A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
DrugDrug NameDrug Indication
DB00262CarmustineFor the treatment of brain tumors, multiple myeloma, Hodgkin's disease and Non-Hodgkin's lymphomas.
DB00398SorafenibSorafenib is indicated for the treatment of unresectable hepatocellular carcinoma and advanced renal cell carcinoma.
DB00414AcetohexamideUsed in the management of diabetes mellitus type 2 (adult-onset).
DB00428StreptozocinFor the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma).
DB00672ChlorpropamideFor treatment of NIDDM in conjunction with diet and exercise.
DB00744ZileutonFor the prophylaxis and chronic treatment of asthma in adults and children 12 years of age and older.
DB00839TolazamideFor use as an adjunct to diet to lower the blood glucose in patients with non-insulin dependent diabetes mellitus (Type II) whose hyperglycemia cannot be satisfactorily controlled by diet alone.
DB01016GlyburideIndicated as an adjunct to diet to lower the blood glucose in patients with NIDDM whose hyperglycemia cannot be satisfactorily controlled by diet alone.
DB01067GlipizideIndicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.[label]
DB01120GliclazideFor the treatment of NIDDM in conjunction with diet and exercise.
DB01124TolbutamideFor treatment of NIDDM (non-insulin-dependent diabetes mellitus) in conjunction with diet and exercise.
DB01206LomustineFor the treatment of primary and metastatic brain tumors as a component of combination chemotherapy in addition to appropriate surgical and/or radiotherapeutic procedures. Also used in combination with other agents as secondary therapy for the treatment of refractory or relapsed Hodgkin's disease.
DB01251GliquidoneUsed in the treatment of diabetes mellitus type 2.
DB01289GlisoxepideFor the treatment of diabetes mellitus type 2.
DB04106FotemustineNot Available
DB04846CeliprololCeliprolol is indicated for the management of mild to moderate hypertension and effort-induced angina pectoris.
DB04862MerimepodibFor the treatment of hepatitis C virus (HCV) infection.
DB05470VX-702Investigated for use/treatment in coronary artery disease, inflammatory disorders (unspecified), and rheumatoid arthritis.
DB05500AVN-944Investigated for use/treatment in cancer/tumors (unspecified), leukemia (unspecified), lymphoma (unspecified), multiple myeloma, and pancreatic cancer.
DB06080ABT-869Investigated for use/treatment in leukemia (myeloid), myelodysplastic syndrome, and solid tumors.
DB06103VX-148Investigated for use/treatment in autoimmune diseases, psoriasis and psoriatic disorders, and viral infection.
DB06134SNS-314Investigated for use/treatment in solid tumors.
DB08805MetiamidePotential in the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion.
DB08896RegorafenibRegorafenib is indicated for the treatment of patients with metastatic colorectal cancer (CRC) who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if KRAS wild type, an anti-EGFR therapy. Regorafenib is also indicated for the treatment of patients with locally advanced, unresectable or metastatic gastrointestinal stromal tumor (GIST) who have been previously treated with imatinib mesylate and sunitinib malate.
DB08962GlibornurideNot Available
DB09078LenvatinibLenvatinib is indicated for the treatment of following conditions. - Treatment of locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer. - Treatment of advanced renal cell carcinoma (RCC) in combination with everolimus following one prior antiangiogenic therapy. - First-line treatment of unresectable hepatocellular carcinoma (HCC).
DB11100AllantoinAllantoin is commonly applied in a variety of topical vehicles or applications such as cosmetic creams, toothpastes, mouthwashes, shampoos, lipsticks, anti-acne products, and lotions [A32213] for the purpose of moisturizing skin, enhancing the smoothness of skin, stimulating the healing of wounds, and soothing irritated skin [A32213, FDA Label].
DB11155TriclocarbanTriclocarban (TCC), or 3,4,4'-trichlorocarbanilide, is an antibacterial agent used in bar and liquid soaps and body washes [L2685].
