Carbamates

Derivatives of carbamic acid, H2NC(=O)OH. Included under this heading are N-substituted and O-substituted carbamic acids. In general carbamate esters are referred to as urethanes, and polymers that include repeating units of carbamate are referred to as POLYURETHANES. Note however that polyurethanes are derived from the polymerization of ISOCYANATES and the singular term URETHANE refers to the ethyl ester of carbamic acid.
DrugDrug NameDrug Description
DB00371MeprobamateAn anxiolytic drug used for the short-term management of anxiety symptoms.
DB00395CarisoprodolA centrally acting muscle relaxant used to relieve the discomfort associated with various musculoskeletal conditions.
DB00423MethocarbamolA CNS depressant indicated with rest, physical therapy and other treatments to control the discomfort associated with various acute musculoskeletal conditions.
DB00518AlbendazoleA benzimidazole anthelmintic used to treat parenchymal neurocysticercosis and other helminth infections.
DB00525TolnaftateAn antifungal agent used to treat various skin infections caused by fungi.
DB00643MebendazoleA benzimidazole anthelmintic used to treat helminth infections.
DB00711DiethylcarbamazineAn anthelmintic used to treat filarial infections like Wuchereria bancrofti and Loa loa.
DB00822DisulfiramA carbamate derivative used to treat alcohol addiction.
DB00949FelbamateAn anticonvulsant used to treat severe epilepsy.
DB00981PhysostigmineA cholinesterase inhibitor used to treat glaucoma and anticholinergic toxicity.
DB00989RivastigmineA cholinesterase inhibitor used to treat mild to moderate dementia in Alzheimer's and Parkinson's.
DB01264DarunavirA HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies.
DB02520DitiocarbA chelating agent that has been used to mobilize toxic metals from the tissues of man and experimental animals. It is the main metabolite of DISULFIRAM.
DB04827UrethaneUrethane, formerly marketed as an inactive ingredient in Profenil injection, was determined to be carcinogenic and was removed from the Canadian, US, and UK markets in 1963.
DB04892PhenserineFor the treatment of Alzheimer's disease (AD).
DB05464NOX-700Investigated for use/treatment in diabetes mellitus (type 2).
DB06525GanstigmineInvestigated for use/treatment in alzheimer's disease.
DB08974FlubendazoleFlubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe.
DB09065CobicistatA CYP3A inhibitor used to increase the systemic exposure of atazanavir or darunavir in combination with other antiretroviral agents in the treatment of HIV-1 infection.
DB11410FenbendazoleFenbendazole is a benzimidazole that presents a wide spectrum anthelmintic effect. It is used against a number of gastrointestinal parasites including giardia, roundworms, hookworms, whipworms, the Taenia genus of tapeworms,...
DB13245ThiramThiram may be used in dermatology as a scabicide . Thiram is mainly used as a fungicide for plants and treatment for seeds, however, this use is being investigated for...
DB13360TolciclateNot Annotated
DB13871Albendazole oxideNot Annotated
DB06797MebutamateMebutamate is a sedative and anxiolytic drug with anti-hypertensive (blood pressure lowering) effects comparable to those of other barbiturates but is only around 1/3rd the potency of secobarbital as a...
DB13572EmylcamateNot Annotated
DB14178Tetramethylthiuram monosulfideNot Annotated
DB14194Zinc DibutyldithiocarbamateZinc Dibutyldithiocarbamate is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6...
DB15317PosiphenPosiphen is under investigation in clinical trial NCT02925650 (Safety, Tolerability, PK and PD of Posiphen® in Subjects With Early Alzheimer's Disease).
DB01019BethanecholA muscarinic agonist used to treat postoperative and postpartum nonobstructive functional urinary retention and neurogenic atony of the bladder with retention.
