Ergot Alkaloids and Derivatives

Alkaloids originally isolated from the ergot fungus Claviceps purpurea (Hypocreaceae). They include compounds that are structurally related to ergoline (ERGOLINES) and ergotamine (ERGOTAMINES). Many of the ergot alkaloids act as alpha-adrenergic antagonists.
DrugDrug NameDrug Indication
DB00247MethysergideFor the treatment of vascular headache
DB00320DihydroergotamineFor the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes.
DB00589LisurideFor the management of Parkinson's Disease
DB00696ErgotamineFor use as therapy to abort or prevent vascular headache, e.g., migraine, migraine variants, or so called "histaminic cephalalgia".
DB00699NicergolineFor the treatment of senile dementia, migraines of vascular origin, transient ischemia, platelet hyper-aggregability, and macular degeneration.
DB01049Ergoloid mesylateIt was labeled by the FDA for the treatment of symptoms of an idiopathic decline in the mental capacity not related to a potentially reversible condition[A32913] as well as for age-related cognitive impairment.[A32926] The prescription of this drug is conditioned to the corroboration that the patient is not suffering from a potentially reversible and treatable condition especially delirium and dementiform illness secondary to systemic disease, primary neurological disease or primary mood disturbance.[L2637] To know more about the individual components of the ergoloid mixture, please visit [DB13345] and [DB11274]
DB01253ErgometrineUsed to treat postpartum haemorrhage and postabortion haemorrhage in patients with uterine atony.
DB13345DihydroergocristineDihydroergocristine is used in some countries such as Brasil as a single agent for the treatment of cerebral and peripheric vascular events.[L2649] To know more about dihydroergocristine as part of the ergoloid mesylate mixture, please visit [DB01049].
DB00353MethylergometrineFor the prevention and control of excessive bleeding following vaginal childbirth
DB00248CabergolineFor the treatment of hyperprolactinemic disorders, either idiopathic or due to prolactinoma (prolactin-secreting adenomas). May also be used to manage symptoms of Parkinsonian Syndrome as monotherapy during initial symptomatic management or as an adjunct to levodopa therapy during advanced stages of disease.
DB01186PergolideIndicated as adjunctive treatment to levodopa/carbidopa in the management of the signs and symptoms of Parkinson's disease. It was withdrawn from the US and Canadian markets in 2007 due to an increased risk of cardiac valvulopathy.
DB01200BromocriptineFor the treatment of galactorrhea due to hyperprolactinemia, prolactin-dependent menstrual disorders and infertility, prolactin-secreting adenomas, prolactin-dependent male hypogonadism, as adjunct therapy to surgery or radiotherapy for acromegaly or as monotherapy is special cases, as monotherapy in early Parksinsonian Syndrome or as an adjunct with levodopa in advanced cases with motor complications. Bromocriptine has also been used off-label to treat restless legs syndrome and neuroleptic malignant syndrome.
DB04829Lysergic acid diethylamideNot Available
DB11273DihydroergocornineTo know more about the approved indications please visit [DB01049]
DB13385DihydroergocryptineNot Available
DB13399TergurideNot Available
DB13520MetergolineNot Available
DrugDrug NameTargetType
DB00247Methysergide5-hydroxytryptamine receptor 2Atarget
DB00247Methysergide5-hydroxytryptamine receptor 1Atarget
DB00247Methysergide5-hydroxytryptamine receptor 7target
DB00247Methysergide5-hydroxytryptamine receptor 2Ctarget