DB11521ImidocarbNot Available
DB11662RabusertibNot Available
DB116882-chloroethyl-3-sarcosinamide-1-nitrosoureaNot Available
DB11694IlorasertibNot Available
DB11800TivozanibNot Available
DB11853RelugolixNot Available
DB11886InfigratinibNot Available
DB12135ElubrixinNot Available
DB12138PF-03715455Not Available
DB12355NetazepideNot Available
DB12574LY-295501Not Available
DB12744CGI-1842Not Available
DB12758AtreleutonNot Available
DB12836GrapiprantThe effects of grapiprant have been investigated in the area of analgesia and anti-inflammation due to the effects that have been reported about this molecule.[A39816] This molecule has been approved and widely accepted to be used in veterinary for pain reduction in arthritis.[A39835] In humans, it has been researched to be used in the control of pain and inflammation associated with osteoarthritis.[A39844, A39843] The effect of grapiprant can be explained through the function of prostaglandin E2 (PGE2) which is a key mediator of swelling redness and pain which are classic signs of inflammation. The effect of PGE2 results from its action through four receptor EP1, EP2, EP3 and EP4 from which the EP4 is the primary mediator of PGE2-driven inflammation.[A39817]
DB12968DONUNot Available
DB13069NimustineNot Available
DB13370BromisovalNot Available
DB13406CarbutamideNot Available
DB13522MebicarNot Available
DB13647SemustineNot Available
DB13675MetahexamideNot Available
DB13832RanimustineNot Available
DB13838NoxytiolinNot Available
DB02234S-EthylisothioureaNot Available
DB12555NelotanserinNot Available
DB12874QuizartinibNot Available
DB01005HydroxyureaFor management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
DB11978GlasdegibGlasdegib, in combination with cytarabine, is indicated for the treatment of newly diagnosed acute myeloid leukemia in adult patients who are over 75 years old or that have co-morbidities that preclude intensive induction chemotherapy.[L5080] Acute myeloid leukemia is characterized by abnormal production of myeloblasts, red cells, or platelets. It is considered a cancer of blood and bone marrow and it is the most common type of acute leukemia in adults.[L4832]
DB15006FlufenoxuronNot Available
DB15197RSV-604Not Available
DB11129Carbamide peroxideIndicated as a dental bleaching agent. Indicated as an oral wound healing agent in oral mucosal injuries. Indicated as an aid in the removal of hardened ear wax.
DB13072GDC-0349Not Available
DrugDrug NameTargetType
DB00262CarmustineGlutathione reductase, mitochondrialtarget
DB00262CarmustineDNAtarget
DB00262CarmustineCytochrome P450 1A2enzyme
DB00262CarmustineRNAtarget
DB00398SorafenibSerine/threonine-protein kinase B-raftarget
DB00398SorafenibReceptor-type tyrosine-protein kinase FLT3target
DB00398SorafenibRAF proto-oncogene serine/threonine-protein kinasetarget
DB00398SorafenibVascular endothelial growth factor receptor 3target
DB00398SorafenibPlatelet-derived growth factor receptor betatarget
DB00398SorafenibMast/stem cell growth factor receptor Kittarget
DB00398SorafenibVascular endothelial growth factor receptor 2target
DB00398SorafenibCytochrome P450 3A4enzyme
DB00398SorafenibUDP-glucuronosyltransferase 1-9enzyme
DB00398SorafenibCytochrome P450 2B6enzyme
DB00398SorafenibCytochrome P450 2C8enzyme
DB00398SorafenibCytochrome P450 3A5enzyme
DB00398SorafenibCytochrome P450 3A7enzyme
DB00398SorafenibCytochrome P450 2C9enzyme
DB00398SorafenibMultidrug resistance-associated protein 4transporter
DB00398SorafenibMultidrug resistance protein 1transporter
DB00398SorafenibCanalicular multispecific organic anion transporter 1transporter
DB00398SorafenibATP-binding cassette sub-family G member 2transporter