DrugDrug NameTargetType
DB00371MeprobamateGamma-aminobutyric acid receptor subunit alpha-1target
DB00371MeprobamateGamma-aminobutyric acid receptor subunit alpha-2target
DB00371MeprobamateGamma-aminobutyric acid receptor subunit alpha-3target
DB00371MeprobamateGamma-aminobutyric acid receptor subunit alpha-4target
DB00371MeprobamateGamma-aminobutyric acid receptor subunit alpha-5target
DB00371MeprobamateGamma-aminobutyric acid receptor subunit alpha-6target
DB00371MeprobamateGABA-A receptor (anion channel)target
DB00395CarisoprodolCytochrome P450 2C19enzyme
DB00395CarisoprodolGamma-aminobutyric acid receptor subunit alpha-1target
DB00395CarisoprodolGamma-aminobutyric acid receptor subunit beta-2target
DB00395CarisoprodolGamma-aminobutyric acid receptor subunit gamma-2target
DB00395CarisoprodolGamma-aminobutyric acid receptor subunit alpha-5target
DB00395CarisoprodolGamma-aminobutyric acid receptor subunit alpha-3target
DB00423MethocarbamolCarbonic anhydrase 1target
DB00518AlbendazoleTubulin alpha-1A chaintarget
DB00518AlbendazoleTubulin beta-4B chaintarget
DB00518AlbendazoleCytochrome P450 3A4enzyme
DB00518AlbendazoleFumarate reductase flavoprotein subunittarget
DB00518AlbendazoleCytochrome P450 1A1enzyme
DB00518AlbendazoleCytochrome P450 1A2enzyme
DB00518AlbendazoleTubulin beta-2 chaintarget
DB00518AlbendazoleCytochrome P450 2C19enzyme
DB00525TolnaftateSqualene monooxygenasetarget
DB00643MebendazoleTubulin alpha-1A chaintarget
DB00643MebendazoleTubulin beta-4B chaintarget
DB00643MebendazoleCytochrome P450 1A1enzyme
DB00643MebendazoleCytochrome P450 3A Subfamilyenzyme
DB00711DiethylcarbamazineArachidonate 5-lipoxygenasetarget
DB00711DiethylcarbamazineProstaglandin G/H synthase 1target
DB00711DiethylcarbamazineCholinesteraseenzyme
DB00822DisulfiramAldehyde dehydrogenase, mitochondrialtarget
DB00822DisulfiramCytochrome P450 2E1enzyme
DB00822DisulfiramDopamine beta-hydroxylasetarget
DB00822DisulfiramCytochrome P450 3A4enzyme
DB00822DisulfiramCytochrome P450 3A5enzyme
DB00822DisulfiramBile salt export pumptransporter
DB00949FelbamateGlutamate receptor ionotropic, NMDA 3Atarget
DB00949FelbamateGlutamate receptor ionotropic, NMDA 2Btarget
DB00949FelbamateGlutamate receptor ionotropic, NMDA 2Atarget
DB00949FelbamateCytochrome P450 2C19enzyme
DB00949FelbamateCytochrome P450 3A4enzyme
DB00949FelbamateCytochrome P450 2E1enzyme
DB00949FelbamateCytochrome P450 2C9enzyme
DB00981PhysostigmineAcetylcholinesterasetarget
DB00981PhysostigmineNeuronal acetylcholine receptor subunit alpha-4target
DB00981PhysostigmineNeuronal acetylcholine receptor subunit beta-2target
DB00989RivastigmineAcetylcholinesterasetarget
DB00989RivastigmineCholinesterasetarget
DB01264DarunavirHuman immunodeficiency virus type 1 proteasetarget
DB01264DarunavirCytochrome P450 3A4enzyme
DB01264DarunavirSolute carrier organic anion transporter family member 1B1transporter
DB01264DarunavirP-glycoprotein 1transporter
DB02520DitiocarbCytochrome P450 2E1enzyme
DB02520DitiocarbCytochrome P450 3A4enzyme
DB02520DitiocarbCytochrome P450 3A5enzyme
DB04827UrethaneCytosolic phospholipase A2enzyme
DB04827UrethaneMyeloperoxidaseenzyme
DB04827UrethaneAldehyde oxidaseenzyme
DB04892PhenserineAcetylcholinesterasetarget
DB04892PhenserineCholinesterasetarget
DB04892PhenserineAmyloid beta A4 proteintarget
DB05464NOX-700Nuclear factor NF-kappa-B p100 subunittarget
DB05464NOX-700Nuclear factor NF-kappa-B p105 subunittarget
DB06525GanstigmineAcetylcholinesterasetarget
DB09065CobicistatCytochrome P450 2D6enzyme
DB09065CobicistatP-glycoprotein 1transporter
DB09065CobicistatATP-binding cassette sub-family G member 2transporter
DB09065CobicistatCytochrome P450 3A4enzyme
DB09065CobicistatCytochrome P450 3A5enzyme
DB09065CobicistatCytochrome P450 3A7enzyme
DB09065CobicistatCytochrome P450 3A43enzyme
DB09065CobicistatSolute carrier organic anion transporter family member 1B1transporter
DB09065CobicistatSolute carrier organic anion transporter family member 1B3transporter
DB01019BethanecholMuscarinic acetylcholine receptor M2target
DB01019BethanecholMuscarinic acetylcholine receptor M1target
DB01019BethanecholMuscarinic acetylcholine receptor M3target
DB01019BethanecholMuscarinic acetylcholine receptor M4target