DB00247Methysergide5-hydroxytryptamine receptor 2Btarget
DB00247Methysergide5-hydroxytryptamine receptor 1Btarget
DB00247Methysergide5-hydroxytryptamine receptor 1Ftarget
DB00247Methysergide5-hydroxytryptamine receptor 1Etarget
DB00247MethysergideCytochrome P450 3A4enzyme
DB00320Dihydroergotamine5-hydroxytryptamine receptor 1Dtarget
DB00320Dihydroergotamine5-hydroxytryptamine receptor 1Btarget
DB00320DihydroergotamineCytochrome P450 3A4enzyme
DB00320DihydroergotamineAlpha-2A adrenergic receptortarget
DB00320Dihydroergotamine5-hydroxytryptamine receptor 2Btarget
DB00320DihydroergotamineP-glycoprotein 1transporter
DB00589LisurideDopamine D1 receptortarget
DB00589Lisuride5-hydroxytryptamine receptor 1Atarget
DB00589LisurideDopamine D2 receptortarget
DB00589LisurideAlpha-2A adrenergic receptortarget
DB00589LisurideAlpha-2B adrenergic receptortarget
DB00589LisurideAlpha-2C adrenergic receptortarget
DB00589LisurideDopamine D3 receptortarget
DB00589Lisuride5-hydroxytryptamine receptor 1Dtarget
DB00589Lisuride5-hydroxytryptamine receptor 2Btarget
DB00589Lisuride5-hydroxytryptamine receptor 2Atarget
DB00589LisurideDopamine D4 receptortarget
DB00589Lisuride5-hydroxytryptamine receptor 2Ctarget
DB00589LisurideDopamine D5 receptortarget
DB00589Lisuride5-hydroxytryptamine receptor 1Btarget
DB00589LisurideCytochrome P450 3A4enzyme
DB00589Lisuride5-hydroxytryptamine receptor 7target
DB00696ErgotamineAlpha-1A adrenergic receptortarget
DB00696Ergotamine5-hydroxytryptamine receptor 1Dtarget
DB00696Ergotamine5-hydroxytryptamine receptor 1Btarget
DB00696Ergotamine5-hydroxytryptamine receptor 2Atarget
DB00696ErgotamineAlpha-2A adrenergic receptortarget
DB00696ErgotamineDopamine D2 receptortarget
DB00696ErgotamineAlpha-2B adrenergic receptortarget
DB00696ErgotamineSodium-dependent noradrenaline transportertarget
DB00696ErgotamineCytochrome P450 3A4enzyme
DB00696ErgotamineAlpha-1B adrenergic receptortarget
DB00696ErgotamineAlpha-1D adrenergic receptortarget
DB00696ErgotamineP-glycoprotein 1transporter
DB00696ErgotamineD(1) dopamine receptortarget
DB00696Ergotamine5-hydroxytryptamine receptor 1Atarget
DB00696Ergotamine5-hydroxytryptamine receptor 1Ftarget
DB00696Ergotamine5-hydroxytryptamine receptor 2Ctarget
DB00696Ergotamine5-hydroxytryptamine receptor 2Btarget
DB00699NicergolineAlpha-1A adrenergic receptortarget
DB00699NicergolineCytochrome P450 2D6enzyme
DB01049Ergoloid mesylateDopamine receptortarget
DB01049Ergoloid mesylateAlpha adrenergic receptortarget
DB01049Ergoloid mesylateBeta adrenergic receptortarget
DB01049Ergoloid mesylateSerotonin Receptorstarget
DB01049Ergoloid mesylateCytochrome P450 3A4enzyme
DB01253ErgometrineCytochrome P450 3A4enzyme
DB01253ErgometrineP-glycoprotein 1transporter
DB01253ErgometrineAlpha-1A adrenergic receptortarget
DB13345DihydroergocristineSerotonin Receptorstarget
DB13345DihydroergocristineBeta adrenergic receptortarget
DB13345DihydroergocristineAlpha adrenergic receptortarget
DB13345DihydroergocristineDopamine receptortarget
DB13345DihydroergocristineBile salt export pumptransporter
DB13345DihydroergocristineCytochrome P450 3A4enzyme
DB00353MethylergometrineDopamine D1 receptortarget
DB00353MethylergometrineCytochrome P450 3A4enzyme
DB00353Methylergometrine5-hydroxytryptamine receptor 2Btarget
DB00248CabergolineDopamine D2 receptortarget
DB00248Cabergoline5-hydroxytryptamine receptor 2Btarget
DB00248CabergolineDopamine D3 receptortarget
DB00248Cabergoline5-hydroxytryptamine receptor 2Atarget
DB00248CabergolineAlpha-2B adrenergic receptortarget
DB00248Cabergoline5-hydroxytryptamine receptor 1Dtarget
