Chemicals used to destroy pests of any sort. The concept includes fungicides (FUNGICIDES, INDUSTRIAL); INSECTICIDES; RODENTICIDES; etc.
DrugDrug NameDrug Indication
DB00265CrotamitonFor eradication of scabies (Sarcoptes scabiei) and for symptomatic treatment of pruritic skin.
DB00431LindaneFor the treatment of patients infested with Sarcoptes scabiei or pediculosis capitis who have either failed to respond to adequate doses, or are intolerant of other approved therapies.
DB00602IvermectinFor the treatment of intestinal (i.e., nondisseminated) strongyloidiasis due to the nematode parasite Strongyloides stercoralis. Also for the treatment of onchocerciasis (river blindness) due to the nematode parasite Onchocerca volvulus. Can be used to treat scabies caused by Sarcoptes scabiei.
DB00676Benzyl benzoateUsed to kill lice and the mites responsible for the skin condition scabies.
DB00682Warfarin**Indicated** for:[label,L6616] 1) Prophylaxis and treatment of venous thromboembolism and related pulmonary embolism. 2) Prophylaxis and treatment of thromboembolism associated with atrial fibrillation. 3) Prophylaxis and treatment of thromboembolism associated with cardiac valve replacement. 4) Use as adjunct therapy to reduce mortality, recurrent myocardial infarction, and thromboembolic events post myocardial infarction. **Off-label** uses include: 1) Secondary prevention of stroke and transient ischemic attacks in patients with rheumatic mitral valve disease but without atrial fibrillation.[A179182]
DB00772MalathionFor patients infected with Pediculus humanus capitis (head lice and their ova) of the scalp hair.
DB03895Malachite GreenNot Available
DB04539GlyphosateNot Available
DB04628AllosamidinNot Available
DB04657CarboxinNot Available
DB04930PermethrinFor the treatment of infestation with Sarcoptes scabiei (scabies).
DB06803NiclosamideFor the treatment of tapeworm and intestinal fluke infections: Taenia saginata (Beef Tapeworm), Taenia solium (Pork Tapeworm), Diphyllobothrium latum (Fish Tapeworm), Fasciolopsis buski (large intestinal fluke). Niclosamide is also used as a molluscicide in the control of schistosomiasis.
DB08823SpinosadSpinosad is indicated for the topical treatment of head lice in children four years old and over and in adults.
DB09350Piperonyl butoxideFor the treatment of head, pubic (crab), and body lice.
DB11087Pyrethrum extractNot Available
DB11282DiethyltoluamideDiethyltoluamide, or DEET, is an active ingredient that is predominantly indicated for as an insect repellant used to repel biting pests like mosquitoes and ticks [L2774]. Products containing DEET currently are available to the public in a variety of liquids, lotions, sprays, and impregnated materials like towelettes or roll-ons [L2774].
DB11326Boric acidNo FDA- or EMA-approved therapeutic indications on its own.
DB11373AmitrazNot Available
DB11390CoumaphosNot Available
DB11392CythioateNot Available
DB11397DichlorvosNot Available
DB11400DoramectinNot Available
DB11405EprinomectinNot Available
DB11408FamphurNot Available
DB11412FenthionNot Available
DB11421ImidaclopridNot Available
DB11424LufenuronNot Available
DB11431MoxidectinMoxidectin is indicated for the treatment of river blindness, also called onchocerciasis, in patients aged 12 years and older. River blindness is caused by a parasitic worm _Onchocerca volvulus_ and it is manifested as severe itching, disfiguring skin conditions and visual impairment caused by the worm's larvae.[L2971] The transmission of _Onchocerca volvulus_ is performed person to person by black flies that breed in fast-flowing rivers in sub-Saharan Africa, Yemen and South and Central America. The larvae released by the adult parasite invade skin and eyes where they can produce the severe disease manifestations.[L2971]
DB11448PhosmetNot Available
DB11457RotenoneNot Available
DB11473MetrifonateNot Available
DB12231TemefosNot Available
DB12989NeosaxitoxinNot Available
DB13009CarbendazimNot Available
DB13245ThiramNot Available
DB13336DimethylphthalateNot Available
DB13495ParaoxonNot Available
DB13600DeltamethrinNot Available
DB13717PhenothrinNot Available
DB13721CypermethrinNot Available
DB13746BioallethrinBioallethrin was used for lice and scabies infestation. Other pyrethroids are now used in place of bioallethrin.
