Azoles of two nitrogens at the 1,2 positions, next to each other, in contrast with IMIDAZOLES in which they are at the 1,3 positions.
DrugDrug NameDrug Description
DB00272BetazoleFor use clinically to test gastric secretory function.
DB00482CelecoxibAn NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis.
DB00812PhenylbutazoneAn NSAID used to treat backache and ankylosing spondylitis.
DB00889GranisetronA 5HT3 antagonist used to treat nausea and vomiting in cancer therapy and postoperatively.
DB01129RabeprazoleA proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome.
DB01138SulfinpyrazoneA platelet inhibitory and uricosuric agent used to inhibit thrombotic and embolic processes and to manage the chronic phases of gout .
DB01424AminophenazoneFormerly widely used as an antipyretic and analgesic in rheumatism, neuritis, and common colds. Currently used to measure total body water.
DB01435AntipyrineAn antipyretic agent used for the symptomatic treatment of acute otitis media, most commonly in combination with benzocaine.
DB01495DichloralphenazoneDichloralphenazone is a sedative composed of chloral hydrate and phenazone. It is typically found in combination products Nodolor and Midrin containing isometheptene and acetaminophen used for the relief of tension...
DB019973-Bromo-7-NitroindazoleNot Available
DB022077-NitroindazoleNot Available
DB031006-NitroindazoleNot Available
DB03585OxyphenbutazoneA nonsteroidal anti-inflammatory drug (NSAID) no longer commonly used for the symptomatic relief of musculoskeletal pain.
DB045345-NitroindazoleNot Available
DB04817MetamizoleUsed in the past as a powerful painkiller and fever reducer.
DB05262OxypurinolIntended for the treatment of congestive heart failure and hyperuricemia.
DB05586FaciniclineInvestigated for use/treatment in alzheimer's disease, neurologic disorders, and schizophrenia and schizoaffective disorders.
DB06070SNX-5422Investigated for use/treatment in cancer/tumors (unspecified).
DB06080ABT-869Investigated for use/treatment in leukemia (myeloid), myelodysplastic syndrome, and solid tumors.
DB06266LonidamineInvestigated for use/treatment in benign prostatic hyperplasia, prostate disorders, and cancer/tumors (unspecified).
DB06626AxitinibAn oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy.
DB06729SulfaphenazoleFor the treatment bacterial infections.
DB08940KebuzoneKebuzone (also known as ketophenylbutazone ) is a non-steroidal anti-inflammatory drug.
DB08991EpirizoleEpirizole is an oral nonsteroidal anti-inflammatory drug (NSAID) used for muscle and joint pain.
DB09084BenzydamineA locally-acting NSAID indicated for the symptomatic relief of pain in acute sore throat and for the symptomatic relief of oropharyngeal mucositis caused by radiation therapy.
DB11663PictilisibPictilisib has been used in trials studying the treatment of Solid Cancers, Breast Cancer, Advanced Solid Tumours, Metastatic Breast Cancer, and Non-Hodgkin's Lymphoma, Solid Cancers, among others.
DB11793NiraparibA poly-ADP ribose polymerase inhibitor used to treat recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer responding to platinum based chemotherapy.
DB11814PF-03882845PF-03882845 has been used in trials studying the basic science of Diabetes Mellitus, Type 2 and Type 2 Diabetic Nephropathy.
DB11986EntrectinibEntrectinib is indicated for the treatment of metastatic ROS1-positive non-small cell lung cancer in adults. Entrectinib is also indicated in adults and children over 12 years old for the treatment...
DB12121EntospletinibEntospletinib has been used in trials studying the treatment of Oncology, Follicular Lymphoma, B-cell Malignancies, Mantle Cell Lymphoma, and Non-Hodgkin Lymphoma, among others.
DB12229CerlapirdineCerlapirdine has been investigated for the treatment of Alzheimer Disease.
DB12243EdaravoneA free radical scavenger used to delay the progression of ALS.
DB12253GDC-0810ARN-810 has been used in trials studying the basic science and treatment of Breast Cancer.
DB12280AZD-5423AZD5423 has been used in trials studying the basic science and treatment of Asthma, Bioavailability and AUC, and Chronic Obstructive Pulmonary Disease (COPD).
DB12381MerestinibMerestinib has been used in trials studying the treatment of Cancer, Solid Tumor, Advanced cancer, ColoRectal Cancer, and Metastatic Cancer, among others.
DB12432CC-401CC-401 has been used in trials studying the treatment of Myeloid Leukemia.
DB12739BindaritBindarit has been used in trials studying the prevention and treatment of Coronary Restenosis and Diabetic Nephropathy.
DB13022LY-2874455LY2874455 has been used in trials studying the treatment of Advanced Cancer.
DB13035AG-24322AG-024322 has been used in trials studying the treatment of Neoplasms and Lymphoma, Non-Hodgkin.
DB13232SuxibuzoneNot Annotated
DB13364FeprazoneNot Annotated
DB13407NifenazoneNot Annotated
DB13501BendazacPrior to the withdrawal of bendazac from various international regions of use due to concerns for hepatotoxicity [A39891, A39892, A39893, L4778] the chemical had demonstrated potential usefulness predominantly as the...
