Benzylidene Compounds

Compounds containing the PhCH= radical.
DrugDrug NameDrug Description
DB00255DiethylstilbestrolUsed in the treatment of prostate cancer. Previously used in the prevention of miscarriage or premature delivery in pregnant women prone to miscarriage or premature delivery.
DB00269ChlorotrianiseneUsed to treat symptoms of menopause, deficiencies in ovary function (including underdevelopment of female sexual characteristics and some types of infertility), and in rare cases, prostate cancer. Chlorotrianisene may also...
DB00481RaloxifeneA selective estrogen receptor modulator that is used to prevent and treat osteoporosis and reduce the risk of invasive breast cancer in high-risk postmenopausal women.
DB00539ToremifeneA first generation nonsteroidal selective estrogen receptor modulator used to treat certain breast cancers.
DB00675TamoxifenA selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer following surgery, or reduce the risk of breast cancer in high risk women.
DB00882ClomifeneA medication used to induce ovulation.
DB01344TolevamerA potassium-binding resin used in the treatment of hyperkalemia.
DB01432CholestyramineA bile acid sequestrant used as an adjunct in the reduction of elevated serum cholesterol in patients with primary hypercholesterolemia, and for the relief of pruritus associated with partial biliary obstruction.
DB02709ResveratrolBeing investigated for the treatment of Herpes labialis infections (cold sores).
DB04468AfimoxifeneFor the potential treatment of menstrual-cycle related mastalgia, fibrocystic breast disease, breast disease, gynecomastia and Keloid scarring.
DB04938OspemifeneA non-hormonal estrogen receptor modulator (SERM) used to treat moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause.
DB05073SRT501Investigated for use/treatment in diabetes mellitus type 2 and neurologic disorders.
DB05143OXI-4503Investigated for use/treatment in cancer/tumors (unspecified).
DB06083TapinarofInvestigated for use/treatment in psoriasis and psoriatic disorders.
DB06640FispemifeneInvestigated for use/treatment in male hormonal deficiencies/abnormalities.
DB06735EnclomipheneNot Annotated
DB07931HexestrolA synthetic estrogen that has been used as a hormonal antineoplastic agent.
DB08399PICEATANNOLNot Available
DB09148Florbetaben (18F)A radiopharmaceutical diagnostic agent used during Positron Emission Tomography (PET) imaging of the brain to estimate β-amyloid neuritic plaque density in adult patients to diagnose the causes of cognitive impairment.
DB11263PolydatinPolydatin, or Piceid, is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensis or Polygonum cuspidatum, polydatin...
DB12320PalovarotenePalovarotene has been used in trials studying the treatment of Fibrodysplasia Ossificans Progressiva.
DB12577FosbretabulinFosbretabulin has been investigated for the treatment of Anaplastic Thyroid Cancer.
DB12596CombretastatinCombretastatin has been investigated for the treatment of Anaplastic Thyroid Cancer.
DB14680Combretastatin A4Not Annotated
DB14753HydroxystilbamidineUsed in the treatment of nonprogressive blastomycosis of the skin and other mycoses.
DB138692-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenolTIMBD is an azaresveratrol analog.
DrugDrug NameTargetType
DB00255DiethylstilbestrolEstrogen receptor alphatarget
DB00255DiethylstilbestrolEstrogen-related receptor gammatarget
DB00255DiethylstilbestrolTransthyretincarrier
DB00255DiethylstilbestrolCatechol O-methyltransferaseenzyme
DB00255DiethylstilbestrolCytochrome P450 19A1enzyme
DB00255DiethylstilbestrolATP-binding cassette sub-family G member 2transporter
DB00255DiethylstilbestrolP-glycoprotein 1transporter
DB00255DiethylstilbestrolEstrogen receptor betatarget
DB00255DiethylstilbestrolCytochrome P450 3A4enzyme
DB00255DiethylstilbestrolCytochrome P450 2C8enzyme
DB00255DiethylstilbestrolCytochrome P450 2C9enzyme
DB00255DiethylstilbestrolCytochrome P450 2E1enzyme
