Organophosphonates

Name
Organophosphonates
Accession Number
DBCAT000698
Description

Carbon-containing phosphonic acid compounds. Included under this heading are compounds that have carbon bound to either OXYGEN atom or the PHOSPHOROUS atom of the (P=O)O2 structure.

Drugs
DrugDrug Description
Pamidronic acidA bisphosphonate used to treat Paget's disease, to treat hypercalcemia of malignancy, and to treat osteolytic bone lesions.
Zoledronic acidA bisphosphonate used to treat malignancy associated hypercalcemia, multiple myeloma, and bone metastasis from solid tumors.
FoscarnetAn antiviral used to treat CMV, HIV, and HSV infections.
Alendronic acidA bisphosphonate drug that prevents osteoclastic bone resorption and is used for the prevention and treatment of osteoporosis.
IsoflurophateFor use in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia.
IbandronateA bisphosphonate used to treat osteoporosis in postmenopausal women.
Clodronic acidA bisphosphonate used to treat osteoporosis in postmenopausal women, hypercalcemia of malignancy, and osteolysis.
FosfomycinA broad spectrum antibiotic used to treat uncomplicated urinary tract infections.
Risedronic acidA bisphosphonate used to treat osteoporosis and Paget's disease.
Etidronic acidA bisphosphonate drug that prevents osteoclastic bone resorption; used for the prevention and treatment of osteoporosis.
Tiludronic acidA bisphosphonate used for the treatment of Paget's disease of bone.
Adenosine Phosphonoacetic AcidNot Available
Phosphonoacetic AcidA simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent. [PubChem]
FosmidomycinNot Available
Sparfosic acidSparfosic acid is a solid. This compound belongs to the n-acyl-alpha amino acids. These are compounds containing an alpha amino acid which bears an acyl group at the terminal nitrogen...
Incadronic acidIncadronate has been investigated in the treatment of myeloma,[A14426,A14431] leukemia, and other cancers. It has also been investigated in patients with hypercalcemia of malignancy.
Minodronic acidInvestigated for use/treatment in multiple myeloma, breast cancer, osteoporosis, and lung cancer.
Technetium Tc-99m medronateA diagnostic radiopharmaceutical agent used as a bone imaging agent to delineate areas of altered osteogenesis.
MetrifonateMetrifonate or trichlorfon is an irreversible organophosphate acetylcholinesterase inhibitor. It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate.
Neridronic AcidNot Annotated
ApomineApomine has been used in trials studying the treatment of Osteoporosis and Unspecified Adult Solid Tumor, Protocol Specific.
TenofovirTenofovir has been shown to be effective against HIV, herpes simplex virus-2, and hepatitis B virus. To know more about the specific product indications, please visit the information in the...
Oxidronic acidOxidronic acid is a diagnostic skeletal imaging agent used to demonstrate areas of altered osteogenesis in adult and pediatric patients.
CidofovirAn antiviral agent used to treat Cytomegalovirus (CMV) retinitis in patients with AIDS.
Technetium Tc-99m oxidronateTechnetium Tc-99m oxidronate is indicated in adult and pediatric patients to be used in skeletal imaging for diagnosis of areas that can present altered osteogenesis. When administered intravenously, it is...
Drugs & Drug Targets
DrugTargetType
Pamidronic acidFarnesyl pyrophosphate synthasetarget
Pamidronic acidHydroxylapatitetarget
Pamidronic acidGeranylgeranyl pyrophosphate synthasetarget
Pamidronic acidCaspase-3target
