Sugar Alcohols

Polyhydric alcohols having no more than one hydroxy group attached to each carbon atom. They are formed by the reduction of the carbonyl group of a sugar to a hydroxyl group.(From Dorland, 28th ed)
DrugDrug NameDrug Indication
DB00271DiatrizoateUsed, alone or in combination, for a wide variety of diagnostic imaging methods, including angiography, urography, cholangiography, computed tomography, hysterosalpingography, and retrograde pyelography. It can be used for imaging the gastrointestinal tract in patients allergic to barium.
DB00742MannitolUsed for the promotion of diuresis before irreversible renal failure becomes established, the reduction of intracranial pressure, the treatment of cerebral edema, and the promotion of urinary excretion of toxic substances.
DB00743Gadobenic acidGadobenate Dimeglumine is an MRI contrast agent used primarily for MR imaging of the liver. It can also be used for MRI of the heart, as well as and central nervous system in adults to visualize lesions with abnormal brain vascularity or abnormalities in the blood brain barrier, the brain, spine, or other associated tissues.
DB00883Isosorbide dinitrateFor the prevention of angina pectoris due to coronary artery disease.
DB01020Isosorbide mononitrateFor the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
DB01613Erythrityl tetranitrateFor the prevention of angina.
DB01638SorbitolUsed as a non-stimulant laxative via an oral suspension or enema.
DB01692DithioerythritolNot Available
DB018402-Deoxy-D-Glucitol 6-(E)-VinylhomophosphonateNot Available
DB018594-Diphosphocytidyl-2-C-Methyl-D-Erythritol 2-PhosphateNot Available
DB01863Inositol 1,3,4,5-TetrakisphosphateNot Available
DB021722,5-Dideoxy-2,5-Imino-D-GlucitolNot Available
DB02261Platelet Activating FactorNot Available
DB02492GhavamiolNot Available
DB02942Inositol 1,3-BisphosphateNot Available
DB03864MonothioglycerolNot Available
DB04878VogliboseFor the treatment of diabetes. It is specifically used for lowering post-prandial blood glucose levels thereby reducing the risk of macrovascular complications.
DB08909Glycerol phenylbutyrateGlycerol phenylbutyrate is a nitrogen-binding agent for the chronic management of adult and pediatric patients ≥2 years of age with urea cycle disorders (UCDs) who cannot be managed by dietary protein restriction and/or amino acid supplementation alone.
DB09132Gadoteric acidGadoteric acid is indicated for intravenous use with magnetic resonance imaging (MRI) in brain (intracranial), spine and associated tissues in adult and pediatric patients (2 years of age and older) to detect and visualize areas with disruption of the blood brain barrier (BBB) and/or abnormal vascularity.
DB09133Iothalamic acidConray is indicated for use in excretory urography, cerebral angiography, peripheral arteriography, venography, arthrography, direct cholangiography, endoscopic retrograde cholangiopancreatography, contrast enhancement of computed tomographic brain images, cranial computerized angiotomography, intravenous digital subtraction angiography and arterial digital subtraction angiography. Conray may also be used for enhancement of computed tomographic scans performed for detection and evaluation of lesions in the liver, pancreas, kidneys, abdominal aorta, mediastinum, abdominal cavity and retroperitoneal space.
DB09401IsosorbideIndicated for the prevention and treatment of angina pectoris due to coronary artery disease. The onset of action of oral isosorbide mononitrate is not sufficiently rapid for this product to be useful in aborting an acute anginal episode.[label]
DB09462GlycerinIt is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.
DB11195XylitolIndicated for use as a sugar substitute, and oral hygiene active ingredient.
DB12214LuseogliflozinNot Available
DB12873DianhydrogalactitolNot Available
DB12916MitolactolNot Available
DB12969MethylinositolNot Available
DB13178InositolInositol may be used in food without any limitation. As a drug, inositol is used as a nutrient supplement in special dietary foods and infant formula.[L2561] As it presents a relevant role in ensuring oocyte fertility, inositol has been studied for its use in the management of polycystic ovaries.[A32751] Inositol is also being researched for the treatment of diabetes,[A32766] prevention of metabolic syndrome,[A32768] aid agent for weight loss,[A32769] treatment of depression, psychiatric disorder and anxiety disorder[A32770] and for prevention of cancer.[A32771]
DB13444Ioxitalamic acidIoxitalamate in both of its available forms is indicated for exploration of the digestive tract by tomodensitometry or by regular gastroduodenal radiography. Its use is restrained to the cases in which the administration of barium sulfate is not recommended or contraindicated.[F55] The intravascular administration of ioxitalamate is contraindicated as it may present significant side effects.[F54]
DB13543MitobronitolNot Available
DB13732Meglumine antimoniateNot Available
DB14557EthylhexylglycerinNot Available
DB14704RibitolNot Available
DB03106scyllo-inositolNot Available
DB034011D-myo-inositol 1,4,5-trisphosphateNot Available
DB036462,3-di-O-phytanyl-sn-glycerolNot Available
DB03956Inositol 2,4,5-trisphosphateNot Available
DB00144Phosphatidyl serinePhosphatidylserine has demonstrated some usefulness in treating cognitive impairment, including Alzheimer's disease, age-associated memory impairment and some non-Alzheimer's dementias. More research is needed before phosphatidylserine can be indicated for immune enhancement or for reduction of exercise stress.
