Cardenolides

C(23)-steroids with methyl groups at C-10 and C-13 and a five-membered lactone at C-17. They are aglycone constituents of CARDIAC GLYCOSIDES and must have at least one double bond in the molecule. The class includes cardadienolides and cardatrienolides. Members include DIGITOXIN and DIGOXIN and their derivatives and the STROPHANTHINS.
DrugDrug NameDrug Indication
DB00390DigoxinDigoxin is indicated in the following conditions: 1) For the treatment of mild to moderate heart failure in adult patients.[L6775] 2) To increase myocardial contraction in children diagnosed with heart failure.[L6775] 3) To maintain control ventricular rate in adult patients diagnosed with chronic atrial fibrillation.[L6775] In adults with heart failure, when it is clinically possible, digoxin should be administered in conjunction with a diuretic and an angiotensin-converting enzyme (ACE) inhibitor for optimum effects.[L6775]
DB00511AcetyldigitoxinUsed for fast digitalization in congestive heart failure.
DB01078DeslanosideFor the treatment and management of Congestive cardiac insufficiency, arrhythmias and heart failure.
DB01092OuabainFor the treatment of atrial fibrillation and flutter and heart failure
DB01396DigitoxinFor the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure.
DB13240CymarinNot Available
DB13401MetildigoxinNot Available
DB13467Lanatoside CNot Available
DB13537GitoformateNot Available
DrugDrug NameTargetType
DB00390DigoxinSodium/potassium-transporting ATPase subunit alpha-1target
DB00390DigoxinCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB00390DigoxinMultidrug resistance protein 1transporter
DB00390DigoxinSolute carrier organic anion transporter family member 4C1transporter
DB00390DigoxinBile salt export pumptransporter
DB00390DigoxinSolute carrier organic anion transporter family member 1A2transporter
DB00390DigoxinOrganic solute transporter subunit alphatransporter
DB00390DigoxinOrganic solute transporter subunit betatransporter
DB00390DigoxinSolute carrier organic anion transporter family member 1B1transporter
DB00511AcetyldigitoxinSodium/potassium-transporting ATPase subunit alpha-1target
DB01078DeslanosideSodium/potassium-transporting ATPase subunit alpha-1target
DB01092OuabainSodium/potassium-transporting ATPase subunit alpha-1target
DB01092OuabainSolute carrier organic anion transporter family member 1A2transporter
DB01092OuabainSolute carrier family 22 member 8transporter
DB01092OuabainSolute carrier organic anion transporter family member 4C1transporter
DB01092OuabainSolute carrier organic anion transporter family member 1B3transporter
DB01092OuabainSolute carrier organic anion transporter family member 1C1transporter
DB01092OuabainSolute carrier organic anion transporter family member 1B1transporter
DB01092OuabainCytochrome P450 1A1enzyme
DB01092OuabainSodium/potassium-transporting ATPase subunit alpha-2target
DB01092OuabainSodium/potassium-transporting ATPase subunit alpha-3target
DB01396DigitoxinSodium/potassium-transporting ATPase subunit alpha-1target
DB01396DigitoxinSerum albumincarrier
DB01396DigitoxinCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB01396DigitoxinCytochrome P450 3A4enzyme
DB01396DigitoxinSolute carrier organic anion transporter family member 1A2transporter
DB01396DigitoxinSolute carrier organic anion transporter family member 4C1transporter
DB01396DigitoxinMultidrug resistance protein 1transporter