Anesthetics, Local

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
DrugDrug NameDrug Description
DB00281LidocaineA local anesthetic used in a wide variety of superficial and invasive procedures.
DB00296RopivacaineAn analgesic drug used for local or regional anesthesia for surgery and short-term management of pain.
DB00297BupivacaineA local anesthetic used in a wide variety of superficial and invasive procedures.
DB00645DyclonineAn topical anesthetic used prior to examination to suppress the gag reflex or for pain relief from canker sores and fever blisters.
DB00721ProcaineA local anesthetic used for anesthesia, peripheral nerve block, and spinal nerve block.
DB00750PrilocaineA local anesthetic used in dental procedures.
DB00807ProparacaineA topical anesthetic used for ophthalmic practice.
DB00961MepivacaineA local anesthetic used for local or regional analgesia or anesthesia.
DB01002LevobupivacaineFor the production of local or regional anesthesia for surgery and obstetrics, and for post-operative pain management
DB01086BenzocaineA topical local anesthetic used for the temporary relief of pain and itching associated with minor burns, sunburn, scrapes and insect bites or minor skin irritations.
DB01161ChloroprocaineA local anesthetic agent indicated for intrathecal injection in adults for the production of subarachnoid block, or spinal anesthesia.
DB08987EtidocaineEtidocaine is marketed under the name Duranest. It is an injectable local anesthetic during surgery, labor, and delivery. Etidocaine has a long duration of activity, but has the main disadvantage...
DB09009ArticaineA local anesthetic used for inducing local, infiltrative, or conductive anesthesia in both simple and complex dental procedures.
DB09085TetracaineA local anaesthetic agent used to induce local analgesia in the eyes and skin during medical procedures.
DB13259Ethyl chlorideEthyl chloride, or chloroethane, has a chemical formula C2H5Cl. It was commonly used in the production of tetraethyllead (TEL), which is an additive for gasoline. It was also used in...
DB00892OxybuprocaineA local anesthetic used in ophthalmology.
DB03255PhenolAn antiseptic and disinfectant used in a variety of settings.
DB00527CinchocaineAn anesthetic used for local or regional anesthesia.
DB00907CocaineAn ester local anesthetic used during diagnostic procedures and surgeries in or through the nasal cavities.
DB01075DiphenhydramineA H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.
DB05232TetrodotoxinFor the treatment of chronic and breakthrough pain in advanced cancer patients as well as for the treatment of opioid dependence.
DB06770Benzyl alcoholAn antiparasitic agent used for the topical treatment of head lice infestation in patients 6 months of age and older.
DB09342PropoxycainePropoxycaine is a local anesthetic medication. It was used beginning in the 1950s during dental procedures . It has been combined with procaine to accelerate its onset of action and...
DB09345PramocaineA local anesthetic and antipruritic agent found in various topical preparations.
DB11148ButambenAnesthesia of mucus membranes other than the eyes.
DB11502ButacaineNot Annotated
DB13683QuinisocaineNot Annotated
DB06774CapsaicinA topical analgesic agent used for the symptomatic relief of neuropathic pain associated with post-herpetic neuralgia, as well as other muscle and joint pain.
DB12532OxetacaineAn antacid used to treat gastritis, peptic ulcer disease, heartburn, esophagitis, hiatus hernia, and anorexia.