DB00255DiethylstilbestrolSteroid hormone receptor ERR1target
DB00255DiethylstilbestrolSteroid hormone receptor ERR2target
DB00255DiethylstilbestrolNuclear receptor coactivator 2target
DB00255DiethylstilbestrolNuclear receptor subfamily 1 group I member 2target
DB00255DiethylstilbestrolAndrogen receptortarget
DB00255DiethylstilbestrolSex hormone-binding globulintarget
DB00255DiethylstilbestrolSolute carrier organic anion transporter family member 1B1transporter
DB00255DiethylstilbestrolSolute carrier organic anion transporter family member 2B1transporter
DB00255DiethylstilbestrolBile salt export pumptransporter
DB00269ChlorotrianiseneEstrogen receptor alphatarget
DB00269ChlorotrianiseneCytochrome P450 19A1enzyme
DB00481RaloxifeneEstrogen receptor alphatarget
DB00481RaloxifeneEstrogen receptor betatarget
DB00481RaloxifeneAldehyde oxidaseenzyme
DB00481RaloxifeneCytochrome P450 2C8enzyme
DB00481RaloxifeneCytochrome P450 2B6enzyme
DB00481RaloxifeneCytochrome P450 19A1enzyme
DB00481RaloxifeneCytochrome P450 3A4enzyme
DB00481RaloxifeneSerpin B9target
DB00481RaloxifeneTrefoil factor 1target
DB00481RaloxifeneUDP-glucuronosyltransferase 1-1enzyme
DB00481RaloxifeneSerum albumincarrier
DB00481RaloxifeneAlpha-1-acid glycoprotein 1carrier
DB00481RaloxifeneSolute carrier organic anion transporter family member 1B1transporter
DB00481RaloxifeneSolute carrier organic anion transporter family member 1B3transporter
DB00481RaloxifeneP-glycoprotein 1transporter
DB00481RaloxifeneATP-binding cassette sub-family G member 2transporter
DB00481RaloxifeneCanalicular multispecific organic anion transporter 1transporter
DB00481RaloxifeneCanalicular multispecific organic anion transporter 2transporter
DB00481RaloxifeneMultidrug resistance-associated protein 4transporter
DB00481RaloxifeneUDP-glucuronosyltransferase 1-10enzyme
DB00481RaloxifeneUDP-glucuronosyltransferase 1-8enzyme
DB00539ToremifeneEstrogen receptor alphatarget
DB00539ToremifeneCytochrome P450 3A4enzyme
DB00539ToremifeneP-glycoprotein 1transporter
DB00539ToremifeneCytochrome P450 1A1enzyme
DB00539ToremifeneSex hormone-binding globulintarget
DB00675TamoxifenEstrogen receptor alphatarget
DB00675TamoxifenEstrogen receptor betatarget
DB00675TamoxifenCytochrome P450 2C9enzyme
DB00675TamoxifenCytochrome P450 3A4enzyme
DB00675TamoxifenCytochrome P450 2D6enzyme
DB00675TamoxifenCytochrome P450 2C8enzyme
DB00675TamoxifenCytochrome P450 2B6enzyme
DB00675TamoxifenLiver carboxylesterase 1enzyme
DB00675TamoxifenCytochrome P450 3A5enzyme
DB00675TamoxifenCytochrome P450 1A1enzyme
DB00675TamoxifenCytochrome P450 1B1enzyme
DB00675TamoxifenCytochrome P450 2C19enzyme
DB00675TamoxifenDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB00675TamoxifenDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00675TamoxifenCytochrome P450 3A7enzyme
DB00675TamoxifenP-glycoprotein 1transporter
DB00675TamoxifenATP-binding cassette sub-family G member 2transporter
DB00675TamoxifenCytochrome P450 19A1enzyme
DB00675TamoxifenCytochrome P450 2A6enzyme
DB00675TamoxifenCytochrome P450 2E1enzyme
DB00675TamoxifenUDP-glucuronosyltransferase 1-10enzyme
DB00675TamoxifenSulfotransferase 1A1enzyme
DB00675TamoxifenCanalicular multispecific organic anion transporter 1transporter
DB00675Tamoxifen3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerasetarget
DB00675TamoxifenProtein kinase Ctarget
DB00675TamoxifenAndrogen receptortarget
DB00675TamoxifenPotassium voltage-gated channel subfamily H member 2target
DB00675TamoxifenNuclear receptor subfamily 1 group I member 2target
DB00675TamoxifenEstrogen-related receptor gammatarget
DB00675TamoxifenSex hormone-binding globulintarget
DB00675TamoxifenBile salt export pumptransporter
DB00675TamoxifenThyroxine-binding globulincarrier
DB00675TamoxifenBile salt sulfotransferaseenzyme
DB00675TamoxifenCytochrome P450 1A2enzyme
DB00675TamoxifenUDP-glucuronosyltransferase 2B7enzyme
DB00675TamoxifenUDP-glucuronosyltransferase 2B17enzyme
