Histamine Agents

Name
Histamine Agents
Accession Number
DBCAT000651
Description

Drugs used for their actions on histaminergic systems. Included are drugs that act at histamine receptors, affect the life cycle of histamine, or affect the state of histaminergic cells.

Drugs
DrugDrug Description
BetazoleFor use clinically to test gastric secretory function.
ClemastineAn antihistamine with sedative and anticholinergic effects used to treat the symptoms of allergic rhinitis.
CetirizineA selective Histamine-1 antagonist drug used in allergic rhinitis and chronic urticaria.
TerfenadineFor the treatment of allergic rhinitis, hay fever, and allergic skin disorders.
BuclizineFor prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness and vertigo (dizziness caused by other medical problems).
DoxylamineAn antihistamine used to treat insomnia and allergy symptoms and is used with pyridoxine in the treatment of nausea and vomiting in pregnancy.
MirtazapineA tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite.
ProfenamineAn antidyskinetic phenothiazine used to treat the symptoms of Parkinson's disease.
DexbrompheniramineAn antihistamine used to treat allergy symptoms including upper respiratory tract symptoms.
TriprolidineA sedating antihistamine combined with pseudoephedrine and guaifenesin in various types of cold and allergy medications to relieve allergy symptoms, hay fever and common cold symptoms, and to aid in sleep.
CyproheptadineA serotonin and histamine antagonist used in the treatment of allergy symptoms and in combination with epinephrine in the treatment of anaphylaxis.
CimetidineA histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion.
HydroxyzineAn antihistamine used to treat anxiety and tension associated with psychoneuroses, as well as allergic conditions such as pruritus and chronic urticaria.
CinnarizineFor the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins.
NizatidineAn H2 receptor antagonist used to treat GERD and a variety of ulcers.
AstemizoleA second generation antihistamine used to treat allergy symptoms.
AzatadineAn H1 receptor antagonist used to treat perennial and allergic rhinitis as well as eustachian tube congestion.
MeclizineA histamine H1 antagonist used to treat nausea, vomiting, and dizziness associated with motion sickness.
CarbinoxamineA first generation antihistamine used to treat allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis, allergic reactions, and mild allergic reactions.
EpinastineAn H1 receptor antagonist used to prevent itching in allergic conjunctivitis.
OlopatadineA histamine H1 antagonist used to treat allergic conjunctivitis and rhinitis.
TripelennamineA histamine H1 antagonist used to treat hypersensitivity reactions, coughs, and the common cold.
BrompheniramineA histamine H1 antagonist used to treat coughs, upper respiratory symptoms, and nasal congestion associated with allergies and the common cold.
PemirolastA medication used to treat allergies such as hay fever and allergic conjunctivitis.
KetotifenA histamine H1 receptor blocker used to treat mild asthma and allergic conjunctivitis.
FamotidineA histamine H2 receptor antagonist used to treat duodenal ulcers, benign gastric ulcers, GERD, and Zollinger-Ellison syndrome.
FexofenadineA selective H1-antagonist for the symptomatic treatment of seasonal allergic rhinitis and chronic idiopathic urticaria.
DesloratadineA second generation tricyclic antihistamine used to treat seasonal and non seasonal allergic rhinitis, pruritus, and urticaria.
AzelastineA histamine H1-receptor antagonist used intranasally to treat allergic and vasomotor rhinitis and in an ophthalmic solution to treat allergic conjunctivitis.
DimenhydrinateA medication used to prevent and treat nausea, vomiting, vertigo, and motion sickness.
PromethazineA first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness.
MequitazineFor the treatment of Hay fever, urticaria (hives) and allergic rhinitis
DiphenhydramineA H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.
EmedastineA selective H1-receptor antagonist used topically to manage symptoms of allergic conjunctivitis.
LevocabastineA selective histamine H1 receptor antagonist indicated for the management of seasonal allergic conjunctivitis symptoms.
ChlorpheniramineA histamine-H1 receptor antagonist indicated for the management of symptoms associated with upper respiratory allergies.
DoxepinA psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia.
CyclizineAn antihistamine and antiemetic drug used for the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness, and vertigo.
