Phenothiazines

Compounds containing dibenzo-1,4-thiazine. Some of them are neuroactive.
DrugDrug NameDrug Description
DB00433ProchlorperazineA phenothiazine derivative used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting.
DB00477ChlorpromazineA phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children.
DB00623FluphenazineA phenothiazine used to treat patients requiring long-term neuroleptic therapy.
DB00679ThioridazineA phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder.
DB00831TrifluoperazineA phenothiazine used to treat depression, anxiety, and agitation.
DB00850PerphenazineA phenothiazine used to treat schizophrenia as well as nausea and vomiting.
DB01069PromethazineA first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness.
DB01403MethotrimeprazineA phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder.
DB00372ThiethylperazineFor the treatment or relief of nausea and vomiting.
DB00420PromazineA phenothiazine used to manage schizophrenia.
DB00508TriflupromazineUsed mainly in the management of psychoses. Also used to control nausea and vomiting.
DB00680MoricizineAn antiarrhythmic used to treat arrhythmias.
DB00933MesoridazineA phenothiazine antipsychotic used to treat schizophrenia, organic brain disorders, alcoholism, and psychoneuroses.
DB01246AlimemazineAn antihistamine agent used to prevent and relieve allergic conditions which cause pruritus and other allergic skin conditions, including urticaria.
DB01614AcepromazineAcepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and...
DB01615AceprometazineAceprometazine is often used in combination with meprobamate for the treatment of sleep disorders.
DB05687BL-1020Investigated for use/treatment in schizophrenia and schizoaffective disorders.
DB09241Methylene blueAn oxidation-reduction agent used for the treatment of pediatric and adult patients with acquired methemoglobinemia.
DB11540PropiopromazineNot Annotated
DB12710PerazinePerazine has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others.
DB13382ChlorproethazineNot Annotated
DB13420ThiazinamNot Annotated
DB01608PericiazineA phenothiazine used with other medications to treat aggressiveness, impulsiveness, and hostility associated with psychiatric conditions such as schizophrenia.
DB01622ThioproperazineAn antipsychotic indicated for the management of acute and chronic schizophrenia, including cases that are refractory to more common neuroleptics. May also be used to treat manic syndromes.
DB09000CyamemazineCyamemazine (Tercian), also known as cyamepromazine, is a typical antipsychotic drug of the phenothiazine class used primarily in the treatment of schizophrenia and psychosis-associated anxiety. Cyamemazine actually behaves like an...
DB13784DixyrazineNot Annotated
DB01063AcetophenazineFor the treatment of disorganized and psychotic thinking. Also used to help treat false perceptions (e.g. hallucinations or delusions.)
DB13213ButaperazineButaperazine was approved in 1967 , and possibly discontinued in the 1980s .
DB01621PipotiazineAn antipsychotic indicated for the management of chronic, non-agitated schizophrenic patients.
DB14651Perphenazine enanthateNot Annotated
DrugDrug NameTargetType
DB00433ProchlorperazineDopamine D2 receptortarget
DB00433ProchlorperazineCytochrome P450 2D6enzyme
DB00433ProchlorperazineHistamine H1 receptortarget
DB00433ProchlorperazineAlpha-1 adrenergic receptorstarget
DB00433ProchlorperazineAlpha-2 adrenergic receptorstarget
DB00477ChlorpromazineDopamine D2 receptortarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 2Atarget
DB00477ChlorpromazineCytochrome P450 2D6enzyme
DB00477ChlorpromazineCholinesteraseenzyme
DB00477ChlorpromazineCytochrome P450 1A2enzyme
DB00477ChlorpromazineSerum albumincarrier
DB00477ChlorpromazineP-glycoprotein 1transporter
DB00477ChlorpromazineDopamine D1 receptortarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 1Atarget
DB00477ChlorpromazineAlpha-1A adrenergic receptortarget
DB00477ChlorpromazineAlpha-1B adrenergic receptortarget
DB00477ChlorpromazineCytochrome P450 2E1enzyme
DB00477ChlorpromazineCytochrome P450 3A4enzyme
DB00477ChlorpromazineHistamine H1 receptortarget
DB00477ChlorpromazinePotassium voltage-gated channel subfamily H member 2target
DB00477ChlorpromazineD(1) dopamine receptortarget
