Pyrrolidines

Name
Pyrrolidines
Accession Number
DBCAT000663
Description

Compounds also known as tetrahydropyridines with general molecular formula (CH2)4NH.

Drugs
DrugDrug Description
ClemastineAn antihistamine with sedative and anticholinergic effects used to treat the symptoms of allergic rhinitis.
ProcyclidineAn antispasmodic drug used to treat parkinsonism of various types and in the treatment of extrapyramidal symptoms.
DoxapramA short acting respiratory stimulant used to treat acute respiratory insufficiency in COPD patients.
EthosuximideAn anticonvulsant used to treat petit mal seizures.
PhensuximideFor the treatment of epilepsy.
GlycopyrroniumAn anticholinergic agent used to treat hyperhidrosis, severe drooling, COPD, used with other medications to treat ulcers, and used in anesthesia.
PentoliniumUsed to produce controlled hypotension during surgical procedures and in hypertensive crises.
ClindamycinA lincosamide antibiotic used to treat serious infections caused by susceptible anaerobic, streptococcal, staphylococcal, and pneumococcal bacteria.
LevetiracetamA novel anticonvulsant agent used as an adjunct medication to manage partial onset, myoclonic, and generalized tonic-clonic seizures in patients with epilepsy.
BepridilFor the treatment of hypertension, and chronic stable angina (classic effort-associated angina).
LincomycinAn antibiotic indicated only for the treatment of serious infections, and is typically reserved for use in cases of penicillin allergy or where penicillin is inappropriate.
RolipramA phosphodiesterase inhibitor with antidepressant properties.
GhavamiolNot Available
Domoic AcidNot Available
Pidolic acidThere is currently no clinically approved and/or marketed medicine that relies upon pidolic acid as an active ingredient for any formal therapeutic indication. Although pidolic acid may be sold in...
AniracetamCompound with anti-depressive properties used as a mental performance enhancer.
RupintrivirInvestigated for use/treatment in viral infection.
MethsuximideA succinimide anticonvulsant that increases the seizure threshold. Primarily used for childhood absence seizures. Functions by suppressing paroxysmal spike-and-wave patterns associated with lapses of consciousness in absence seizures.
BrivaracetamAn anticonvulsant used for the treatment of partial-onset seizures that functions by binding to synaptic vesicle glycoprotein 2A (SV2A) in the brain.
Povidone-iodineA topical antiseptic agent used for the treatment and prevention of infection in wounds.
RaltegravirAn antiretroviral agent used for the treatment of HIV infections in conjunction with other antiretrovirals.
AnisomycinAnisomycin (sometimes known as flagecidin), is an antibiotic retrieved from the bacteria Streptomyces griseolus. This drug acts to inhibit bacterial protein and DNA synthesis.
PiracetamIndicated in adult patients suffering from myoclonus of cortical origin, irrespective of aetiology, and should be used in combination with other anti-myoclonic therapies .
PovidoneWhen in complex with iodine, indicated for inducing antisepsis for prevention of infection in minor cuts, scrapes, and burns.
PidotimodFor use as immunostimulant therapy for treatment of cell-mediated immunosuppression with respiratory or urinary infections .
PirlimycinPirlimycin hydrochloride is an antibiotic belonging to the lincosamide class. Often marketed as Pirsue, this drug is used to treat mastitis in cattle.
EtiracetamEtiracetam is under investigation in clinical trial NCT01137110 (Comparison of Short Duration Levetiracetam to Extended Course for Seizure Prophylaxis After Subarachnoid Hemorrhage (SAH)).
TivantinibTivantinib has been investigated in Solid Tumors.
Oxothiazolidinecarboxylic acidProcysteine has been used in trials studying the treatment of HIV Infections.
Methyl pyrrolidoneN Methyl Pyrrolidone is under investigation for the treatment of Multiple Myeloma.
NefiracetamNefiracetam has been used in trials studying the treatment of Alzheimer's Disease.
SuccinimideNot Annotated
PecilocinNot Annotated
SeletracetamInvestigated for use/treatment in epilepsy.
UlodesineUlodesine has been used in trials studying the treatment of Gout, Arthritis, Hyperuricemia, and Joint Disease.
VildagliptinA once-daily dipeptidyl peptidase 4 (DPP-4) inhibitor used in the management of type 2 diabetes mellitus.
AtrasentanInvestigated for use/treatment in prostate cancer and cancer/tumors (unspecified).
VoruciclibVoruciclib is under investigation in clinical trial NCT03547115 (A Phase 1 Study of Voruciclib in Subjects With B-Cell Malignancies or AML).
GW-813893Not Available
Drugs & Drug Targets
