Quinolines

DrugDrug NameDrug Indication
DB00218MoxifloxacinFor the treatment of sinus and lung infections such as sinusitis, pneumonia, and secondary infections in chronic bronchitis. Also for the treatment of bacterial conjunctivitis (pinkeye).
DB00358MefloquineFor the treatment of mild to moderate acute malaria caused by Mefloquineuine-susceptible strains of Plasmodium falciparum (both chloroquine-susceptible and resistant strains) or by Plasmodium vivax. Also for the prophylaxis of Plasmodium falciparum and Plasmodium vivax malaria infections, including prophylaxis of chloroquine-resistant strains of Plasmodium falciparum.
DB00365GrepafloxacinFor treatment of adults with mild to moderate infections caused by susceptible strains of Haemophilus influenzae, Streptococcus pneumoniae, or Moraxella catarrhalis.
DB00467EnoxacinFor the treatment of adults (≥18 years of age) with the following infections caused by susceptible strains of the designated microorganisms: (1) uncomplicated urethral or cervical gonorrhea due to Neisseria gonorrhoeae, (2) uncomplicated urinary tract infections (cystitis) due to Escherichia coli, Staphylococcus epidermidis, or Staphylococcus saprophyticus, and (3) complicated urinary tract infections due to Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus epidermidis, or Enterobacter cloacae.
DB00468QuinineFor the treatment of malaria and leg cramps
DB00487PefloxacinFor the treatment of uncomplicated gonococcal urethritis in males and for gram-negative-bacterial infections in the gastrointestinal system and the genitourinary tract.
DB00521CarteololFor the treatment of intraocular hypertension and chronic open-angle glaucoma
DB00527CinchocaineFor production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks.
DB00537CiprofloxacinFor the treatment of the following infections caused by susceptible organisms: urinary tract infections, acute uncomplicated cystitis, chronic bacterial prostatitis, lower respiratory tract infections, acute sinusitis, skin and skin structure infections, bone and joint infections, complicated intra-abdominal infections (used in combination with metronidazole), infectious diarrhea, typhoid fever (enteric fever), uncomplicated cervical and urethral gonorrhea, and inhalational anthrax (post-exposure).
DB00608ChloroquineFor the suppressive treatment and for acute attacks of malaria due to P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum, Second-line agent in treatment of Rheumatoid Arthritis
DB00613AmodiaquineFor treatment of acute malarial attacks in non-immune subjects.
DB00685TrovafloxacinFor treatment of infections caused by susceptible strains of the designated microorganisms in uncomplicated urethral gonorrhea in males and endocervical and rectal gonorrhea in females caused by Neisseria gonorrhoeae as well as non gonoccocal urethritis and cervicitis due to Chlamydia trachomatis.
DB00716NedocromilFor the treatment of mild to moderate asthma
DB00724ImiquimodFor the topical treatment of clinically typical, nonhyperkeratotic, nonhypertrophic actinic keratoses on the face or scalp in immunocompetent adults. Also indicated for the treatment of external genital and perianal warts/condyloma acuminata in individuals 12 years old and above.
DB00779Nalidixic AcidFor the treatment of urinary tract infections caused by susceptible gram-negative microorganisms, including the majority of E. Coli, Enterobacter species, Klebsiella species, and Proteus species.
DB00817RosoxacinFor the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients.
DB00908QuinidineFor the treatment of ventricular pre-excitation and cardiac dysrhythmias
DB00978LomefloxacinFor the treatment of bacterial infections of the respiratory tract (chronic bronchitis) and urinary tract, and as a pre-operative prophylactic to prevent urinary tract infection caused by: S.pneumoniae, H.influenzae, S.aureus, P.aeruginosa, E. cloacae, P. mirabilis, C. civersus, S. asprphyticus, E.coli, and K.pneumoniae.
DB01044GatifloxacinFor the treatment of bronchitis, sinusitis, community-acquired pneumonia, and skin infections (abscesses, wounds) caused by S. pneumoniae, H. influenzae, S. aureus, M. pneumoniae, C. pneumoniae, L. pneumophila, S. pyogenes
DB01059NorfloxacinFor the treatment of urinary tract infection
DB01087PrimaquineFor the treatment of malaria.
DB01096OxamniquineFor treatment of Schistosomiasis caused by Schistosoma mansoni
DB01137LevofloxacinFor the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms: Corynebacterium species, Staphylococus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus (Groups C/F/G), Viridans group streptococci, Acinetobacter lwoffii, Haemophilus influenzae, Serratia marcescens.
DB01155GemifloxacinFor the treatment of bacterial infection caused by susceptible strains such as S. pneumoniae, H. influenzae, H. parainfluenzae, or M. catarrhalis, S. pneumoniae (including multi-drug resistant strains [MDRSP]), M. pneumoniae, C. pneumoniae, or K. pneumoniae.
DB01165OfloxacinFor the treatment of infections (respiratory tract, kidney, skin, soft tissue, UTI), urethral and cervical gonorrhoea.