DB13328ButanilicaineNot Annotated
DB13578MetabutethamineNot Annotated
DrugDrug NameTargetType
DB00281LidocaineSodium channel protein type 5 subunit alphatarget
DB00281LidocaineSodium channel protein type 10 subunit alphatarget
DB00281LidocaineEpidermal growth factor receptortarget
DB00281LidocaineSodium channel protein type 9 subunit alphatarget
DB00281LidocaineCytochrome P450 1A2enzyme
DB00281LidocaineCytochrome P450 2D6enzyme
DB00281LidocaineCytochrome P450 3A4enzyme
DB00281LidocaineCytochrome P450 3A5enzyme
DB00281LidocaineCytochrome P450 3A7enzyme
DB00281LidocaineSolute carrier family 22 member 5transporter
DB00281LidocaineP-glycoprotein 1transporter
DB00281LidocaineCytochrome P450 2A6enzyme
DB00281LidocaineCytochrome P450 2B6enzyme
DB00281LidocaineCytochrome P450 2C8enzyme
DB00281LidocaineCytochrome P450 2C9enzyme
DB00281LidocaineSodium channel protein type 4 subunit alphatarget
DB00281LidocaineAlpha-1-acid glycoprotein 1target
DB00281LidocaineAlpha-1-acid glycoprotein 2target
DB00296RopivacaineSodium channel protein type 10 subunit alphatarget
DB00296RopivacaineCytochrome P450 1A2enzyme
DB00296RopivacaineCytochrome P450 2B6enzyme
DB00296RopivacaineCytochrome P450 3A4enzyme
DB00297BupivacaineSodium channel protein type 10 subunit alphatarget
DB00297BupivacaineProstaglandin E2 receptor EP1 subtypetarget
DB00297BupivacaineCytochrome P450 3A4enzyme
DB00297BupivacaineCytochrome P450 2C19enzyme
DB00297BupivacaineCytochrome P450 2D6enzyme
DB00645DyclonineSodium channel protein type 10 subunit alphatarget
DB00721ProcaineSodium channel protein type 10 subunit alphatarget
DB00721ProcaineGlutamate receptor ionotropic, NMDA 3Atarget
DB00721Procaine5-hydroxytryptamine receptor 3Atarget
DB00721ProcaineSodium-dependent dopamine transportertarget
DB00721ProcaineNeuronal acetylcholine receptor subunit alpha-2target
DB00721ProcaineCholinesteraseenzyme
DB00721ProcaineDNAtarget
DB00721ProcaineCalcium-activated potassium channeltarget
DB00721ProcaineCytosolic phospholipase A2target
DB00721Procaine60 kDa lysophospholipasetarget
DB00721ProcaineMonoamine oxidasetarget
DB00750PrilocaineSodium channel protein type 5 subunit alphatarget
DB00807ProparacaineSodium channel protein type 10 subunit alphatarget
DB00961MepivacaineSodium channel protein type 10 subunit alphatarget
DB01002LevobupivacaineSodium channel protein type 10 subunit alphatarget
DB01002LevobupivacaineCytochrome P450 3A4enzyme
DB01002LevobupivacaineCytochrome P450 1A2enzyme
DB01086BenzocaineSodium channel protein type 10 subunit alphatarget
DB01086BenzocaineP-glycoprotein 1transporter
DB01086BenzocaineLiver carboxylesterase 1enzyme
DB01161ChloroprocaineSodium channel protein type 10 subunit alphatarget
DB01161ChloroprocaineNeuronal acetylcholine receptor subunit alpha-10target
DB01161ChloroprocaineSodium-dependent dopamine transportertarget
DB01161ChloroprocaineGlutamate receptor ionotropic, NMDA 3Atarget
DB01161Chloroprocaine5-hydroxytryptamine receptor 3Atarget
DB01161ChloroprocaineCholinesteraseenzyme
DB09085TetracaineRyanodine receptor 1target
DB09085TetracaineRyanodine receptor 2target
DB09085TetracaineVoltage-gated sodium channel alpha subunittarget
DB00892OxybuprocaineSodium channel protein type 10 subunit alphatarget
DB00892OxybuprocaineCholinesteraseenzyme
DB03255PhenolThermolysintarget
DB03255PhenolLysozymetarget
DB03255PhenolNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferasetarget
