Pyrimidine Nucleosides

Pyrimidines with a RIBOSE attached that can be phosphorylated to PYRIMIDINE NUCLEOTIDES.
DrugDrug NameDrug Description
DB00249IdoxuridineA pyrimidine analog antiviral used for the treatment of viral eye infections, including herpes simplex keratitis.
DB00322FloxuridineAn antimetabolite used as palliative management for liver metastases of gastrointestinal malignancy.
DB00432TrifluridineA nucleoside metabolic inhibitor used to treat keratoconjunctivitis and epithelial keratitis caused by simplex virus, and as a part of chemotherapy for certain types of metastatic gastrointestinal cancers.
DB00441GemcitabineA nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer.
DB00495ZidovudineA dideoxynucleoside used in the treatment of HIV infection.
DB00552PentostatinAn adenosine deaminase inhibitor used to treat hairy cell leukemia.
DB00649StavudineA dideoxynucleoside used in the treatment of HIV infection.
DB00709LamivudineA reverse transcriptase inhibitor used to treat HIV and hepatitis B infections.
DB00879EmtricitabineA nucleoside reverse transcriptase inhibitor used for the treatment and prophylaxis of HIV.
DB00928AzacitidineA pyrimidine nucleoside analogue used to treat certain subtypes of myelodysplastic syndrome.
DB00943ZalcitabineA dideoxynucleoside used to treat HIV.
DB00987CytarabineA pyrimidine nucleoside analogue used to treat acute non-lymphocytic leukemia, lymphocytic leukemia, and the blast phase of chronic myelocytic leukemia.
DB01101CapecitabineA nucleoside metabolic inhibitor indicated to treat colon, colorectal and breast cancer.
DB01262DecitabineA chemotherapeutic agent used for the treatment of myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia, and conditions related to refractory anemia.
DB01265TelbivudineA thymidine nucleoside analog used for the treatment of chronic hepatitis B with clinical evidence of viral replication or persistent elevations in serum aminotransferases (ALT or AST).
DB016295-fluorouridine5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to the pyrimidine nucleosides and analogues. These are compounds comprising a pyrimidine...
DB02097CytidineNot Available
DB02281FormycinNot Available
DB02745UridineNot Available
DB03068ZebularineA chemically stable, cytidine analog that displays anti-tumor properties. It acts as a transition state analog inhibitor of cytidine deaminase by binding to the active site as covalent hydrates. Also...
DB04198Formycin BNot Available
DB043853-DeazacytidineNot Available
DB04485ThymidineThymidine is a pyrimidine deoxynucleoside. Thymidine is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA. In cell biology it is used to synchronize the cells in...
DB04627CyclouridineNot Available
DB04983DenufosolFor use as an inhaled treatment for cystic fibrosis.
DB05116ThymectacinInvestigated for use/treatment in colorectal cancer.
DB05494ElacytarabineInvestigated for use/treatment in leukemia (unspecified) and melanoma.
DB06236ElvucitabineInvestigated for use/treatment in hepatitis (viral, B) and HIV infection.
DB06433TezacitabineInvestigated for use/treatment in colorectal cancer, lung cancer, leukemia (unspecified), and gastric cancer.
DB06656TAS-106Investigated for use/treatment in solid tumors and cancer/tumors (unspecified).
DB06683ClevudineInvestigated for use/treatment in hepatitis (viral, B).
DB08934SofosbuvirA direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents.
DB08937TAS-102TAS-102 (Taiho Pharma USA, Inc.) is an anti-cancer drug under development and in stage 3 clinical trials for the treatment of colorectal cancer. It is composed of the thymidine phosphorylase...
DB09144Uridine triacetateA pyrimidine analog used for the reversal of overdose, regardless of the presence of symptoms, and early-onset, severe or life-threatening CNS toxicity or cardiotoxicity of fluorouracil or capecitabine.
DB116672'-cyano-2'-deoxy-1-(beta-D-arabinofuranosyl)cytosine2'-cyano-2'-deoxy-1-(beta-D-arabinofuranosyl)cytosine has been used in trials studying the treatment of Advanced Colorectal Cancer.
DB11918GuadecitabineGuadecitabine is under investigation for the treatment of Previously Treated Metastatic Colorectal Cancer.
DB11998SorivudineSorivudine has been used in trials studying the treatment of Chickenpox and HIV Infections.
DB12028BroxuridineBroxuridine has been used in trials studying the treatment of Leukemia, Stage I Prostate Cancer, Stage IIB Prostate Cancer, and Stage IIA Prostate Cancer.
DB12045MericitabineMericitabine has been investigated for the treatment of Hepatitis C, Chronic. Mericitabine is a polymerase inhibitor being developed for the treatment of chronic hepatitis C. Mericitabine is a prodrug of...
