Name
Pyrazoles
Accession Number
DBCAT000650
Description

Azoles of two nitrogens at the 1,2 positions, next to each other, in contrast with IMIDAZOLES in which they are at the 1,3 positions.

Drugs
DrugDrug Description
BetazoleFor use clinically to test gastric secretory function.
CelecoxibAn NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis.
PhenylbutazoneAn NSAID used to treat backache and ankylosing spondylitis.
GranisetronA 5HT3 antagonist used to treat nausea and vomiting in cancer therapy and postoperatively.
RabeprazoleA proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome.
SulfinpyrazoneA platelet inhibitory and uricosuric agent used to inhibit thrombotic and embolic processes and to manage the chronic phases of gout .
AminophenazoneFormerly widely used as an antipyretic and analgesic in rheumatism, neuritis, and common colds. Currently used to measure total body water.
AntipyrineAn antipyretic agent used for the symptomatic treatment of acute otitis media, most commonly in combination with benzocaine.
DichloralphenazoneDichloralphenazone is a sedative composed of chloral hydrate and phenazone. It is typically found in combination products Nodolor and Midrin containing isometheptene and acetaminophen used for the relief of tension...
3-Bromo-7-NitroindazoleNot Available
7-NitroindazoleNot Available
6-NitroindazoleNot Available
OxyphenbutazoneA nonsteroidal anti-inflammatory drug (NSAID) no longer commonly used for the symptomatic relief of musculoskeletal pain.
5-NitroindazoleNot Available
MetamizoleUsed in the past as a powerful painkiller and fever reducer.
OxypurinolIntended for the treatment of congestive heart failure and hyperuricemia.
FaciniclineInvestigated for use/treatment in alzheimer's disease, neurologic disorders, and schizophrenia and schizoaffective disorders.
SNX-5422Investigated for use/treatment in cancer/tumors (unspecified).
ABT-869Investigated for use/treatment in leukemia (myeloid), myelodysplastic syndrome, and solid tumors.
LonidamineInvestigated for use/treatment in benign prostatic hyperplasia, prostate disorders, and cancer/tumors (unspecified).
AxitinibAn oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy.
SulfaphenazoleFor the treatment bacterial infections.
KebuzoneKebuzone (also known as ketophenylbutazone ) is a non-steroidal anti-inflammatory drug.
EpirizoleEpirizole is an oral nonsteroidal anti-inflammatory drug (NSAID) used for muscle and joint pain.
BenzydamineA locally-acting NSAID indicated for the symptomatic relief of pain in acute sore throat and for the symptomatic relief of oropharyngeal mucositis caused by radiation therapy.
PictilisibPictilisib has been used in trials studying the treatment of Solid Cancers, Breast Cancer, Advanced Solid Tumours, Metastatic Breast Cancer, and Non-Hodgkin's Lymphoma, Solid Cancers, among others.
NiraparibA poly-ADP ribose polymerase inhibitor used to treat recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer responding to platinum based chemotherapy.
PF-03882845PF-03882845 has been used in trials studying the basic science of Diabetes Mellitus, Type 2 and Type 2 Diabetic Nephropathy.
EntrectinibEntrectinib is indicated for the treatment of metastatic ROS1-positive non-small cell lung cancer in adults. Entrectinib is also indicated in adults and children over 12 years old for the treatment...
EntospletinibEntospletinib has been used in trials studying the treatment of Oncology, Follicular Lymphoma, B-cell Malignancies, Mantle Cell Lymphoma, and Non-Hodgkin Lymphoma, among others.
CerlapirdineCerlapirdine has been investigated for the treatment of Alzheimer Disease.
EdaravoneA free radical scavenger used to delay the progression of ALS.
GDC-0810ARN-810 has been used in trials studying the basic science and treatment of Breast Cancer.
AZD-5423AZD5423 has been used in trials studying the basic science and treatment of Asthma, Bioavailability and AUC, and Chronic Obstructive Pulmonary Disease (COPD).
MerestinibMerestinib has been used in trials studying the treatment of Cancer, Solid Tumor, Advanced cancer, ColoRectal Cancer, and Metastatic Cancer, among others.
CC-401CC-401 has been used in trials studying the treatment of Myeloid Leukemia.
BindaritBindarit has been used in trials studying the prevention and treatment of Coronary Restenosis and Diabetic Nephropathy.
LY-2874455LY2874455 has been used in trials studying the treatment of Advanced Cancer.
AG-24322AG-024322 has been used in trials studying the treatment of Neoplasms and Lymphoma, Non-Hodgkin.
SuxibuzoneNot Annotated
FeprazoneNot Annotated
NifenazoneNot Annotated
BendazacPrior to the withdrawal of bendazac from various international regions of use due to concerns for hepatotoxicity [A39891, A39892, A39893, L4778] the chemical had demonstrated potential usefulness predominantly as the...
