Ergot Alkaloids and Derivatives
- Ergot Alkaloids and Derivatives
- Accession Number
- DBCAT000606 (DBCAT002711)
Alkaloids originally isolated from the ergot fungus Claviceps purpurea (Hypocreaceae). They include compounds that are structurally related to ergoline (ERGOLINES) and ergotamine (ERGOTAMINES). Many of the ergot alkaloids act as alpha-adrenergic antagonists.
- ATC Classification
Drug Drug Description Methysergide An ergot alkaloid used for the prophylaxis of migraine and cluster headaches. Dihydroergotamine An ergot alkaloid used in the acute treatment of migraine headache and cluster headache. Lisuride For the management of Parkinson's Disease Ergotamine A alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches. Nicergoline For the treatment of senile dementia, migraines of vascular origin, transient ischemia, platelet hyper-aggregability, and macular degeneration. Ergoloid mesylate A nootropic with an unknown mechanism of action indicated in individuals over sixty who manifest signs and symptoms of an idiopathic decline in mental capacity. Ergometrine An ergot alkaloid used for the treatment of postpartum haemorrhage and post abortion hemorrhage in patients with uterine atony. Dihydroergocristine An ergot alkaloid used to delay progressive mental decline in conditions like Alzheimer's. Methylergometrine An ergot alkaloid used to prevent and control uterine atony and hemorrhage before and after delivery. Cabergoline A dopamine receptor agonist used for the treatment of hyperprolactinemic conditions due to various causes. Pergolide A long-acting dopamine agonist that is uncommonly used for the management of Parkinson's disease, due to the risk for cardiac valvulopathy. Bromocriptine A dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome. Lysergic acid diethylamide Debate continues over the nature and causes of chronic flashbacks. Explanations in terms of LSD physically remaining in the body for months or years after consumption have been discounted by... Dihydroergocornine A nootropic with an unknown mechanism of action indicated in individuals over sixty who manifest signs and symptoms of an idiopathic decline in mental capacity. Dihydroergocryptine Not Annotated Terguride Not Annotated Metergoline Metergoline is an ergot-derived psychoactive drug that acts as a ligand for serotonin and dopamine receptors. Metergoline is an antagonist at various 5-HT receptor subtypes at a relatively low concentration...
- Drugs & Drug Targets