DB12074CensavudineCensavudine has been used in trials studying the treatment of HIV-1 Infection.
DB12423Fozivudine TidoxilFozivudine Tidoxil has been used in trials studying the treatment of HIV Infections.
DB12470DexelvucitabineDexelvucitabine has been used in trials studying the treatment of HIV Infections and Human Immunodeficiency Virus.
DB12484TetrahydrouridineTetrahydrouridine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Sickle Cell Disease, and Head and Neck Cancer, among others.
DB12564Gemcitabine elaidateGemcitabine elaidate has been used in trials studying the treatment of Solid Tumor, Lung Cancer, Non-small-cell Lung Cancer, and Metastatic Pancreatic Adenocarcinoma.
DB12606NetivudineNetivudine has been used in trials studying the treatment of Chickenpox and HIV Infections.
DB12753RacivirRacivir, also known as RCV, is an oxothiolane nucleoside reverse transcriptase inhibitor similar to emtricitabine and lamivudine. Racivir is a 50:50 mixture of emtricitabine DB00879 and its positive enantiomer. Racivir...
DB12855ApricitabineApricitabine has been used in trials studying the treatment of HIV Infections.
DB12901FiacitabineFiacitabine has been used in trials studying the treatment of HIV Infections and Cytomegalovirus Infections.
DB12906LY-2334737LY2334737 has been used in trials studying the treatment of Solid Tumor, Metastatic Tumor, and Malignant Solid Tumor.
DB12947DoxifluridineDoxifluridine has been investigated for the treatment of Stomach Cancer.
DB129575-fluoro-2'-deoxycytidine5-fluoro-2'-deoxycytidine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Head and Neck Neoplasms, and Urinary Bladder Neoplasms, among others.
DB130302'-fluoro-5-ethylarabinosyluracil2'-fluoro-5-ethylarabinosyluracil (FAU) has been used in trials studying the treatment of Small Intestine Lymphoma, Stage IV Mantle Cell Lymphoma, Waldenström Macroglobulinemia, Splenic Marginal Zone Lymphoma, and Recurrent Mantle Cell Lymphoma,...
DB13172TunicamycinTunicamycin is a mixture of homologous nucleoside antibiotics that inhibits the UDP-HexNAc: polyprenol-P HexNAc-1-P family of enzymes. One member of this family is the enzyme GlcNAc phosphotransferase (GPT), which catalyzes...
DB13421EdoxudineA deoxythymidine analog used to treat herpetic keratitis.
DB139212'-C-methylcytidineA nucleoside analog with anti-hepatitis C virus (HCV) activity. Upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation and viral RNA-dependent RNA polymerase activity. This blocks...
DB03312BrivudineBrivudine is used in the treatment of herpes zoster. Although not approved in the U.S. or Canada, it is approved in several European countries.
DB14808LumicitabineLumicitabine is under investigation in clinical trial NCT03010059 (A Study to Assess the Relative Bioavailability of JNJ64041575 Administered as 2 Different New Concept Formulations (Oral Suspension and Tablet) Compared to...
DB15427FialuridineFialuridine is under investigation in clinical trial NCT01337466 (Biodistribution and Dosimetry Evaluation of [124I]FIAU).
DB14906AdafosbuvirAdafosbuvir is under investigation in clinical trial NCT02894905 (A Study to Evaluate the Effect of Renal Impairment on the Pharmacokinetics of AL-335).
DB15206UprifosbuvirUprifosbuvir is under investigation in clinical trial NCT02332707 (Efficacy and Safety of Grazoprevir (MK-5172) and Uprifosbuvir (MK-3682) With Elbasvir (MK-8742) or Ruzasvir (MK-8408) for Chronic Hepatitis C Genotype (GT)1 and...