AlimemazineAn antihistamine agent used to prevent and relieve allergic conditions which cause pruritus and other allergic skin conditions, including urticaria.
PhenindamineUsed to treat sneezing, runny nose, itching, watery eyes, hives, rashes, itching, and other symptoms of allergies and the common cold.
PheniramineAn antihistamine used to treat allergic rhinitis and pruritus.
Butyric AcidA four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.
MethapyrileneMethapyrilene, formerly marketed in many drug products, was shown to be a potent carcinogen. Manufacturers voluntarily withdrew methapyriline drug products from the market in May and June 1979.
FlunarizineA selective calcium-entry blocker used as migraine prophylaxis in patients with severe and frequent episodes who have not responded adequately to more common treatments.
TesmilifeneIntended for the treatment of various forms of cancer.
HistamineAn ingredient of topical drugs for the relief of joint pain or muscle aches and pains.
MianserinFor the treatment of depression.
LevocetirizineAn H1-receptor antagonist used to treat symptoms associated with chronic allergic rhinitis and uncomplicated cases of chronic idiopathic urticaria.
EsmirtazapineInvestigated for use/treatment in insomnia and sleep disorders.
MepyramineAn antihistamine agent used for the symptomatic treatment of allergy, hypersensitivity reactions, and pruritic skin disorders.
BetahistineAn antivertigo agent used for the reduction of episodes of vertigo association with Ménière's disease.
AlcaftadineA H1 histamine receptor antagonist for ophthalmic use to prevent itching associated with allergic conjunctivitis.
LodoxamideAn ophthalmic agent used for the treatment of the ocular disorders referred to by the terms vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis.
TranilastFor the treatment of bronchial asthma, keloid and hypertrophic scar, and allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
AntazolineAn antihistamine agent used for the symptomatic treatment of nasal congestion and allergic conjunctivitis.
ChloropyramineFor the treatment of allergic conjunctivitis, allergic rhinitis, bronchial asthma, and other atopic (allergic) conditions.
DimetindeneIndicated as symptomatic treatment of allergic reactions: urticaria, allergies of the upper respiratory tract such as hey fever and perennial rhinitis, food and drug allergies; pruritus of various origins, except...
IsothipendylFor the topical treatment of itching associated with allergic reactions.
MetiamidePotential in the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion.
Roxatidine acetateFor the treatment of disorders of the upper gastro-intestinal region that are due to an excess of hydrochloric acid in the gastric juice, i.e. duodenal ulcers, benign gastric ulcers. Also...
DimetotiazineDimetotiazine has considerable antiemetic & serotonin antagonistic action used mainly in allergic skin conditions.
ChlorphenoxamineChlorphenoxamine is marketed under the name Phenoxene. It is an antihistamine and anticholinergic used to treat itching as well as for its antiparkinsonian effect.
AcrivastineAn antihistamine agent used for the symptomatic relief of seasonal allergic rhinitis such as sneezing, rhinorrhea, pruritus, lacrimation, and nasal congestion.
Dexchlorpheniramine maleateA first generation antihistamine used to treat allergic and vasomotor rhinitis, allergic conjunctivitis, and mild urticaria and angioedema.
ThonzylamineThozylamine is indicated for use in the symptomatic control of allergic rhinitis or other upper respiratory allergic symptoms [FDA Label]. It is typically a part of combination over the counter...
EbastineEbastine is under investigation for the treatment of Irritable Bowel Syndrome (IBS). Ebastine has been investigated for the treatment of Urticaria.
OzagrelOzagrel has been used in trials studying the treatment of Dry Eye Syndromes.
MizolastineMizolastine is under investigation in clinical trial NCT01928316 (A Bioequivalence Study of Domestic (Made in China) and Imported Mizolastine Tablets in Healthy Volunteers).
LafutidineLafutidine has been investigated in Peptic Ulcer, Community-acquired Pneumonia, and Gastroesophageal Reflux Disease (GERD).
OxatomideOxatomide has been used in trials studying the treatment of Muscular Dystrophy, Duchenne.
