Sequestering Agents

Compounds that bind to and reduce the biological availability of a chemical or pharmaceutical agent.
DrugDrug NameDrug Indication
DB00258Calcium acetateCalcium acetate is one of a number of calcium salts used to treat hyperphosphatemia (too much phosphate in the blood) in patients with kidney disease.
DB00375ColestipolColestipol is indicated as adjunctive therapy to diet for the reduction of elevated serum total and low-density lipoprotein cholesterol (LDL-C) in patients with primary hypercholesterolemia (a condition that features elevated LDL-C) who do not respond adequately to diet [FDA Label, L6115, F4555]. Therapy with lipid-altering agents like colestipol should be a component of multiple risk factor intervention in those individuals at significantly increased risk for atherosclerotic vascular disease due to hypercholesterolemia [FDA Label, L6115, F4555]. Treatment should begin and continue with dietary therapy [FDA Label, L6115, F4555]. In general, a minimum of six months of intensive dietary therapy and counseling should be carried out prior to initiation of drug therapy such as that with colestipol [FDA Label, F4555]. Shorter periods may be considered in patients with severe elevations of LDL-C or with definite coronary heart disease [FDA Label, F4555]. Although colestipol is effective in all types of hypercholesterolemia, some regional prescribing information note in particular that it is medically most appropriate in patients with Fredrickson's type II hyperlipoproteinemia [L6115]. Nevertheless, in patients with combined hypercholesterolemia and hypertriglyceridemia, although colestipol may be helpful in reducing elevated cholesterol, it is not formally indicated where hypertriglyceridemia is the abnormality of greatest concern [F4567].
DB00566SuccimerFor the treatment of lead poisoning in pediatric patients with blood lead levels above 45 µg/dL. May also be used to treat mercury or arsenic poisoning.
DB00658SevelamerFor the control of serum phosphorus in patients with Chronic Kidney Disease (CKD) on hemodialysis.
DB00746DeferoxamineUsed to treat acute iron or aluminum toxicity (an excess of aluminum in the body) in certain patients. Also used in certain patients with anemia who must receive many blood transfusions.
DB00859PenicillamineFor treatment of Wilson's disease, cystinuria and active rheumatoid arthritis.
DB00974Edetic acidFor the reduction of blood levels and depot stores of lead in lead poisoning (acute and chronic) and lead encephalopathy, in both pediatric populations and adults.
DB01344TolevamerUsed to treat abnormally high potassium levels.
DB01609DeferasiroxFor the treatment of chronic iron overload due to blood transfusions (transfusional hemosiderosis) in patients 2 years of age and older.
DB023651,10-PhenanthrolineNot Available
DB02520DitiocarbNot Available
DB03040Nitrilotriacetic AcidNot Available
DB04267Dipicolinic AcidNot Available
DB04272Citric acidNot Available
DB04795ThenoyltrifluoroacetoneNot Available
DB04936TagatoseIntended for use as a therapeutic adjunct in the treatment of type II diabetes.
DB05088TetrathiomolybdateInvestigated for use/treatment in liver disease and pulmonary fibrosis.
DB05540AlanosineInvestigated for use/treatment in brain cancer and cancer/tumors (unspecified).
DB06782DimercaprolFor the treatment of arsenic, gold and mercury poisoning. Indicated in acute lead poisoning when used concomitantly with edetate calcium disodium (DB00974).
DB06824TriethylenetetramineTrientine is a copper chelator used in the treatment of Wilson's disease as an alternative to D-penicillamine. It tends to be used in patients who are experiencing serious adverse effects from penicillamine therapy or intolerance of penicillamine.
DB08826DeferiproneDeferiprone is indicated in thalassemia syndromes when first line chelation agents are not adequate to treat transfusional iron overload.
DB09132Gadoteric acidGadoteric acid is indicated for intravenous use with magnetic resonance imaging (MRI) in brain (intracranial), spine and associated tissues in adult and pediatric patients (2 years of age and older) to detect and visualize areas with disruption of the blood brain barrier (BBB) and/or abnormal vascularity.
DB09499Thiosulfuric acidIndicated for sequential intravenous use with sodium nitrite for the treatment of acute cyanide poisoning that is judged to be life-threatening.