DB03666Zidovudine monophosphateNot Available
DB04542Zidovudine diphosphateNot Available
DrugDrug NameTargetType
DB00249IdoxuridineThymidine kinasetarget
DB00249IdoxuridineDNAtarget
DB00322FloxuridineThymidylate synthasetarget
DB00322FloxuridineThymidine phosphorylaseenzyme
DB00322FloxuridineCytochrome P450 2C9enzyme
DB00322FloxuridineThyroxine-binding globulincarrier
DB00432TrifluridineThymidylate synthasetarget
DB00432TrifluridineDNAtarget
DB00432TrifluridineThymidine kinase, cytosolicenzyme
DB00432TrifluridineThymidine phosphorylaseenzyme
DB00432TrifluridineSolute carrier family 22 member 6transporter
DB00432TrifluridineSodium/nucleoside cotransporter 1transporter
DB00432TrifluridineEquilibrative nucleoside transporter 1transporter
DB00432TrifluridineEquilibrative nucleoside transporter 2transporter
DB00432TrifluridineSerum albumincarrier
DB00441GemcitabineRibonucleoside-diphosphate reductase large subunittarget
DB00441GemcitabineUMP-CMP kinasetarget
DB00441GemcitabineThymidylate synthasetarget
DB00441GemcitabineCytidine deaminaseenzyme
DB00441GemcitabineDeoxycytidine kinaseenzyme
DB00441GemcitabineP-glycoprotein 1transporter
DB00441GemcitabineMultidrug resistance-associated protein 7transporter
DB00441GemcitabineEquilibrative nucleoside transporter 1transporter
DB00441GemcitabineDNAtarget
DB00441GemcitabineSodium/nucleoside cotransporter 1transporter
DB00441GemcitabineEquilibrative nucleoside transporter 2transporter
DB00441GemcitabineSolute carrier family 28 member 3transporter
DB00495ZidovudineSerum albumincarrier
DB00495ZidovudineCytochrome P450 2A6enzyme
DB00495ZidovudineCytochrome P450 2C9enzyme
DB00495ZidovudineCytochrome P450 3A4enzyme
DB00495ZidovudineReverse transcriptase/RNaseHtarget
DB00495ZidovudineSolute carrier family 22 member 2transporter
DB00495ZidovudineSolute carrier family 22 member 6transporter
DB00495ZidovudineSolute carrier family 22 member 7transporter
DB00495ZidovudineSolute carrier family 22 member 8transporter
DB00495ZidovudineSolute carrier family 22 member 11transporter
DB00495ZidovudineSodium/nucleoside cotransporter 1transporter
DB00495ZidovudineEquilibrative nucleoside transporter 2transporter
DB00495ZidovudineP-glycoprotein 1transporter
DB00495ZidovudineMultidrug resistance-associated protein 4transporter
DB00495ZidovudineMultidrug resistance-associated protein 5transporter
DB00495ZidovudineATP-binding cassette sub-family G member 2transporter
DB00495ZidovudineTelomerase reverse transcriptasetarget
DB00495ZidovudineThymidine kinase, cytosolicenzyme
DB00495ZidovudineUDP-glucuronosyltransferase 2B7enzyme
DB00495ZidovudineUDP-glucuronosyltransferase 1-1enzyme
DB00552PentostatinAdenosine deaminasetarget
DB00649StavudineSolute carrier family 22 member 6transporter
DB00649StavudineReverse transcriptase/RNaseHtarget
DB00649StavudineSodium/nucleoside cotransporter 1transporter
DB00649StavudineSerum albumincarrier
DB00709LamivudineDNAtarget
DB00709LamivudineProtein Ptarget
DB00709LamivudineMultidrug resistance-associated protein 1transporter
DB00709LamivudineSolute carrier family 22 member 6transporter
DB00709LamivudineATP-binding cassette sub-family G member 2transporter
DB00709LamivudineReverse transcriptase/RNaseHtarget
DB00709LamivudineSolute carrier family 22 member 1transporter
DB00709LamivudineSolute carrier family 22 member 2transporter
DB00709LamivudineSolute carrier family 22 member 3transporter
DB00709LamivudineDeoxycytidine kinaseenzyme
DB00709LamivudineUMP-CMP kinaseenzyme
DB00709LamivudinePhosphoglycerate kinase 1enzyme
DB00709LamivudineNucleoside diphosphate kinase Aenzyme
DB00709LamivudineNucleoside diphosphate kinase Benzyme
DB00709LamivudineCholine-phosphate cytidylyltransferase Aenzyme
DB00709LamivudineEthanolamine-phosphate cytidylyltransferaseenzyme
DB00709LamivudineP-glycoprotein 1transporter
DB00709LamivudineMultidrug resistance-associated protein 4transporter
DB00709LamivudineCanalicular multispecific organic anion transporter 2transporter
DB00709LamivudineCanalicular multispecific organic anion transporter 1transporter
DB00709Lamivudine5'(3')-deoxyribonucleotidase, cytosolic typeenzyme