DB00675TamoxifenEstrogen sulfotransferaseenzyme
DB00675TamoxifenATP-binding cassette sub-family A member 1transporter
DB00675TamoxifenMitogen-activated protein kinase 8target
DB00675TamoxifenSerum albumincarrier
DB00882ClomifeneEstrogen receptor alphatarget
DB00882ClomifeneP-glycoprotein 1transporter
DB00882ClomifeneSex hormone-binding globulintarget
DB00882ClomifeneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DB01344TolevamerPotassiumtarget
DB01432CholestyramineBile acidstarget
DB02709ResveratrolTransthyretincarrier
DB02709ResveratrolRibosyldihydronicotinamide dehydrogenase [quinone]target
DB02709ResveratrolProstaglandin G/H synthase 1target
DB02709ResveratrolCasein kinase II subunit alphatarget
DB02709ResveratrolProstaglandin G/H synthase 2target
DB02709ResveratrolCytochrome P450 1A1enzyme
DB02709ResveratrolCytochrome P450 3A4enzyme
DB02709ResveratrolCytochrome P450 1A2enzyme
DB02709ResveratrolCytochrome P450 1B1enzyme
DB02709ResveratrolArachidonate 15-lipoxygenasetarget
DB02709ResveratrolArachidonate 5-lipoxygenasetarget
DB02709ResveratrolAryl hydrocarbon receptortarget
DB02709ResveratrolPhosphatidylinositol 4-kinase type 2-betatarget
DB02709ResveratrolIntegrin alpha-5target
DB02709ResveratrolIntegrin beta-3target
DB02709ResveratrolSerum albumincarrier
DB02709ResveratrolAmyloid beta A4 proteintarget
DB02709ResveratrolAlpha-synucleintarget
DB02709ResveratrolEstrogen receptor alphatarget
DB02709ResveratrolMelatonin receptor type 1Atarget
DB02709ResveratrolMelatonin receptor type 1Btarget
DB02709ResveratrolC-type lectin domain family 14 member Atarget
DB02709ResveratrolNuclear receptor subfamily 1 group I member 2target
DB02709ResveratrolNuclear receptor subfamily 1 group I member 3target
DB02709ResveratrolSolute carrier family 2, facilitated glucose transporter member 1target
DB02709ResveratrolCarbonyl reductase [NADPH] 1target
DB02709ResveratrolPeroxisome proliferator-activated receptor alphatarget
DB02709ResveratrolPeroxisome proliferator-activated receptor gammatarget
DB02709ResveratrolRAC-alpha serine/threonine-protein kinasetarget
DB02709ResveratrolFar upstream element-binding protein 2target
DB02709ResveratrolTyrosine--tRNA ligase, cytoplasmictarget
DB04468AfimoxifeneEstrogen receptor alphatarget
DB04468AfimoxifeneEstrogen receptor betatarget
DB04468AfimoxifeneEstrogen-related receptor gammatarget
DB04468AfimoxifeneTrefoil factor 1target
DB04468AfimoxifeneSteroid hormone receptor ERR1target
DB04468AfimoxifeneNuclear receptor subfamily 1 group I member 2target
DB04468AfimoxifeneSex hormone-binding globulintarget
DB04938OspemifeneEstrogen receptor alphatarget
DB04938OspemifeneCytochrome P450 3A4enzyme
DB04938OspemifeneCytochrome P450 2C9enzyme
DB04938OspemifeneCytochrome P450 2C19enzyme
DB04938OspemifeneCytochrome P450 2B6enzyme
DB04938OspemifeneCytochrome P450 2D6enzyme
DB05073SRT501NAD-dependent protein deacetylase sirtuin-1target
DB06083TapinarofInterleukin-12 subunit betatarget
DB06083TapinarofInterleukin-2target
DB06083TapinarofInterleukin-6target
DB06083TapinarofInterleukin-8target
DB06735EnclomipheneCytochrome P450 2D6enzyme
DB07931HexestrolAldo-keto reductase family 1 member C1target
DB07931HexestrolEstrogen receptor alphatarget
DB07931HexestrolNuclear receptor subfamily 1 group I member 2target
DB07931HexestrolNuclear receptor subfamily 1 group I member 3target
DB08399PICEATANNOLATP synthase subunit alpha, mitochondrialtarget
DB08399PICEATANNOLATP synthase subunit beta, mitochondrialtarget
DB08399PICEATANNOLATP synthase subunit gamma, mitochondrialtarget
DB09148Florbetaben (18F)Cytochrome P450 2J2enzyme
DB09148Florbetaben (18F)Leukotriene-B(4) omega-hydroxylase 1enzyme
DB09148Florbetaben (18F)Amyloid beta A4 proteintarget
DB14753HydroxystilbamidineDNAtarget
DB138692-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenolEstrogen receptor betatarget
DB138692-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenolEstrogen receptor alphatarget