LavoltidineLavoltidine has been used in trials studying the diagnostic of Reflux, Gastroesophageal and Gastroesophageal Reflux Disease.
BamipineNot Annotated
DexchlorpheniramineDexchlorpheniramine is a potent S-enantiomer of chlorpheniramine. The salt form dexchlorpheniramine maleate as the active ingredient is available as a prescription drug indicated for adjuctive therapy for allergic and anaphylactic...
TritoqualineNot Annotated
QuifenadineNot Annotated
DeptropineNot Annotated
SKF-91488Not Available
Drugs & Drug Targets
DrugTargetType
BetazoleHistamine H2 receptortarget
ClemastineHistamine H1 receptortarget
ClemastineCytochrome P450 2D6enzyme
CetirizineHistamine H1 receptortarget
CetirizineP-glycoprotein 1transporter
TerfenadineHistamine H1 receptortarget
TerfenadinePotassium voltage-gated channel subfamily H member 2target
TerfenadineCytochrome P450 3A4enzyme
TerfenadineCytochrome P450 2D6enzyme
TerfenadineMuscarinic acetylcholine receptor M3target
TerfenadineCytochrome P450 3A5enzyme
TerfenadineCytochrome P450 3A7enzyme
TerfenadineP-glycoprotein 1transporter
TerfenadineCytochrome P450 2C8enzyme
TerfenadineCytochrome P450 2J2enzyme
TerfenadineMuscarinic acetylcholine receptor M1target
TerfenadineMuscarinic acetylcholine receptor M5target
TerfenadineMuscarinic acetylcholine receptor M4target
TerfenadineMuscarinic acetylcholine receptor M2target
TerfenadineBile salt export pumptransporter
BuclizineHistamine H1 receptortarget
BuclizineMuscarinic acetylcholine receptor M1target
DoxylamineHistamine H1 receptortarget
DoxylamineMuscarinic acetylcholine receptortarget
DoxylamineCYP2B proteinenzyme
DoxylamineNuclear receptor subfamily 1 group I member 3target
Mirtazapine5-hydroxytryptamine receptor 2Atarget
Mirtazapine5HT3 serotonin receptortarget
MirtazapineAlpha-2A adrenergic receptortarget
Mirtazapine5-hydroxytryptamine receptor 2Ctarget
MirtazapineKappa-type opioid receptortarget
MirtazapineHistamine H1 receptortarget
MirtazapineCytochrome P450 1A2enzyme
MirtazapineCytochrome P450 3A4enzyme
MirtazapineCytochrome P450 2D6enzyme
MirtazapineAlpha-1 adrenergic receptorstarget
MirtazapineSodium-dependent serotonin transportertransporter
ProfenamineGlutamate receptor ionotropic, NMDA 3Atarget
ProfenamineMuscarinic acetylcholine receptor M1target
ProfenamineCholinesteraseenzyme
ProfenamineMuscarinic acetylcholine receptor M2target
DexbrompheniramineHistamine H1 receptortarget
TriprolidineHistamine H1 receptortarget
Cyproheptadine5-hydroxytryptamine receptor 2Atarget
CyproheptadineHistamine H1 receptortarget
CyproheptadineMuscarinic acetylcholine receptor M1target
CyproheptadineMuscarinic acetylcholine receptor M2target
CyproheptadineMuscarinic acetylcholine receptor M3target
Cyproheptadine5-hydroxytryptamine receptor 2Ctarget
CyproheptadineUDP-glucuronosyltransferase 1-3enzyme
Cyproheptadine5-hydroxytryptamine receptor 7target
CimetidineHistamine H2 receptortarget
CimetidineCytochrome P450 1A2enzyme
CimetidineCytochrome P450 2D6enzyme
CimetidineCytochrome P450 2C19enzyme
CimetidineCytochrome P450 3A4enzyme
CimetidineCytochrome P450 3A5enzyme
CimetidineP-glycoprotein 1transporter
CimetidineSolute carrier family 22 member 2transporter
CimetidineSolute carrier family 22 member 1transporter
CimetidineSolute carrier family 22 member 3transporter
CimetidineSolute carrier family 22 member 5transporter
CimetidineSolute carrier family 22 member 6transporter