DB01208SparfloxacinFor the treatment of adults with the following infections caused by susceptible strains microorganisms: community-acquired pneumonia (caused by Chlamydia pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, Mycoplasma pneumoniae, or Streptococcus pneumoniae) and acute bacterial exacerbations of chronic bronchitis (caused by Chlamydia pneumoniae, Enterobacter cloacae, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Staphylococcus aureus, or Streptococcus pneumoniae).
DB01232SaquinavirFor the treatment of HIV-1 with advanced immunodeficiency together with antiretroviral nucleoside analogues.
DB01238AripiprazoleFor the treatment of schizophrenia and related psychotic disorders.
DB01243ChloroxineUsed in the treatment of dandruff and mild to moderately severe seborrheic dermatitis of the scalp.
DB01366ProcaterolFor the treatment of asthma and chronic obstructive pulmonary disease (COPD).
DB01405TemafloxacinFor the treatment of lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections.
DB01422NitroxolineNitroxoline is an antibiotic agent.
DB01611HydroxychloroquineFor the suppressive treatment and treatment of acute attacks of malaria due to Plasmodium vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum. It is also indicated for the treatment of discoid and systemic lupus erythematosus, and rheumatoid arthritis.
DB03205Pyrroloquinoline QuinoneNot Available
DB04209DequaliniumEffective local treatment as vaginal tablets for infections such as fluor vaginalis, bacterial vaginosis, aerobic vaginitis, vulvo-vaginal candidiasis and trichomoniasis. Used as a topical antimicrobial agent.
DB04576FleroxacinFleroxacin is a broad-spectrum antimicrobial fluoroquinolone.
DB04815ClioquinolUsed as a topical antifungal treatment.
DB04909SitamaquineInvestigated for use/treatment in infectious and parasitic disease (unspecified).
DB04960TipifarnibInvestigated for use/treatment in colorectal cancer, leukemia (myeloid), pancreatic cancer, and solid tumors.
DB05039IndacaterolFor the long term, once-daily-dosing maintenance of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema.
DB05119RilapladibInvestigated for use/treatment in atherosclerosis and cardiovascular disorders.
DB05234LGD2941For the treatment and prevention of osteoporosis.
DB05422OPC-14523Investigated for use/treatment in bulimia, depression, and obsessive-compulsive disorders.
DB05488Technetium Tc-99m ciprofloxacinInvestigated for use/treatment in infectious and parasitic disease (unspecified).
DB05524PelitinibInvestigated for use/treatment in colorectal cancer and lung cancer.
DB05928DovitinibInvestigated for use/treatment in multiple myeloma and solid tumors.
DB06160GarenoxacinInvestigated for use/treatment in bacterial infection.
DB06600NemonoxacinInvestigated for use/treatment in bacterial infection and pneumonia.
DB06608TafenoquineTafenoquine is used for the treatment and prevention of relapse of Vivax malaria in patients 16 years and older. Tafenoquine is not indicated to treat acute vivax malaria.[A35671] Malaria is a disease that remains to occur in many tropical countries. Vivax malaria, caused by _Plasmodium vivax_, is known to be less virulent and seldom causes death. However, it causes a substantive illness-related burden in endemic areas and it is known to present dormant forms in the hepatocytes named hypnozoites which can remain dormant for weeks or even months. This dormant form produces ongoing relapses.[A35671]
DB06638QuarfloxinInvestigated for use/treatment in leukemia (lymphoid).
DB06685LaquinimodInvestigated for use/treatment in multiple sclerosis.
DB06771BesifloxacinTreatment of bacterial conjunctivitis. Bacterial isolates that are susceptible to besifloxacin include: CDC coryneform group G; Corynebacterium pseudodiphtheriticum; Corynebacterium striatum; Haemophilus influenzae; Moraxella lacunata; Staphylococcus aureus; Staphylococcus epidermidis; Staphylococcus hominis; Staphylococcus lugdunensis; Streptococcus mitis group; Streptococcus oralis; Streptococcus pneumoniae; Streptococcus salivarius*
DB06816PyrviniumPyrvinium was once used in the treatment of pinworm infestations [T39].
DB08089LGD-2226Not Available
DB08820IvacaftorWhen used as monotherapy as the product Kalydeco, ivacaftor is indicated for the managmenet of CF in patients age 2 years and older who have a mutation in the CFTR gene that is responsive to ivacaftor potentiation. Ivacaftor received expanded approval in May 2017 for the following 33 CFTR mutations: E56K, P67L, R74W, D110E, D110H, R117C, R117H, G178R, E193K, L206W, R347H, R352Q, A455E, S549N, S549R, G551D, G551S, D579G, S945L, S977F, F1052V, K1060T, A1067T, G1069R, R1070Q, R1070W, F1074L, D1152H, G1244E, S1251N, S1255P, D1270N, and G1349D [L768, FDA Label]. When used in combination with the drug [DB09280] as the product Orkambi, ivacaftor is indicated for the management of CF patients age 6 years and older who are homozygous for the F508del mutation in the CFTR gene.