PropyphenazoneNot Annotated
MofebutazoneNot Annotated
MuzolimineNot Annotated
FomepizoleAn inhibitor of alcohol dehydrogenase used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning.
RimonabantFor use in conjunction with diet and exercise for patients with a body mass index greater than 30 kg/m2, or patients wih a BMI greater than 27 kg/m2 with associated...
LorecivivintLorecivivint is under investigation in clinical trial NCT03246399 (A Study of the Safety, Tolerability, and Pharmacokinetics of SM04690 Injectable Suspension Following Single Intradiscal Injection in Subjects With Degenerative Disc Disease).
A-674563Not Available
VazegepantVazegepant is an antagonist of the calcitonin gene-related peptide (CGRP) receptor currently in phase 3 trials in an intranasal formulation for the treatment of migraine. If FDA approved, it will...
Drugs & Drug Targets
DrugTargetType
BetazoleHistamine H2 receptortarget
CelecoxibProstaglandin G/H synthase 2target
Celecoxib3-phosphoinositide-dependent protein kinase 1target
CelecoxibCytochrome P450 2C9enzyme
CelecoxibCytochrome P450 2D6enzyme
CelecoxibMultidrug resistance-associated protein 4transporter
CelecoxibCytochrome P450 3A4enzyme
CelecoxibCytochrome P450 2C8enzyme
CelecoxibCarbonic anhydrase 2target
CelecoxibCarbonic anhydrase 3target
CelecoxibBile salt export pumptransporter
CelecoxibCadherin-11target
CelecoxibP-glycoprotein 1transporter
CelecoxibATP-binding cassette sub-family G member 2transporter
PhenylbutazoneProstaglandin G/H synthase 2target
PhenylbutazoneProstacyclin synthasetarget
PhenylbutazoneCytochrome P450 2C9enzyme
PhenylbutazoneSolute carrier family 22 member 6transporter
PhenylbutazoneSolute carrier family 22 member 8transporter
PhenylbutazoneSolute carrier family 22 member 11transporter
PhenylbutazoneProstaglandin G/H synthase 1target
PhenylbutazoneCytochrome P450 3A4enzyme
Granisetron5-hydroxytryptamine receptor 3Atarget
GranisetronCytochrome P450 3A4enzyme
GranisetronCytochrome P450 1A1enzyme
RabeprazolePotassium-transporting ATPase alpha chain 1target
RabeprazoleCytochrome P450 3A4enzyme
RabeprazoleCytochrome P450 2C19enzyme
RabeprazoleATP-binding cassette sub-family G member 2transporter
RabeprazoleCytochrome P450 1A1enzyme
RabeprazoleCytochrome P450 1A2enzyme
RabeprazoleCytochrome P450 2C9enzyme
RabeprazoleCytochrome P450 2D6enzyme
RabeprazoleCytochrome P450 2C8enzyme
SulfinpyrazoneMultidrug resistance-associated protein 1target
SulfinpyrazoneCanalicular multispecific organic anion transporter 1target
SulfinpyrazoneFatty acid-binding protein, intestinalcarrier
SulfinpyrazoneCytochrome P450 2C9enzyme
SulfinpyrazoneCanalicular multispecific organic anion transporter 2transporter
SulfinpyrazoneMultidrug resistance-associated protein 4transporter
SulfinpyrazoneMultidrug resistance-associated protein 5transporter
SulfinpyrazoneMultidrug resistance-associated protein 6transporter
SulfinpyrazoneMultidrug resistance-associated protein 1transporter
SulfinpyrazoneCanalicular multispecific organic anion transporter 1transporter
SulfinpyrazoneCytochrome P450 3A4enzyme
SulfinpyrazoneCytochrome P450 2B6enzyme
SulfinpyrazoneCytochrome P450 2C8enzyme
SulfinpyrazoneSolute carrier family 22 member 12target
SulfinpyrazoneNuclear receptor subfamily 1 group I member 2target
SulfinpyrazoneBile salt export pumptransporter
AminophenazoneCytochrome P450 2C19enzyme
AminophenazoneCytochrome P450 1A2enzyme
AminophenazoneCytochrome P450 2C8enzyme
AminophenazoneSolute carrier family 22 member 6transporter
AminophenazoneCytochrome P450 2C9enzyme
AminophenazoneCytochrome P450 2D6enzyme
AminophenazoneCytochrome P450 3A4enzyme
AminophenazoneCytochrome P450 2C18enzyme
AminophenazoneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
AntipyrineCytochrome P450 2C8enzyme
AntipyrineCytochrome P450 2C9enzyme
