Potassium-Sparing Diuretics

Name
Potassium-Sparing Diuretics
Accession Number
DBCAT002702  (DBCAT000816, DBCAT002346)
Description

A subclass of diuretics that limits the secretion of POTASSIUM into the URINE.

Drugs
DrugDrug Description
TriamtereneA potassium-sparing diuretic used in the treatment of edema and in the management of hypertension.
AmilorideA pyrizine compound used to treat hypertension and congestive heart failure.
SpironolactoneAn aldosterone receptor antagonist used to treat edema, hypertension, heart failure, and aldosteronism.
EplerenoneAn aldosterone receptor antagonist used to improve survival of patients with symptomatic heart failure and to reduce blood pressure.
Canrenoic acidAn aldosterone antagonist used in primary hyperaldosteronism and other disorders related to aberrant aldosterone levels.
CanrenoneAn antimineralocorticoid and active metabolite of spironolactone used in the treatment of primary hyperaldosteronism and edematous states caused by secondary hyperaldosteronism (e.g. heart failure).
Drugs & Drug Targets
DrugTargetType
TriamtereneAmiloride-sensitive sodium channel subunit gammatarget
TriamtereneAmiloride-sensitive sodium channel subunit alphatarget
TriamtereneAmiloride-sensitive sodium channel subunit betatarget
TriamtereneAmiloride-sensitive sodium channel subunit deltatarget
TriamtereneCytochrome P450 1A2enzyme
AmilorideAmiloride-sensitive sodium channel subunit betatarget
AmilorideAcid-sensing ion channel 1target
AmilorideAmiloride-sensitive amine oxidase [copper-containing]target
AmilorideAmiloride-sensitive sodium channel subunit alphatarget
AmilorideAmiloride-sensitive sodium channel subunit gammatarget
AmilorideSodium/hydrogen exchanger 1target
AmilorideAcid-sensing ion channel 2target
AmilorideAmiloride-sensitive sodium channel subunit deltatarget
AmilorideUrokinase-type plasminogen activatortarget
AmilorideSolute carrier family 22 member 2transporter
AmilorideSolute carrier family 22 member 4transporter
AmilorideAmiloride-sensitive amine oxidase [copper-containing]enzyme
AmilorideAmiloride-sensitive amine oxidase [copper-containing]enzyme
SpironolactoneMineralocorticoid receptortarget
SpironolactoneCytochrome P450 2C8enzyme
SpironolactoneCanalicular multispecific organic anion transporter 1transporter
SpironolactoneP-glycoprotein 1transporter
SpironolactoneSolute carrier organic anion transporter family member 1A2transporter
SpironolactoneCytochrome P450 11B1, mitochondrialenzyme
SpironolactoneAndrogen receptortarget
SpironolactoneProgesterone receptortarget
SpironolactoneGlucocorticoid receptortarget
SpironolactoneNuclear receptor subfamily 1 group I member 2target
SpironolactoneBile salt export pumptransporter
SpironolactoneSerum albumincarrier
Spironolactonealpha1-acid glycoproteincarrier
SpironolactoneEstrogen receptortarget
SpironolactoneCytochrome P450 11B2, mitochondrialenzyme
SpironolactoneVoltage-dependent L-type calcium channeltarget
EplerenoneMineralocorticoid receptortarget
EplerenoneCytochrome P450 3A4enzyme
EplerenoneCytochrome P450 3A5enzyme
EplerenoneCytochrome P450 11B2, mitochondrialenzyme