DB10516CaseinNot Available
DB11175Zinc picolinateNot Available
DB11234PoliglusamNot Available
DB11255Chromium picolinateNot Available
DB11748BenfotiamineNot Available
DB12996ActeosideNot Available
DB13381Sodium feredetateNot Available
DB14007Pentetic acidDTPA is widely used in industry and medicine. As a medical agent, it is approved for its use in medical imaging and for the decorporation of internally deposited radionuclides.[A32501] It is FDA approved for the treatment of individuals with known or suspected internal contamination with plutonium, americium or curium to increase the rates of elimination.[L2243] Due to the pharmacokinetic elimination by the kidneys, pentetic acid conjugated with technetium Tc-99m is being used clinically to estimate physiological parameters such as glomerular filtration rat and effective renal plasma flow.[T168]
DB03995BetadexNot Available
DB12192EmeramideNot Available
DrugDrug NameTargetType
DB00258Calcium acetatePhosphatetarget
DB00375ColestipolBile acidstarget
DB00746DeferoxamineXanthine dehydrogenase/oxidaseenzyme
DB00746DeferoxamineAmyloid beta A4 proteintarget
DB00859PenicillamineSolute carrier organic anion transporter family member 1B1transporter
DB00974Edetic acidLeadtarget
DB00974Edetic acidIrontarget
DB00974Edetic acidManganese cationtarget
DB00974Edetic acidAdenosine deaminaseenzyme
DB00974Edetic acidSerum paraoxonase/lactonase 3enzyme
DB00974Edetic acidCytochrome P450 19A1enzyme
DB01609DeferasiroxCytochrome P450 3A4enzyme
DB01609DeferasiroxUDP-glucuronosyltransferase 1-1enzyme
DB01609DeferasiroxUDP-glucuronosyltransferase 1-3enzyme
DB01609DeferasiroxUDP-glucuronosyltransferase 1-9enzyme
DB01609DeferasiroxCytochrome P450 2C8enzyme
DB01609DeferasiroxCytochrome P450 1A2enzyme
DB023651,10-PhenanthrolineMethyl-accepting chemotaxis protein IItarget
DB023651,10-PhenanthrolineMetallo-beta-lactamase L1target
DB02520DitiocarbCytochrome P450 2E1enzyme
DB02520DitiocarbCytochrome P450 3A4enzyme
DB02520DitiocarbCytochrome P450 3A5enzyme
DB03040Nitrilotriacetic AcidLactotransferrintarget
DB04267Dipicolinic Acid4-hydroxy-tetrahydrodipicolinate reductasetarget
DB04267Dipicolinic Acid4-hydroxy-tetrahydrodipicolinate reductasetarget
DB04272Citric acidCell division protein FtsZtarget
DB04272Citric acidAngiogenintarget
DB04272Citric acidBeta-lactamase 2target
DB04272Citric acidUridine-cytidine kinase 2target
DB04272Citric acidTumor necrosis factor ligand superfamily member 13Btarget
DB04272Citric acidBetaine--homocysteine S-methyltransferase 1target
DB04272Citric acidTryptophan--tRNA ligasetarget
DB04272Citric acidAldose reductasetarget
DB04272Citric acidCitrate synthase, mitochondrialtarget
DB04272Citric acidHeparan sulfate glucosamine 3-O-sulfotransferase 3A1target
DB04272Citric acidcGMP-specific 3',5'-cyclic phosphodiesterasetarget
DB04272Citric acidProto-oncogene tyrosine-protein kinase Srctarget
DB04272Citric acidRibonuclease pancreatictarget
DB04272Citric acidIsocitrate dehydrogenase [NADP]target
DB04272Citric acidGlycine N-methyltransferasetarget
DB04272Citric acidEosinophil cationic proteintarget
DB04272Citric acidBeta-lactamasetarget
DB04272Citric acidMolybdenum cofactor guanylyltransferasetarget
DB04272Citric acidFumarate hydratase class IItarget
DB04272Citric acid6-phosphogluconolactonasetarget
DB04272Citric acidOxygen-insensitive NAD(P)H nitroreductasetarget
DB04272Citric acidGag-Pro-Pol polyproteintarget
