Name
Azirines
Accession Number
DBCAT000711
Description

Unsaturated azacyclopropane compounds that are three-membered heterocycles of a nitrogen and two carbon atoms.

Drugs
DrugDrug Description
MitomycinAn antimetabolite used as an adjunct to ab externo (outside approach) eye surgeries for the treatment of glaucoma and used as a chemotherapeutic agent for various malignancies.
TretazicarTretazicar is under investigation in clinical trial NCT00746590 (Study of Anti-tumour Effects and Safety of Prolarix™ in Hepatocellular Carcinoma).
ThiotepaAn alkylating agent used to prevent graft rejection in stem cell transplantation and to treat a variety of malignancies including certain types of adenocarcinoma and superficial bladder carcinomas.
PorfiromycinInvestigated for use/treatment in head and neck cancer.
ApaziquoneApaziquone has been investigated for the treatment of Bladder Cancer and Bladder Neoplasms.
TriaziquoneNot Annotated
CarboquoneNot Annotated
TretamineToxic alkylating agent used in industry; also as antineoplastic and research tool to produce chromosome aberrations and cancers.
DiaziquoneNot Annotated
Drugs & Drug Targets
DrugTargetType
MitomycinDNAtarget
MitomycinNADPH--cytochrome P450 reductaseenzyme
TretazicarOxygen-insensitive NAD(P)H nitroreductasetarget
TretazicarRibosyldihydronicotinamide dehydrogenase [quinone]target
ThiotepaCytochrome P450 2B6enzyme
ThiotepaCytochrome P450 3A4enzyme
ThiotepaDNAtarget
ThiotepaCholinesteraseenzyme
PorfiromycinXanthine dehydrogenase/oxidaseenzyme
TretamineCholinesteraseenzyme