DB00477ChlorpromazineDopamine D3 receptortarget
DB00477ChlorpromazineDopamine D4 receptortarget
DB00477ChlorpromazineDopamine D5 receptortarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 2Ctarget
DB00477Chlorpromazine5-hydroxytryptamine 2 receptortarget
DB00477ChlorpromazineAlpha-1 adrenergic receptorstarget
DB00477ChlorpromazineAlpha-2 adrenergic receptorstarget
DB00477ChlorpromazineMuscarinic acetylcholine receptor M1target
DB00477ChlorpromazineMuscarinic acetylcholine receptor M3target
DB00477ChlorpromazineSphingomyelin phosphodiesterasetarget
DB00477ChlorpromazineCalmodulintarget
DB00477Chlorpromazinealpha1-acid glycoproteintarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 6target
DB00477Chlorpromazine5-hydroxytryptamine receptor 7target
DB00477ChlorpromazineHistamine H4 receptortarget
DB00477ChlorpromazineBile salt export pumptransporter
DB00623FluphenazineDopamine D2 receptortarget
DB00623FluphenazineCalmodulintarget
DB00623FluphenazineDopamine D1 receptortarget
DB00623FluphenazineCytochrome P450 2D6enzyme
DB00623FluphenazineP-glycoprotein 1transporter
DB00623FluphenazineCytochrome P450 2E1enzyme
DB00623FluphenazineAndrogen receptortarget
DB00623Fluphenazine5-hydroxytryptamine receptor 2Atarget
DB00623Fluphenazine5-hydroxytryptamine receptor 2Ctarget
DB00679ThioridazineAlpha-1A adrenergic receptortarget
DB00679ThioridazineDopamine D2 receptortarget
DB00679Thioridazine5-hydroxytryptamine receptor 2Atarget
DB00679ThioridazineDopamine D1 receptortarget
DB00679ThioridazineCytochrome P450 2C19enzyme
DB00679ThioridazineCytochrome P450 2D6enzyme
DB00679ThioridazineAlpha-1B adrenergic receptortarget
DB00679ThioridazinePotassium voltage-gated channel subfamily H member 2target
DB00679ThioridazineCytochrome P450 2E1enzyme
DB00831TrifluoperazineDopamine D2 receptortarget
DB00831TrifluoperazineAlpha-1A adrenergic receptortarget
DB00831TrifluoperazineNeuron-specific vesicular protein calcyontarget
DB00831TrifluoperazineXanthine dehydrogenase/oxidaseenzyme
DB00831TrifluoperazineUDP-glucuronosyltransferase 1-4enzyme
DB00831TrifluoperazineCytochrome P450 1A2enzyme
DB00831TrifluoperazineP-glycoprotein 1transporter
DB00831TrifluoperazineCalmodulintarget
DB00831TrifluoperazineTroponin C, slow skeletal and cardiac musclestarget
DB00831TrifluoperazineProtein S100-A4target
DB00850PerphenazineDopamine D1 receptortarget
DB00850PerphenazineDopamine D2 receptortarget
DB00850PerphenazineCalmodulintarget
DB00850PerphenazineCytochrome P450 2D6enzyme
DB00850PerphenazineCytochrome P450 1A2enzyme
DB00850PerphenazineCytochrome P450 2C18enzyme
DB00850PerphenazineCytochrome P450 2C19enzyme
DB00850PerphenazineCytochrome P450 2C8enzyme
DB00850PerphenazineCytochrome P450 2C9enzyme
DB00850PerphenazineCytochrome P450 3A4enzyme
DB01069PromethazineDopamine D2 receptortarget
DB01069PromethazineHistamine H1 receptortarget
DB01069PromethazineMuscarinic acetylcholine receptor M4target
DB01069PromethazineMuscarinic acetylcholine receptor M1target
DB01069PromethazineMuscarinic acetylcholine receptor M5target
DB01069PromethazineMuscarinic acetylcholine receptor M2target
DB01069PromethazineMuscarinic acetylcholine receptor M3target
DB01069PromethazineCalmodulintarget
DB01069PromethazineCytochrome P450 2D6enzyme
DB01069PromethazineCytochrome P450 2B6enzyme
DB01069PromethazineP-glycoprotein 1transporter
DB01069PromethazineCytochrome P450 2C9enzyme
DB01069PromethazineHistamine H2 receptortarget
DB01069PromethazineAlpha adrenergic receptortarget
DB01069PromethazineP2 Purinoceptorstarget
DB01069PromethazineVoltage-gated sodium channel alpha subunittarget
DB01069PromethazineVoltage-gated Potassium Channelstarget
DB01069PromethazineCanalicular multispecific organic anion transporter 2transporter
DB01069PromethazineMultidrug resistance-associated protein 4transporter
DB01069PromethazineSerum albumincarrier
DB01403MethotrimeprazineDopamine D3 receptortarget
DB01403MethotrimeprazineHistamine H1 receptortarget
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M1target
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M2target
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M3target
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M4target
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M5target