DB03438LysophosphatidylglycerolNot Available
DB04143Indole-3-Glycerol PhosphateNot Available
DB04327PhosphatidylethanolamineNot Available
DB04660Choline alfoscerateNot Available
DB04897LucinactantIntended for the prevention of respiratory distress syndrome (RDS) in premature infants at high risk for RDS.
DB05456ETC-588Investigated for use/treatment in atherosclerosis, coronary artery disease, and vascular diseases.
DB09114Colfosceril palmitateColfosceril palmitate is indicated for the treatment of respiratory distress syndrome (RDS) in premature infants. The official label is referred as a intratracheal suspension for prophylactic treatment of infants of less than 1350 grams of birth weight under risk of developing RDS, or in infants with birth weight greater than 1350 grams with pulmonary immaturity, or as rescue treatment of infants that already developed RDS.[L1109] The central feature of RDS is a surfactant deficiency due to lung immaturity. This lung condition is more frequently presented due to risk factors like prematurity, delayed lung maturation caused by maternal diabetes or male gender, or surfactant dysfuntion due to perinatal asphyxia, pulmonary infection or delivery without labor.[T70]
DB09561Sodium glycerophosphateSodium glycerophosphate is indicated for use as a source of phosphate in total parenteral nutrition [FDA Label]. It is used in combination with amino acids, dextrose, lipid emulsions, and other electrolytes.
DB11283DL-dimyristoylphosphatidylcholineDL-dimyristoylphosphatidylcholine is not an active pharmaceutical agent and has no indication.
DB11284DL-dimyristoylphosphatidylglycerolDL-dimyristoylphosphatidylglycerol is not an considered an active pharmacological ingredient in pharmaceutical preparations and so has no official indications.
DB13615MifamurtideIndicated in children, adolescents and young adults for the treatment of high-grade, resectable, non-metastatic osteosarcoma after macroscopically complete surgical resection, typically in combination with post-operative multi-agent chemotherapy [L1203].
DB140991,2-DistearoyllecithinNot Available
DB15259VB-201Not Available
DrugDrug NameTargetType
DB00742MannitolMultidrug resistance protein 1transporter
DB00742MannitolMannitol dehydrogenaseenzyme
DB00743Gadobenic acidSerum albumincarrier
DB00883Isosorbide dinitrateAtrial natriuretic peptide receptor 1target
DB00883Isosorbide dinitrateCytochrome P450 2E1enzyme
DB01020Isosorbide mononitrateGuanylate cyclase soluble subunit alpha-2target
DB01613Erythrityl tetranitrateAtrial natriuretic peptide receptor 1target
DB01613Erythrityl tetranitrateAtrial natriuretic peptide receptor 2target
DB01638SorbitolXylose isomerasetarget
DB01638SorbitolXylose isomerasetarget
DB01638SorbitolXylose isomerasetarget
DB01638SorbitolMalate synthase Gtarget
DB01692DithioerythritolListeriolysin regulatory proteintarget
DB01692Dithioerythritol6,7-dimethyl-8-ribityllumazine synthasetarget
DB01692DithioerythritolThymidine kinase, cytosolictarget
DB018402-Deoxy-D-Glucitol 6-(E)-VinylhomophosphonateInositol-3-phosphate synthase 1target
DB018594-Diphosphocytidyl-2-C-Methyl-D-Erythritol 2-Phosphate2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthasetarget
DB01863Inositol 1,3,4,5-TetrakisphosphateRAC-alpha serine/threonine-protein kinasetarget
DB01863Inositol 1,3,4,5-TetrakisphosphatePleckstrin homology domain-containing family A member 4target
DB01863Inositol 1,3,4,5-TetrakisphosphateTyrosine-protein kinase BTKtarget
DB01863Inositol 1,3,4,5-TetrakisphosphateDual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositidetarget
DB01863Inositol 1,3,4,5-TetrakisphosphateInositol-trisphosphate 3-kinase Atarget
DB01863Inositol 1,3,4,5-TetrakisphosphateCytohesin-2target
DB01863Inositol 1,3,4,5-TetrakisphosphateCytohesin-3target
DB01863Inositol 1,3,4,5-Tetrakisphosphate3-phosphoinositide-dependent protein kinase 1target
DB021722,5-Dideoxy-2,5-Imino-D-GlucitolXylose isomerasetarget
DB02261Platelet Activating FactorGanglioside GM2 activatortarget
DB02261Platelet Activating FactorMultidrug resistance protein 1transporter
DB02261Platelet Activating FactorPlatelet-activating factor receptortarget
