Progesterone Congeners

Name
Progesterone Congeners
Accession Number
DBCAT000686
Description

Steroidal compounds related to PROGESTERONE, the major mammalian progestational hormone. Progesterone congeners include important progesterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with progestational activities.

Drugs
DrugDrug Description
PregnenoloneA 21-carbon steroid, derived from cholesterol and found in steroid hormone-producing tissues. Pregnenolone is the precursor to gonadal steroid hormones and the adrenal corticosteroids.
Hydroxyprogesterone caproateA synthetic progestin used for the prevention of spontaneous preterm births in singleton pregnancies in women who have previously had a spontaneous preterm birth.
AltrenogestAltrenogest, also known as allyltrenbolone, is a steroidal progestin that is widely used in veterinary medicine to suppress estrus in animals.
NorgestometNorgestomet, also known as 11β-methyl-17-hydroxy-19-norprogesterone acetate, is a steroidal progestin used in veterinary medicine to control estrus and ovulation in cattle.
NomegestrolNomegestrol is an ingredient in the EMA-authorised product Zoely.
MethylestrenoloneNot Annotated
FlumedroxoneNot Annotated
DemegestoneDemegestone is a progesterone receptor agonist that was previously used to treat luteal insufficiency. It was previously marketed in France as Lutionex, but has since been discontinued.
Nomegestrol acetateNomegestrol acetate, also known as NOMAC, is a progestin used in oral contraceptives, menopausal hormone therapy, and for the treatment of gynecological disorders.
Norethindrone enanthateNot Annotated
Medroxyprogesterone acetateA progestin used as a contraceptive and in the treatment of secondary amenorrhea, abnormal uterine bleeding, pain from endometriosis, endometrial and renal carcinomas, paraphilia in males, and GnRH-dependent precocious puberty.
EtonogestrelA long-acting synthetic derived progestin contraceptive used in various devices such as contraceptive rings and intradermal implants.
DrospirenoneA progestin used in oral contraceptive pills for the prevention of pregnancy and other conditions.
BrexanoloneBrexanolone is a synthetic neuroactive steroid gamma-aminobutyric acid A (GABA(a)) receptor positive modulator indicated for the treatment of postpartum depression (PPD) in adult women [FDA Label][A176080, A176083, F4063, F4066, F4072].
Drugs & Drug Targets
DrugTargetType
PregnenoloneSulfotransferase family cytosolic 2B member 1target
PregnenoloneSolute carrier family 10 member 6transporter
PregnenoloneNuclear receptor subfamily 1 group I member 2target
PregnenoloneCytochrome P450 3A4enzyme
Hydroxyprogesterone caproateProgesterone receptortarget
Hydroxyprogesterone caproateCytochrome P450 3A4enzyme
Hydroxyprogesterone caproateCytochrome P450 3A5enzyme
Hydroxyprogesterone caproateCytochrome P450 2C19enzyme
NomegestrolCytochrome P450 3A4enzyme
DemegestoneProgesterone receptortarget
DemegestoneCytochrome P450 3A4enzyme
Nomegestrol acetateCytochrome P450 3A4enzyme
Norethindrone enanthateCytochrome P450 3A4enzyme
Medroxyprogesterone acetateProgesterone receptortarget
Medroxyprogesterone acetateEstrogen receptor alphatarget
Medroxyprogesterone acetateCytochrome P450 3A4enzyme
Medroxyprogesterone acetateCytochrome P450 2C8enzyme
Medroxyprogesterone acetate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
Medroxyprogesterone acetateCytochrome P450 2C9enzyme
Medroxyprogesterone acetateCytochrome P450 3A1enzyme
Medroxyprogesterone acetateSerum albumincarrier
Medroxyprogesterone acetateP-glycoprotein 1target
Medroxyprogesterone acetateGABA(A) Receptortarget
Medroxyprogesterone acetateP-glycoprotein 1transporter
EtonogestrelProgesterone receptortarget
EtonogestrelCytochrome P450 3A4enzyme
EtonogestrelSerum albumincarrier
EtonogestrelSex hormone-binding globulincarrier
DrospirenoneProgesterone receptortarget
DrospirenoneMineralocorticoid receptortarget
DrospirenoneAndrogen receptortarget
DrospirenoneProstaglandin G/H synthase 2enzyme
DrospirenoneSerum paraoxonase/arylesterase 1enzyme
DrospirenoneGlucocorticoid receptortarget
DrospirenoneCytochrome P450 3A4enzyme
BrexanoloneGABA(A) Receptortarget
BrexanoloneAldose reductaseenzyme