- Pyrimidine Nucleosides
- Accession Number
Pyrimidines with a RIBOSE attached that can be phosphorylated to PYRIMIDINE NUCLEOTIDES.
Drug Drug Description Idoxuridine A pyrimidine analog antiviral used for the treatment of viral eye infections, including herpes simplex keratitis. Floxuridine An antimetabolite used as palliative management for liver metastases of gastrointestinal malignancy. Trifluridine A nucleoside metabolic inhibitor used to treat keratoconjunctivitis and epithelial keratitis caused by simplex virus, and as a part of chemotherapy for certain types of metastatic gastrointestinal cancers. Gemcitabine A nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer. Zidovudine A dideoxynucleoside used in the treatment of HIV infection. Pentostatin An adenosine deaminase inhibitor used to treat hairy cell leukemia. Stavudine A dideoxynucleoside used in the treatment of HIV infection. Lamivudine A reverse transcriptase inhibitor used to treat HIV and hepatitis B infections. Emtricitabine A nucleoside reverse transcriptase inhibitor used for the treatment and prophylaxis of HIV. Azacitidine A pyrimidine nucleoside analogue used to treat certain subtypes of myelodysplastic syndrome. Zalcitabine A dideoxynucleoside used to treat HIV. Cytarabine A pyrimidine nucleoside analogue used to treat acute non-lymphocytic leukemia, lymphocytic leukemia, and the blast phase of chronic myelocytic leukemia. Capecitabine A nucleoside metabolic inhibitor indicated to treat colon, colorectal and breast cancer. Decitabine A chemotherapeutic agent used for the treatment of myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia, and conditions related to refractory anemia. Telbivudine A thymidine nucleoside analog used for the treatment of chronic hepatitis B with clinical evidence of viral replication or persistent elevations in serum aminotransferases (ALT or AST). 5-fluorouridine 5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to the pyrimidine nucleosides and analogues. These are compounds comprising a pyrimidine... Cytidine Not Available Formycin Not Available Uridine Not Available Zebularine A chemically stable, cytidine analog that displays anti-tumor properties. It acts as a transition state analog inhibitor of cytidine deaminase by binding to the active site as covalent hydrates. Also... Formycin B Not Available 3-Deazacytidine Not Available Thymidine Thymidine is a pyrimidine deoxynucleoside. Thymidine is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA. In cell biology it is used to synchronize the cells in... Cyclouridine Not Available Denufosol For use as an inhaled treatment for cystic fibrosis. Thymectacin Investigated for use/treatment in colorectal cancer. Elacytarabine Investigated for use/treatment in leukemia (unspecified) and melanoma. Elvucitabine Investigated for use/treatment in hepatitis (viral, B) and HIV infection. Tezacitabine Investigated for use/treatment in colorectal cancer, lung cancer, leukemia (unspecified), and gastric cancer. TAS-106 Investigated for use/treatment in solid tumors and cancer/tumors (unspecified). Clevudine Investigated for use/treatment in hepatitis (viral, B). Sofosbuvir A direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents. TAS-102 TAS-102 (Taiho Pharma USA, Inc.) is an anti-cancer drug under development and in stage 3 clinical trials for the treatment of colorectal cancer. It is composed of the thymidine phosphorylase... Uridine triacetate A pyrimidine analog used for the reversal of overdose, regardless of the presence of symptoms, and early-onset, severe or life-threatening CNS toxicity or cardiotoxicity of fluorouracil or capecitabine. 