AntipyrineCytochrome P450 1A2enzyme
AntipyrineCytochrome P450 2C19enzyme
AntipyrineCytochrome P450 3A4enzyme
AntipyrineSolute carrier family 22 member 6transporter
AntipyrineCytochrome P450 2A6enzyme
AntipyrineCytochrome P450 2B6enzyme
AntipyrineCytochrome P450 2C18enzyme
AntipyrineCytochrome P450 2D6enzyme
AntipyrineCytochrome P450 2E1enzyme
AntipyrineProstaglandin G/H synthase 2target
AntipyrineProstaglandin G/H synthase 1target
3-Bromo-7-NitroindazoleNitric oxide synthase, endothelialtarget
3-Bromo-7-NitroindazoleNitric oxide synthase, braintarget
3-Bromo-7-NitroindazoleNitric oxide synthase, inducibletarget
7-NitroindazoleNitric oxide synthase, endothelialtarget
7-NitroindazoleNitric oxide synthase, inducibletarget
6-NitroindazoleNitric oxide synthase, inducibletarget
6-NitroindazoleNitric oxide synthase, endothelialtarget
OxyphenbutazoneGroup IIE secretory phospholipase A2target
OxyphenbutazoneSerum albumincarrier
OxyphenbutazoneSolute carrier family 22 member 6transporter
5-NitroindazoleNitric oxide synthase, inducibletarget
5-NitroindazoleNitric oxide synthase, endothelialtarget
MetamizoleProstaglandin G/H synthase 1target
MetamizoleCytochrome P450 2B6enzyme
MetamizoleCytochrome P450 3A4enzyme
OxypurinolXanthine dehydrogenase/oxidasetarget
SNX-5422Heat shock protein HSP 90-alphatarget
SNX-5422Heat shock protein HSP 90-betatarget
ABT-869Receptor-type tyrosine-protein kinase FLT3target
ABT-869Vascular endothelial growth factor receptor 1target
ABT-869Vascular endothelial growth factor receptor 2target
ABT-869Vascular endothelial growth factor receptor 3target
ABT-869Mast/stem cell growth factor receptor Kittarget
ABT-869Macrophage colony-stimulating factor 1 receptortarget
LonidamineCystic fibrosis transmembrane conductance regulatortarget
LonidamineHexokinase-1target
AxitinibVascular endothelial growth factor receptor 1target
AxitinibVascular endothelial growth factor receptor 2target
AxitinibVascular endothelial growth factor receptor 3target
AxitinibCytochrome P450 3A4enzyme
AxitinibCytochrome P450 3A5enzyme
AxitinibCytochrome P450 1A2enzyme
AxitinibCytochrome P450 2C19enzyme
AxitinibUDP-glucuronosyltransferase 1-1enzyme
AxitinibP-glycoprotein 1transporter
AxitinibSolute carrier organic anion transporter family member 1B1transporter
SulfaphenazoleCytochrome P450 2C9enzyme
SulfaphenazoleCytochrome P450 2B6enzyme
SulfaphenazoleCytochrome P450 2C8enzyme
SulfaphenazoleCytochrome P450 2D6enzyme
SulfaphenazoleDihydropteroate synthasetarget
NiraparibPoly [ADP-ribose] polymerase 1target
NiraparibPoly [ADP-ribose] polymerase 2target
NiraparibCarboxylesteraseenzyme
NiraparibBeta-glucuronidaseenzyme
EntrectinibCytochrome P450 3A4enzyme
EntrectinibP-glycoprotein 1transporter
EntrectinibHigh affinity nerve growth factor receptortarget
EntrectinibBDNF/NT-3 growth factors receptortarget
EntrectinibNT-3 growth factor receptortarget
EntrectinibProto-oncogene tyrosine-protein kinase ROStarget
EntrectinibTyrosine-protein kinase JAK2target
EntrectinibActivated CDC42 kinase 1target
EdaravoneSolute carrier family 22 member 6transporter
EdaravoneSolute carrier family 22 member 8transporter
BendazacFree radicalstarget
BendazacProstaglandin G/H synthase 1target
BendazacProstaglandin G/H synthase 2target
FomepizoleAlcohol dehydrogenase 1Atarget
FomepizoleAlcohol dehydrogenase 1Btarget
FomepizoleAlcohol dehydrogenase 1Ctarget
FomepizoleCatalasetarget
FomepizoleCytochrome P450 2E1enzyme
FomepizoleCytochrome P450 2A6enzyme
RimonabantCannabinoid receptor 1target
RimonabantCytochrome P450 3A4enzyme
RimonabantG-protein coupled receptor 55target
A-674563cAMP-dependent protein kinase catalytic subunit alphatarget
A-674563cAMP-dependent protein kinase inhibitor alphatarget
VazegepantCalcitonin gene-related peptide type 1 receptortarget