Norsteroids

Steroids which have undergone contraction in ring size or reduction in side chains.
DrugDrug NameDrug Indication
DB00294EtonogestrelEtonogestrel is administered in subdermal implants as long-acting reversible contraception. It is known to be effective in postpartum insertion including breastfeeding women.[A175990] Etonogestrel is part of the long-acting contraceptive implants that prevent pregnancy. The implant's effect can remain for 5 years.[L5698]
DB00304DesogestrelOral desogestrel is used in combination with [ethinylestradiol] as a contraceptive agent for the prevention of pregnancy.[FDA label] Desogestrel is part of the combined oral contraceptives that contain a mix of estrogen and progestin which inhibit ovulation.[L5698]
DB00367LevonorgestrelFor the treatment of menopausal and postmenopausal disorders and alone or in combination with other hormones as an oral contraceptive.
DB00717NorethisteroneFor the treatment of secondary amenorrhea, endometriosis, and abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as submucous fibroids or uterine cancer.
DB00823Ethynodiol diacetateFor the prevention of pregnancy in women who elect to use this product as a method of contraception.
DB00957NorgestimateFor the prevention of pregnancy
DB00977EthinylestradiolFor treatment of moderate to severe vasomotor symptoms associated with the menopause, female hypogonadism, prostatic carcinoma-palliative therapy of advanced disease, breast cancer, as an oral contraceptive, and as emergency contraceptive.
DB01357MestranolMestranol was used as one of the first oral contraceptives.
DB01493EthylestrenolNot Available
DB04575QuinestrolUsed in hormone replacement therapy, treating symptoms of menopause such as hot flashes. Also used to treat breast and prostate cancer.
DB05253Telapristone acetateFor the treatment of uterine fibroids and endometriosis.
DB06713NorelgestrominNorelgestromin is used for contraception and menopausal hormonal therapy. Norelgestromin may potentially be used in breast cancer treatment due to its inhibitory effect on estrone sulfatase . They convert sulfated steroid precursors to estrogen during pregnancy.
DB06730GestodeneNot Available
DB08867UlipristalAs the product Ella (available in Canada and the US), ulipristal is indicated for use as emergency contraception after unprotected intercourse or possible contraceptive failure when administered within 120 hours (5 days) after unprotected intercourse or a known or suspected contraceptive failure. As the product Fibristal (available in Canada), ulipristal is indicated for treatment of the signs and symptoms of uterine fibroids in adult women.
DB09070TiboloneFor the relief of post-menopausal symptoms and for the prevention of osteoporosis [L1724].
DB09371NorethynodrelNot Available
DB09389NorgestrelNorgestrel in combination with ethinyl estradiol is indicated for the prevention of pregnancy in women who elect to use this product as a method of contraception.
DB11619GestrinoneEndometriosis with or without accompanying sterility. Treatment is limited to a single course of 6 months duration per lifetime [L1699, L1700].
DB12474LynestrenolNot Available
DB12787NorethandroloneNot Available
DB13129TrimegestoneNot Available
DB13418MoxestrolNot Available
DB13563NorgestrienoneNot Available
DB13602PromegestoneNot Available
DB13685QuingestanolNot Available
DB13857DemegestoneNot Available
DB13866EtynodiolNot Available
DB13981Nomegestrol acetateNot Available
DB14583Segesterone acetateSegesterone acetate in combination with ethinyl estradiol is indicated for use by females of reproductive potential to prevent pregnancy as a combination hormonal contraceptive (CHC). It induces contraception for thirteen 28-day cycles (1 year) following vaginal administration. The vaginal system must remain in place continuously for 3 weeks (21 days) followed by a 1-week (7-day) vaginal system-free interval. The use in females with a body mass index of >29 kg/m^2 has not been adequately evaluated [FDA Label].
