Antimitotic Agents

Name
Antimitotic Agents
Accession Number
DBCAT000715
Description

Agents that arrest cells in MITOSIS, most notably TUBULIN MODULATORS.

Drugs
DrugDrug Description
VindesineA vinca alkaloid derived from vinblastine used for various types of malignancies, but mainly acute lymphocytic leukemia (ALL).
VincristineA vinca alkaloid used to treat acute leukemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis.
VinblastineA vinca alkaloid used to treat breast cancer, testicular cancer, neuroblastoma, Hodgkin's and non-Hodgkins lymphoma, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.
PodofiloxA topical agent used for the treatment of external genital warts and perianal warts.
PaclitaxelA taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer.
DocetaxelA taxoid antineoplastic agent used in the treatment of various cancers, such as locally advanced or metastatic breast cancer, metastatic prostate cancer, gastric adenocarcinoma, and head and neck cancer.
ColchicineAn alkaloid used to treat gout and Familial Mediterranean Fever as well as prevent major cardiovascular events.
Trastuzumab emtansineAn antineoplastic agent and antibody-drug conjugate used to treat HER2-overexpressing breast cancer.
VinorelbineA vinca alkaloid used in the treatment of metastatic non-small cell lung carcinoma (NSLC) and in conjunction with other drugs in locally advanced NSCLC.
MonastrolNot Available
FilanesibInvestigated for use/treatment in cancer/tumors (unspecified).
BI 2536BI 2536 is under investigation in clinical trial NCT00376623 (Efficacy and Safety of BI 2536 in Advanced or Metastatic Non Small Cell Lung Cancer).
AlbendazoleA benzimidazole anthelmintic used to treat parenchymal neurocysticercosis and other helminth infections.
MebendazoleA benzimidazole anthelmintic used to treat helminth infections.
Epothilone DInvestigated for use/treatment in colorectal cancer, lung cancer, breast cancer, solid tumors, and prostate cancer.
2-MethoxyestradiolFor the treatment of breast cancer and inflammatory diseases such as rheumatoid arthritis.
PatupiloneInvestigated for use/treatment in ovarian cancer, lung cancer, brain cancer, breast cancer, and gastric cancer.
NocodazoleNocodazole is an antineoplastic agent which exerts its effect by depolymerizing microtubules.
CombretastatinCombretastatin has been investigated for the treatment of Anaplastic Thyroid Cancer.
Dolastatin 10Dolastatin 10 has been used in trials studying the treatment of Sarcoma, Leukemia, Lymphoma, Liver Cancer, and Kidney Cancer, among others.
DemecolcineNot Annotated
KX-2361Not Annotated
Lorvotuzumab mertansineLorvotuzumab mertansine has been used in trials studying the treatment of SCLC, Leukemia, Ovarian Cancer, Multiple Myeloma, and Merkel Cell Carcinoma, among others.
Drugs & Drug Targets
DrugTargetType
VindesineTubulin beta-1 chaintarget
VindesineCytochrome P450 3A4enzyme
VincristineTubulin beta chaintarget
VincristineCytochrome P450 3A4enzyme
VincristineCytochrome P450 3A5enzyme
VincristineCytochrome P450 3A7enzyme
VincristineP-glycoprotein 1transporter
VincristineCanalicular multispecific organic anion transporter 2transporter
VincristineSolute carrier family 22 member 3transporter
VincristineMultidrug resistance-associated protein 1transporter
VincristineMultidrug resistance-associated protein 7transporter
VincristineCanalicular multispecific organic anion transporter 1transporter
VincristineBile salt export pumptransporter
VincristineATP-binding cassette sub-family G member 2transporter
VincristineTubulin alpha-4A chaintarget
VincristineRalA-binding protein 1transporter
VincristineSolute carrier organic anion transporter family member 1B1transporter
VincristineSolute carrier organic anion transporter family member 1B3transporter
VinblastineTubulin beta chaintarget
VinblastineTranscription factor AP-1target
VinblastineCytochrome P450 3A4enzyme
VinblastineP-glycoprotein 1transporter
VinblastineMultidrug resistance-associated protein 1transporter
VinblastineCanalicular multispecific organic anion transporter 1transporter
VinblastineMultidrug resistance-associated protein 6transporter
VinblastineBile salt export pumptransporter
VinblastineTubulin alpha-1A chaintarget
VinblastineTubulin delta chaintarget
VinblastineTubulin epsilon chaintarget
VinblastineTubulin gamma-1 chaintarget
VinblastineCytochrome P450 2D6enzyme