DB13752TetramethrinNot Available
DB13828CyfluthrinNot Available
DB139631,2-dichlorobenzeneNot Available
DB14150Chloric acidNot Available
DB07338AcifluorfenNot Available
DB02994Cacodylic acidNot Available
DB01460DiethyltryptamineNot Available
DB14972MethamidophosNot Available
DrugDrug NameTargetType
DB00431LindaneGamma-aminobutyric acid receptor subunit beta-1target
DB00431LindaneGlycine receptor subunit alpha-1target
DB00431LindaneGlycine receptor subunit alpha-2target
DB00431LindaneGlycine receptor subunit alpha-3target
DB00431LindaneGlycine receptor subunit betatarget
DB00431LindaneGamma-aminobutyric acid receptor subunit beta-3target
DB00431LindaneGamma-aminobutyric acid receptor subunit rho-1target
DB00431LindaneProgesterone receptortarget
DB00431LindaneEstrogen receptor alphatarget
DB00431LindaneNuclear receptor subfamily 1 group I member 2target
DB00602IvermectinGamma-aminobutyric acid receptor subunit beta-3target
DB00602IvermectinGlycine receptor subunit alpha-3target
DB00602IvermectinMultidrug resistance protein 1transporter
DB00602IvermectinMultidrug resistance-associated protein 1transporter
DB00602IvermectinCanalicular multispecific organic anion transporter 1transporter
DB00602IvermectinATP-binding cassette sub-family G member 2transporter
DB00602IvermectinCytochrome P450 3A4enzyme
DB00602IvermectinSolute carrier organic anion transporter family member 1B1transporter
DB00602IvermectinSolute carrier organic anion transporter family member 1B3transporter
DB00682WarfarinVitamin K epoxide reductase complex subunit 1target
DB00682WarfarinCytochrome P450 2C8enzyme
DB00682WarfarinCytochrome P450 1A2enzyme
DB00682WarfarinCytochrome P450 2C9enzyme
DB00682WarfarinAlpha-1-acid glycoprotein 1carrier
DB00682WarfarinSerum albumincarrier
DB00682WarfarinCytochrome P450 2C19enzyme
DB00682WarfarinCytochrome P450 3A4enzyme
DB00682WarfarinCytochrome P450 2C18enzyme
DB00682WarfarinNuclear receptor subfamily 1 group I member 2target
DB00772MalathionCytochrome P450 1A2enzyme
DB00772MalathionCytochrome P450 2B6enzyme
DB03895Malachite GreenHTH-type transcriptional regulator QacRtarget
DB04539Glyphosate3-phosphoshikimate 1-carboxyvinyltransferasetarget
DB04539Glyphosate3-phosphoshikimate 1-carboxyvinyltransferasetarget
DB04539GlyphosateCytochrome P450 19A1target
DB04539GlyphosateSerum albumincarrier
DB04628AllosamidinChitinase Btarget
DB04628AllosamidinChitinase Atarget
DB04657CarboxinSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialtarget
DB04930PermethrinCytochrome P450 2B6enzyme
DB04930PermethrinCytochrome P450 3A4enzyme
DB04930PermethrinSodium channel protein type 1 subunit alphatarget
DB04930PermethrinEstrogen receptor alphatarget
DB04930PermethrinNuclear receptor subfamily 1 group I member 2target
DB06803NiclosamideCytochrome P450 2C9enzyme
DB06803NiclosamideCytochrome P450 1A2enzyme
DB11087Pyrethrum extractNuclear receptor subfamily 1 group I member 2target
DB11397DichlorvosSerum albumincarrier
DB11400DoramectinCytochrome P450 3A4enzyme
DB11405EprinomectinCytochrome P450 3A4enzyme
DB11421ImidaclopridCHRNA7-FAM7A fusion proteintarget
DB11431MoxidectinCYP2B proteinenzyme
DB11431MoxidectinMultidrug resistance protein 1transporter
DB11431MoxidectinATP-binding cassette sub-family G member 2transporter
DB11431MoxidectinGlutamate-gated chloride channeltarget
DB11431MoxidectinGABAA gated chloride channeltarget
DB11431MoxidectinABC transporterstarget
DB13746BioallethrinVoltage gated sodium channeltarget
DB13746BioallethrinSodium channel proteintarget
DB13746BioallethrinVoltage-dependent N-type calcium channeltarget
DB13746BioallethrinVoltage-dependent T-type calcium channeltarget
DB13746BioallethrinVoltage-dependent P/Q-type calcium channeltarget
DB13746BioallethrinVoltage-dependent L-type calcium channeltarget
DB13746BioallethrinCytochrome P450 2C8enzyme
DB13746BioallethrinCytochrome P450 2C9enzyme
DB13746BioallethrinCytochrome P450 2C19enzyme
DB13746BioallethrinCytochrome P450 3A4enzyme
DB13746BioallethrinCytochrome P450 2A1enzyme
DB13746BioallethrinCytochrome P450 1A1enzyme
DB13746BioallethrinCytochrome P450 2C6enzyme
DB13746BioallethrinCytochrome P450 2C11enzyme
DB13746BioallethrinCytochrome P450 3A1enzyme
DB13746BioallethrinCytochrome P450 3A2enzyme
DB07338AcifluorfenProtoporphyrinogen oxidasetarget
DB07338AcifluorfenProtoporphyrinogen oxidasetarget
DB02994Cacodylic acidGag-Pol polyproteintarget
DB02994Cacodylic acidNitric oxide synthase, endothelialtarget
DB02994Cacodylic acidAldose reductasetarget
DB02994Cacodylic acidGuanine nucleotide-binding protein G(t) subunit alpha-1target