Phenyl Ethers

Name
Phenyl Ethers
Accession Number
DBCAT000812
Description

Ethers that are linked to a benzene ring structure.

Drugs
DrugDrug Description
MexiletineA class 1B antiarrhythmic agent used in the treatment of documented ventricular arrhythmias that warrant treatment.
MethocarbamolA CNS depressant indicated with rest, physical therapy and other treatments to control the discomfort associated with various acute musculoskeletal conditions.
ClofibrateA fibric acid derivative used to treat hypertriglyceridemia and high cholesterol.
ProparacaineA topical anesthetic used for ophthalmic practice.
GuaifenesinAn expectorant commonly found in OTC products for the symptomatic relief from congested chests and coughs associated with cold, bronchitis, and/or other breathing illnesses.
FenofibrateA peroxisome proliferator receptor alpha activator used to lower LDL-C, total-C, triglycerides, and Apo B, while increasing HDL-C in hypercholesterolemia, dyslipidemia, and hypertriglyceridemia.
GemfibrozilA lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia.
BezafibrateA lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder.
P-Anisic AcidNot Available
VernakalantAn antiarrhythmic medication used to treat patients with atrial fibrillation.
BNC105Investigated for use/treatment in cancer/tumors (unspecified).
TriclosanAn antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew.
EtofibrateEtofibrate is a fibrate produced by the combination of clofibrate ester linked to niacin. These components separate in the body slowly allowing for pharmacokinetics similar to controlled-release formulations.
BromoprideBromopride in indicated in the treatment of nausea and vomiting, including PONV (post-operative nausea and vomiting), gastroesophageal reflux disease (GERD/GORD), as well as endoscopy preparation and radiographic studies of the...
CiprofibrateNot Annotated
TrimebutineA spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery.
PropoxycainePropoxycaine is a local anesthetic medication. It was used beginning in the 1950s during dental procedures . It has been combined with procaine to accelerate its onset of action and...
MequinolA topical agent used in combination with tretinoin to treat solar lentigines.
NonivamideNonivamide is used as a topical analgesic and is also used as a flavoring ingredient , , .
GuaiacolIt is used medicinally as an expectorant, antiseptic, and local anesthetic. Guaiacol is used in traditional dental pulp sedation, and has the property of inducing cell proliferation; guaiacol is a...
HexobendineHexobendine is a medication used to cause vasodilation, to treat several conditions including angina pectoris. It has not been approved in the United States or the United Kingdom, but has...
BucetinBucetin is an analgesic and antipyretic medication which was approved for use in Germany but was withdrawn from the market in 1986 due to renal toxicity caused by the medication...
SimfibrateNot Annotated
ClofibrideNot Annotated
Anethole trithioneA medication used to treat dry mouth associated with medication or radiotherapy of the head and neck.
Fenofibric acidA fibrate used to treat severe hypertriglyceridemia, primary hypercholesterolemia, or mixed dyslipidemia.
Diclofop-methylHerbicide for control of wild oat & foxtails in cereal crops.
Potassium GuaiacolsulfonateGuaiacolsulfonate is an aromatic sulfonic acid. Potassium guaiacolsulfonate salt is an expectorant that thins the mucus in the lungs and reduces chest congestion.
Vanillic acidA flavoring agent. It is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (J Biotechnol 1996;50(2-3):107-13).
AliskirenA direct renin inhibitor used to manage hypertension.
Methyl vanillateNot Available
ZingeroneZingerone is a pungent component of ginger.
4-VinylguaiacolNot Available
Drugs & Drug Targets
DrugTargetType
MexiletineSodium channel protein type 5 subunit alphatarget
MexiletineCytochrome P450 1A2enzyme
MexiletineCytochrome P450 2D6enzyme
MexiletineCytochrome P450 2B6enzyme
MexiletineCytochrome P450 2E1enzyme
MexiletineCytochrome P450 3A4enzyme
MexiletineAryl hydrocarbon receptortarget
MethocarbamolCarbonic anhydrase 1target
ClofibratePeroxisome proliferator-activated receptor alphatarget
ClofibrateCytochrome P450 3A4enzyme
ClofibrateGlutathione S-transferase A2enzyme
ClofibrateCytochrome P450 2E1enzyme
ClofibrateCytochrome P450 1A1enzyme
ClofibrateCytochrome P450 4A11enzyme
ClofibrateThyroxine-binding globulincarrier
ProparacaineSodium channel protein type 10 subunit alphatarget
