Propylene Glycols

Derivatives of propylene glycol (1,2-propanediol). They are used as humectants and solvents in pharmaceutical preparations.
DrugDrug NameDrug Indication
DB00429Carboprost TromethamineFor aborting pregnancy between the 13th and 20th weeks of gestation as calculated from the first day of the last normal menstrual period and in the following conditions related to second trimester abortion: 1. Failure of expulsion of the fetus during the course of treatment by another method; 2. Premature rupture of membranes in intrauterine methods with loss of drug and insufficient or absent uterine activity; 3. Requirement of a repeat intrauterine instillation of drug for expulsion of the fetus; 4. Inadvertent or spontaneous rupture of membranes in the presence of a previable fetus and absence of adequate activity for expulsion. Also for the treatment of postpartum hemorrhage due to uterine atony which has not responded to conventional methods of management.
DB00446ChloramphenicolUsed in treatment of cholera, as it destroys the vibrios and decreases the diarrhea. It is effective against tetracycline-resistant vibrios. It is also used in eye drops or ointment to treat bacterial conjunctivitis.
DB00856ChlorphenesinUsed, along with rest and physical therapy, to treat injuries and other painful muscular conditions. Investigated for use in trigeminal neuralgia (tic douloureux), a neuropathic disorder characterized by severe facial pain. Was investigated as a modulator of histamine release.
DB01839Propylene glycolNot Available
DB03754TromethamineFor the prevention and correction of metabolic acidosis.
DB06154Pentaerythritol TetranitrateNot Available
DB06794LodoxamideIndicated in the treatment of the ocular disorders referred to by the terms vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis.
DB07492BROMAMPHENICOLNot Available
DB07565Chloramphenicol succinateNot Available
DB08621ThiamphenicolNot Available
DB08868FingolimodFingolimod is a sphingosine 1-phosphate receptor modulator indicated for the treatment of patients with relapsing forms of multiple sclerosis to reduce the frequency of clinical exacerbations and to delay the accumulation of physical disability.
DrugDrug NameTargetType
DB00429Carboprost TromethamineProstaglandin E2 receptor EP1 subtypetarget
DB00446ChloramphenicolComplement decay-accelerating factortarget
DB00446ChloramphenicolDr hemagglutinin structural subunittarget
DB00446ChloramphenicolCytochrome P450 2C19enzyme
DB00446ChloramphenicolCytochrome P450 3A4enzyme
DB00446ChloramphenicolCytochrome P450 3A5enzyme
DB00446ChloramphenicolCytochrome P450 3A7enzyme
DB00446ChloramphenicolSolute carrier family 22 member 6transporter
DB00446Chloramphenicol50S ribosomal protein L16target
DB00446ChloramphenicolChloramphenicol acetyltransferase 3enzyme
DB00446ChloramphenicolChloramphenicol acetyltransferaseenzyme
DB00446ChloramphenicolChloramphenicol 3-O phosphotransferaseenzyme
DB00446ChloramphenicolCytochrome P450 2C8enzyme
DB00446ChloramphenicolCytochrome P450 2C9enzyme
DB00856ChlorphenesinCYP2B proteinenzyme
DB00856ChlorphenesinCytochrome P450 19A1enzyme
DB00856ChlorphenesinCytochrome P450 3A4enzyme
DB00856ChlorphenesinXanthine dehydrogenase/oxidaseenzyme
DB00856ChlorphenesinProstaglandin G/H synthase 2enzyme
DB00856ChlorphenesinCholinesteraseenzyme
DB01839Propylene glycolCoagulation factor XIII A chaintarget
DB01839Propylene glycolHaloalkane dehalogenasetarget
DB01839Propylene glycolClavaminate synthase 1target
DB01839Propylene glycolLactaldehyde reductasetarget
DB01839Propylene glycolB12-independent glycerol dehydratasetarget
DB03754TromethamineCholera enterotoxin subunit Btarget
DB03754TromethamineS-adenosylmethionine decarboxylase proenzymetarget
DB03754TromethamineBiotin synthasetarget
DB03754TromethamineVascular endothelial growth factor Atarget
DB03754Tromethamine6-phosphogluconolactonasetarget
DB03754TromethamineDecorintarget
DB03754TromethamineAutolysintarget
DB03754TromethamineCytochrome c4target
DB03754TromethamineSoluble calcium-activated nucleotidase 1target
DB03754TromethamineLipoprotein NlpItarget
DB03754TromethamineDNA protection during starvation proteintarget
DB03754TromethaminePutative glucose-6-phosphate 1-epimerasetarget
DB03754TromethamineEndonuclease 8-like 1target
DB07492BROMAMPHENICOLDr hemagglutinin structural subunittarget
DB07565Chloramphenicol succinateDr hemagglutinin structural subunittarget
DB08621ThiamphenicolDr hemagglutinin structural subunittarget
DB08868FingolimodLeukotriene-B(4) omega-hydroxylase 1enzyme
DB08868FingolimodSphingosine 1-phosphate receptor 5target
DB08868FingolimodSphingosine kinase 1enzyme
DB08868FingolimodCytochrome P450 2D6enzyme
DB08868FingolimodCytochrome P450 2E1enzyme
DB08868FingolimodCytochrome P450 3A4enzyme
DB08868FingolimodCytochrome P450 4F12enzyme
DB08868FingolimodHistone deacetylase 1target