Synthetic or naturally occurring substances related to coumarin, the delta-lactone of coumarinic acid.
DrugDrug NameDrug Indication
DB00682Warfarin**Indicated** for:[label,L6616] 1) Prophylaxis and treatment of venous thromboembolism and related pulmonary embolism. 2) Prophylaxis and treatment of thromboembolism associated with atrial fibrillation. 3) Prophylaxis and treatment of thromboembolism associated with cardiac valve replacement. 4) Use as adjunct therapy to reduce mortality, recurrent myocardial infarction, and thromboembolic events post myocardial infarction. **Off-label** uses include: 1) Secondary prevention of stroke and transient ischemic attacks in patients with rheumatic mitral valve disease but without atrial fibrillation.[A179182]
DB01418AcenocoumarolFor the treatment and prevention of thromboembolic diseases. More specifically, it is indicated for the prevention of cerebral embolism, deep vein thrombosis, pulmonary embolism, thromboembolism in infarction and transient ischemic attacks. It is used for the treatment of deep vein thrombosis and myocardial infarction.
DB12823TecarfarinNot Available
DB00266DicoumarolFor decreasing blood clotting. Often used along with heparin for treatment of deep vein thrombosis.
DB00946PhenprocoumonUsed for the prevention and treatment of thromboembolic disease including venous thrombosis, thromboembolism, and pulmonary embolism as well as for the prevention of ischemic stroke in patients with atrial fibrillation (AF).
DB01051NovobiocinFor the treatment of infections due to staphylococci and other susceptible organisms
DB034104-hydroxycoumarinNot Available
DB03966ClorobiocinNot Available
DB04571TrioxsalenTrioxsalen is a pigmenting photosensitizing agent used in conjunction with ultraviolet light in the treatment of vitiligo.
DB04886Calanolide AFor use in combination treatment of HIV infection (AIDS).
DB07118HymecromoneNot Available
DB08794Ethyl biscoumacetateNot Available
DB11390CoumaphosNot Available
DB11419HaloxonNot Available
DB12216BergaptenNot Available
DB13155EsculinAs medication, esculin is sometimes used as a vasoprotective agent. Esculin is also used in a microbiology laboratory to aid in the identification of bacterial species (especially Enterococci and Listeria), as all strains of Group D Streptococci hydrolyze ├Žsculin in 40% bile.
DB131774-methylumbelliferyl beta-D-glucosideNot Available
DB13279CarbocromenNot Available
DB13367CloricromenNot Available
DB13912Coumermycin A1Not Available
DrugDrug NameTargetType
DB00682WarfarinVitamin K epoxide reductase complex subunit 1target
DB00682WarfarinCytochrome P450 2C8enzyme
DB00682WarfarinCytochrome P450 1A2enzyme
DB00682WarfarinCytochrome P450 2C9enzyme
DB00682WarfarinAlpha-1-acid glycoprotein 1carrier
DB00682WarfarinSerum albumincarrier
DB00682WarfarinCytochrome P450 2C19enzyme
DB00682WarfarinCytochrome P450 3A4enzyme
DB00682WarfarinCytochrome P450 2C18enzyme
DB00682WarfarinNuclear receptor subfamily 1 group I member 2target
DB01418AcenocoumarolVitamin K epoxide reductase complex subunit 1target
DB01418AcenocoumarolCytochrome P450 2C9enzyme
DB01418AcenocoumarolCytochrome P450 1A2enzyme
DB01418AcenocoumarolSerum albumincarrier
DB01418AcenocoumarolAlpha-1-acid glycoprotein 1carrier
DB01418AcenocoumarolCytochrome P450 2C19enzyme
DB01418AcenocoumarolCytochrome P450 3A4enzyme
DB00266DicoumarolVitamin K epoxide reductase complex subunit 1target
DB00266DicoumarolNAD(P)H dehydrogenase [quinone] 1target
DB00266DicoumarolQuinone oxidoreductasetarget
DB00266DicoumarolCytochrome P450 2C9enzyme
DB00266DicoumarolSerum albumincarrier
DB00266DicoumarolCytochrome P450 2C6enzyme
DB00266DicoumarolCytochrome P450 2C11enzyme
DB00946PhenprocoumonVitamin K epoxide reductase complex subunit 1target
DB00946PhenprocoumonAlpha-1-acid glycoprotein 1carrier
DB00946PhenprocoumonSerum albumincarrier
DB00946PhenprocoumonCytochrome P450 2C9enzyme
DB00946PhenprocoumonCytochrome P450 3A4enzyme
DB00946PhenprocoumonCytochrome P450 2C8enzyme
DB01051NovobiocinDNA gyrase subunit Btarget
DB01051NovobiocinSolute carrier family 22 member 6transporter
DB01051NovobiocinSolute carrier family 22 member 8transporter
DB01051NovobiocinSolute carrier family 22 member 11transporter
DB01051NovobiocinATP-binding cassette sub-family G member 2transporter
DB01051NovobiocinDNA topoisomerase 1target
DB01051NovobiocinSolute carrier organic anion transporter family member 1B1transporter
DB01051NovobiocinSolute carrier organic anion transporter family member 1B3transporter
DB01051NovobiocinSolute carrier organic anion transporter family member 2B1transporter
DB034104-hydroxycoumarinMajor NAD(P)H-flavin oxidoreductasetarget
DB034104-hydroxycoumarinCytochrome P450 3A4enzyme
DB03966ClorobiocinDNA gyrase subunit Btarget
DB04886Calanolide AGag-Pol polyproteintarget
DB04886Calanolide ACytochrome P450 3A4enzyme
DB07118HymecromoneArylsulfate sulfotransferasetarget
DB08794Ethyl biscoumacetateGlutamine synthetaseenzyme
DB08794Ethyl biscoumacetateCytochrome P450 3A4enzyme
DB13155EsculinGlutaminase kidney isoform, mitochondrialenzyme
DB13155EsculinAndrogen receptortarget