DB08903BedaquilineBedaquiline is indicated as part of combination therapy in adults (≥ 18 years) with pulmonary multi-drug resistant tuberculosis (MDR-TB).
DB08972FlumequineNot Available
DB09047FinafloxacinFinafloxacin is indicated for the treatment of acute otitis externa (AOE) with or without an otowick, caused by susceptible strains of Pseudomonas aeruginosa and Staphylococcus aureus in patients age 1 year and older.
DB09097QuinagolideIndicated for the treatment of hyperprolactinemia (idiopathic or originating from a prolactin-secreting pituitary microadenoma or macroadenoma).
DB09101ElvitegravirElvitegravir in combination with an HIV protease inhibitor coadministered with ritonavir and with other antiretroviral drug(s) is indicated for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults.
DB09115DiiodohydroxyquinolineUsed in the treatment of amoebiasis.
DB09128BrexpiprazoleAs an adjunctive treatment of major depressive disorder (MDD) and for treatment of schizophrenia.
DB09335AlatrofloxacinNot Available
DB11145OxyquinolineOxyquinoline is used as a biocidal component of several over the counter products. These products are marketed for the purposes of inhibiting abnormal biological growth in the vagina and restoring natural pH.
DB11366RoquinimexInvestigated as a treatment for some cancers (including as adjuvant therapy after bone marrow transplantation in acute leukemia) and autoimmune diseases, such as multiple sclerosis and recent-onset type I diabetes.
DB11491SarafloxacinNot Available
DB11656RebamipideNot Available
DB11692PavinetantNot Available
DB11774PazufloxacinNot Available
DB11892PrulifloxacinNot Available
DB11937Kynurenic AcidNot Available
DB11943DelafloxacinDelafloxacin is indicated for the treatment of acute bacterial skin and skin structure infections caused by the Gram-positive organisms Staphylococcus aureus (including methicillin-resistant and methicillin-susceptible isolates), Staphylococcus haemolyticus, Staphylococcus lugdunensis, Streptococcus agalactiae, Streptococcus anginosus Group (including Streptococcus anginosus, Streptococcus intermedius, and Streptococcus constellatus), Streptococcus pyogenes, and Enterococcus faecalis as well as the Gram-negative organisms Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae, and Pseudomonas aeruginosa [FDA Label].
DB12051SetrobuvirNot Available
DB12100AbediterolNot Available
DB12137GSK-256066Not Available
DB12211PSI-697Not Available
DB12447NadifloxacinNot Available
DB12479ZabofloxacinNot Available
DB12640CP-609754Not Available
DB12924OzenoxacinOzenoxacin cream is indicated for the topical treatment of impetigo caused by *Staphylococcus aureus* or *Streptococcus pyogenes* in patients aged 2 months of age and older [FDA Label].
DB13261SitafloxacinNot Available
DB13627Oxolinic acidNot Available
DB13772RufloxacinNot Available
DB13937LGD-3303Not Available
DB14025ClinafloxacinNot Available
DB14185Aripiprazole lauroxilAripiprazole lauroxil is indicated for the treatment of schizophrenia and related psychotic disorders.
DrugDrug NameTargetType
DB00218MoxifloxacinCytochrome P450 1A2enzyme
DB00218MoxifloxacinDNA gyrase subunit Atarget
DB00218MoxifloxacinDNA topoisomerase 4 subunit Atarget
DB00218MoxifloxacinDNA topoisomerase 2-alphatarget
DB00358MefloquineCholinesteraseenzyme
DB00358MefloquineCytochrome P450 3A4enzyme
DB00358MefloquineCytochrome P450 19A1enzyme
DB00358MefloquineCytochrome P450 2D6enzyme
DB00358MefloquineAcetylcholinesteraseenzyme
DB00358MefloquineHemoglobin subunit alphatarget
DB00358MefloquineAdenosine receptor A2atarget
DB00358MefloquineFe(II)-protoporphyrin IXtarget
DB00358MefloquineMultidrug resistance protein 1transporter
DB00365GrepafloxacinCytochrome P450 3A4enzyme
DB00365GrepafloxacinCytochrome P450 1A2enzyme
DB00365GrepafloxacinDNA gyrase subunit Atarget
DB00365GrepafloxacinDNA topoisomerase 4 subunit Atarget
DB00365GrepafloxacinSolute carrier family 22 member 2transporter
DB00365GrepafloxacinSolute carrier family 22 member 5transporter