GuaifenesinNMDA receptortarget
FenofibratePeroxisome proliferator-activated receptor alphatarget
FenofibrateMatrix metalloproteinase-25target
FenofibrateCytochrome P450 2C8enzyme
FenofibrateCytochrome P450 2C9enzyme
FenofibrateNuclear receptor subfamily 1 group I member 2target
FenofibrateUDP-glucuronosyltransferase 1-9enzyme
FenofibrateBile salt export pumptransporter
FenofibrateSerum albumincarrier
FenofibrateCytochrome P450 2C19enzyme
FenofibrateCytochrome P450 2A6enzyme
FenofibrateLiver carboxylesterase 1enzyme
FenofibrateCarbonyl reductase [NADPH] 1enzyme
FenofibrateAldo-keto reductase family 1 member C1enzyme
FenofibrateAldo-keto reductase family 1 member C2enzyme
FenofibrateAldo-keto reductase family 1 member C3enzyme
FenofibrateAldose reductaseenzyme
GemfibrozilPeroxisome proliferator-activated receptor alphatarget
GemfibrozilCytochrome P450 2C9enzyme
GemfibrozilCytochrome P450 2C8enzyme
GemfibrozilCytochrome P450 1A2enzyme
GemfibrozilCytochrome P450 2C19enzyme
GemfibrozilUDP-glucuronosyltransferase 1-1enzyme
GemfibrozilCytochrome P450 3A4enzyme
GemfibrozilUDP-glucuronosyltransferase 1-3enzyme
GemfibrozilSolute carrier organic anion transporter family member 1B1target
GemfibrozilUDP-glucuronosyltransferase 2B7enzyme
GemfibrozilUDP-glucuronosyltransferase 1-9enzyme
GemfibrozilUDP-glucuronosyltransferase 2B4enzyme
GemfibrozilUDP-glucuronosyltransferase 2B17enzyme
GemfibrozilSerum albumincarrier
GemfibrozilSolute carrier family 22 member 8target
GemfibrozilSolute carrier organic anion transporter family member 2B1target
GemfibrozilSolute carrier organic anion transporter family member 1B3target
BezafibratePeroxisome proliferator-activated receptor alphatarget
BezafibrateSolute carrier organic anion transporter family member 1B1transporter
BezafibratePeroxisome proliferator-activated receptor deltatarget
BezafibratePeroxisome proliferator-activated receptor gammatarget
BezafibrateCytochrome P450 1A1enzyme
BezafibrateCytochrome P450 2C8enzyme
BezafibrateCytochrome P450 3A4enzyme
BezafibrateNuclear receptor subfamily 1 group I member 2target
BezafibrateRetinoic acid receptor RXR-alphatarget
BezafibrateRetinoic acid receptor RXR-betatarget
BezafibrateRetinoic acid receptor RXR-gammatarget
P-Anisic AcidGroup IIE secretory phospholipase A2target
P-Anisic AcidPhospholipase A2target
VernakalantCytochrome P450 2D6enzyme
VernakalantSodium channel protein type 5 subunit alphatarget
VernakalantPotassium voltage-gated channel subfamily A member 5target
VernakalantPotassium voltage-gated channel subfamily D member 3target
VernakalantPotassium voltage-gated channel subfamily H member 2target
TriclosanEnoyl-[acyl-carrier-protein] reductase [NADH] FabItarget
TriclosanEnoyl-[acyl-carrier-protein] reductase [NADH]target
TriclosanEnoyl-[acyl-carrier-protein] reductase [NADH] FabItarget
TriclosanEnoyl-[acyl-carrier-protein] reductase [NADH]target
TriclosanEnoyl-[acyl-carrier-protein] reductase [NADPH] FabItarget
TriclosanNuclear receptor subfamily 1 group I member 2target
TriclosanAndrogen receptortarget
TriclosanNuclear receptor subfamily 1 group I member 3target
TriclosanPeroxisome proliferator-activated receptor gammatarget
TriclosanThyroid peroxidasetarget
BromoprideDopamine D2 receptortarget
CiprofibratePeroxisome proliferator-activated receptor alphatarget
TrimebutineMu-type opioid receptortarget
TrimebutineVoltage-dependent L-type calcium channeltarget
TrimebutineCalcium-activated potassium channeltarget
TrimebutineVoltage-dependent T-type calcium channeltarget
TrimebutineMuscarinic acetylcholine receptor M1target
TrimebutineMuscarinic acetylcholine receptor M2target
TrimebutineMuscarinic acetylcholine receptor M3target
TrimebutineMuscarinic acetylcholine receptor M4target
TrimebutineCytochrome P450 3A4enzyme
PropoxycaineLiver carboxylesterase 1enzyme
PropoxycaineVoltage-gated sodium channel alpha subunittarget
NonivamideTransient receptor potential cation channel subfamily V member 1target
GuaiacolSerum albumintarget
Fenofibric acidPeroxisome proliferator-activated receptor alphatarget
Fenofibric acidMatrix metalloproteinase-25target
Fenofibric acidPeroxisome proliferator-activated receptor gammatarget
Fenofibric acidPeroxisome proliferator-activated receptor deltatarget
Fenofibric acidNuclear receptor subfamily 1 group I member 2target
Vanillic acidChorismate--pyruvate lyasetarget
AliskirenRenintarget
AliskirenCytochrome P450 3A4enzyme
Methyl vanillateEndo-1,4-beta-xylanase Ytarget