DB01403MethotrimeprazineAlpha-1A adrenergic receptortarget
DB01403MethotrimeprazineAlpha-1B adrenergic receptortarget
DB01403MethotrimeprazineAlpha-1D adrenergic receptortarget
DB01403MethotrimeprazineCytochrome P450 2D6enzyme
DB01403MethotrimeprazineDopamine D2 receptortarget
DB01403MethotrimeprazineDopamine D1 receptortarget
DB01403MethotrimeprazineDopamine D5 receptortarget
DB01403MethotrimeprazineDopamine D4 receptortarget
DB01403MethotrimeprazineAlpha-2A adrenergic receptortarget
DB01403MethotrimeprazineAlpha-2B adrenergic receptortarget
DB01403MethotrimeprazineAlpha-2C adrenergic receptortarget
DB01403Methotrimeprazine5-hydroxytryptamine receptor 2Atarget
DB01403Methotrimeprazine5-hydroxytryptamine receptor 2Ctarget
DB01403MethotrimeprazineCytochrome P450 2E1enzyme
DB00372ThiethylperazineDopamine D1 receptortarget
DB00372ThiethylperazineDopamine D4 receptortarget
DB00372ThiethylperazineDopamine D2 receptortarget
DB00420PromazineDopamine D2 receptortarget
DB00420PromazineMuscarinic acetylcholine receptor M4target
DB00420PromazineMuscarinic acetylcholine receptor M2target
DB00420PromazineMuscarinic acetylcholine receptor M3target
DB00420PromazineAlpha-1B adrenergic receptortarget
DB00420PromazineDopamine D1 receptortarget
DB00420PromazineMuscarinic acetylcholine receptor M5target
DB00420Promazine5-hydroxytryptamine receptor 2Atarget
DB00420Promazine5-hydroxytryptamine receptor 2Ctarget
DB00420PromazineAlpha-1A adrenergic receptortarget
DB00420PromazineMuscarinic acetylcholine receptor M1target
DB00420PromazineDopamine D4 receptortarget
DB00420PromazineHistamine H1 receptortarget
DB00420PromazineAlpha-1D adrenergic receptortarget
DB00420PromazineCytochrome P450 2C19enzyme
DB00420PromazineCytochrome P450 1A2enzyme
DB00420PromazineCytochrome P450 3A4enzyme
DB00420PromazineCytochrome P450 2C9enzyme
DB00420PromazineCytochrome P450 2D6enzyme
DB00508TriflupromazineDopamine D1 receptortarget
DB00508TriflupromazineDopamine D2 receptortarget
DB00508TriflupromazineMuscarinic acetylcholine receptor M1target
DB00508TriflupromazineMuscarinic acetylcholine receptor M2target
DB00508Triflupromazine5-hydroxytryptamine receptor 2Btarget
DB00508TriflupromazineP-glycoprotein 1transporter
DB00508TriflupromazineCholinesteraseenzyme
DB00680MoricizineSodium channel protein type 5 subunit alphatarget
DB00933MesoridazineDopamine D2 receptortarget
DB00933Mesoridazine5-hydroxytryptamine receptor 2Atarget
DB00933MesoridazineCytochrome P450 2D6enzyme
DB01246AlimemazineHistamine H1 receptortarget
DB01614AcepromazineDopamine D2 receptortarget
DB01614AcepromazineDopamine D1 receptortarget
DB01614Acepromazine5-hydroxytryptamine receptor 2Atarget
DB01614Acepromazine5-hydroxytryptamine receptor 1Atarget
DB01614AcepromazineAlpha-1A adrenergic receptortarget
DB01614AcepromazineAlpha-1B adrenergic receptortarget
DB01614AcepromazineSerum albumincarrier
DB01615AceprometazineHistamine H1 receptortarget
DB05687BL-1020Dopamine D2 receptortarget
DB05687BL-10205-hydroxytryptamine receptor 2Atarget
DB09241Methylene blueGuanylate cyclase soluble subunit alpha-2target
DB09241Methylene blueNitric oxide synthase, braintarget
DB01608PericiazineAlpha-1B adrenergic receptortarget
DB01608PericiazineAlpha-2A adrenergic receptortarget
DB01608PericiazineDopamine D1 receptortarget
DB01608PericiazineAndrogen receptortarget
DB01622ThioproperazineDopamine D2 receptortarget
DB01622ThioproperazineDopamine D1 receptortarget
DB01622Thioproperazine5-hydroxytryptamine receptor 2Atarget
DB01622Thioproperazine5-hydroxytryptamine receptor 1Atarget
DB01622ThioproperazineAlpha-1A adrenergic receptortarget
DB01622ThioproperazineAlpha-1B adrenergic receptortarget
DB01622ThioproperazineSerum albumincarrier
DB01063AcetophenazineDopamine D2 receptortarget
DB01063AcetophenazineDopamine D1 receptortarget
DB01063AcetophenazineAndrogen receptortarget
DB01621PipotiazineCytochrome P450 2D6enzyme
DB01621PipotiazineCytochrome P450 3A4enzyme
DB01621PipotiazineDopamine D2 receptortarget
DB01621PipotiazineDopamine D1 receptortarget
DB01621Pipotiazine5-hydroxytryptamine receptor 2Atarget
DB01621Pipotiazine5-hydroxytryptamine receptor 1Atarget
DB01621PipotiazineSolute carrier family 22 member 1transporter
DB01621PipotiazineSerum albumincarrier
DB01621PipotiazineCytochrome P450 2C19enzyme