Pamidronic acidCaspase-9target
Zoledronic acidFarnesyl pyrophosphate synthasetarget
Zoledronic acidGeranylgeranyl pyrophosphate synthasetarget
Zoledronic acidHydroxylapatitetarget
Zoledronic acidMultidrug resistance-associated protein 1transporter
FoscarnetDNA polymerase catalytic subunittarget
FoscarnetDNA polymerase catalytic subunittarget
FoscarnetSolute carrier family 22 member 6transporter
FoscarnetMonocarboxylate transporter 1transporter
Alendronic acidFarnesyl pyrophosphate synthasetarget
Alendronic acidTyrosine-protein phosphatase non-receptor type 4target
Alendronic acidReceptor-type tyrosine-protein phosphatase Starget
Alendronic acidReceptor-type tyrosine-protein phosphatase epsilontarget
Alendronic acidV-type proton ATPase catalytic subunit Atarget
Alendronic acidHydroxylapatitetarget
IsoflurophateCholinesterasetarget
IsoflurophateAcetylcholinesterasetarget
IsoflurophateCholinesteraseenzyme
IsoflurophateSerum albumincarrier
IsoflurophateSerotransferrintarget
IbandronateFarnesyl pyrophosphate synthasetarget
IbandronateHydroxylapatitetarget
IbandronateGeranylgeranyl pyrophosphate synthasetarget
Clodronic acidADP/ATP translocase 2target
Clodronic acidADP/ATP translocase 1target
Clodronic acidADP/ATP translocase 3target
Clodronic acidHydroxylapatitetarget
Clodronic acidProstaglandin G/H synthase 2enzyme
FosfomycinUDP-N-acetylglucosamine 1-carboxyvinyltransferasetarget
Risedronic acidFarnesyl pyrophosphate synthasetarget
Risedronic acidHydroxylapatitetarget
Risedronic acidProstaglandin G/H synthase 2enzyme
Etidronic acidHydroxylapatitetarget
Etidronic acidReceptor-type tyrosine-protein phosphatase Starget
Etidronic acidV-type proton ATPase catalytic subunit Atarget
Etidronic acidADP/ATP translocase 1target
Etidronic acidADP/ATP translocase 2target
Etidronic acidADP/ATP translocase 3target
Tiludronic acidTyrosine-protein phosphatase non-receptor type 12target
Tiludronic acidV-ATPase Subunitstarget
Tiludronic acidHydroxylapatitetarget
Tiludronic acidAdenosine triphosphate (ATP)target
Tiludronic acidSerum albumincarrier
Tiludronic acidTyrosine-protein phosphatase non-receptor type 6target
Tiludronic acidReceptor-type tyrosine-protein phosphatase epsilontarget
Adenosine Phosphonoacetic AcidNucleoside diphosphate kinase Atarget
Phosphonoacetic AcidAlkaline phosphatasetarget
Fosmidomycin1-deoxy-D-xylulose 5-phosphate reductoisomerasetarget
Sparfosic acidAspartate carbamoyltransferase catalytic chaintarget
Sparfosic acidCAD proteintarget
Incadronic acidFarnesyl pyrophosphate synthasetarget
Incadronic acidCaspase-3target
Incadronic acidCaspase-4target
Incadronic acidCaspase-7target
Minodronic acidFarnesyl pyrophosphate synthasetarget
Minodronic acidGeranylgeranyl pyrophosphate synthasetarget
TenofovirP-glycoprotein 1transporter
TenofovirSolute carrier family 22 member 6transporter
TenofovirSolute carrier family 22 member 8transporter
TenofovirMultidrug resistance-associated protein 4transporter
TenofovirCytochrome P450 3A4enzyme
TenofovirNucleoside diphosphate kinase Aenzyme
TenofovirNucleoside diphosphate kinase Benzyme
TenofovirAdenylate kinase isoenzyme 1enzyme
TenofovirAdenylate kinase 2, mitochondrialenzyme
TenofovirReverse transcriptase/RNaseHtarget
TenofovirReverse transcriptasetarget
TenofovirDNA polymerasetarget
TenofovirSerum albumincarrier
CidofovirDNA polymerase catalytic subunittarget
CidofovirSolute carrier family 22 member 6transporter
CidofovirThymidine phosphorylaseenzyme
Technetium Tc-99m oxidronateSerum albumincarrier