DB13524PropyphenazoneNot Annotated
DB13629MofebutazoneNot Annotated
DB13801MuzolimineNot Annotated
DB01213FomepizoleAn inhibitor of alcohol dehydrogenase used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning.
DB06155RimonabantFor use in conjunction with diet and exercise for patients with a body mass index greater than 30 kg/m2, or patients wih a BMI greater than 27 kg/m2 with associated...
DB14883LorecivivintLorecivivint is under investigation in clinical trial NCT03246399 (A Study of the Safety, Tolerability, and Pharmacokinetics of SM04690 Injectable Suspension Following Single Intradiscal Injection in Subjects With Degenerative Disc Disease).
DrugDrug NameTargetType
DB00272BetazoleHistamine H2 receptortarget
DB00482CelecoxibProstaglandin G/H synthase 2target
DB00482Celecoxib3-phosphoinositide-dependent protein kinase 1target
DB00482CelecoxibCytochrome P450 2C9enzyme
DB00482CelecoxibCytochrome P450 2D6enzyme
DB00482CelecoxibMultidrug resistance-associated protein 4transporter
DB00482CelecoxibCytochrome P450 3A4enzyme
DB00482CelecoxibCytochrome P450 2C8enzyme
DB00482CelecoxibCarbonic anhydrase 2target
DB00482CelecoxibCarbonic anhydrase 3target
DB00482CelecoxibBile salt export pumptransporter
DB00482CelecoxibP-glycoprotein 1transporter
DB00482CelecoxibATP-binding cassette sub-family G member 2transporter
DB00812PhenylbutazoneProstaglandin G/H synthase 2target
DB00812PhenylbutazoneProstacyclin synthasetarget
DB00812PhenylbutazoneCytochrome P450 2C9enzyme
DB00812PhenylbutazoneSolute carrier family 22 member 6transporter
DB00812PhenylbutazoneSolute carrier family 22 member 8transporter
DB00812PhenylbutazoneSolute carrier family 22 member 11transporter
DB00812PhenylbutazoneProstaglandin G/H synthase 1target
DB00812PhenylbutazoneCytochrome P450 3A4enzyme
DB00889Granisetron5-hydroxytryptamine receptor 3Atarget
DB00889GranisetronCytochrome P450 3A4enzyme
DB00889GranisetronCytochrome P450 1A1enzyme
DB01129RabeprazolePotassium-transporting ATPase alpha chain 1target
DB01129RabeprazoleCytochrome P450 3A4enzyme
DB01129RabeprazoleCytochrome P450 2C19enzyme
DB01129RabeprazoleATP-binding cassette sub-family G member 2transporter
DB01129RabeprazoleCytochrome P450 1A1enzyme
DB01129RabeprazoleCytochrome P450 1A2enzyme
DB01129RabeprazoleCytochrome P450 2C9enzyme
DB01129RabeprazoleCytochrome P450 2D6enzyme
DB01129RabeprazoleCytochrome P450 2C8enzyme
DB01138SulfinpyrazoneMultidrug resistance-associated protein 1target
DB01138SulfinpyrazoneCanalicular multispecific organic anion transporter 1target
DB01138SulfinpyrazoneFatty acid-binding protein, intestinalcarrier
DB01138SulfinpyrazoneCytochrome P450 2C9enzyme
DB01138SulfinpyrazoneCanalicular multispecific organic anion transporter 2transporter
DB01138SulfinpyrazoneMultidrug resistance-associated protein 4transporter
DB01138SulfinpyrazoneMultidrug resistance-associated protein 5transporter
DB01138SulfinpyrazoneMultidrug resistance-associated protein 6transporter
DB01138SulfinpyrazoneMultidrug resistance-associated protein 1transporter
DB01138SulfinpyrazoneCanalicular multispecific organic anion transporter 1transporter
DB01138SulfinpyrazoneCytochrome P450 3A4enzyme
DB01138SulfinpyrazoneCytochrome P450 2B6enzyme
DB01138SulfinpyrazoneCytochrome P450 2C8enzyme
DB01138SulfinpyrazoneSolute carrier family 22 member 12target
DB01138SulfinpyrazoneNuclear receptor subfamily 1 group I member 2target
DB01138SulfinpyrazoneBile salt export pumptransporter
DB01424AminophenazoneCytochrome P450 2C19enzyme
DB01424AminophenazoneCytochrome P450 1A2enzyme
DB01424AminophenazoneCytochrome P450 2C8enzyme
DB01424AminophenazoneSolute carrier family 22 member 6transporter
DB01424AminophenazoneCytochrome P450 2C9enzyme
DB01424AminophenazoneCytochrome P450 2D6enzyme
DB01424AminophenazoneCytochrome P450 3A4enzyme
DB01424AminophenazoneCytochrome P450 2C18enzyme
DB01424AminophenazoneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DB01435AntipyrineCytochrome P450 2C8enzyme
DB01435AntipyrineCytochrome P450 2C9enzyme