CimetidineSolute carrier family 22 member 8transporter
CimetidineMultidrug and toxin extrusion protein 1transporter
CimetidineSolute carrier family 22 member 4transporter
CimetidineSolute carrier family 22 member 11transporter
CimetidineSolute carrier family 22 member 7transporter
CimetidineCytochrome P450 11B1, mitochondrialenzyme
CimetidineCytochrome P450 2C8enzyme
CimetidineCytochrome P450 2C9enzyme
CimetidineCytochrome P450 2E1enzyme
CimetidineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
CimetidineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
CimetidineBile salt export pumptransporter
CimetidineMultidrug and toxin extrusion protein 2transporter
HydroxyzineHistamine H1 receptortarget
HydroxyzineCytochrome P450 2D6enzyme
HydroxyzineCytochrome P450 3A4enzyme
HydroxyzineCytochrome P450 3A5enzyme
HydroxyzinePotassium voltage-gated channel subfamily H member 2target
HydroxyzineP-glycoprotein 1transporter
HydroxyzineSerum albumincarrier
CinnarizineHistamine H1 receptortarget
CinnarizineDopamine D2 receptortarget
CinnarizineVoltage-dependent T-type calcium channel subunit alpha-1Htarget
CinnarizineCytochrome P450 2D6enzyme
CinnarizineCytochrome P450 2B6enzyme
CinnarizineCytochrome P450 2C9enzyme
CinnarizineCytochrome P450 1A1enzyme
CinnarizineCytochrome P450 1A2enzyme
CinnarizineCytochrome P450 2A6enzyme
CinnarizineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
CinnarizineVoltage-dependent L-type calcium channel subunit alpha-1Starget
CinnarizineVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
CinnarizineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
CinnarizineVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
CinnarizineVoltage-dependent T-type calcium channel subunit alpha-1Itarget
CinnarizineD(1) dopamine receptortarget
CinnarizineMuscarinic acetylcholine receptortarget
CinnarizineCytochrome P450 3A4enzyme
NizatidineHistamine H2 receptortarget
NizatidineP-glycoprotein 1transporter
NizatidineCholinesteraseenzyme
AstemizoleHistamine H1 receptortarget
AstemizolePotassium voltage-gated channel subfamily H member 2target
AstemizoleCytochrome P450 3A4enzyme
AstemizoleCytochrome P450 3A5enzyme
AstemizoleCytochrome P450 3A7enzyme
AstemizoleP-glycoprotein 1transporter
AstemizoleCytochrome P450 2D6enzyme
AstemizoleCytochrome P450 2J2enzyme
AstemizolePotassium voltage-gated channel subfamily H member 1target
AstemizoleMicrotubule-associated protein tautarget
AstemizoleBile salt export pumptransporter
AzatadineHistamine H1 receptortarget
AzatadineCytochrome P450 3A4enzyme
MeclizineHistamine H1 receptortarget
MeclizineNuclear receptor subfamily 1 group I member 3target
MeclizineCytochrome P450 2D6enzyme
MeclizineSerum albumincarrier
CarbinoxamineHistamine H1 receptortarget
EpinastineHistamine H1 receptortarget
EpinastineHistamine H2 receptortarget
EpinastineAlpha-1A adrenergic receptortarget
EpinastineAlpha-2A adrenergic receptortarget
Epinastine5-hydroxytryptamine receptor 2Atarget
Epinastine5-hydroxytryptamine receptor 7target
EpinastineP-glycoprotein 1transporter
EpinastineCytochrome P450 2B6enzyme
EpinastineCytochrome P450 2D6enzyme
EpinastineCytochrome P450 3A4enzyme
OlopatadineHistamine H1 receptortarget
OlopatadineProtein S100-A1target
OlopatadineProtein S100-A12target
OlopatadineProtein S100-Btarget
OlopatadineProtein S100-A13target
OlopatadineProtein S100-A2target
OlopatadineCytochrome P450 3A4enzyme
OlopatadineSerum albumincarrier
OlopatadineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
OlopatadineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
OlopatadineP-glycoprotein 1transporter
OlopatadineHistamine H2 receptortarget
OlopatadineHistamine H3 receptortarget
TripelennamineHistamine H1 receptortarget
TripelennamineCytochrome P450 2D6enzyme
BrompheniramineHistamine H1 receptortarget
BrompheniramineMuscarinic acetylcholine receptor M1target
BrompheniramineMuscarinic acetylcholine receptor M2target
BrompheniramineMuscarinic acetylcholine receptor M3target
BrompheniramineMuscarinic acetylcholine receptor M4target
BrompheniramineMuscarinic acetylcholine receptor M5target
KetotifenHistamine H1 receptortarget
Ketotifen6-phosphogluconate dehydrogenase, decarboxylatingtarget
FamotidineHistamine H2 receptortarget
FamotidineSolute carrier family 22 member 2transporter
FamotidineSolute carrier family 22 member 8transporter
FamotidineMultidrug and toxin extrusion protein 1transporter
FamotidineCytochrome P450 1A2enzyme
FamotidineSolute carrier family 22 member 6transporter
FexofenadineHistamine H1 receptortarget
FexofenadineP-glycoprotein 1transporter
FexofenadineSolute carrier organic anion transporter family member 2B1transporter
FexofenadineSolute carrier organic anion transporter family member 1A2transporter
FexofenadineSolute carrier organic anion transporter family member 1B1transporter
FexofenadineSolute carrier organic anion transporter family member 1B3transporter
FexofenadineSolute carrier family 22 member 8transporter
FexofenadineCanalicular multispecific organic anion transporter 1transporter
FexofenadineCanalicular multispecific organic anion transporter 2transporter
FexofenadineSerum albumincarrier
Fexofenadinealpha1-acid glycoproteincarrier
DesloratadineHistamine H1 receptortarget
DesloratadineP-glycoprotein 1transporter
AzelastineHistamine H1 receptortarget
AzelastineCytochrome P450 1A2enzyme
AzelastineCytochrome P450 2D6enzyme
AzelastineCytochrome P450 3A4enzyme
AzelastineCytochrome P450 2C19enzyme
AzelastineCytochrome P450 1A1enzyme
AzelastineCytochrome P450 3A5enzyme
AzelastineCytochrome P450 2C9enzyme
AzelastineCytochrome P450 2C8enzyme
AzelastineP-glycoprotein 1transporter
AzelastineCytochrome P450 2A6enzyme
AzelastineCytochrome P450 2E1enzyme
AzelastineHistamine H2 receptortarget
AzelastinePhospholipase A2target
AzelastineLeukotriene C4 synthasetarget
AzelastineCytochrome P450 2B6enzyme
DimenhydrinateHistamine H1 receptortarget
PromethazineDopamine D2 receptortarget
PromethazineHistamine H1 receptortarget
PromethazineMuscarinic acetylcholine receptor M4target
PromethazineMuscarinic acetylcholine receptor M1target
PromethazineMuscarinic acetylcholine receptor M5target
PromethazineMuscarinic acetylcholine receptor M2target
PromethazineMuscarinic acetylcholine receptor M3target
PromethazineCalmodulintarget
PromethazineCytochrome P450 2D6enzyme
PromethazineCytochrome P450 2B6enzyme
PromethazineP-glycoprotein 1transporter
PromethazineCytochrome P450 2C9enzyme
PromethazineHistamine H2 receptortarget
PromethazineAlpha adrenergic receptortarget
PromethazineP2 Purinoceptorstarget
PromethazineVoltage-gated sodium channel alpha subunittarget
PromethazineVoltage-gated Potassium Channelstarget
PromethazineCanalicular multispecific organic anion transporter 2transporter
PromethazineMultidrug resistance-associated protein 4transporter
PromethazineSerum albumincarrier
MequitazineHistamine H1 receptortarget