DB00248CabergolineDopamine D4 receptortarget
DB00248CabergolineAlpha-2A adrenergic receptortarget
DB00248Cabergoline5-hydroxytryptamine receptor 1Atarget
DB00248CabergolineAlpha-2C adrenergic receptortarget
DB00248CabergolineDopamine D5 receptortarget
DB00248CabergolineDopamine D1 receptortarget
DB00248Cabergoline5-hydroxytryptamine receptor 1Btarget
DB00248Cabergoline5-hydroxytryptamine receptor 2Ctarget
DB00248CabergolineCytochrome P450 3A4enzyme
DB00248Cabergoline5-hydroxytryptamine receptor 7target
DB00248CabergolineAlpha-1A adrenergic receptortarget
DB00248CabergolineAlpha-1B adrenergic receptortarget
DB00248CabergolineAlpha-1D adrenergic receptortarget
DB00248CabergolineBeta-1 adrenergic receptortarget
DB00248CabergolineBeta-2 adrenergic receptortarget
DB00248CabergolineD(1) dopamine receptortarget
DB00248CabergolineP-glycoprotein 1transporter
DB01186PergolideDopamine D2 receptortarget
DB01186PergolideDopamine D1 receptortarget
DB01186PergolideDopamine D3 receptortarget
DB01186Pergolide5-hydroxytryptamine receptor 1Atarget
DB01186PergolideAlpha-1A adrenergic receptortarget
DB01186PergolideAlpha-2A adrenergic receptortarget
DB01186PergolideAlpha-2B adrenergic receptortarget
DB01186PergolideAlpha-2C adrenergic receptortarget
DB01186PergolideAlpha-1B adrenergic receptortarget
DB01186PergolideAlpha-1D adrenergic receptortarget
DB01186PergolideDopamine D4 receptortarget
DB01186PergolideDopamine D5 receptortarget
DB01186Pergolide5-hydroxytryptamine receptor 1Btarget
DB01186Pergolide5-hydroxytryptamine receptor 1Dtarget
DB01186Pergolide5-hydroxytryptamine receptor 2Atarget
DB01186Pergolide5-hydroxytryptamine receptor 2Btarget
DB01186Pergolide5-hydroxytryptamine receptor 2Ctarget
DB01186PergolideCytochrome P450 2D6enzyme
DB01186PergolideCytochrome P450 3A4enzyme
DB01200BromocriptineDopamine D2 receptortarget
DB01200BromocriptineCytochrome P450 3A4enzyme
DB01200Bromocriptine5-hydroxytryptamine receptor 1Dtarget
DB01200BromocriptineAlpha-2A adrenergic receptortarget
DB01200BromocriptineDopamine D3 receptortarget
DB01200Bromocriptine5-hydroxytryptamine receptor 1Atarget
DB01200BromocriptineAlpha-2C adrenergic receptortarget
DB01200BromocriptineAlpha-2B adrenergic receptortarget
DB01200Bromocriptine5-hydroxytryptamine receptor 2Btarget
DB01200BromocriptineDopamine D4 receptortarget
DB01200Bromocriptine5-hydroxytryptamine receptor 2Atarget
DB01200Bromocriptine5-hydroxytryptamine receptor 1Btarget
DB01200Bromocriptine5-hydroxytryptamine receptor 2Ctarget
DB01200BromocriptineDopamine D5 receptortarget
DB01200BromocriptineDopamine D1 receptortarget
DB01200BromocriptineAlpha-1A adrenergic receptortarget
DB01200BromocriptineAlpha-1B adrenergic receptortarget
DB01200BromocriptineAlpha-1D adrenergic receptortarget
DB01200Bromocriptine5-hydroxytryptamine receptor 7target
DB01200BromocriptineP-glycoprotein 1transporter
DB04829Lysergic acid diethylamide5-hydroxytryptamine receptor 1Atarget
DB04829Lysergic acid diethylamide5-hydroxytryptamine receptor 2Btarget
DB04829Lysergic acid diethylamide5-hydroxytryptamine receptor 6target
DB04829Lysergic acid diethylamideCytochrome P450 3A4enzyme
DB04829Lysergic acid diethylamideCytochrome P450 2D6enzyme
DB11273DihydroergocornineSerotonin Receptorstarget
DB11273DihydroergocornineBeta adrenergic receptortarget
DB11273DihydroergocornineAlpha adrenergic receptortarget
DB11273DihydroergocornineCytochrome P450 3A4enzyme
DB13385DihydroergocryptineCytochrome P450 3A4enzyme
DB13399TergurideCytochrome P450 3A4enzyme
DB13520MetergolineSodium channel protein type 2 subunit alphatarget