability of a Single Dose of AZD6482). Fallypride Fallypride is under investigation in clinical trial NCT02310360 (Striatal and Extra-striatal Dopamine Release in Response to Food in Healthy Humans). Iodohippuric acid Iodohippuric acid is under investigation in clinical trial NCT02599844 (Impact of Pediatric Acute Renal Injury in Severe Sepsis in Young Adults). Deferasirox An iron chelator used to treat chronic iron overload caused by blood transfusions. Also used in patients with non-transfusion-dependent thalassemia syndromes, and in patients with elevated liver iron concentration and serum ferritin. Axitinib An oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy. Methyl vanillate Not Available Defactinib Defactinib has been investigated for the treatment of Malignant Pleural Mesothelioma. CEP-37440 CEP-37440 has been used in trials studying the treatment of Solid Tumors. 4SC-202 4SC-202 has been used in trials studying the treatment of Advanced Hematologic Malignancies. LGD-6972 LGD-6972 is under investigation in clinical trial NCT01919684 (Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LGD-6972 in Healthy Subjects and Subjects With Type 2 Diabetes Mellitus). p-Hydroxymercuribenzoic acid Not Available Ethyl salicylate Not Annotated 4-hydroxybenzoic acid Not Available Capmatinib A kinase inhibitor targeting c-Met receptor tyrosine kinase in the treatment of non-small cell lung cancer with MET exon 14 skipping.
- Drugs & Drug Targets