DB00709LamivudineSerum albumincarrier
DB00879EmtricitabineReverse transcriptase/RNaseHtarget
DB00879EmtricitabineDeoxycytidine kinaseenzyme
DB00879EmtricitabineSerum albumincarrier
DB00879EmtricitabineMultidrug and toxin extrusion protein 1transporter
DB00928AzacitidineDNA (cytosine-5)-methyltransferase 1target
DB00928AzacitidineCytidine deaminaseenzyme
DB00928AzacitidineDNAtarget
DB00928AzacitidineRNAtarget
DB00943ZalcitabineDeoxycytidine kinaseenzyme
DB00943ZalcitabineSolute carrier family 22 member 6transporter
DB00943ZalcitabineSolute carrier family 22 member 7transporter
DB00943ZalcitabineReverse transcriptase/RNaseHtarget
DB00943ZalcitabineEquilibrative nucleoside transporter 1transporter
DB00943ZalcitabineEquilibrative nucleoside transporter 2transporter
DB00943ZalcitabineSerum albumincarrier
DB00987CytarabineDNA polymerase betatarget
DB00987CytarabineCytidine deaminaseenzyme
DB00987CytarabineSolute carrier family 22 member 4transporter
DB00987CytarabineMultidrug resistance-associated protein 7transporter
DB00987CytarabineEquilibrative nucleoside transporter 1transporter
DB00987CytarabineDNAtarget
DB00987CytarabineCytochrome P450 3A4enzyme
DB00987CytarabineDeoxycytidine kinaseenzyme
DB00987Cytarabine5'-nucleotidaseenzyme
DB00987CytarabineDeoxycytidylate deaminaseenzyme
DB01101CapecitabineThymidylate synthasetarget
DB01101CapecitabineThymidine phosphorylaseenzyme
DB01101CapecitabineCytidine deaminaseenzyme
DB01101CapecitabineLiver carboxylesterase 1enzyme
DB01101CapecitabineDihydropyrimidine dehydrogenase [NADP(+)]enzyme
DB01101CapecitabineCytochrome P450 2C9enzyme
DB01101CapecitabineDNAtarget
DB01101CapecitabineRNAtarget
DB01262DecitabineDNAtarget
DB01262DecitabineDNA (cytosine-5)-methyltransferase 1target
DB01262DecitabineDeoxycytidine kinaseenzyme
DB01265TelbivudineProtein Ptarget
DB01265TelbivudineDNAtarget
DB016295-fluorouridineUridine phosphorylasetarget
DB016295-fluorouridineSuperoxide dismutase [Cu-Zn]target
DB016295-fluorouridineThyroxine-binding globulincarrier
DB02097CytidineUridine-cytidine kinase 2target
DB02281FormycinS-methyl-5'-thioadenosine phosphorylasetarget
DB02281Formycin5'-methylthioadenosine/S-adenosylhomocysteine nucleosidasetarget
DB02745UridineU6 snRNA-associated Sm-like protein LSm6target
DB02745UridineNucleoside-specific channel-forming protein tsxtarget
DB02745UridineEquilibrative nucleoside transporter 1transporter
DB03068ZebularineCytidine deaminasetarget
DB04198Formycin BPurine nucleoside phosphorylase DeoD-typetarget
DB04198Formycin BHypoxanthine-guanine phosphoribosyltransferasetarget
DB043853-DeazacytidineCytidine deaminasetarget
DB04485ThymidineThymidylate kinasetarget
DB04485ThymidineThymidine kinasetarget
DB04485ThymidineUridine phosphorylasetarget
DB04485ThymidineThymidine kinasetarget
DB04485ThymidineThymidine kinase 2, mitochondrialtarget
DB04485ThymidineNucleoside-specific channel-forming protein tsxtarget
DB04485ThymidineGlucose-1-phosphate thymidylyltransferasetarget
DB04485ThymidineSolute carrier family 28 member 3transporter
DB04627CyclouridineUridine phosphorylasetarget
DB04983DenufosolP2Y purinoceptor 2target
DB05116ThymectacinThymidylate synthasetarget
DB05494ElacytarabineDeoxycytidine kinasetarget
DB06433TezacitabineRibonucleoside-diphosphate reductase large subunittarget
DB06433TezacitabineThymidine phosphorylaseenzyme
DB08934SofosbuvirP-glycoprotein 1transporter
DB08934SofosbuvirATP-binding cassette sub-family G member 2transporter
DB08934SofosbuvirRNA-dependent RNA-polymerasetarget
DB08934SofosbuvirLysosomal protective proteinenzyme
DB08934SofosbuvirCarboxylesteraseenzyme
DB08934SofosbuvirHistidine triad nucleotide-binding protein 1enzyme
DB08934SofosbuvirUMP-CMP kinaseenzyme
DB08934SofosbuvirNucleoside diphosphate kinase Aenzyme
DB12855ApricitabineReverse transcriptase/RNaseHtarget
DB13421EdoxudineSerum albumincarrier
DB13421EdoxudineDNA polymerasetarget
DB03312BrivudineThymidine kinasetarget
DB03666Zidovudine monophosphateThymidylate kinasetarget
DB03666Zidovudine monophosphateThymidylate kinasetarget
DB04542Zidovudine diphosphateNucleoside diphosphate kinase Atarget