DB00398SorafenibCytochrome P450 1A2enzyme
DB00398SorafenibCytochrome P450 2C19enzyme
DB00398SorafenibCytochrome P450 2D6enzyme
DB00398SorafenibUDP-glucuronosyltransferase 1-1enzyme
DB00398SorafenibRalA-binding protein 1transporter
DB00398SorafenibFibroblast growth factor receptor 1target
DB00398SorafenibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB00398SorafenibVascular endothelial growth factor receptor 1target
DB00398SorafenibSolute carrier organic anion transporter family member 1B1transporter
DB00414AcetohexamideATP-sensitive inward rectifier potassium channel 1target
DB00414AcetohexamideCarbonyl reductase [NADPH] 1enzyme
DB00414AcetohexamideSerum albumincarrier
DB00414AcetohexamideCytochrome P450 2C9enzyme
DB00428StreptozocinDNAtarget
DB00428StreptozocinMultidrug resistance protein 1transporter
DB00428StreptozocinSolute carrier family 2, facilitated glucose transporter member 2target
DB00428StreptozocinO-GlcNAcase BT_4395target
DB00428StreptozocinCytochrome P450 1A1enzyme
DB00428StreptozocinCytochrome P450 1A2enzyme
DB00428StreptozocinCytochrome P450 2E1enzyme
DB00428StreptozocinBifunctional protein NCOATtarget
DB00672ChlorpropamideATP-binding cassette sub-family C member 8target
DB00672ChlorpropamideSolute carrier family 15 member 1transporter
DB00672ChlorpropamideSolute carrier family 15 member 2transporter
DB00672ChlorpropamideSolute carrier family 22 member 6transporter
DB00672ChlorpropamideCytochrome P450 2C9enzyme
DB00672ChlorpropamideCytochrome P450 2C19enzyme
DB00672ChlorpropamideProstaglandin G/H synthase 1enzyme
DB00744ZileutonArachidonate 5-lipoxygenasetarget
DB00744ZileutonCytochrome P450 2C9enzyme
DB00744ZileutonCytochrome P450 1A2enzyme
DB00744ZileutonCytochrome P450 3A4enzyme
DB00744ZileutonProstaglandin G/H synthase 1enzyme
DB00744ZileutonUDP-glucuronosyltransferase 1-9enzyme
DB00744ZileutonSerum albumincarrier
DB00839TolazamideSulfonylurea receptor 1, Kir6.2target
DB00839TolazamideCytochrome P450 2C9enzyme
DB01016GlyburideATP-binding cassette sub-family C member 9target
DB01016GlyburideBile salt export pumptarget
DB01016GlyburideATP-binding cassette sub-family A member 1target
DB01016GlyburideCystic fibrosis transmembrane conductance regulatortarget
DB01016GlyburideSulfonylurea receptor 1, Kir6.2target
DB01016GlyburideG protein-activated inward rectifier potassium channel 4target
DB01016GlyburideCytochrome P450 2C9enzyme
DB01016GlyburideCanalicular multispecific organic anion transporter 2transporter
DB01016GlyburideBile salt export pumptransporter
DB01016GlyburideMultidrug resistance protein 1transporter
DB01016GlyburideMultidrug resistance-associated protein 1transporter
DB01016GlyburideSolute carrier family 15 member 1transporter
DB01016GlyburideSolute carrier organic anion transporter family member 1A2transporter
DB01016GlyburideSolute carrier family 15 member 2transporter
DB01016GlyburideSolute carrier family 22 member 6transporter
DB01016GlyburideCanalicular multispecific organic anion transporter 1transporter
DB01016GlyburideATP-binding cassette sub-family G member 2transporter
DB01016GlyburideSolute carrier family 22 member 7transporter
DB01016GlyburideSolute carrier organic anion transporter family member 2B1transporter
DB01016GlyburideCytochrome P450 2C19enzyme
DB01016GlyburideCytochrome P450 3A4enzyme
DB01016GlyburideSerum albumincarrier
DB01016GlyburideMitochondrial ATP-sensitive potassium channeltarget
DB01016GlyburideCarnitine O-palmitoyltransferase 1, liver isoformtarget
DB01067GlipizideCytochrome P450 2C9enzyme
DB01067GlipizidePeroxisome proliferator-activated receptor gammatarget
