Nicotinic Acids

2-, 3-, or 4-Pyridinecarboxylic acids. Pyridine derivatives substituted with a carboxy group at the 2-, 3-, or 4-position. The 3-carboxy derivative (NIACIN) is active as a vitamin.
DrugDrug NameDrug Description
DB00627NiacinA B vitamin used to treat hypertriglyceridemia and pellagra.
DB00393NimodipineA calcium channel blocker used to improve neurological outcomes in patients with subarachnoid hemorrhage due to a ruptured intracranial aneurysm.
DB00398SorafenibA kinase inhibitor used in the treatment of unresectable liver carcinoma and advanced renal carcinoma.
DB02701NicotinamideAn ingredient found in a variety of cosmetic products.
DB04365ArecolineAn alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the...
DB04552Niflumic acidUsed in the treatment of rheumatoid arthritis.
DB05575MotesanibInvestigated for use/treatment in solid tumors.
DB06397NicaravenInvestigated for use/treatment in cerebrovascular disease (unspecified).
DB08840N-methylnicotinamideN-methylnicotinamide is an experimental drug with no approved indication.
DB09092XanthinolA vasodilatory niacin found in diet supplements.
DB09218ClonixinIndicated for use in the management of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation.
DB09220NicorandilIndicated for the prevention and treatment of chronic stable angina pectoris and reduction in the risk of acute coronary syndromes.
DB09237LevamlodipineA calcium channel blocker used to treat hypertension.
DB09285MorniflumateMorniflumate is indicated for the treatment of inflammatory conditions affecting the airways, ENT system, urogenital tract and bone and joint systems in adults. In Italy, morniflumate is also indicated for...
DB11518FlunixinFlunixin is a non-steroidal anti-inflammatory drug for use in pigs, cattle and horses. It exerts analgesic and antipyretic effects. This drug is often prepared for use in meglumine salt form....
DB11708PeficitinibPeficitinib has been used in trials studying the treatment and basic science of Psoriasis, Pharmacodynamics, Drug Interactions, Colitis, Ulcerative, and RHEUMATOID ARTHRITIS, among others.
DB12381MerestinibMerestinib has been used in trials studying the treatment of Cancer, Solid Tumor, Advanced cancer, ColoRectal Cancer, and Metastatic Cancer, among others.
DB12585OndelopranOndelopran has been used in trials studying the treatment of Alcohol Dependence.
DB12792BoscalidBoscalid has been investigated for the treatment of OSDI, Glaucoma, Staining, Schirmers, and Disease Severity, among others.
DB13407NifenazoneNot Annotated
DB13422NicofuranoseNot Annotated
DB13441NiceritrolNot Annotated
DB13655NikethamideNot Annotated
DB13687NiaprazineNiaprazine is a selective brain catecholamine depletor.
DB13744Piromidic acidNot Annotated
DB13823Pipemidic acidNot Annotated
DB13882Methyl nicotinateA methyl ester of niacin used to treat muscle and joint pain.
DB14529Chromium nicotinateA medication used to treat chromium deficiencies and associated symptoms and also in total parenteral nutrition.
DB14875AZD-4017AZD-4017 is under investigation in clinical trial NCT01173471 (A Phase IIa Study to Assess the Tolerability, Safety, and Efficacy of AZD4017 for Raised Intra-ocular Pressure).
DB14904PimasertibPimasertib is under investigation in clinical trial NCT01378377 (Combination Trial of Pimasertib (MSC1936369B) With Temsirolimus).
DB14933Nicotinamide ribosideNicotinamide riboside is under investigation in clinical trial NCT03432871 (Nicotinamide Riboside and Mitochondrial Biogenesis).
DB11710TrigonellamideTrigonellamide is under investigation in clinical trial NCT01930240 (The Safety of a Hypolipidemic Agent in Healthy Normal Volunteers).
DB11982GDC-0623GDC-0623 has been used in trials studying the treatment of Solid Cancers.
DB12597ABL-001ABL001 has been used in trials studying the health services research of Chronic Myelogenous Leukemia and Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia.