DB01435AntipyrineCytochrome P450 1A2enzyme
DB01435AntipyrineCytochrome P450 2C19enzyme
DB01435AntipyrineCytochrome P450 3A4enzyme
DB01435AntipyrineSolute carrier family 22 member 6transporter
DB01435AntipyrineCytochrome P450 2A6enzyme
DB01435AntipyrineCytochrome P450 2B6enzyme
DB01435AntipyrineCytochrome P450 2C18enzyme
DB01435AntipyrineCytochrome P450 2D6enzyme
DB01435AntipyrineCytochrome P450 2E1enzyme
DB01435AntipyrineProstaglandin G/H synthase 2target
DB01435AntipyrineProstaglandin G/H synthase 1target
DB019973-Bromo-7-NitroindazoleNitric oxide synthase, endothelialtarget
DB019973-Bromo-7-NitroindazoleNitric oxide synthase, braintarget
DB019973-Bromo-7-NitroindazoleNitric oxide synthase, inducibletarget
DB022077-NitroindazoleNitric oxide synthase, endothelialtarget
DB022077-NitroindazoleNitric oxide synthase, inducibletarget
DB031006-NitroindazoleNitric oxide synthase, inducibletarget
DB031006-NitroindazoleNitric oxide synthase, endothelialtarget
DB03585OxyphenbutazoneGroup IIE secretory phospholipase A2target
DB03585OxyphenbutazoneSerum albumincarrier
DB03585OxyphenbutazoneSolute carrier family 22 member 6transporter
DB045345-NitroindazoleNitric oxide synthase, inducibletarget
DB045345-NitroindazoleNitric oxide synthase, endothelialtarget
DB04817MetamizoleProstaglandin G/H synthase 1target
DB04817MetamizoleCytochrome P450 2B6enzyme
DB04817MetamizoleCytochrome P450 3A4enzyme
DB05262OxypurinolXanthine dehydrogenase/oxidasetarget
DB06070SNX-5422Heat shock protein HSP 90-alphatarget
DB06070SNX-5422Heat shock protein HSP 90-betatarget
DB06080ABT-869Receptor-type tyrosine-protein kinase FLT3target
DB06080ABT-869Vascular endothelial growth factor receptor 1target
DB06080ABT-869Vascular endothelial growth factor receptor 2target
DB06080ABT-869Vascular endothelial growth factor receptor 3target
DB06080ABT-869Mast/stem cell growth factor receptor Kittarget
DB06080ABT-869Macrophage colony-stimulating factor 1 receptortarget
DB06266LonidamineCystic fibrosis transmembrane conductance regulatortarget
DB06626AxitinibVascular endothelial growth factor receptor 1target
DB06626AxitinibVascular endothelial growth factor receptor 2target
DB06626AxitinibVascular endothelial growth factor receptor 3target
DB06626AxitinibCytochrome P450 3A4enzyme
DB06626AxitinibCytochrome P450 3A5enzyme
DB06626AxitinibCytochrome P450 1A2enzyme
DB06626AxitinibCytochrome P450 2C19enzyme
DB06626AxitinibUDP-glucuronosyltransferase 1-1enzyme
DB06626AxitinibP-glycoprotein 1transporter
DB06626AxitinibSolute carrier organic anion transporter family member 1B1transporter
DB06729SulfaphenazoleCytochrome P450 2C9enzyme
DB06729SulfaphenazoleCytochrome P450 2B6enzyme
DB06729SulfaphenazoleCytochrome P450 2C8enzyme
DB06729SulfaphenazoleCytochrome P450 2D6enzyme
DB06729SulfaphenazoleDihydropteroate synthasetarget
DB11793NiraparibPoly [ADP-ribose] polymerase 1target
DB11793NiraparibPoly [ADP-ribose] polymerase 2target
DB11986EntrectinibCytochrome P450 3A4enzyme
DB11986EntrectinibP-glycoprotein 1transporter
DB11986EntrectinibHigh affinity nerve growth factor receptortarget
DB11986EntrectinibBDNF/NT-3 growth factors receptortarget
DB11986EntrectinibNT-3 growth factor receptortarget
DB11986EntrectinibProto-oncogene tyrosine-protein kinase ROStarget
DB11986EntrectinibTyrosine-protein kinase JAK2target
DB11986EntrectinibActivated CDC42 kinase 1target
DB12243EdaravoneSolute carrier family 22 member 6transporter
DB12243EdaravoneSolute carrier family 22 member 8transporter
DB13501BendazacFree radicalstarget
DB13501BendazacProstaglandin G/H synthase 1target
DB13501BendazacProstaglandin G/H synthase 2target
DB01213FomepizoleAlcohol dehydrogenase 1Atarget
DB01213FomepizoleAlcohol dehydrogenase 1Btarget
DB01213FomepizoleAlcohol dehydrogenase 1Ctarget
DB01213FomepizoleCytochrome P450 2E1enzyme
DB01213FomepizoleCytochrome P450 2A6enzyme
DB06155RimonabantCannabinoid receptor 1target
DB06155RimonabantCytochrome P450 3A4enzyme
DB06155RimonabantG-protein coupled receptor 55target