DB00365GrepafloxacinCanalicular multispecific organic anion transporter 1transporter
DB00365GrepafloxacinMultidrug resistance protein 1transporter
DB00365GrepafloxacinMultidrug resistance-associated protein 1transporter
DB00365GrepafloxacinSolute carrier family 22 member 6transporter
DB00467EnoxacinCytochrome P450 1A2enzyme
DB00467EnoxacinDNA gyrase subunit Atarget
DB00467EnoxacinDNA topoisomerase 4 subunit Atarget
DB00467EnoxacinDNA topoisomerase 2-alphatarget
DB00468QuinineCytochrome P450 3A4enzyme
DB00468QuinineCytochrome P450 3A5enzyme
DB00468QuinineCytochrome P450 1A1enzyme
DB00468QuinineCytochrome P450 2D6enzyme
DB00468QuinineCytochrome P450 1A2enzyme
DB00468QuinineCytochrome P450 2C8enzyme
DB00468QuinineCytochrome P450 2C9enzyme
DB00468QuinineCytochrome P450 2C19enzyme
DB00468QuinineCytochrome P450 2E1enzyme
DB00468QuinineCytochrome P450 3A7enzyme
DB00468QuininePlatelet glycoprotein IXtarget
DB00468QuinineIntermediate conductance calcium-activated potassium channel protein 4target
DB00468QuinineFe(II)-protoporphyrin IXtarget
DB00468QuinineSolute carrier family 22 member 2transporter
DB00468QuinineSolute carrier family 22 member 1transporter
DB00468QuinineSolute carrier family 22 member 5transporter
DB00468QuinineMultidrug resistance protein 1transporter
DB00468QuinineSolute carrier organic anion transporter family member 1A2transporter
DB00468QuinineSolute carrier family 22 member 4transporter
DB00468QuinineSolute carrier organic anion transporter family member 1B1transporter
DB00487PefloxacinCytochrome P450 1A2enzyme
DB00487PefloxacinDNA gyrase subunit Atarget
DB00487PefloxacinDNA topoisomerase 4 subunit Atarget
DB00487PefloxacinDNA topoisomerase 2-alphatarget
DB00487PefloxacinDNA topoisomerase 1target
DB00521CarteololCytochrome P450 2D6enzyme
DB00521CarteololBeta-2 adrenergic receptortarget
DB00521CarteololBeta-1 adrenergic receptortarget
DB00527CinchocaineCholinesteraseenzyme
DB00527CinchocaineSodium channel protein type 5 subunit alphatarget
DB00527CinchocaineSodium channel protein type 10 subunit alphatarget
DB00527CinchocaineCalmodulintarget
DB00537CiprofloxacinCytochrome P450 1A2enzyme
DB00537CiprofloxacinCytochrome P450 3A4enzyme
DB00537CiprofloxacinCytochrome P450 3A5enzyme
DB00537CiprofloxacinCytochrome P450 3A7enzyme
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 4 subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 2-alphatarget
DB00537CiprofloxacinPotassium voltage-gated channel subfamily H member 2target
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 4 subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 4 subunit Btarget
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinMultidrug resistance protein MdtKtarget
DB00537CiprofloxacinGyrase Atarget
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinMultidrug resistance protein 1transporter
DB00537CiprofloxacinMultidrug and toxin extrusion protein 1transporter
DB00537CiprofloxacinMultidrug and toxin extrusion protein 2transporter
DB00608ChloroquineCytochrome P450 2D6enzyme
DB00608ChloroquineCytochrome P450 3A4enzyme
DB00608ChloroquineCytochrome P450 1A1enzyme
DB00608ChloroquineCytochrome P450 2C8enzyme
DB00608ChloroquineCytochrome P450 3A5enzyme
DB00608ChloroquineTumor necrosis factortarget
DB00608ChloroquineToll-like receptor 9target
DB00608ChloroquineGlutathione S-transferase A2target
DB00608ChloroquineFe(II)-protoporphyrin IXtarget
DB00608ChloroquineGlutathione S-transferasetarget
DB00608ChloroquineMultidrug resistance protein 1transporter
DB00613AmodiaquineCytochrome P450 2C8enzyme
DB00613AmodiaquineCytochrome P450 2D6enzyme
DB00613AmodiaquineCytochrome P450 1A1enzyme
DB00613AmodiaquineCytochrome P450 1B1enzyme
DB00613AmodiaquineCytochrome P450 2C9enzyme
DB00613AmodiaquineHistamine N-methyltransferasetarget
DB00613AmodiaquineFe(II)-protoporphyrin IXtarget
DB00613AmodiaquineMultidrug resistance protein 1transporter
DB00685TrovafloxacinCytochrome P450 1A2enzyme
DB00685TrovafloxacinDNA gyrase subunit Atarget
DB00685TrovafloxacinDNA topoisomerase 4 subunit Atarget
DB00685TrovafloxacinDNA topoisomerase 2-alphatarget