DrugDrug NameTargetType
DB00627NiacinHydroxycarboxylic acid receptor 2target
DB00627NiacinNicotinamide N-methyltransferasetarget
DB00627NiacinNicotinate-nucleotide pyrophosphorylase [carboxylating]target
DB00627NiacinHydroxycarboxylic acid receptor 3target
DB00627NiacinSolute carrier family 22 member 5transporter
DB00627NiacinSolute carrier organic anion transporter family member 2B1transporter
DB00627NiacinMonocarboxylate transporter 1transporter
DB00627NiacinCytochrome P450 2D6enzyme
DB00627NiacinSodium-coupled monocarboxylate transporter 1transporter
DB00627NiacinMonocarboxylate transporter 4transporter
DB00627NiacinThyroxine-binding globulincarrier
DB00627NiacinCytochrome P450 3A4enzyme
DB00627NiacinCytochrome P450 2E1enzyme
DB00393NimodipineCytochrome P450 3A4enzyme
DB00393NimodipineMineralocorticoid receptortarget
DB00393NimodipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB00393NimodipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB00393NimodipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00393NimodipineVoltage-dependent L-type calcium channel subunit beta-2target
DB00393NimodipineVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
DB00393NimodipineVoltage-dependent L-type calcium channel subunit beta-1target
DB00393NimodipineVoltage-dependent L-type calcium channel subunit beta-3target
DB00393NimodipineVoltage-dependent L-type calcium channel subunit beta-4target
DB00393NimodipineAryl hydrocarbon receptortarget
DB00398SorafenibSerine/threonine-protein kinase B-raftarget
DB00398SorafenibReceptor-type tyrosine-protein kinase FLT3target
DB00398SorafenibRAF proto-oncogene serine/threonine-protein kinasetarget
DB00398SorafenibVascular endothelial growth factor receptor 3target
DB00398SorafenibPlatelet-derived growth factor receptor betatarget
DB00398SorafenibMast/stem cell growth factor receptor Kittarget
DB00398SorafenibVascular endothelial growth factor receptor 2target
DB00398SorafenibCytochrome P450 3A4enzyme
DB00398SorafenibUDP-glucuronosyltransferase 1-9enzyme
DB00398SorafenibCytochrome P450 2B6enzyme
DB00398SorafenibCytochrome P450 2C8enzyme
DB00398SorafenibCytochrome P450 3A5enzyme
DB00398SorafenibCytochrome P450 3A7enzyme
DB00398SorafenibCytochrome P450 2C9enzyme
DB00398SorafenibMultidrug resistance-associated protein 4transporter
DB00398SorafenibP-glycoprotein 1transporter
DB00398SorafenibCanalicular multispecific organic anion transporter 1transporter
DB00398SorafenibATP-binding cassette sub-family G member 2transporter
DB00398SorafenibCytochrome P450 1A2enzyme
DB00398SorafenibCytochrome P450 2C19enzyme
DB00398SorafenibCytochrome P450 2D6enzyme
DB00398SorafenibUDP-glucuronosyltransferase 1-1enzyme
DB00398SorafenibRalA-binding protein 1transporter
DB00398SorafenibFibroblast growth factor receptor 1target
DB00398SorafenibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB00398SorafenibVascular endothelial growth factor receptor 1target
DB00398SorafenibSolute carrier organic anion transporter family member 1B1transporter
DB02701NicotinamideNAD-dependent protein deacylase sirtuin-5, mitochondrialtarget
DB02701NicotinamideADP-ribosyl cyclase 2target
DB02701NicotinamideExotoxin Atarget
DB02701NicotinamideL-lactate dehydrogenase A chaintarget
DB02701NicotinamidePoly [ADP-ribose] polymerase 1target
DB02701NicotinamideCytochrome P450 2D6enzyme
DB02701NicotinamideCytochrome P450 2E1enzyme
DB02701NicotinamideCytochrome P450 3A4enzyme
DB04365ArecolineMuscarinic acetylcholine receptor M1target
DB04365ArecolineMuscarinic acetylcholine receptor M3target
DB04552Niflumic acidPhospholipase A2target
DB04552Niflumic acidChloride channel protein ClC-Katarget
DB04552Niflumic acidMonocarboxylate transporter 2transporter
DB04552Niflumic acidMonocarboxylate transporter 1transporter
DB04552Niflumic acidProstaglandin G/H synthase 2target
DB04552Niflumic acidProstaglandin G/H synthase 1target
DB04552Niflumic acidCytosolic phospholipase A2target
DB04552Niflumic acidUDP-glucuronosyltransferase 1-9target
DB04552Niflumic acidUDP-glucuronosyltransferase 1-9enzyme
DB08840N-methylnicotinamideSolute carrier family 22 member 2transporter
DB08840N-methylnicotinamideMultidrug and toxin extrusion protein 1transporter
DB08840N-methylnicotinamideMultidrug and toxin extrusion protein 2transporter
DB08840N-methylnicotinamideAldehyde oxidaseenzyme
DB09092Xanthinol60S ribosomal protein L3target
DB09092XanthinolNAD(P) transhydrogenase, mitochondrialtarget
DB09092XanthinolGlyceraldehyde-3-phosphate dehydrogenasetarget
DB09092XanthinolIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrialtarget
DB09092Xanthinol2-oxoglutarate dehydrogenase, mitochondrialtarget
DB09092XanthinolMalate dehydrogenase, mitochondrialtarget
DB09220NicorandilATP-binding cassette sub-family C member 9target
DB09237LevamlodipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB09237LevamlodipineCytochrome P450 3A4enzyme
DB09237LevamlodipineNitric oxide synthase, endothelialtarget
DB09237LevamlodipineNitric oxide synthase, inducibletarget
DB09237LevamlodipineNitric oxide synthase, inducibleenzyme
DB09237LevamlodipineNitric oxide synthase, endothelialenzyme
DB09237LevamlodipineSerum albumincarrier
DB09237LevamlodipineP-glycoprotein 1transporter
DB09237LevamlodipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB09237LevamlodipineIleal sodium/bile acid cotransportertransporter
DB09237LevamlodipineSolute carrier family 22 member 5transporter
DB09285MorniflumateArachidonate 5-lipoxygenasetarget
DB09285MorniflumateProstaglandin G/H synthase 2target
DB09285MorniflumateArachidonate 5-lipoxygenaseenzyme
DB09285MorniflumateProstaglandin G/H synthase 2enzyme
DB09285MorniflumateLeukotriene B4 receptor 1target
DB09285MorniflumateThromboxane A2 receptortarget
DB09285MorniflumateUDP-glucuronosyltransferase 1-9enzyme
DB13823Pipemidic acidCytochrome P450 1A2enzyme
DB14529Chromium nicotinateSerotransferrincarrier
DB14529Chromium nicotinateCytochrome b5target