DB14677Gestonorone caproateNot Available
DB14678Norethindrone enanthateNot Available
DB14679Quingestanol acetateNot Available
DrugDrug NameTargetType
DB00294EtonogestrelEstrogen receptor alphatarget
DB00294EtonogestrelProgesterone receptortarget
DB00294EtonogestrelCytochrome P450 3A4enzyme
DB00294EtonogestrelSerum albumincarrier
DB00294EtonogestrelSex hormone-binding globulincarrier
DB00304DesogestrelProgesterone receptortarget
DB00304DesogestrelEstrogen receptor alphatarget
DB00304DesogestrelCytochrome P450 3A4enzyme
DB00304DesogestrelSerum albumincarrier
DB00304DesogestrelSex hormone-binding globulincarrier
DB00304DesogestrelCytochrome P450 2C9enzyme
DB00304DesogestrelUDP-glucuronosyltransferase 1-1enzyme
DB00367LevonorgestrelProgesterone receptortarget
DB00367LevonorgestrelEstrogen receptor alphatarget
DB00367Levonorgestrel3-oxo-5-alpha-steroid 4-dehydrogenase 1target
DB00367LevonorgestrelCytochrome P450 3A4enzyme
DB00367LevonorgestrelCytochrome P450 19A1enzyme
DB00367LevonorgestrelAndrogen receptortarget
DB00367LevonorgestrelSex hormone-binding globulintarget
DB00717NorethisteroneProgesterone receptortarget
DB00717NorethisteroneCytochrome P450 3A4enzyme
DB00717NorethisteroneMultidrug resistance protein 1transporter
DB00717NorethisteroneCytochrome P450 2C19enzyme
DB00717NorethisteroneCytochrome P450 3A5enzyme
DB00717NorethisteroneCytochrome P450 3A7enzyme
DB00717NorethisteroneSerum albumincarrier
DB00717NorethisteroneSex hormone-binding globulincarrier
DB00823Ethynodiol diacetateEstrogen receptor alphatarget
DB00823Ethynodiol diacetateProgesterone receptortarget
DB00823Ethynodiol diacetateCytochrome P450 3A4enzyme
DB00957NorgestimateProgesterone receptortarget
DB00957NorgestimateEstrogen receptor alphatarget
DB00957NorgestimateCanalicular multispecific organic anion transporter 1transporter
DB00957NorgestimateCytochrome P450 3A4enzyme
DB00957NorgestimateAndrogen receptortarget
DB00977EthinylestradiolEstrogen receptor alphatarget
DB00977EthinylestradiolNuclear receptor subfamily 1 group I member 2target
DB00977EthinylestradiolCytochrome P450 3A4enzyme
DB00977EthinylestradiolCytochrome P450 2C8enzyme
DB00977EthinylestradiolBile salt export pumptransporter
DB00977EthinylestradiolSodium/bile acid cotransportertransporter
DB00977EthinylestradiolCanalicular multispecific organic anion transporter 1transporter
DB00977EthinylestradiolMultidrug resistance protein 1transporter
DB00977EthinylestradiolSex hormone-binding globulintarget
DB00977EthinylestradiolUDP-glucuronosyltransferase 1-1enzyme
DB01357MestranolEstrogen receptor alphatarget
DB01357MestranolCytochrome P450 2C9enzyme
DB01357MestranolCytochrome P450 3A4enzyme
DB01357MestranolCytochrome P450 2C8enzyme
DB04575QuinestrolEstrogen receptor alphatarget
DB05253Telapristone acetateProgesterone receptortarget
DB06713NorelgestrominSteryl-sulfataseenzyme
DB06713NorelgestrominProgesterone receptortarget
DB06713NorelgestrominSerum albumintarget
DB06713NorelgestrominAndrogen receptortarget
DB06713NorelgestrominCytochrome P450 3A4enzyme
DB06730GestodeneCytochrome P450 3A5enzyme
DB06730GestodeneCytochrome P450 3A7enzyme
DB06730GestodeneProgesterone receptortarget
DB06730GestodeneCytochrome P450 3A4enzyme
DB08867UlipristalProgesterone receptortarget
DB08867UlipristalGlucocorticoid receptortarget
DB08867UlipristalAndrogen receptortarget
DB08867UlipristalCytochrome P450 3A4enzyme
DB08867UlipristalCytochrome P450 1A2enzyme
DB08867UlipristalSerum albumincarrier
DB08867UlipristalAlpha-1-acid glycoprotein 1carrier
DB09070TiboloneEstrogen receptor alphatarget
DB09070TiboloneSteryl-sulfataseenzyme
DB09070Tibolone3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1enzyme
DB09070Tibolone3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
DB09070TiboloneSulfotransferase 1A1enzyme
DB09371NorethynodrelEstrogen receptor alphatarget
DB09371NorethynodrelAndrogen receptortarget
DB09371NorethynodrelSex hormone-binding globulintarget
DB09371NorethynodrelCytochrome P450 3A4enzyme
DB09389NorgestrelProgesterone receptortarget
DB09389Norgestrel3-oxo-5-alpha-steroid 4-dehydrogenase 1target
DB09389NorgestrelAndrogen receptortarget
DB09389NorgestrelCytochrome P450 3A4enzyme
DB09389NorgestrelCytochrome P450 19A1enzyme
DB11619GestrinoneSex hormone-binding globulintarget
DB11619GestrinoneProgesterone receptortarget
DB11619GestrinoneGlucocorticoid receptortarget
DB11619GestrinoneAndrogen receptortarget
DB11619GestrinoneGonadotropin-releasing hormone receptortarget
DB11619GestrinoneEstrogen receptor alphatarget
DB11619GestrinoneCytochrome P450 3A4enzyme
DB12474LynestrenolCytochrome P450 3A4enzyme
DB12474LynestrenolCytochrome P450 2C9enzyme
DB12474LynestrenolCytochrome P450 2C19enzyme
DB13602PromegestoneCytochrome P450 3A4enzyme
DB13685QuingestanolCytochrome P450 3A4enzyme
DB13857DemegestoneProgesterone receptortarget
DB13857DemegestoneCytochrome P450 3A4enzyme
DB13866EtynodiolCytochrome P450 3A4enzyme
DB13981Nomegestrol acetateCytochrome P450 3A4enzyme
DB14583Segesterone acetateGlucocorticoid receptortarget
DB14583Segesterone acetateProgesterone receptortarget
DB14583Segesterone acetateAndrogen receptortarget
DB14583Segesterone acetateCytochrome P450 3A4enzyme