Pregnadienetriols

Doubly unsaturated pregnane derivatives substituted with three hydroxy groups anywhere within the ring structure or side chains.
DrugDrug NameDrug Description
DB00223DiflorasoneA topical corticosteroid used to treat the symptoms of various inflammatory skin conditions that cause erythema, pruritus, and discomfort.
DB00240AlclometasoneA topical corticosteroid used to relieve the symptoms of corticosteroid-responsive dermatoses.
DB00394Beclomethasone dipropionateAn inhaled corticosteroid used as maintenance treatment in the prophylaxis of asthma attacks.
DB00443BetamethasoneA systemic corticosteroid used to relieve inflammation in various conditions, including but not limited to allergic states, dermatologic disorders, gastrointestinal diseases, and hematological disorders.
DB00547DesoximetasoneA glucocorticoid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses.
DB00596UlobetasolA lipocortin corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses.
DB00663FlumethasoneA corticosteroid used to treat contact dermatitis, atopic dermatitis, eczema, psoriasis, diaper rash, and other skin conditions.
DB00860PrednisoloneA glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.
DB00959MethylprednisoloneA corticosteroid used to treat inflammation or immune reactions across a variety of organ systems, endocrine conditions, and neoplastic diseases.
DB01013Clobetasol propionateA corticosteroid used to treat corticosteroid-responsive dermatoses and plaque psoriasis.
DB01130PrednicarbateA medium potency topical corticosteroid used to manage pruritus and inflammation associated with responsive skin conditions.
DB01234DexamethasoneA glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders.
DB01260DesonideA topical corticosteroid used for the symptomatic treatment of inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.
DB01384ParamethasoneFor the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than hydrocortisone with supplementary...
DB05825NCX 1015Investigated for use/treatment in arthritis and arthritic pain and inflammatory bowel disease.
DB06781DifluprednateA topical corticosteroid used for the symptomatic treatment of inflammation and pain associated with ocular surgery.
DB09378FluprednisoloneA synthetic glucocorticoid with anti-inflammatory properties.
DB11487Dexamethasone isonicotinateDexamethasone isonicotinate is an anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, topically, and parenterally. Its unintended mineralocorticoid action may cause salt and water retention.
DB11522IsoflupredoneNot Annotated
DB11750ClobetasolClobetasol is under investigation for the treatment of Scleroderma. Clobetasol has been investigated for the prevention of Psoriasis and Cutaneous Atrophy Due to Corticosteroids.
DB12832PrednimustinePrednimustine has been used in trials studying the treatment of Lymphoma.
DB13158ClobetasoneA corticosteroid used to treat dry eyes, eczema, and dermatitis.
DB13208PrednylidenePrednylidene is an experimental systemic glucocorticoid.
DB13728HalometasoneNot Annotated
DB14221Beclomethasone 17-monopropionateAn ester of beclomethasone.
DB14631Prednisolone phosphateA corticosteroid used to treat inflammation, immune reactions, as well as endocrine or neoplastic conditions.
DB14632Prednisolone tebutateNot Annotated
DB14633Prednisolone hemisuccinateNot Annotated
DB14640Isoflupredone acetateNot Annotated
DB14643Methylprednisolone aceponateNot Annotated
DB14644Methylprednisolone hemisuccinateA water soluble corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders.
DB14649Dexamethasone acetateNot Annotated
DB14657Paramethasone acetateNot Annotated
DB14669Betamethasone phosphateNot Annotated
DB14703Dexamethasone metasulfobenzoateAn ophthalmic and auricular corticosteroid used with antibiotics for the treatment of otitis externa, blepharitis, and other inflammatory eye conditions.
DB15566Prednisolone acetateA glucocorticoid used to treat a wide variety of endocrine, inflammatory, and immune conditions as well as for palliation of neoplastic conditions.
DrugDrug NameTargetType
DB00223DiflorasoneGlucocorticoid receptortarget
DB00240AlclometasoneCorticosteroid-binding globulincarrier
DB00240AlclometasoneGlucocorticoid receptortarget
DB00240AlclometasoneCytochrome P450 3A4enzyme
DB00394Beclomethasone dipropionateCorticosteroid-binding globulincarrier
DB00394Beclomethasone dipropionateGlucocorticoid receptortarget
DB00394Beclomethasone dipropionateCytochrome P450 3A5enzyme
DB00394Beclomethasone dipropionateCytochrome P450 3A4enzyme
DB00394Beclomethasone dipropionateP-glycoprotein 1transporter
DB00394Beclomethasone dipropionateATP-binding cassette sub-family G member 2transporter
DB00394Beclomethasone dipropionateSolute carrier organic anion transporter family member 1B1transporter
DB00394Beclomethasone dipropionateSolute carrier organic anion transporter family member 1B3transporter
DB00443BetamethasoneGlucocorticoid receptortarget
DB00443BetamethasoneCytochrome P450 3A4enzyme
DB00443BetamethasoneP-glycoprotein 1transporter