MequitazineCytochrome P450 2D6enzyme
MequitazineCytochrome P450 3A4enzyme
DiphenhydramineHistamine H1 receptortarget
DiphenhydramineCytochrome P450 2D6enzyme
DiphenhydramineCytochrome P450 2C9enzyme
DiphenhydramineCytochrome P450 2C19enzyme
DiphenhydramineSolute carrier family 22 member 2transporter
DiphenhydramineSolute carrier family 22 member 5transporter
DiphenhydramineProstaglandin G/H synthase 1enzyme
DiphenhydramineMuscarinic acetylcholine receptor M2target
EmedastineHistamine H1 receptortarget
LevocabastineNeurotensin receptor type 2target
LevocabastineHistamine H1 receptortarget
ChlorpheniramineHistamine H1 receptortarget
ChlorpheniramineCytochrome P450 3A4enzyme
ChlorpheniramineCytochrome P450 2D6enzyme
ChlorpheniramineSodium-dependent serotonin transportertarget
ChlorpheniramineSodium-dependent noradrenaline transportertarget
ChlorpheniramineSodium-dependent dopamine transportertarget
ChlorpheniramineCytochrome P450 3A5enzyme
ChlorpheniramineCytochrome P450 3A7enzyme
ChlorpheniramineSolute carrier family 22 member 2transporter
ChlorpheniramineSolute carrier family 22 member 1transporter
DoxepinSodium-dependent serotonin transportertarget
DoxepinSodium-dependent noradrenaline transportertarget
DoxepinHistamine H1 receptortarget
DoxepinHistamine H2 receptortarget
DoxepinCytochrome P450 2D6enzyme
DoxepinMuscarinic acetylcholine receptor M1target
DoxepinMuscarinic acetylcholine receptor M2target
DoxepinMuscarinic acetylcholine receptor M3target
DoxepinMuscarinic acetylcholine receptor M4target
DoxepinMuscarinic acetylcholine receptor M5target
DoxepinAlpha-1A adrenergic receptortarget
Doxepin5-hydroxytryptamine receptor 1Atarget
Doxepin5-hydroxytryptamine receptor 2Atarget
DoxepinCytochrome P450 2C19enzyme
DoxepinCytochrome P450 2C9enzyme
DoxepinCytochrome P450 1A2enzyme
DoxepinP-glycoprotein 1transporter
Doxepin5-hydroxytryptamine receptor 2Btarget
Doxepin5-hydroxytryptamine receptor 2Ctarget
DoxepinAlpha-1B adrenergic receptortarget
DoxepinAlpha-1D adrenergic receptortarget
DoxepinCytochrome P450 3A4enzyme
Doxepin5-hydroxytryptamine receptor 6target
DoxepinHistamine H4 receptortarget
DoxepinPotassium voltage-gated channel subfamily H member 2target
DoxepinSerum albumincarrier
DoxepinAlpha-1-acid glycoprotein 1carrier
CyclizineHistamine H1 receptortarget
CyclizineEstrogen sulfotransferasetarget
CyclizineCytochrome P450 2C9enzyme
AlimemazineHistamine H1 receptortarget
PhenindamineHistamine H1 receptortarget
PheniramineHistamine H1 receptortarget
PheniramineNuclear receptor subfamily 1 group I member 3target
PheniramineHistamine H4 receptortarget
Butyric Acid(S)-2-haloacid dehalogenasetarget
Butyric AcidCholinesterasetarget
Butyric Acid2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolasetarget
Butyric AcidCholinesteraseenzyme
FlunarizineHistamine H1 receptortarget
FlunarizineVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
FlunarizineVoltage-dependent T-type calcium channel subunit alpha-1Htarget
FlunarizineVoltage-dependent T-type calcium channel subunit alpha-1Itarget
FlunarizineCalmodulintarget
FlunarizineCytochrome P450 2D6enzyme
FlunarizineCytochrome P450 2C9enzyme
FlunarizineCytochrome P450 1A1enzyme
FlunarizineCytochrome P450 1A2enzyme
FlunarizineCytochrome P450 2A6enzyme
FlunarizineCytochrome P450 3A4enzyme
TesmilifeneP-glycoprotein 1target
TesmilifeneHistamine H1 receptortarget
TesmilifeneCytochrome P450 3A4enzyme
TesmilifeneCytochrome P450 2D6enzyme