DB00716NedocromilCysteinyl leukotriene receptor 1target
DB00716NedocromilCysteinyl leukotriene receptor 2target
DB00716NedocromilProstaglandin D2 receptortarget
DB00716NedocromilfMet-Leu-Phe receptortarget
DB00716NedocromilHeat shock protein HSP 90-alphatarget
DB00724ImiquimodCytochrome P450 3A4enzyme
DB00724ImiquimodToll-like receptor 7target
DB00724ImiquimodToll-like receptor 8target
DB00779Nalidixic AcidTryptophan 2,3-dioxygenaseenzyme
DB00779Nalidixic AcidDNAtarget
DB00779Nalidixic AcidSolute carrier family 22 member 6transporter
DB00817RosoxacinCytochrome P450 1A2enzyme
DB00817RosoxacinDNA topoisomerase 4 subunit Atarget
DB00817RosoxacinDNA gyrase subunit Btarget
DB00908QuinidineAlpha-1-acid glycoprotein 1carrier
DB00908QuinidineCytochrome P450 1A2enzyme
DB00908QuinidineCytochrome P450 2E1enzyme
DB00908QuinidineCytochrome P450 1A1enzyme
DB00908QuinidineCytochrome P450 2D6enzyme
DB00908QuinidineCytochrome P450 3A4enzyme
DB00908QuinidineCytochrome P450 3A7enzyme
DB00908QuinidineCytochrome P450 2B6enzyme
DB00908QuinidineCytochrome P450 2C9enzyme
DB00908QuinidineCytochrome P450 2C8enzyme
DB00908QuinidineSodium channel protein type 5 subunit alphatarget
DB00908QuinidinePotassium voltage-gated channel subfamily H member 2target
DB00908QuinidinePotassium channel subfamily K member 1target
DB00908QuinidinePotassium channel subfamily K member 6target
DB00908QuinidineAlpha-1A adrenergic receptortarget
DB00908QuinidineAlpha-1B adrenergic receptortarget
DB00908QuinidineAlpha-1D adrenergic receptortarget
DB00908QuinidineSolute carrier family 22 member 2transporter
DB00908QuinidineSolute carrier family 22 member 1transporter
DB00908QuinidineSolute carrier family 22 member 5transporter
DB00908QuinidineMultidrug resistance protein 1transporter
DB00908QuinidineSolute carrier organic anion transporter family member 1A2transporter
DB00908QuinidineSolute carrier family 22 member 8transporter
DB00908QuinidineCanalicular multispecific organic anion transporter 1transporter
DB00908QuinidineSolute carrier family 22 member 4transporter
DB00908QuinidineSolute carrier organic anion transporter family member 1B1transporter
DB00908QuinidineBile salt export pumptransporter
DB00978LomefloxacinCytochrome P450 1A2enzyme
DB00978LomefloxacinDNA gyrase subunit Atarget
DB00978LomefloxacinDNA topoisomerase 4 subunit Atarget
DB00978LomefloxacinDNA topoisomerase 2-alphatarget
DB00978LomefloxacinSolute carrier family 22 member 5transporter
DB00978LomefloxacinCanalicular multispecific organic anion transporter 1transporter
DB01044GatifloxacinSerum albumincarrier
DB01044GatifloxacinCytochrome P450 1A2enzyme
DB01044GatifloxacinDNA gyrase subunit Atarget
DB01044GatifloxacinDNA gyrase subunit Btarget
DB01044GatifloxacinDNA topoisomerase 4 subunit Atarget
DB01044GatifloxacinDNA topoisomerase 4 subunit Btarget
DB01059NorfloxacinCytochrome P450 1A2enzyme
DB01059NorfloxacinCytochrome P450 3A4enzyme
DB01059NorfloxacinCytochrome P450 3A5enzyme
DB01059NorfloxacinCytochrome P450 3A7enzyme
DB01059NorfloxacinCytochrome P450 1A1enzyme
DB01059NorfloxacinDNA gyrase subunit Atarget
DB01059NorfloxacinDNA topoisomerase 4 subunit Atarget
DB01059NorfloxacinDNA topoisomerase 2-alphatarget
DB01059NorfloxacinSolute carrier family 22 member 5transporter
DB01059NorfloxacinSolute carrier family 22 member 6transporter
DB01087PrimaquineCytochrome P450 1A1enzyme
DB01087PrimaquineCytochrome P450 1A2enzyme
DB01087PrimaquineCytochrome P450 3A4enzyme
DB01087PrimaquineCytochrome P450 1B1enzyme
DB01087PrimaquineCytochrome P450 2D6enzyme
DB01087PrimaquineKeratin, type II cytoskeletal 7target
DB01087PrimaquineRibosyldihydronicotinamide dehydrogenase [quinone]target
DB01087PrimaquineFe(II)-protoporphyrin IXtarget
DB01087PrimaquineMultidrug resistance protein 1transporter
DB01096OxamniquineCytochrome P450 2D6enzyme
DB01096OxamniquineDNAtarget
DB01137LevofloxacinCytochrome P450 1A2enzyme
DB01137LevofloxacinCytochrome P450 3A4enzyme
DB01137LevofloxacinDNA gyrase subunit Atarget
DB01137LevofloxacinDNA topoisomerase 4 subunit Atarget
