|DB00262||Carmustine||For the treatment of brain tumors, multiple myeloma, Hodgkin's disease and Non-Hodgkin's lymphomas.|
|DB00398||Sorafenib||Sorafenib is indicated for the treatment of unresectable hepatocellular carcinoma and advanced renal cell carcinoma. |
|DB00414||Acetohexamide||Used in the management of diabetes mellitus type 2 (adult-onset).|
|DB00428||Streptozocin||For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma).|
|DB00672||Chlorpropamide||For treatment of NIDDM in conjunction with diet and exercise. |
|DB00744||Zileuton||For the prophylaxis and chronic treatment of asthma in adults and children 12 years of age and older.|
|DB00839||Tolazamide||For use as an adjunct to diet to lower the blood glucose in patients with non-insulin dependent diabetes mellitus (Type II) whose hyperglycemia cannot be satisfactorily controlled by diet alone.|
|DB01016||Glyburide||Indicated as an adjunct to diet to lower the blood glucose in patients with NIDDM whose hyperglycemia cannot be satisfactorily controlled by diet alone.|
|DB01067||Glipizide||Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.[label] |
|DB01120||Gliclazide||For the treatment of NIDDM in conjunction with diet and exercise. |
|DB01124||Tolbutamide||For treatment of NIDDM (non-insulin-dependent diabetes mellitus) in conjunction with diet and exercise.|
|DB01206||Lomustine||For the treatment of primary and metastatic brain tumors as a component of combination chemotherapy in addition to appropriate surgical and/or radiotherapeutic procedures. Also used in combination with other agents as secondary therapy for the treatment of refractory or relapsed Hodgkin's disease.|
|DB01251||Gliquidone||Used in the treatment of diabetes mellitus type 2.|
|DB01289||Glisoxepide||For the treatment of diabetes mellitus type 2.|
|DB04846||Celiprolol||Celiprolol is indicated for the management of mild to moderate hypertension and effort-induced angina pectoris. |
|DB04862||Merimepodib||For the treatment of hepatitis C virus (HCV) infection.|
|DB05470||VX-702||Investigated for use/treatment in coronary artery disease, inflammatory disorders (unspecified), and rheumatoid arthritis.|
|DB05500||AVN-944||Investigated for use/treatment in cancer/tumors (unspecified), leukemia (unspecified), lymphoma (unspecified), multiple myeloma, and pancreatic cancer.|
|DB06080||ABT-869||Investigated for use/treatment in leukemia (myeloid), myelodysplastic syndrome, and solid tumors.|
|DB06103||VX-148||Investigated for use/treatment in autoimmune diseases, psoriasis and psoriatic disorders, and viral infection.|
|DB06134||SNS-314||Investigated for use/treatment in solid tumors.|
|DB08805||Metiamide||Potential in the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion.|
|DB08896||Regorafenib||Regorafenib is indicated for the treatment of patients with metastatic colorectal cancer (CRC) who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if KRAS wild type, an anti-EGFR therapy. Regorafenib is also indicated for the treatment of patients with locally advanced, unresectable or metastatic gastrointestinal stromal tumor (GIST) who have been previously treated with imatinib mesylate and sunitinib malate.|
|DB09078||Lenvatinib||Lenvatinib is indicated for the treatment of following conditions.
- Treatment of locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer.
- Treatment of advanced renal cell carcinoma (RCC) in combination with everolimus following one prior antiangiogenic therapy.
- First-line treatment of unresectable hepatocellular carcinoma (HCC).|
|DB11100||Allantoin||Allantoin is commonly applied in a variety of topical vehicles or applications such as cosmetic creams, toothpastes, mouthwashes, shampoos, lipsticks, anti-acne products, and lotions [A32213] for the purpose of moisturizing skin, enhancing the smoothness of skin, stimulating the healing of wounds, and soothing irritated skin [A32213, FDA Label].|
|DB11155||Triclocarban||Triclocarban (TCC), or 3,4,4'-trichlorocarbanilide, is an antibacterial agent used in bar and liquid soaps and body washes [L2685].|
|DB12836||Grapiprant||The effects of grapiprant have been investigated in the area of analgesia and anti-inflammation due to the effects that have been reported about this molecule.[A39816]
This molecule has been approved and widely accepted to be used in veterinary for pain reduction in arthritis.[A39835] In humans, it has been researched to be used in the control of pain and inflammation associated with osteoarthritis.[A39844, A39843]
The effect of grapiprant can be explained through the function of prostaglandin E2 (PGE2) which is a key mediator of swelling redness and pain which are classic signs of inflammation. The effect of PGE2 results from its action through four receptor EP1, EP2, EP3 and EP4 from which the EP4 is the primary mediator of PGE2-driven inflammation.[A39817]|
|DB01005||Hydroxyurea||For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.|
|DB11978||Glasdegib||Glasdegib, in combination with cytarabine, is indicated for the treatment of newly diagnosed acute myeloid leukemia in adult patients who are over 75 years old or that have co-morbidities that preclude intensive induction chemotherapy.[L5080]
Acute myeloid leukemia is characterized by abnormal production of myeloblasts, red cells, or platelets. It is considered a cancer of blood and bone marrow and it is the most common type of acute leukemia in adults.[L4832]|
|DB11129||Carbamide peroxide||Indicated as a dental bleaching agent.
Indicated as an oral wound healing agent in oral mucosal injuries.
Indicated as an aid in the removal of hardened ear wax.|