Neuroprotective Agents

Neuroprotective Agents
Accession Number

Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.

DrugDrug Description
TopiramateAn anticonvulsant drug used in the control of epilepsy and in the prophylaxis and treatment of migraines.
RiluzoleA glutamate antagonist used to treat amyotrophic lateral sclerosis.
MethylprednisoloneA corticosteroid used to treat inflammation or immune reactions across a variety of organ systems, endocrine conditions, and neoplastic diseases.
RivastigmineA cholinesterase inhibitor used to treat mild to moderate dementia in Alzheimer's and Parkinson's.
SelegilineA monoamine oxidase inhibitor used to treat major depressive disorder and Parkinson's.
CilostazolAn antiplatelet agent and vasodilator used for the symptomatic relief of intermittent claudication.
RasagilineAn irreversible inhibitor of monoamine oxidase used for the symptomatic management of idiopathic Parkinson's disease as initial monotherapy and as adjunct therapy to levodopa.
TenocyclidineBecause of its high affinity for the phencyclidine binding site on the NMDA receptor, the 3H radiolabelled form of tenocyclidine is widely used in research into NMDA receptors.
7-NitroindazoleNot Available
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineNot Available
Huperzine AInvestigated for use/treatment in alzheimer's disease.
SGS-742Investigated for use/treatment in alzheimer's disease, attention deficit/hyperactivity disorder (ADHD), memory loss, and schizophrenia and schizoaffective disorders.
D-JNKI-1Investigated for use/treatment in hearing loss.
NalmefeneAn opioid antagonist used in conjunction with psychosocial support to help adults with alcohol dependence reduce alcohol consumption.
ZiconotideAn N-type calcium channel antagonist used to manage patients with severe chronic pain who cannot tolerate, or who have not responded adequately to other treatments such as intrathecal morphine and systemic analgesics.
DexanabinolInvestigated for use/treatment in traumatic brain injuries and neurologic disorders.
RemacemideInvestigated for use/treatment in epilepsy, huntington's disease, and parkinson's disease.
ClomethiazoleInvestigated for use/treatment in strokes.
PropentofyllineInvestigated for use/treatment in alzheimer's disease.
Z-Val-Ala-Asp fluoromethyl ketoneNon-methylated, competitive, and irreversible inhibitor of caspase 1, as well as other caspases,1 which can be used directly with purified enzymes. It does not require an esterase to hydrolyze the...
PiracetamIndicated in adult patients suffering from myoclonus of cortical origin, irrespective of aetiology, and should be used in combination with other anti-myoclonic therapies .
Epigallocatechin gallateEpigallocatechin gallate has been investigated for the treatment of Hypertension and Diabetic Nephropathy.
VinpocetineVinpocetine has been investigated for the treatment of Epilepsy.
TempolTempol has been used in trials studying the treatment of Anal Cancer.
ButylphthalideButylphthalide has been used in trials studying the prevention of Restenosis.
EliprodilEliprodil has been used in trials studying the treatment of Parkinson Disease and Movement Disorders.
TirilazadTirilazad has been used in trials studying the treatment of Spinal Cord Injury.
NefiracetamNefiracetam has been used in trials studying the treatment of Alzheimer's Disease.
GacyclidineGacyclidine has been used in trials studying the treatment of Tinnitus.
NizofenoneNot Annotated
MeclofenoxateNot Annotated
LinopirdineNot Annotated
FosfructoseNot Annotated
Methylprednisolone hemisuccinateA water soluble corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders.
DextrorphanNot Annotated
EbselenEbselen has been investigated for the treatment and basic science of Meniere's Disease, Type 2 Diabetes Mellitus, and Type 1 Diabetes Mellitus.
AlmitrineFor the treatment of chronic obstructive pulmonary disease.
BrimapitideBrimapitide is under investigation in clinical trial NCT01570205 (Safety, Tolerability and PK of a Single iv Infusion of 10, 40, and 80 µg/kg XG-102 Administered to Healthy Volunteers).
EdaravoneA free radical scavenger used to delay the progression of ALS.
Drugs & Drug Targets
TopiramateGamma-aminobutyric acid receptor subunit alpha-1target
TopiramateVoltage-gated sodium channel alpha subunittarget
TopiramateCarbonic anhydrase 2target
TopiramateCarbonic anhydrase 4target