DB01137LevofloxacinDNA topoisomerase 2-alphatarget
DB01137LevofloxacinSolute carrier family 22 member 2transporter
DB01137LevofloxacinMultidrug resistance protein 1transporter
DB01137LevofloxacinSolute carrier family 22 member 4transporter
DB01137LevofloxacinSolute carrier family 22 member 6transporter
DB01137LevofloxacinMultidrug and toxin extrusion protein 1transporter
DB01137LevofloxacinMultidrug and toxin extrusion protein 2transporter
DB01155GemifloxacinCytochrome P450 1A2enzyme
DB01155GemifloxacinDNA gyrase subunit Atarget
DB01155GemifloxacinDNA topoisomerase 4 subunit Atarget
DB01165OfloxacinCytochrome P450 1A2enzyme
DB01165OfloxacinDNA gyrase subunit Atarget
DB01165OfloxacinDNA topoisomerase 4 subunit Atarget
DB01165OfloxacinDNA topoisomerase 2-alphatarget
DB01165OfloxacinSolute carrier family 22 member 5transporter
DB01165OfloxacinMultidrug resistance-associated protein 1transporter
DB01165OfloxacinSolute carrier family 22 member 6transporter
DB01165OfloxacinCanalicular multispecific organic anion transporter 1transporter
DB01165OfloxacinSolute carrier family 22 member 4transporter
DB01165OfloxacinBile salt export pumptransporter
DB01208SparfloxacinCytochrome P450 1A2enzyme
DB01208SparfloxacinDNA gyrase subunit Atarget
DB01208SparfloxacinDNA topoisomerase 4 subunit Atarget
DB01208SparfloxacinDNA topoisomerase 2-alphatarget
DB01208SparfloxacinSolute carrier family 22 member 5transporter
DB01208SparfloxacinCanalicular multispecific organic anion transporter 1transporter
DB01208SparfloxacinMultidrug resistance protein 1transporter
DB01232SaquinavirAlpha-1-acid glycoprotein 1carrier
DB01232SaquinavirSerum albumincarrier
DB01232SaquinavirCytochrome P450 3A4enzyme
DB01232SaquinavirCytochrome P450 3A5enzyme
DB01232SaquinavirCytochrome P450 3A7enzyme
DB01232SaquinavirCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB01232SaquinavirCytochrome P450 2C8enzyme
DB01232SaquinavirCytochrome P450 2D6enzyme
DB01232SaquinavirHuman immunodeficiency virus type 1 proteasetarget
DB01232SaquinavirMultidrug resistance protein 1transporter
DB01232SaquinavirSolute carrier family 22 member 1transporter
DB01232SaquinavirSolute carrier organic anion transporter family member 1A2transporter
DB01232SaquinavirATP-binding cassette sub-family G member 2transporter
DB01232SaquinavirSolute carrier organic anion transporter family member 1B1transporter
DB01232SaquinavirMultidrug resistance-associated protein 1transporter
DB01232SaquinavirCanalicular multispecific organic anion transporter 1transporter
DB01232SaquinavirSolute carrier organic anion transporter family member 2B1transporter
DB01232SaquinavirBile salt export pumptransporter
DB01238AripiprazoleCytochrome P450 3A4enzyme
DB01238AripiprazoleCytochrome P450 2D6enzyme
DB01238AripiprazoleCytochrome P450 3A5enzyme
DB01238AripiprazoleCytochrome P450 3A7enzyme
DB01238AripiprazoleD(2) dopamine receptortarget
DB01238Aripiprazole5-hydroxytryptamine receptor 1Atarget
DB01238Aripiprazole5-hydroxytryptamine receptor 2Atarget
DB01238Aripiprazole5-hydroxytryptamine receptor 1Btarget
DB01238Aripiprazole5-hydroxytryptamine receptor 1Dtarget
DB01238Aripiprazole5-hydroxytryptamine receptor 1Etarget
DB01238AripiprazoleD(1A) dopamine receptortarget
DB01238AripiprazoleD(1B) dopamine receptortarget
DB01238AripiprazoleD(3) dopamine receptortarget
DB01238AripiprazoleD(4) dopamine receptortarget
DB01238Aripiprazole5-hydroxytryptamine receptor 2Ctarget
DB01238Aripiprazole5-hydroxytryptamine receptor 3Atarget
DB01238Aripiprazole5-hydroxytryptamine receptor 6target
DB01238Aripiprazole5-hydroxytryptamine receptor 7target
DB01238AripiprazoleHistamine H1 receptortarget
DB01238AripiprazoleAlpha-1A adrenergic receptortarget
DB01238AripiprazoleAlpha-1B adrenergic receptortarget
DB01238AripiprazoleAlpha-2A adrenergic receptortarget
DB01238AripiprazoleAlpha-2B adrenergic receptortarget
DB01238AripiprazoleAlpha-2C adrenergic receptortarget
DB01238AripiprazoleMuscarinic acetylcholine receptor M1target
DB01238AripiprazoleMuscarinic acetylcholine receptor M2target
