Anti-Infective Agents, Urinary

Substances capable of killing agents causing urinary tract infections or of preventing them from spreading.
DrugDrug NameDrug Indication
DB00260CycloserineUsed in combination with up to 5 other drugs as a treatment for Mycobacterium avium complex (MAC) and is also used to treat tuberculosis (TB).
DB00440TrimethoprimFor the treatment of urinary tract infections, uncomplicated pyelonephritis (with sulfamethoxazole) and mild acute prostatitis. May be used as pericoital (with sulfamethoxazole) or continuous prophylaxis in females with recurrent cystitis. May be used as an alternative to treat asymptomatic bacteriuria during pregnancy (only before the last 6 weeks of pregnancy). Other uses include: alternative agent in respiratory tract infections (otitis, sinusitus, bronchitis and pneumonia), treatment of Pneumocystis jirovecii pneumonia (acute or prophylaxis), Nocardia infections, and traveller's diarrhea.
DB00614FurazolidoneFor the specific and symptomatic treatment of bacterial or protozoal diarrhea and enteritis caused by susceptible organisms.
DB00634SulfacetamideFor the treatment of bacterial vaginitis, keratitis, acute conjunctivitis, and blepharitis.
DB00664SulfametopyrazineFor the treatment of urinary tract infection and chronic bronchitis.
DB00698NitrofurantoinNitrofurantoin is indicated to treat acute uncomplicated urinary tract infections.[L6856,L6859,L6862]
DB01137LevofloxacinFor the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms: Corynebacterium species, Staphylococus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus (Groups C/F/G), Viridans group streptococci, Acinetobacter lwoffii, Haemophilus influenzae, Serratia marcescens.
DB01163AmdinocillinUsed in the treatment of urinary tract infections caused by some strains of E. coli and klebsiella and enterobacter species. Used mainly against Gram negative organisms.
DB01165OfloxacinFor the treatment of infections (respiratory tract, kidney, skin, soft tissue, UTI), urethral and cervical gonorrhoea.
DB01299SulfadoxineSulfadoxine is used in combination with pyrimethamine for the treatment or prevention of malaria. It can also be used to treat various infections in livestock as well. Sulfadoxine and pyrimethamine is indicated for the treatment of Plasmodium falciparum malaria in those patients in whom chloroquine resistance is suspected.
DB01422NitroxolineNitroxoline is an antibiotic agent.
DB01605PivmecillinamUsed to treat infections due to mecillinam-sensitive organisms such as urinary tract infections, salmonellosis and typhoid fever.
DB06799MethenamineFor prophylactic or suppressive treatment of frequently recurring urinary tract infections when long-term therapy is considered necessary. This drug is not used to treat infection and should only be used after appropriate eradication of infection with antimicrobial agents.
DB06821SulfameterNot Available
DB08972FlumequineNot Available
DB09047FinafloxacinFinafloxacin is indicated for the treatment of acute otitis externa (AOE) with or without an otowick, caused by susceptible strains of Pseudomonas aeruginosa and Staphylococcus aureus in patients age 1 year and older.
DB11461SulfachlorpyridazineNot Available
DB13475FurazidinNot Available
DB13506CarfecillinNot Available
DB13627Oxolinic acidNot Available
DB13730NifurtoinolNot Available
DB13744Piromidic acidNot Available
DB13823Pipemidic acidNot Available
DB00828FosfomycinFor the treatment of uncomplicated urinary tract infections (acute cystitis) in women due to susceptible strains of Escherichia coli and Enterococcus faecalis.