DB01067GlipizideATP-binding cassette sub-family C member 8target
DB01067GlipizideCytochrome P450 3A4enzyme
DB01067GlipizideUDP-glucuronosyltransferase 1-1enzyme
DB01067GlipizideBile salt export pumptransporter
DB01067GlipizideSerum albumincarrier
DB01120GliclazideATP-binding cassette sub-family C member 8target
DB01120GliclazideSerum albumincarrier
DB01120GliclazideVascular endothelial growth factor Atarget
DB01120GliclazideCytochrome P450 2C9enzyme
DB01120GliclazideCytochrome P450 2C19enzyme
DB01124TolbutamideATP-sensitive inward rectifier potassium channel 1target
DB01124TolbutamideCytochrome P450 2C19enzyme
DB01124TolbutamideCytochrome P450 2C9enzyme
DB01124TolbutamideCytochrome P450 2C8enzyme
DB01124TolbutamideATP-binding cassette sub-family C member 8target
DB01124TolbutamideSolute carrier family 15 member 1transporter
DB01124TolbutamideSolute carrier organic anion transporter family member 1A2transporter
DB01124TolbutamideSolute carrier family 15 member 2transporter
DB01124TolbutamideSolute carrier family 22 member 6transporter
DB01124TolbutamideSolute carrier organic anion transporter family member 2B1transporter
DB01124TolbutamideCytochrome P450 2C18enzyme
DB01124TolbutamideSerum albumincarrier
DB01206LomustineDNAtarget
DB01206LomustineCytochrome P450 3A4enzyme
DB01206LomustineCytochrome P450 2D6enzyme
DB01206LomustineStathmin-4target
DB01251GliquidoneATP-binding cassette sub-family C member 8target
DB01251GliquidoneATP-sensitive inward rectifier potassium channel 8target
DB01251GliquidoneCytochrome P450 2C9enzyme
DB01289GlisoxepideATP-sensitive inward rectifier potassium channel 8target
DB01289GlisoxepideCytochrome P450 2C9enzyme
DB04106FotemustineThioredoxin reductase 1, cytoplasmictarget
DB04846CeliprololBeta-1 adrenergic receptortarget
DB04846CeliprololBeta-2 adrenergic receptortarget
DB04846CeliprololBeta-3 adrenergic receptortarget
DB04846CeliprololAlpha-2A adrenergic receptortarget
DB04846CeliprololAlpha-2B adrenergic receptortarget
DB04846CeliprololAlpha-2C adrenergic receptortarget
DB04846CeliprololCytochrome P450 2D6enzyme
DB04862MerimepodibInosine-5'-monophosphate dehydrogenasetarget
DB05470VX-702Mitogen-activated protein kinase 14target
DB05470VX-702Tumor necrosis factortarget
DB05470VX-702Interleukin-1 betatarget
DB05470VX-702Interleukin-6target
DB06080ABT-869Receptor-type tyrosine-protein kinase FLT3target
DB06080ABT-869Vascular endothelial growth factor receptor 1target
DB06080ABT-869Vascular endothelial growth factor receptor 2target
DB06080ABT-869Vascular endothelial growth factor receptor 3target
DB06080ABT-869Mast/stem cell growth factor receptor Kittarget
DB06080ABT-869Macrophage colony-stimulating factor 1 receptortarget
DB06103VX-148Inosine-5'-monophosphate dehydrogenase 1target
DB06103VX-148Inosine-5'-monophosphate dehydrogenase 2target
DB06134SNS-314Aurora kinase Atarget
DB06134SNS-314Aurora kinase Ctarget
DB08805MetiamideHistamine H2 receptortarget
DB08896RegorafenibCytochrome P450 3A4enzyme
DB08896RegorafenibUDP-glucuronosyltransferase 1-9enzyme
DB08896RegorafenibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB08896RegorafenibVascular endothelial growth factor receptor 1target
DB08896RegorafenibVascular endothelial growth factor receptor 2target
DB08896RegorafenibVascular endothelial growth factor receptor 3target
DB08896RegorafenibMast/stem cell growth factor receptor Kittarget
DB08896RegorafenibPlatelet-derived growth factor receptor alphatarget
DB08896RegorafenibPlatelet-derived growth factor receptor betatarget
DB08896RegorafenibFibroblast growth factor receptor 1target
DB08896RegorafenibFibroblast growth factor receptor 2target
DB08896RegorafenibAngiopoietin-1 receptortarget