DB04272Citric acidL-amino-acid oxidasetarget
DB04272Citric acidMacrophage migration inhibitory factortarget
DB04272Citric acidCarboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1target
DB04272Citric acid1-deoxy-D-xylulose 5-phosphate reductoisomerasetarget
DB04272Citric acidTryptophan synthase alpha chaintarget
DB04272Citric acidSialidasetarget
DB04272Citric acidKHG/KDPG aldolasetarget
DB04272Citric acidCytochrome c peroxidasetarget
DB04272Citric acidHepatocyte growth factor-regulated tyrosine kinase substratetarget
DB04272Citric acidInvasintarget
DB04272Citric acidIntron-associated endonuclease 1target
DB04272Citric acidShort tail fiber proteintarget
DB04272Citric acidMalate dehydrogenase, mitochondrialtarget
DB04272Citric acidN5-carboxyaminoimidazole ribonucleotide mutasetarget
DB04272Citric acid50S ribosomal protein L4target
DB04272Citric acidCarboxypeptidase Btarget
DB04272Citric acidHexon proteintarget
DB04272Citric acidRiboflavin biosynthesis protein RibFtarget
DB04272Citric acidBeta-fructosidasetarget
DB04272Citric acidPutative stringent starvation protein Atarget
DB04272Citric acidCitrate synthasetarget
DB04272Citric acidRNA 3'-terminal phosphate cyclasetarget
DB04272Citric acidU6 snRNA-associated Sm-like protein LSm6target
DB04272Citric acidPleckstrin homology domain-containing family A member 1target
DB04272Citric acidFe(3+)-binding periplasmic proteintarget
DB04272Citric acidSignal recognition particle receptor FtsYtarget
DB04272Citric acidNicotinate-nucleotide adenylyltransferasetarget
DB04272Citric acidN utilization substance protein B homologtarget
DB04272Citric acidComplement component C8 gamma chaintarget
DB04272Citric acidRibonucleoside-diphosphate reductase subunit betatarget
DB04272Citric acidGlutamine synthetase 1target
DB04272Citric acidCitrate synthasetarget
DB04272Citric acidProstaglandin F synthasetarget
DB04272Citric acidAdenine phosphoribosyltransferasetarget
DB04272Citric acidGlucose-1-phosphate thymidylyltransferasetarget
DB04272Citric acidGlyoxalase family proteintarget
DB04272Citric acidLaccase domain protein YfiHtarget
DB04272Citric acidRibose-5-phosphate isomerase Atarget
DB04272Citric acidGMP synthase [glutamine-hydrolyzing]target
DB04272Citric acidInosine triphosphate pyrophosphatasetarget
DB04272Citric acidLysozymetarget
DB04272Citric acidGlycerol uptake operon antiterminator regulatory proteintarget
DB04272Citric acid3-carboxy-cis,cis-muconate cycloisomerasetarget
DB04272Citric acidPyruvate decarboxylasetarget
DB04272Citric acidSolute carrier organic anion transporter family member 2B1transporter
DB04795ThenoyltrifluoroacetoneLiver carboxylesterase 1target
DB04795ThenoyltrifluoroacetoneSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialtarget
DB05088TetrathiomolybdateAmyloid beta A4 proteintarget
DB05540AlanosineAspartate carbamoyltransferase catalytic chaintarget
DB05540AlanosineAdenylosuccinate synthetase isozyme 2target
DB05540AlanosineAdenylosuccinate synthetase isozyme 1target
DB05540AlanosineCystine/glutamate transportertransporter
DB06782DimercaprolAmyloid beta A4 proteintarget
DB08826DeferiproneUDP-glucuronosyltransferase 1-6enzyme
DB09499Thiosulfuric acidThiosulfate sulfurtransferaseenzyme
DB14007Pentetic acidTransuranium elementstarget
DB14007Pentetic acidAlpha-1-antitrypsincarrier
DB03995BetadexNeopullulanase 2target
DB03995BetadexMaltose-binding periplasmic proteintarget
DB03995BetadexMaltogenic amylasetarget