DrugDrug NameTargetType
DB00260CycloserineD-alanine--D-alanine ligase Atarget
DB00260CycloserineAlanine racemasetarget
DB00260CycloserineAromatic-L-amino-acid decarboxylaseenzyme
DB00260CycloserineProton-coupled amino acid transporter 2transporter
DB00440TrimethoprimThymidylate synthasetarget
DB00440TrimethoprimDihydrofolate reductasetarget
DB00440TrimethoprimCytochrome P450 2C8enzyme
DB00440TrimethoprimCytochrome P450 3A4enzyme
DB00440TrimethoprimP-glycoprotein 1transporter
DB00440TrimethoprimCytochrome P450 2C9enzyme
DB00440TrimethoprimSolute carrier family 22 member 2transporter
DB00614FurazolidoneAmine oxidase [flavin-containing] Benzyme
DB00614FurazolidoneAmine oxidase [flavin-containing] Aenzyme
DB00634SulfacetamideDihydropteroate synthasetarget
DB00634SulfacetamideDihydropteroate synthase type-1target
DB00634SulfacetamideFolic acid synthesis protein FOL1target
DB00664SulfametopyrazineDihydropteroate synthetasetarget
DB00698Nitrofurantoin30S ribosomal protein S10target
DB00698NitrofurantoinOxygen-insensitive NADPH nitroreductasetarget
DB00698NitrofurantoinProbable pyruvate-flavodoxin oxidoreductasetarget
DB00698NitrofurantoinATP-binding cassette sub-family G member 2transporter
DB00698NitrofurantoinNADPH--cytochrome P450 reductaseenzyme
DB00698NitrofurantoinBile salt export pumptransporter
DB00698NitrofurantoinP-glycoprotein 1transporter
DB00698NitrofurantoinCanalicular multispecific organic anion transporter 1transporter
DB01137LevofloxacinDNA gyrase subunit Atarget
DB01137LevofloxacinDNA topoisomerase 4 subunit Atarget
DB01137LevofloxacinDNA topoisomerase 2-alphatarget
DB01137LevofloxacinCytochrome P450 1A2enzyme
DB01137LevofloxacinSolute carrier family 22 member 2transporter
DB01137LevofloxacinP-glycoprotein 1transporter
DB01137LevofloxacinSolute carrier family 22 member 4transporter
DB01137LevofloxacinSolute carrier family 22 member 6transporter
DB01137LevofloxacinCytochrome P450 3A4enzyme
DB01137LevofloxacinMultidrug and toxin extrusion protein 1transporter
DB01137LevofloxacinMultidrug and toxin extrusion protein 2transporter
DB01137LevofloxacinCytochrome P450 2C9enzyme
DB01163AmdinocillinPenicillin-binding protein 2target
DB01163AmdinocillinPenicillin-binding protein 2atarget
DB01163AmdinocillinPenicillin-binding protein 3target
DB01163AmdinocillinPenicillin-binding protein 1Atarget
DB01163AmdinocillinPenicillin-binding protein 2Btarget
DB01163AmdinocillinPenicillin-binding protein 1btarget
DB01165OfloxacinDNA gyrase subunit Atarget
DB01165OfloxacinDNA topoisomerase 4 subunit Atarget
DB01165OfloxacinDNA topoisomerase 2-alphatarget
DB01165OfloxacinCytochrome P450 1A2enzyme
DB01165OfloxacinSolute carrier family 22 member 5transporter
DB01165OfloxacinMultidrug resistance-associated protein 1transporter
DB01165OfloxacinSolute carrier family 22 member 6transporter
DB01165OfloxacinCanalicular multispecific organic anion transporter 1transporter
DB01165OfloxacinSolute carrier family 22 member 4transporter
DB01165OfloxacinBile salt export pumptransporter
DB01299SulfadoxineDihydropteroate synthetasetarget
DB01299SulfadoxineBifunctional dihydrofolate reductase-thymidylate synthasetarget
DB01422NitroxolineMethionine aminopeptidase 2target
DB01422NitroxolineMagnesium cationtarget
DB01422NitroxolineManganese cationtarget
DB01605PivmecillinamPenicillin-binding protein 1Atarget
DB06821SulfameterDihydropteroate synthasetarget
DB08972FlumequineCytochrome P450 1A2enzyme
DB09047FinafloxacinDNA gyrase subunit Atarget
DB09047FinafloxacinDNA topoisomerase 4 subunit Atarget
DB09047FinafloxacinDNA topoisomerase 2-alphatarget
DB13627Oxolinic acidCytochrome P450 1A2enzyme
DB13823Pipemidic acidCytochrome P450 1A2enzyme
DB00828FosfomycinUDP-N-acetylglucosamine 1-carboxyvinyltransferasetarget