DB08896RegorafenibDiscoidin domain-containing receptor 2target
DB08896RegorafenibHigh affinity nerve growth factor receptortarget
DB08896RegorafenibEphrin type-A receptor 2target
DB08896RegorafenibRAF proto-oncogene serine/threonine-protein kinasetarget
DB08896RegorafenibSerine/threonine-protein kinase B-raftarget
DB08896RegorafenibCytochrome P450 2C8enzyme
DB08896RegorafenibCytochrome P450 2C9enzyme
DB08896RegorafenibCytochrome P450 2B6enzyme
DB08896RegorafenibMitogen-activated protein kinase 11target
DB08896RegorafenibTyrosine-protein kinase FRKtarget
DB08896RegorafenibTyrosine-protein kinase ABL1target
DB08896RegorafenibMultidrug resistance protein 1transporter
DB08896RegorafenibATP-binding cassette sub-family G member 2transporter
DB08896RegorafenibUDP-glucuronosyltransferase 1-1enzyme
DB08962GlibornurideCytochrome P450 2C9enzyme
DB09078LenvatinibVascular endothelial growth factor receptor 1target
DB09078LenvatinibVascular endothelial growth factor receptor 2target
DB09078LenvatinibVascular endothelial growth factor receptor 3target
DB09078LenvatinibFibroblast growth factor receptor 1target
DB09078LenvatinibFibroblast growth factor receptor 2target
DB09078LenvatinibFibroblast growth factor receptor 3target
DB09078LenvatinibFibroblast growth factor receptor 4target
DB09078LenvatinibPlatelet derived growth factor receptor alphatarget
DB09078LenvatinibRETtarget
DB09078LenvatinibMast/stem cell growth factor receptor Kittarget
DB09078LenvatinibMultidrug resistance protein 1transporter
DB09078LenvatinibATP-binding cassette sub-family G member 2transporter
DB09078LenvatinibCytochrome P450 3A4enzyme
DB09078LenvatinibAldehyde oxidaseenzyme
DB09078LenvatinibCytochrome P450 2C8enzyme
DB09078LenvatinibCytochrome P450 2C9enzyme
DB09078LenvatinibCytochrome P450 1A2enzyme
DB09078LenvatinibCytochrome P450 2B6enzyme
DB09078LenvatinibCytochrome P450 2C19enzyme
DB09078LenvatinibSolute carrier family 22 member 6transporter
DB09078LenvatinibSolute carrier family 22 member 8transporter
DB09078LenvatinibSolute carrier family 22 member 2transporter
DB09078LenvatinibSolute carrier organic anion transporter family member 1B1transporter
DB09078LenvatinibBile salt export pumptransporter
DB09078LenvatinibCytochrome P450 2D6enzyme
DB11100AllantoinThyroxine-binding globulincarrier
DB11155TriclocarbanEnoyl-[acyl-carrier-protein] reductase [NADPH] FabItarget
DB11155TriclocarbanCytochrome P450 1A1enzyme
DB11155TriclocarbanCytochrome P450 1B1enzyme
DB12836GrapiprantProstaglandin E2 receptor EP4 subtypetarget
DB12836GrapiprantMultidrug resistance protein 1transporter
DB12836GrapiprantSerum albumincarrier
DB13406CarbutamideCytochrome P450 2C9enzyme
DB13675MetahexamideCytochrome P450 2C9enzyme
DB02234S-EthylisothioureaNitric oxide synthase oxygenasetarget
DB02234S-EthylisothioureaNitric oxide synthase, inducibletarget
DB02234S-EthylisothioureaNitric oxide synthase, endothelialtarget
DB12555Nelotanserin5-hydroxytryptamine receptor 2Atarget
DB12874QuizartinibReceptor-type tyrosine-protein kinase FLT3target
DB01005HydroxyureaRibonucleoside-diphosphate reductase large subunittarget
DB01005HydroxyureaCytochrome P450 2D6enzyme
DB11978GlasdegibCytochrome P450 3A4enzyme
DB11978GlasdegibSmoothened homologtarget
DB11978GlasdegibCytochrome P450 2C8enzyme
DB11978GlasdegibUDP-glucuronosyltransferase 1-9enzyme
DB11978GlasdegibSerum albumincarrier
DB11978GlasdegibMultidrug resistance protein 1transporter
DB11978GlasdegibATP-binding cassette sub-family G member 2transporter
DB11978GlasdegibMultidrug and toxin extrusion protein 1transporter
DB11978GlasdegibMultidrug and toxin extrusion protein 2transporter