DB00443BetamethasoneCytochrome P450 19A1enzyme
DB00443BetamethasoneCytochrome P450 3A5enzyme
DB00547DesoximetasoneGlucocorticoid receptortarget
DB00596UlobetasolCorticosteroid-binding globulincarrier
DB00596UlobetasolGlucocorticoid receptortarget
DB00663FlumethasoneCorticosteroid-binding globulincarrier
DB00663FlumethasoneGlucocorticoid receptortarget
DB00663FlumethasoneCytochrome P450 3A4enzyme
DB00860PrednisoloneCorticosteroid-binding globulincarrier
DB00860PrednisoloneCytochrome P450 3A4enzyme
DB00860PrednisoloneGlucocorticoid receptortarget
DB00860PrednisoloneSolute carrier organic anion transporter family member 1A2transporter
DB00860PrednisoloneP-glycoprotein 1transporter
DB00860PrednisoloneSerum albumincarrier
DB00959MethylprednisoloneGlucocorticoid receptortarget
DB00959MethylprednisoloneCytochrome P450 3A4enzyme
DB00959MethylprednisoloneP-glycoprotein 1transporter
DB00959MethylprednisoloneCytochrome P450 3A Subfamilyenzyme
DB00959MethylprednisoloneCytochrome P450 2A6enzyme
DB00959MethylprednisoloneCytochrome P450 1B1enzyme
DB00959MethylprednisoloneCytochrome P450 2B6enzyme
DB00959MethylprednisoloneCytochrome P450 2C8enzyme
DB00959MethylprednisoloneCytochrome P450 2C9enzyme
DB00959MethylprednisoloneCytochrome P450 2C19enzyme
DB00959MethylprednisoloneAnnexin A1target
DB00959Methylprednisolone20-ketosteroid reductase (20-hydroxysteroid dehydrogenase)enzyme
DB00959Methylprednisolone11beta-hydroxysteroid dehydrogenaseenzyme
DB00959MethylprednisoloneSerum albumincarrier
DB01013Clobetasol propionateGlucocorticoid receptortarget
DB01013Clobetasol propionateCytochrome P450 3A4enzyme
DB01013Clobetasol propionateCytochrome P450 3A5enzyme
DB01130PrednicarbateGlucocorticoid receptortarget
DB01130PrednicarbateCytochrome P450 3A4enzyme
DB01234DexamethasoneGlucocorticoid receptortarget
DB01234DexamethasoneAnnexin A1target
DB01234DexamethasoneNitric oxide synthase, inducibletarget
DB01234DexamethasoneNuclear receptor subfamily 0 group B member 1target
DB01234DexamethasoneCytochrome P450 3A4enzyme
DB01234DexamethasoneCytochrome P450 3A5enzyme
DB01234DexamethasoneCytochrome P450 3A7enzyme
DB01234DexamethasoneBile salt export pumptransporter
DB01234DexamethasoneP-glycoprotein 1transporter
DB01234DexamethasoneCanalicular multispecific organic anion transporter 1transporter
DB01234DexamethasoneSolute carrier organic anion transporter family member 1A2transporter
DB01234DexamethasoneATP-binding cassette sub-family G member 2transporter
DB01234DexamethasoneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DB01234DexamethasoneCytochrome P450 1A1enzyme
DB01234DexamethasoneCytochrome P450 2A6enzyme
DB01234DexamethasoneCytochrome P450 2B6enzyme
DB01234DexamethasoneCytochrome P450 2C19enzyme
DB01234DexamethasoneCytochrome P450 2C8enzyme
DB01234DexamethasoneCytochrome P450 2E1enzyme
DB01234DexamethasoneCytochrome P450 3A43enzyme
DB01234DexamethasoneCytochrome P450 4A11enzyme
DB01234DexamethasoneNuclear receptor subfamily 1 group I member 2target
DB01234DexamethasoneCytochrome P450 11B1, mitochondrialenzyme
DB01234DexamethasoneSerum albumincarrier
DB01234DexamethasoneCorticosteroid 11-beta-dehydrogenase isozyme 2enzyme
DB01234DexamethasoneCorticosteroid 11-beta-dehydrogenase isozyme 1enzyme
DB01234DexamethasoneSolute carrier family 22 member 8transporter
DB01260DesonideGlucocorticoid receptortarget
DB01260DesonideCytochrome P450 3A4enzyme
DB01384ParamethasoneCorticosteroid-binding globulincarrier
DB01384ParamethasoneGlucocorticoid receptortarget
DB01384ParamethasoneCytochrome P450 3A4enzyme
DB01384ParamethasoneCytochrome P450 3A5enzyme
DB06781DifluprednateGlucocorticoid receptortarget
DB06781DifluprednateCytochrome P450 3A4enzyme
DB09378FluprednisoloneCytochrome P450 3A4enzyme
DB11487Dexamethasone isonicotinateCytochrome P450 3A4enzyme
DB11487Dexamethasone isonicotinateCytochrome P450 3A5enzyme
DB11750ClobetasolCytochrome P450 3A4enzyme
DB11750ClobetasolCytochrome P450 3A5enzyme
DB13158ClobetasoneGlucocorticoid receptortarget
DB13158ClobetasoneCytochrome P450 3A4enzyme
DB13208PrednylideneCytochrome P450 3A4enzyme
DB13208PrednylideneCytochrome P450 3A5enzyme
DB13728HalometasoneCytochrome P450 3A4enzyme
DB13728HalometasoneCytochrome P450 3A5enzyme
DB14631Prednisolone phosphateCytochrome P450 3A4enzyme
DB14631Prednisolone phosphateCytochrome P450 3A5enzyme
DB14633Prednisolone hemisuccinateCytochrome P450 3A4enzyme
DB14633Prednisolone hemisuccinateCytochrome P450 3A5enzyme
DB14644Methylprednisolone hemisuccinateCytochrome P450 3A4enzyme
DB14644Methylprednisolone hemisuccinateCytochrome P450 3A5enzyme
DB14669Betamethasone phosphateCytochrome P450 3A4enzyme
DB14669Betamethasone phosphateCytochrome P450 3A5enzyme
DB15566Prednisolone acetateCorticosteroid-binding globulincarrier
DB15566Prednisolone acetateCytochrome P450 3A4enzyme
DB15566Prednisolone acetateGlucocorticoid receptortarget
DB15566Prednisolone acetateSolute carrier organic anion transporter family member 1A2transporter
DB15566Prednisolone acetateP-glycoprotein 1transporter
DB15566Prednisolone acetateSerum albumincarrier