VinblastineSolute carrier organic anion transporter family member 1B1transporter
PodofiloxDNA topoisomerase 2-alphatarget
PodofiloxTubulin alpha-4A chaintarget
PodofiloxTubulin beta chaintarget
PaclitaxelApoptosis regulator Bcl-2target
PaclitaxelTubulin beta-1 chaintarget
PaclitaxelCytochrome P450 2C8enzyme
PaclitaxelCytochrome P450 3A4enzyme
PaclitaxelCytochrome P450 3A5enzyme
PaclitaxelCytochrome P450 3A7enzyme
PaclitaxelBile salt export pumptransporter
PaclitaxelP-glycoprotein 1transporter
PaclitaxelMultidrug resistance-associated protein 1transporter
PaclitaxelMultidrug resistance-associated protein 7transporter
PaclitaxelCytochrome P450 19A1enzyme
PaclitaxelCytochrome P450 1B1enzyme
PaclitaxelSolute carrier organic anion transporter family member 1B3transporter
PaclitaxelNuclear receptor subfamily 1 group I member 2target
PaclitaxelMicrotubule-associated protein 4target
PaclitaxelMicrotubule-associated protein 2target
PaclitaxelMicrotubule-associated protein tautarget
PaclitaxelCanalicular multispecific organic anion transporter 1transporter
DocetaxelApoptosis regulator Bcl-2target
DocetaxelTubulin beta-1 chaintarget
DocetaxelCytochrome P450 3A4enzyme
DocetaxelCytochrome P450 3A5enzyme
DocetaxelCytochrome P450 3A7enzyme
DocetaxelP-glycoprotein 1transporter
DocetaxelMultidrug resistance-associated protein 7transporter
DocetaxelCytochrome P450 1B1enzyme
DocetaxelMicrotubule-associated protein 2target
DocetaxelMicrotubule-associated protein 4target
DocetaxelMicrotubule-associated protein tautarget
DocetaxelSolute carrier organic anion transporter family member 1B3transporter
DocetaxelSolute carrier family 22 member 7transporter
DocetaxelATP-binding cassette sub-family G member 2transporter
DocetaxelCanalicular multispecific organic anion transporter 1transporter
DocetaxelMultidrug resistance-associated protein 1transporter
DocetaxelNuclear receptor subfamily 1 group I member 2target
ColchicineTubulin beta chaintarget
ColchicineCytochrome P450 3A4enzyme
ColchicineP-glycoprotein 1transporter
ColchicineCytochrome P450 2B6enzyme
ColchicineCytochrome P450 2C8enzyme
ColchicineCytochrome P450 2E1enzyme
ColchicineSerum albumincarrier
Trastuzumab emtansineReceptor tyrosine-protein kinase erbB-2target
Trastuzumab emtansineP-glycoprotein 1transporter
Trastuzumab emtansineCytochrome P450 3A4enzyme
Trastuzumab emtansineCytochrome P450 3A5enzyme
VinorelbineTubulin beta chaintarget
VinorelbineCytochrome P450 3A4enzyme
VinorelbineCytochrome P450 2D6enzyme
MonastrolKinesin-like protein KIF11target
FilanesibKinesin-like protein KIF11target
AlbendazoleTubulin alpha-1A chaintarget
AlbendazoleTubulin beta-4B chaintarget
AlbendazoleCytochrome P450 3A4enzyme
AlbendazoleFumarate reductase flavoprotein subunittarget
AlbendazoleCytochrome P450 1A1enzyme
AlbendazoleCytochrome P450 1A2enzyme
AlbendazoleTubulin beta-2 chaintarget
AlbendazoleCytochrome P450 2C19enzyme
AlbendazoleP-glycoprotein 1transporter
MebendazoleTubulin alpha-1A chaintarget
MebendazoleTubulin beta-4B chaintarget
MebendazoleCytochrome P450 1A1enzyme
MebendazoleCytochrome P450 3A Subfamilyenzyme
Epothilone DTubulin alpha 3C/D chaintarget
Epothilone DTubulin beta chaintarget
Epothilone DTubulin beta-1 chaintarget
Epothilone DTubulin beta-4B chaintarget
Epothilone DTubulin beta-4A chaintarget
Epothilone DTubulin alpha-4A chaintarget
Epothilone DTubulin beta-3 chaintarget
Epothilone DTubulin alpha-1C chaintarget
Epothilone DTubulin alpha-8 chaintarget
Epothilone DTubulin alpha-1B chaintarget
Epothilone DTubulin alpha-1A chaintarget
Epothilone DCytochrome P450 3A4enzyme
2-MethoxyestradiolHypoxia-inducible factor 1-alphatarget
2-MethoxyestradiolSex hormone-binding globulincarrier
2-MethoxyestradiolCatechol O-methyltransferasetarget
2-MethoxyestradiolCytochrome P450 1A1target
2-MethoxyestradiolCytochrome P450 1B1target
2-MethoxyestradiolCytochrome P450 19A1target
PatupiloneTubulin alpha 3C/D chaintarget
PatupiloneTubulin beta chaintarget
PatupiloneTubulin beta-1 chaintarget
PatupiloneTubulin beta-4B chaintarget
PatupiloneTubulin beta-4A chaintarget
PatupiloneTubulin alpha-4A chaintarget
PatupiloneTubulin beta-3 chaintarget
PatupiloneTubulin alpha-1C chaintarget
PatupiloneTubulin alpha-8 chaintarget
PatupiloneTubulin alpha-1B chaintarget
PatupiloneTubulin alpha-1A chaintarget
PatupiloneCytochrome P450 3A4enzyme
NocodazoleHematopoietic prostaglandin D synthasetarget
Lorvotuzumab mertansineCytochrome P450 3A4enzyme