2'-cyano-2'-deoxy-1-(beta-D-arabinofuranosyl)cytosine 2'-cyano-2'-deoxy-1-(beta-D-arabinofuranosyl)cytosine has been used in trials studying the treatment of Advanced Colorectal Cancer. Guadecitabine Guadecitabine is under investigation for the treatment of Previously Treated Metastatic Colorectal Cancer. Sorivudine Sorivudine has been used in trials studying the treatment of Chickenpox and HIV Infections. Broxuridine Broxuridine has been used in trials studying the treatment of Leukemia, Stage I Prostate Cancer, Stage IIB Prostate Cancer, and Stage IIA Prostate Cancer. Mericitabine Mericitabine has been investigated for the treatment of Hepatitis C, Chronic. Mericitabine is a polymerase inhibitor being developed for the treatment of chronic hepatitis C. Mericitabine is a prodrug of... Censavudine Censavudine has been used in trials studying the treatment of HIV-1 Infection. Fozivudine Tidoxil Fozivudine Tidoxil has been used in trials studying the treatment of HIV Infections. Dexelvucitabine Dexelvucitabine has been used in trials studying the treatment of HIV Infections and Human Immunodeficiency Virus. Tetrahydrouridine Tetrahydrouridine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Sickle Cell Disease, and Head and Neck Cancer, among others. Gemcitabine elaidate Gemcitabine elaidate has been used in trials studying the treatment of Solid Tumor, Lung Cancer, Non-small-cell Lung Cancer, and Metastatic Pancreatic Adenocarcinoma. Netivudine Netivudine has been used in trials studying the treatment of Chickenpox and HIV Infections. Racivir Racivir, also known as RCV, is an oxothiolane nucleoside reverse transcriptase inhibitor similar to emtricitabine and lamivudine. Racivir is a 50:50 mixture of emtricitabine DB00879 and its positive enantiomer. Racivir... Apricitabine Apricitabine has been used in trials studying the treatment of HIV Infections. Fiacitabine Fiacitabine has been used in trials studying the treatment of HIV Infections and Cytomegalovirus Infections. LY-2334737 LY2334737 has been used in trials studying the treatment of Solid Tumor, Metastatic Tumor, and Malignant Solid Tumor. Doxifluridine Doxifluridine has been investigated for the treatment of Stomach Cancer. 5-fluoro-2'-deoxycytidine 5-fluoro-2'-deoxycytidine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Head and Neck Neoplasms, and Urinary Bladder Neoplasms, among others. 2'-fluoro-5-ethylarabinosyluracil 2'-fluoro-5-ethylarabinosyluracil (FAU) has been used in trials studying the treatment of Small Intestine Lymphoma, Stage IV Mantle Cell Lymphoma, Waldenström Macroglobulinemia, Splenic Marginal Zone Lymphoma, and Recurrent Mantle Cell Lymphoma,... Tunicamycin Tunicamycin is a mixture of homologous nucleoside antibiotics that inhibits the UDP-HexNAc: polyprenol-P HexNAc-1-P family of enzymes. One member of this family is the enzyme GlcNAc phosphotransferase (GPT), which catalyzes... Edoxudine A deoxythymidine analog used to treat herpetic keratitis. 2'-C-methylcytidine A nucleoside analog with anti-hepatitis C virus (HCV) activity. Upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation and viral RNA-dependent RNA polymerase activity. This blocks... Brivudine Brivudine is used in the treatment of herpes zoster. Although not approved in the U.S. or Canada, it is approved in several European countries. Lumicitabine Lumicitabine is under investigation in clinical trial NCT03010059 (A Study to Assess the Relative Bioavailability of JNJ64041575 Administered as 2 Different New Concept Formulations (Oral Suspension and Tablet) Compared to... Fialuridine Fialuridine is under investigation in clinical trial NCT01337466 (Biodistribution and Dosimetry Evaluation of [124I]FIAU). Adafosbuvir Adafosbuvir is under investigation in clinical trial NCT02894905 (A Study to Evaluate the Effect of Renal Impairment on the Pharmacokinetics of AL-335). Uprifosbuvir Uprifosbuvir is under investigation in clinical trial NCT02332707 (Efficacy and Safety of Grazoprevir (MK-5172) and Uprifosbuvir (MK-3682) With Elbasvir (MK-8742) or Ruzasvir (MK-8408) for Chronic Hepatitis C Genotype (GT)1 and... Zidovudine monophosphate Not Available Zidovudine diphosphate Not Available N4-Hydroxycytidine A cytidine analog being investigated to treat COVID-19.
- Drugs & Drug Targets