DB01238AripiprazoleMuscarinic acetylcholine receptor M3target
DB01238AripiprazoleMuscarinic acetylcholine receptor M4target
DB01238AripiprazoleMuscarinic acetylcholine receptor M5target
DB01366ProcaterolBeta-2 adrenergic receptortarget
DB01405TemafloxacinCytochrome P450 1A2enzyme
DB01405TemafloxacinDNA gyrase subunit Atarget
DB01405TemafloxacinDNA topoisomerase 4 subunit Atarget
DB01422NitroxolineMethionine aminopeptidase 2target
DB01422NitroxolineMagnesium cationtarget
DB01422NitroxolineManganese cationtarget
DB01611HydroxychloroquineCytochrome P450 2D6enzyme
DB01611HydroxychloroquineDNAtarget
DB01611HydroxychloroquineToll-like receptor 7target
DB01611HydroxychloroquineToll-like receptor 9target
DB01611HydroxychloroquineMultidrug resistance protein 1transporter
DB03205Pyrroloquinoline QuinoneQuinohemoprotein ethanol dehydrogenase type-1target
DB03205Pyrroloquinoline QuinoneQuinoprotein glucose dehydrogenase Btarget
DB03205Pyrroloquinoline QuinonePyrroloquinoline-quinone synthasetarget
DB03205Pyrroloquinoline QuinoneQuinoprotein ethanol dehydrogenasetarget
DB03205Pyrroloquinoline QuinoneQuinohemoprotein alcohol dehydrogenase ADH IIBtarget
DB04209DequaliniumHTH-type transcriptional regulator QacRtarget
DB04209DequaliniumAcriflavine resistance protein Btarget
DB04209DequaliniumE3 ubiquitin-protein ligase XIAPtarget
DB04209DequaliniumcGMP-gated cation channel alpha-1target
DB04209DequaliniumCalcium-activated potassium channel subunit alpha-1target
DB04576FleroxacinCytochrome P450 1A2enzyme
DB04576FleroxacinDNA topoisomerase 2-alphatarget
DB04576FleroxacinDNA gyrase subunit Atarget
DB04576FleroxacinDNA topoisomerase 4 subunit Atarget
DB04960TipifarnibProtein farnesyltransferase subunit betatarget
DB05039IndacaterolCytochrome P450 3A4enzyme
DB05039IndacaterolUDP-glucuronosyltransferase 1-1enzyme
DB05039IndacaterolBeta-2 adrenergic receptortarget
DB05039IndacaterolMultidrug resistance protein 1transporter
DB05119RilapladibPlatelet-activating factor acetylhydrolasetarget
DB05234LGD2941Androgen receptortarget
DB05422OPC-14523Sodium-dependent serotonin transportertarget
DB05488Technetium Tc-99m ciprofloxacinCytochrome P450 1A2enzyme
DB05488Technetium Tc-99m ciprofloxacinDNA gyrase subunit Btarget
DB05488Technetium Tc-99m ciprofloxacinDNA topoisomerase 2-betatarget
DB05524PelitinibEpidermal growth factor receptortarget
DB05928DovitinibCytochrome P450 1A1enzyme
DB05928DovitinibCytochrome P450 1A2enzyme
DB05928DovitinibUDP-glucuronosyltransferase 1-3enzyme
DB05928DovitinibUDP-glucuronosyltransferase 2B7enzyme
DB05928DovitinibCytochrome P450 2C19enzyme
DB05928DovitinibCytochrome P450 3A4enzyme
DB05928DovitinibNuclear receptor subfamily 1 group I member 2target
DB05928DovitinibCanalicular multispecific organic anion transporter 2transporter
DB05928DovitinibATP-binding cassette sub-family G member 2transporter
DB05928DovitinibSolute carrier organic anion transporter family member 1B1transporter
DB05928DovitinibSolute carrier organic anion transporter family member 2B1transporter
DB05928DovitinibSolute carrier organic anion transporter family member 1B3transporter
DB05928DovitinibMultidrug resistance protein 1transporter
DB06160GarenoxacinCytochrome P450 1A2enzyme
DB06600NemonoxacinCytochrome P450 1A2enzyme
DB06608TafenoquineCytochrome P450 2D6enzyme
DB06608TafenoquineFerredoxin--NADP reductase, apicoplastenzyme
DB06608TafenoquineSolute carrier family 22 member 2transporter
DB06608TafenoquineMultidrug and toxin extrusion protein 1transporter
DB06608TafenoquineMultidrug and toxin extrusion protein 2transporter
DB06685LaquinimodCytochrome P450 3A4enzyme
DB06771BesifloxacinCytochrome P450 1A2enzyme
DB06771BesifloxacinDNA topoisomerase 4 subunit Atarget
DB06771BesifloxacinDNA topoisomerase 4 subunit Atarget
DB06771BesifloxacinDNA gyrase subunit Atarget
DB06771BesifloxacinDNA gyrase subunit Atarget
DB08089LGD-2226Androgen receptortarget
DB08820IvacaftorSerum albumincarrier
DB08820IvacaftorAlpha-1-acid glycoprotein 1carrier
DB08820IvacaftorCytochrome P450 3A4enzyme