TesmilifeneCytochrome P450 1A1enzyme
HistamineHistamine H1 receptortarget
HistamineHistamine H2 receptortarget
HistamineHistamine H3 receptortarget
HistamineHistamine N-methyltransferaseenzyme
HistamineSolute carrier family 22 member 2transporter
HistamineSolute carrier family 22 member 1transporter
HistamineSolute carrier family 22 member 3transporter
HistamineSolute carrier family 22 member 5transporter
HistamineHistamine H4 receptortarget
HistamineSynaptic vesicular amine transportertarget
MianserinHistamine H1 receptortarget
MianserinAlpha-2A adrenergic receptortarget
Mianserin5-hydroxytryptamine receptor 2Atarget
Mianserin5-hydroxytryptamine receptor 2Ctarget
MianserinCytochrome P450 2D6enzyme
MianserinSodium-dependent serotonin transportertarget
MianserinCytochrome P450 3A4enzyme
MianserinCytochrome P450 1A2enzyme
MianserinCytochrome P450 2B6enzyme
MianserinSodium-dependent noradrenaline transportertarget
MianserinHistamine H4 receptortarget
Mianserin5-hydroxytryptamine receptor 1Atarget
MianserinAlpha-2C adrenergic receptortarget
Mianserin5-hydroxytryptamine receptor 2Btarget
Mianserin5-hydroxytryptamine receptor 1Ftarget
MianserinAlpha-2B adrenergic receptortarget
MianserinDopamine D3 receptortarget
MianserinKappa-type opioid receptortarget
MianserinSodium-dependent dopamine transportertarget
Mianserin5-hydroxytryptamine receptor 7target
MianserinDopamine D2 receptortarget
Mianserin5-hydroxytryptamine receptor 6target
MianserinAlpha-1 adrenergic receptorstarget
MianserinD(1) dopamine receptortarget
LevocetirizineHistamine H1 receptortarget
LevocetirizineSolute carrier family 22 member 11transporter
LevocetirizineCytochrome P450 3A4enzyme
LevocetirizineSerum albumincarrier
EsmirtazapineCytochrome P450 2D6enzyme
EsmirtazapineHistamine H1 receptortarget
Esmirtazapine5-hydroxytryptamine receptor 2target
EsmirtazapineAlpha-2 adrenergic receptorstarget
MepyramineCytochrome P450 2D6enzyme
MepyramineHistamine H1 receptortarget
MepyramineSolute carrier family 22 member 4transporter
MepyramineSolute carrier family 22 member 5transporter
BetahistineHistamine H1 receptortarget
BetahistineHistamine H3 receptortarget
AlcaftadineHistamine H1 receptortarget
TranilastHematopoietic prostaglandin D synthasetarget
TranilastCytochrome P450 3A4enzyme
TranilastCytochrome P450 2C9enzyme
AntazolineHistamine H1 receptortarget
ChloropyramineHistamine H1 receptortarget
DimetindeneMuscarinic acetylcholine receptor M2target
DimetindeneHistamine H1 receptortarget
IsothipendylHistamine H1 receptortarget
MetiamideHistamine H2 receptortarget
Roxatidine acetateHistamine H2 receptortarget
AcrivastineHistamine H1 receptortarget
Dexchlorpheniramine maleateCytochrome P450 2D6enzyme
Dexchlorpheniramine maleateHistamine H1 receptortarget
Dexchlorpheniramine maleateSolute carrier family 22 member 1carrier
Dexchlorpheniramine maleateSolute carrier family 22 member 2carrier
Dexchlorpheniramine maleateCytochrome P450 3A4enzyme
ThonzylamineHistamine H1 receptortarget
ThonzylamineMuscarinic acetylcholine receptor M1target
ThonzylamineMuscarinic acetylcholine receptor M2target
ThonzylamineMuscarinic acetylcholine receptor M3target
ThonzylamineMuscarinic acetylcholine receptor M4target
ThonzylamineMuscarinic acetylcholine receptor M5target
EbastineCytochrome P450 3A4enzyme
MizolastineCytochrome P450 2D6enzyme
DexchlorpheniramineCytochrome P450 2D6enzyme
SKF-91488Histamine N-methyltransferasetarget