TopiramateKainate receptorstarget
TopiramateCytochrome P450 2C19enzyme
TopiramateCytochrome P450 3A4enzyme
TopiramateCarbonic anhydrase 1target
TopiramateCarbonic anhydrase 3target
TopiramateVoltage gated L-type calcium channeltarget
TopiramateVoltage-dependent R-type calcium channeltarget
TopiramateSerum albumincarrier
TopiramateP-glycoprotein 1transporter
Topiramate5'-AMP-activated protein kinasetransporter
RiluzoleSodium channel protein type 5 subunit alphatarget
RiluzoleCytochrome P450 1A2enzyme
RiluzoleCystine/glutamate transportertarget
RiluzoleATP-binding cassette sub-family G member 2transporter
RiluzoleCytochrome P450 1A1enzyme
MethylprednisoloneGlucocorticoid receptortarget
MethylprednisoloneCytochrome P450 3A4enzyme
MethylprednisoloneP-glycoprotein 1transporter
MethylprednisoloneCytochrome P450 3A Subfamilyenzyme
MethylprednisoloneCytochrome P450 2A6enzyme
MethylprednisoloneCytochrome P450 1B1enzyme
MethylprednisoloneCytochrome P450 2B6enzyme
MethylprednisoloneCytochrome P450 2C8enzyme
MethylprednisoloneCytochrome P450 2C9enzyme
MethylprednisoloneCytochrome P450 2C19enzyme
MethylprednisoloneAnnexin A1target
Methylprednisolone20-ketosteroid reductase (20-hydroxysteroid dehydrogenase)enzyme
Methylprednisolone11beta-hydroxysteroid dehydrogenaseenzyme
MethylprednisoloneSerum albumincarrier
SelegilineAmine oxidase [flavin-containing] Btarget
SelegilineCytochrome P450 2B6enzyme
SelegilineAmine oxidase [flavin-containing] Atarget
SelegilineCytochrome P450 2A6enzyme
SelegilineCytochrome P450 3A4enzyme
SelegilineP-glycoprotein 1transporter
SelegilineCytochrome P450 1A2enzyme
SelegilineCytochrome P450 2C19enzyme
SelegilineCytochrome P450 2C8enzyme
SelegilineCytochrome P450 2C9enzyme
SelegilineCytochrome P450 2D6enzyme
SelegilineCytochrome P450 2E1enzyme
CilostazolcGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
CilostazolCytochrome P450 2C19enzyme
CilostazolCytochrome P450 3A4enzyme
CilostazolCytochrome P450 3A5enzyme
CilostazolCytochrome P450 3A7enzyme
CilostazolCytochrome P450 1A2enzyme
CilostazolCytochrome P450 2D6enzyme
RasagilineApoptosis regulator Bcl-2target
RasagilineAmine oxidase [flavin-containing] Btarget
RasagilineCytochrome P450 1A2enzyme
TenocyclidineGlutamate receptor ionotropic, NMDA 3Atarget
TenocyclidineGlutamate receptor ionotropic, NMDA 3Btarget
TenocyclidineGlutamate receptor ionotropic, NMDA 2Atarget
TenocyclidineGlutamate receptor ionotropic, NMDA 2Ctarget
TenocyclidineGlutamate receptor ionotropic, NMDA 2Btarget
TenocyclidineGlutamate receptor ionotropic, NMDA 2Dtarget
TenocyclidineAlpha-7 nicotinic cholinergic receptor subunittarget
7-NitroindazoleNitric oxide synthase, endothelialtarget
7-NitroindazoleNitric oxide synthase, inducibletarget
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineCathepsin Btarget
Huperzine AAcetylcholinesterasetarget
SGS-742Gamma-aminobutyric acid type B receptor subunit 1target
SGS-742Gamma-aminobutyric acid type B receptor subunit 2target
NalmefeneMu-type opioid receptortarget
NalmefeneKappa-type opioid receptortarget
NalmefeneDelta-type opioid receptortarget
NalmefeneUDP-glucuronosyltransferase 2B7enzyme
NalmefeneUDP-glucuronosyltransferase 1-3enzyme
NalmefeneUDP-glucuronosyltransferase 1-8enzyme
ZiconotideVoltage-dependent N-type calcium channel subunit alpha-1Btarget
ZiconotideVoltage-dependent P/Q-type calcium channel subunit alpha-1Atarget
DexanabinolTumor necrosis factortarget
RemacemideCytochrome P450 3A4enzyme
ClomethiazoleGamma-aminobutyric acid receptor subunit alpha-1target
ClomethiazoleCytochrome P450 2A6enzyme
ClomethiazoleCytochrome P450 2B6enzyme
ClomethiazoleCytochrome P450 2C19enzyme
ClomethiazoleCytochrome P450 3A4enzyme
PropentofyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
PropentofyllineCytochrome P450 1A2enzyme
Z-Val-Ala-Asp fluoromethyl ketoneCaspase-1target
Epigallocatechin gallateAryl hydrocarbon receptortarget
Epigallocatechin gallateDNA (cytosine-5)-methyltransferase 1target
Epigallocatechin gallateDihydrofolate reductase, mitochondrialtarget
VinpocetineCytochrome P450 3A4enzyme
Methylprednisolone hemisuccinateCytochrome P450 3A4enzyme
Methylprednisolone hemisuccinateCytochrome P450 3A5enzyme
EbselenBifunctional epoxide hydrolase 2target
AlmitrineSodium/potassium-transporting ATPase subunit alpha-1target
EdaravoneSolute carrier family 22 member 6transporter
EdaravoneSolute carrier family 22 member 8transporter