DB08820IvacaftorCytochrome P450 3A5enzyme
DB08820IvacaftorCystic fibrosis transmembrane conductance regulatortarget
DB08820IvacaftorMultidrug resistance protein 1transporter
DB08903BedaquilineCytochrome P450 3A4enzyme
DB08903BedaquilineATP synthase subunit ctarget
DB08972FlumequineCytochrome P450 1A2enzyme
DB09047FinafloxacinDNA gyrase subunit Atarget
DB09047FinafloxacinDNA topoisomerase 4 subunit Atarget
DB09047FinafloxacinDNA topoisomerase 2-alphatarget
DB09097QuinagolideD(2) dopamine receptortarget
DB09097QuinagolideD(1) dopamine receptortarget
DB09101ElvitegravirCytochrome P450 3A4enzyme
DB09101ElvitegravirUDP-glucuronosyltransferase 1A1enzyme
DB09101ElvitegravirIntegrasetarget
DB09128BrexpiprazoleCytochrome P450 2D6enzyme
DB09128BrexpiprazoleCytochrome P450 3A4enzyme
DB09128Brexpiprazole5-hydroxytryptamine receptor 1Atarget
DB09128BrexpiprazoleD(2) dopamine receptortarget
DB09128Brexpiprazole5-hydroxytryptamine receptor 2Atarget
DB09128BrexpiprazoleAlpha-2C adrenergic receptortarget
DB09128BrexpiprazoleAlpha-1B adrenergic receptortarget
DB11491SarafloxacinCytochrome P450 1A2enzyme
DB11692PavinetantNeuromedin-K receptortarget
DB11774PazufloxacinCytochrome P450 1A2enzyme
DB11892PrulifloxacinCytochrome P450 1A2enzyme
DB11937Kynurenic AcidAryl hydrocarbon receptortarget
DB11937Kynurenic AcidG-protein coupled receptor 35target
DB11943DelafloxacinSerum albumincarrier
DB11943DelafloxacinUDP-glucuronosyltransferase 1-1enzyme
DB11943DelafloxacinUDP-glucuronosyltransferase 1-3enzyme
DB11943DelafloxacinUDP-glucuronosyltransferase 2B15enzyme
DB11943DelafloxacinCytochrome P450 2E1enzyme
DB11943DelafloxacinCytochrome P450 2C9enzyme
DB11943DelafloxacinCytochrome P450 3A4enzyme
DB11943DelafloxacinDNA topoisomerase 4 subunit Atarget
DB11943DelafloxacinDNA gyrase subunit Atarget
DB11943DelafloxacinATP-binding cassette sub-family B member 5transporter
DB11943DelafloxacinATP-binding cassette sub-family G member 2transporter
DB12924OzenoxacinDNA gyrase subunit Atarget
DB12924OzenoxacinDNA topoisomerase 4 subunit Atarget
DB13261SitafloxacinCytochrome P450 1A2enzyme
DB13627Oxolinic acidCytochrome P450 1A2enzyme
DB13772RufloxacinCytochrome P450 1A2enzyme
DB14185Aripiprazole lauroxilSerum albumincarrier
DB14185Aripiprazole lauroxilCytochrome P450 3A4enzyme
DB14185Aripiprazole lauroxilCytochrome P450 2D6enzyme
DB14185Aripiprazole lauroxilCytochrome P450 3A5enzyme
DB14185Aripiprazole lauroxilCytochrome P450 3A7enzyme
DB14185Aripiprazole lauroxilD(2) dopamine receptortarget
DB14185Aripiprazole lauroxil5-hydroxytryptamine receptor 1Atarget
DB14185Aripiprazole lauroxil5-hydroxytryptamine receptor 2Atarget
DB14185Aripiprazole lauroxil5-hydroxytryptamine receptor 1Btarget
DB14185Aripiprazole lauroxil5-hydroxytryptamine receptor 1Dtarget
DB14185Aripiprazole lauroxil5-hydroxytryptamine receptor 1Etarget
DB14185Aripiprazole lauroxilD(1A) dopamine receptortarget
DB14185Aripiprazole lauroxilD(1B) dopamine receptortarget
DB14185Aripiprazole lauroxilD(3) dopamine receptortarget
DB14185Aripiprazole lauroxilD(4) dopamine receptortarget
DB14185Aripiprazole lauroxil5-hydroxytryptamine receptor 2Ctarget
DB14185Aripiprazole lauroxil5-hydroxytryptamine receptor 3Atarget
DB14185Aripiprazole lauroxil5-hydroxytryptamine receptor 6target
DB14185Aripiprazole lauroxil5-hydroxytryptamine receptor 7target
DB14185Aripiprazole lauroxilHistamine H1 receptortarget
DB14185Aripiprazole lauroxilAlpha-1A adrenergic receptortarget
DB14185Aripiprazole lauroxilAlpha-1B adrenergic receptortarget
DB14185Aripiprazole lauroxilAlpha-2A adrenergic receptortarget
DB14185Aripiprazole lauroxilAlpha-2B adrenergic receptortarget
DB14185Aripiprazole lauroxilAlpha-2C adrenergic receptortarget
DB14185Aripiprazole lauroxilMuscarinic acetylcholine receptor M1target
DB14185Aripiprazole lauroxilMuscarinic acetylcholine receptor M2target
DB14185Aripiprazole lauroxilMuscarinic acetylcholine receptor M3target
DB14185Aripiprazole lauroxilMuscarinic acetylcholine receptor M4target
DB14185Aripiprazole lauroxilMuscarinic acetylcholine receptor M5target