DB02492GhavamiolAlpha-mannosidase 2target
DB02942Inositol 1,3-BisphosphateEarly endosome antigen 1target
DB03864MonothioglycerolProlyl endopeptidasetarget
DB04878VogliboseMaltase-glucoamylase, intestinaltarget
DB08909Glycerol phenylbutyratePancreatic triacylglycerol lipaseenzyme
DB08909Glycerol phenylbutyrateCytochrome P450 3A4enzyme
DB08909Glycerol phenylbutyrateCytochrome P450 2D6enzyme
DB09401IsosorbideApoptosis regulator Bcl-2target
DB09401IsosorbideBcl-2-like protein 1target
DB09401IsosorbideInduced myeloid leukemia cell differentiation protein Mcl-1target
DB09462GlycerinHematopoietic prostaglandin D synthasetarget
DB09462GlycerinEndoglucanase Gtarget
DB09462GlycerinGlutathione S-transferase Ptarget
DB09462GlycerinGroup IIE secretory phospholipase A2target
DB09462GlycerinInositol-3-phosphate synthase 1target
DB09462GlycerinC4-dicarboxylate transport transcriptional regulatory protein DctDtarget
DB09462GlycerinAlcohol dehydrogenase 1Btarget
DB09462GlycerinInositol 1,4,5-trisphosphate receptor type 1target
DB09462GlycerinCytochrome c4target
DB09462GlycerinTGF-beta receptor type-2target
DB09462GlycerinArgininosuccinate synthasetarget
DB09462GlycerinADP-ribosylation factor 1target
DB09462GlycerinMultidrug resistance protein MexAtarget
DB09462GlycerinBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1target
DB09462GlycerinHistidinol dehydrogenasetarget
DB09462GlycerinDNA mismatch repair protein MutLtarget
DB09462GlycerinGlycerol uptake facilitator proteintarget
DB09462GlycerinRibonucleoside-diphosphate reductase 1 subunit betatarget
DB09462GlycerinA/G-specific adenine glycosylasetarget
DB09462GlycerintRNA (cytosine(38)-C(5))-methyltransferasetarget
DB09462GlycerinCytochrome P450 2E1enzyme
DB09462GlycerinRetinal dehydrogenase 1enzyme
DB09462GlycerinPeroxisome proliferator-activated receptor deltatarget
DB11195XylitolXylose isomerasetarget
DB11195XylitolXylose isomerasetarget
DB11195XylitolXylose isomerasetarget
DB11195XylitolXylose isomerasetarget
DB11195XylitolHyaluronate lyasetarget
DB13178InositolSodium/myo-inositol cotransportertransporter
DB03106scyllo-inositol1-phosphatidylinositol phosphodiesterasetarget
DB03106scyllo-inositolCDP-diacylglycerol--inositol 3-phosphatidyltransferasetarget
DB03106scyllo-inositol1-phosphatidylinositol phosphodiesterasetarget
DB034011D-myo-inositol 1,4,5-trisphosphateCytohesin-2target
DB034011D-myo-inositol 1,4,5-trisphosphateEpsin-1target
DB034011D-myo-inositol 1,4,5-trisphosphate1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1target
DB034011D-myo-inositol 1,4,5-trisphosphateRadixintarget
DB034011D-myo-inositol 1,4,5-trisphosphateSpectrin beta chain, non-erythrocytic 1target
DB034011D-myo-inositol 1,4,5-trisphosphateInositol 1,4,5-trisphosphate receptor type 1target
DB034011D-myo-inositol 1,4,5-trisphosphateInositol-trisphosphate 3-kinase Atarget
DB03956Inositol 2,4,5-trisphosphate1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1target
DB00144Phosphatidyl serinePhosphatidylserine decarboxylase proenzymetarget
DB00144Phosphatidyl serineScavenger receptor class B member 1target
DB00144Phosphatidyl serineProtein kinase C alpha typetarget
DB00144Phosphatidyl serinePhosphatidylserine synthase 1target
DB00144Phosphatidyl serineDiacylglycerol kinase gammatarget
DB00144Phosphatidyl serineDiacylglycerol kinase deltatarget
DB00144Phosphatidyl serinePhosphatidylserine synthase 2target
DB00144Phosphatidyl serineSphingomyelin phosphodiesterase 4target
DB00144Phosphatidyl serineSphingomyelin phosphodiesterase 3target
DB00144Phosphatidyl serineProbable phospholipid-transporting ATPase IAtarget
DB04143Indole-3-Glycerol PhosphateTryptophan synthase alpha chaintarget
DB04143Indole-3-Glycerol PhosphateTryptophan synthase beta chaintarget
DB04327PhosphatidylethanolamineEndothelial protein C receptortarget
DB04327PhosphatidylethanolaminePhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENtarget
DB04660Choline alfoscerateGanglioside GM2 activatortarget
DB13615MifamurtideToll-like receptor 4target
DB13615MifamurtideNucleotide-binding oligomerization domain-containing protein 2target