Progesterone Congeners

Steroidal compounds related to PROGESTERONE, the major mammalian progestational hormone. Progesterone congeners include important progesterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with progestational activities.
DrugDrug NameDrug Indication
DB02789PregnenoloneNot Available
DB06789Hydroxyprogesterone caproateHydroxyprogesterone caproate is indicated for the prevention of spontaneous preterm births in singleton pregnancies in women who have previously had a spontaneous preterm birth. (1)
DB11372AltrenogestNot Available
DB11440NorgestometNot Available
DB11636NomegestrolNot Available
DB13533MethylestrenoloneNot Available
DB13610FlumedroxoneNot Available
DB13857DemegestoneNot Available
DB13981Nomegestrol acetateNot Available
DB14678Norethindrone enanthateNot Available
DB00603Medroxyprogesterone acetateUsed as a contraceptive and to treat secondary amenorrhea, abnormal uterine bleeding, pain associated with endometriosis, endometrial and renal cell carcinomas, paraphilia in males, GnRH-dependent forms of precocious puberty, as well as to prevent endometrial changes associated with estrogens.
DB00294EtonogestrelEtonogestrel is administered in subdermal implants as long-acting reversible contraception. It is known to be effective in postpartum insertion including breastfeeding women.[A175990] Etonogestrel is part of the long-acting contraceptive implants that prevent pregnancy. The implant's effect can remain for 5 years.[L5698]
DB01395DrospirenoneFor the prevention of pregnancy in women who elect an oral contraceptive.
DB14570HydroxyprogesteroneNot Available
DB11859BrexanoloneBrexanolone is a synthetic neuroactive steroid gamma-aminobutyric acid A (GABA(a)) receptor positive modulator indicated for the treatment of postpartum depression (PPD) in adult women [FDA Label][A176080, A176083, F4063, F4066, F4072].
DrugDrug NameTargetType
DB02789PregnenoloneSulfotransferase family cytosolic 2B member 1target
DB02789PregnenoloneSolute carrier family 10 member 6transporter
DB02789PregnenoloneNuclear receptor subfamily 1 group I member 2target
DB02789PregnenoloneCytochrome P450 3A4enzyme
DB06789Hydroxyprogesterone caproateProgesterone receptortarget
DB06789Hydroxyprogesterone caproateCytochrome P450 3A4enzyme
DB06789Hydroxyprogesterone caproateCytochrome P450 3A5enzyme
DB06789Hydroxyprogesterone caproateCytochrome P450 2C19enzyme
DB11636NomegestrolCytochrome P450 3A4enzyme
DB13857DemegestoneProgesterone receptortarget
DB13857DemegestoneCytochrome P450 3A4enzyme
DB13981Nomegestrol acetateCytochrome P450 3A4enzyme
DB00603Medroxyprogesterone acetateProgesterone receptortarget
DB00603Medroxyprogesterone acetateEstrogen receptor alphatarget
DB00603Medroxyprogesterone acetateCytochrome P450 3A4enzyme
DB00603Medroxyprogesterone acetateCytochrome P450 2C8enzyme
DB00603Medroxyprogesterone acetate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
DB00603Medroxyprogesterone acetateCytochrome P450 2C9enzyme
DB00294EtonogestrelEstrogen receptor alphatarget
DB00294EtonogestrelProgesterone receptortarget
DB00294EtonogestrelCytochrome P450 3A4enzyme
DB00294EtonogestrelSerum albumincarrier
DB00294EtonogestrelSex hormone-binding globulincarrier
DB01395DrospirenoneProgesterone receptortarget
DB01395DrospirenoneMineralocorticoid receptortarget
DB01395DrospirenoneAndrogen receptortarget
DB01395DrospirenoneProstaglandin G/H synthase 2enzyme
DB01395DrospirenoneCholinesteraseenzyme
DB01395DrospirenoneCytochrome P450 3A4enzyme
DB14570HydroxyprogesteroneCytochrome P450 3A4enzyme
DB11859BrexanoloneGABA-A receptor (anion channel)target
DB11859BrexanoloneSulfotransferaseenzyme
DB11859BrexanoloneGlucuronosyltransferaseenzyme
DB11859BrexanoloneAldose reductaseenzyme