DB03255PhenolSerum albumintarget
DB00527CinchocaineSodium channel protein type 5 subunit alphatarget
DB00527CinchocaineSodium channel protein type 10 subunit alphatarget
DB00527CinchocaineCalmodulintarget
DB00527CinchocaineCholinesteraseenzyme
DB00907CocaineSodium-dependent noradrenaline transportertarget
DB00907CocaineSodium channel protein type 5 subunit alphatarget
DB00907CocaineSodium channel protein type 11 subunit alphatarget
DB00907CocaineSodium channel protein type 10 subunit alphatarget
DB00907CocaineSodium-dependent serotonin transportertarget
DB00907CocaineSodium-dependent dopamine transportertarget
DB00907CocaineCytochrome P450 3A4enzyme
DB00907CocaineMuscarinic acetylcholine receptor M1target
DB00907CocaineMuscarinic acetylcholine receptor M2target
DB00907CocaineCytochrome P450 3A5enzyme
DB00907CocaineCytochrome P450 3A7enzyme
DB00907CocaineCytochrome P450 2D6enzyme
DB00907CocaineSolute carrier family 22 member 2transporter
DB00907CocaineCytochrome P450 2C8enzyme
DB00907CocaineSigma non-opioid intracellular receptor 1target
DB00907CocaineLiver carboxylesterase 1target
DB00907CocaineCholinesteraseenzyme
DB01075DiphenhydramineHistamine H1 receptortarget
DB01075DiphenhydramineCytochrome P450 2D6enzyme
DB01075DiphenhydramineCytochrome P450 2C9enzyme
DB01075DiphenhydramineCytochrome P450 2C19enzyme
DB01075DiphenhydramineSolute carrier family 22 member 2transporter
DB01075DiphenhydramineSolute carrier family 22 member 5transporter
DB01075DiphenhydramineProstaglandin G/H synthase 1enzyme
DB01075DiphenhydramineMuscarinic acetylcholine receptor M2target
DB05232TetrodotoxinSodium channel protein type 1 subunit alphatarget
DB05232TetrodotoxinSodium channel protein type 2 subunit alphatarget
DB05232TetrodotoxinSodium channel protein type 3 subunit alphatarget
DB05232TetrodotoxinSodium channel protein type 8 subunit alphatarget
DB06770Benzyl alcoholCytochrome P450 2C8enzyme
DB06770Benzyl alcoholCytochrome P450 1A1enzyme
DB06770Benzyl alcoholAldehyde dehydrogenase, mitochondrialenzyme
DB06770Benzyl alcoholCytochrome P450 1A2enzyme
DB06770Benzyl alcoholCytochrome P450 2E1enzyme
DB06770Benzyl alcoholCytochrome P450 2D6enzyme
DB09342PropoxycaineLiver carboxylesterase 1enzyme
DB09342PropoxycaineVoltage-gated sodium channel alpha subunittarget
DB09345PramocaineVoltage-gated sodium channel alpha subunittarget
DB11148ButambenVoltage-dependent calcium channeltarget
DB11148ButambenCholinesteraseenzyme
DB11148ButambenAlpha-1-acid glycoprotein 1carrier
DB11148ButambenSerum albumincarrier
DB11148ButambenATP-sensitive potassium channeltarget
DB11148ButambenTransient receptor potential cation channel subfamily A member 1target
DB11148ButambenTransient receptor potential cation channel subfamily V member 4target
DB06774CapsaicinCytochrome P450 3A4enzyme
DB06774CapsaicinProstaglandin G/H synthase 2enzyme
DB06774CapsaicinMyeloperoxidaseenzyme
DB06774CapsaicinCytochrome P450 1A2enzyme
DB06774CapsaicinCytochrome P450 2E1enzyme
DB06774CapsaicinAmine oxidase [flavin-containing] Aenzyme
DB06774CapsaicinDopamine beta-hydroxylaseenzyme
DB06774CapsaicinGlutamine synthetaseenzyme
DB06774CapsaicinCholinesteraseenzyme
DB06774CapsaicinTransient receptor potential cation channel subfamily V member 1target
DB06774CapsaicinProhibitin-2target
DB12532OxetacaineCytochrome P450 3A4enzyme
DB12532OxetacaineGastrintarget