DrugTargetType
ClemastineHistamine H1 receptortarget
ClemastineCytochrome P450 2D6enzyme
ProcyclidineMuscarinic acetylcholine receptor M1target
ProcyclidineMuscarinic acetylcholine receptor M2target
ProcyclidineMuscarinic acetylcholine receptor M4target
ProcyclidineMuscarinic acetylcholine receptor M3target
DoxapramPotassium channel subfamily K member 3target
DoxapramPotassium channel subfamily K member 9target
EthosuximideVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
EthosuximideCytochrome P450 3A4enzyme
EthosuximideCytochrome P450 2E1enzyme
EthosuximideCytochrome P450 3A Subfamilyenzyme
GlycopyrroniumMuscarinic acetylcholine receptor M1target
GlycopyrroniumMuscarinic acetylcholine receptor M3target
GlycopyrroniumMuscarinic acetylcholine receptor M2target
PentoliniumNeuronal acetylcholine receptor subunit alpha-10target
PentoliniumNeuronal acetylcholine receptor subunit alpha-3target
PentoliniumNeuronal acetylcholine receptor subunit beta-4target
ClindamycinCytochrome P450 3A4enzyme
ClindamycinCytochrome P450 3A5enzyme
ClindamycinAlpha-1-acid glycoprotein 1carrier
ClindamycinP-glycoprotein 1transporter
Clindamycin50S ribosomal protein L1target
LevetiracetamSynaptic vesicle glycoprotein 2Atarget
LevetiracetamP-glycoprotein 1transporter
LevetiracetamVoltage-dependent N-type calcium channel subunit alpha-1Btarget
BepridilVoltage-dependent P/Q-type calcium channel subunit alpha-1Atarget
BepridilSodium/potassium-transporting ATPase subunit alpha-1target
BepridilPotassium voltage-gated channel subfamily KQT member 1target
BepridilTroponin C, slow skeletal and cardiac musclestarget
BepridilCalmodulintarget
BepridilVoltage-dependent T-type calcium channel subunit alpha-1Htarget
BepridilVoltage-dependent calcium channel subunit alpha-2/delta-2target
BepridilCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1Btarget
BepridilCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1Atarget
BepridilP-glycoprotein 1transporter
BepridilCytochrome P450 2D6enzyme
BepridilPotassium voltage-gated channel subfamily H member 2target
BepridilCytochrome P450 3A4enzyme
Lincomycin50S ribosomal protein L10target
RolipramcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
RolipramcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
GhavamiolAlpha-mannosidase 2target
Domoic AcidGlutamate receptor ionotropic, kainate 2target
Pidolic acidAlpha-amylase 2Btarget
Pidolic acidVascular endothelial growth factor Atarget
Pidolic acidPancreatic alpha-amylasetarget
Pidolic acidIg lambda-1 chain C regionstarget
Pidolic acidIg lambda chain V-II region MGCtarget
Pidolic acidTrefoil factor 2target
Pidolic acidCytochrome c2target
Pidolic acidDisintegrin and metalloproteinase domain-containing protein 28target
Pidolic acidEndo-1,4-beta-xylanasetarget
Pidolic acidDissimilatory copper-containing nitrite reductasetarget
Pidolic acidKeratin-associated protein 5-2target
Pidolic acidOrexintarget
Pidolic acidC-C motif chemokine 8target
Pidolic acidCytochrome c'target
Pidolic acidPancreatic alpha-amylaseenzyme
Aniracetam5-hydroxytryptamine receptor 2Atarget
AniracetamDopamine D2 receptortarget
AniracetamGlutamate receptor 2target
AniracetamGlutamate receptor 3target
RupintrivirGenome polyproteintarget
MethsuximideCytochrome P450 2C19enzyme
MethsuximideVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
BrivaracetamSynaptic vesicle glycoprotein 2Atarget
BrivaracetamSodium channel proteintarget
BrivaracetamCytochrome P450 3A4enzyme
BrivaracetamCytochrome P450 2C19enzyme
BrivaracetamCytochrome P450 2B6enzyme
BrivaracetamCytochrome P450 2C9enzyme
RaltegravirUDP-glucuronosyltransferase 1-1enzyme
RaltegravirIntegrasetarget
Anisomycin60S ribosomal protein L10-liketarget
Anisomycin60S ribosomal protein L13atarget
Anisomycin60S ribosomal protein L23target
Anisomycin60S ribosomal protein L15target
Anisomycin60S ribosomal protein L19target
Anisomycin60S ribosomal protein L23atarget
AnisomycinProbable ribosome biogenesis protein RLP24target
Anisomycin60S ribosomal protein L26-like 1target
Anisomycin60S ribosomal protein L8target
Anisomycin60S ribosomal protein L37target
Anisomycin60S ribosomal protein L3target
Anisomycin60S ribosomal protein L11target
AnisomycinNHP2-like protein 1target
TivantinibHepatocyte growth factor receptortarget
SeletracetamSynaptic vesicle glycoprotein 2Atarget
SeletracetamVoltage-dependent N-type calcium channel subunit alpha-1Btarget
SeletracetamGlycine receptor (alpha-1/beta)target
SeletracetamCytochrome P450 3A4enzyme
VildagliptinDipeptidyl peptidase 4target
AtrasentanEndothelin-1 receptortarget
GW-813893Prothrombintarget
GW-813893Coagulation factor Xtarget