Quinazolines

DrugDrug NameDrug Description
DB00457PrazosinAn alpha-blocker that causes a decrease in total peripheral resistance and is used to treat hypertension.
DB00524MetolazoneA thiazide-like diuretic used to treat hypertension.
DB00530ErlotinibAn EGFR tyrosine kinase inhibitor used to treat certain small cell lung cancers or advanced metastatic pancreatic cancers.
DB00590DoxazosinAn alpha-1 adrenergic receptor used to treat mild to moderate hypertension and urinary obstruction due to benign prostatic hyperplasia.
DB01157TrimetrexateA folate antagonist used for the treatment of moderate-to-severe Pneumocystis carinii pneumonia (PCP) in immunocompromised patients as an alternative therapy in combination with leucovorin.
DB01162TerazosinAn alpha-1 adrenergic antagonist used in the treatment of symptomatic benign prostatic hyperplasia and management of hypertension.
DB04833MethaqualoneFor the treatment of insomnia, and as a sedative and muscle relaxant.
DB04866HalofuginoneFor the treatment of scleroderma, cancer, and restenosis.
DB05232TetrodotoxinFor the treatment of chronic and breakthrough pain in advanced cancer patients as well as for the treatment of opioid dependence.
DB06350ElinogrelInvestigated for use/treatment in cardiovascular disorders and myocardial infarction.
DB08882LinagliptinA dipeptidyl peptidase-4 (DPP-4) inhibitor used to manage hyperglycemia in patients with type 2 diabetes mellitus.
DB09054IdelalisibAn antineoplastic kinase inhibitor used to treat chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL).
DB11670SP-8203SP-8203 has been used in trials studying the treatment of Ischemic Stroke.
DB11910MK-0249MK0249 has been used in trials studying the treatment of Hypopnea Syndrome, Alzheimer's Disease, Paranoid Schizophrenia, Sleep Apnea, Obstructive, and Excessive Daytime Sleepiness, among others.
DB11963DacomitinibA medication used to treat non small cell lung cancer with EGFR exon 19 deletion of exon 21 L858R substitution.
DB12367SelurampanelSelurampanel has been investigated in Adrenocortical Adenoma and Sarcoma, Endometrial Stromal.
DB12465KetanserinKetanserin has been investigated for the treatment of Septic Shock, Severe Sepsis, and Diabetic Foot Ulcer.
DB12673ATX-914Axt914 is under investigation in clinical trial NCT00417261 (Safety, Tolerability, Pharmacodynamic and Pharmacokinetic Effects of Single and Multiple-Doses of ATF936 and AXT914 Administered Orally in Healthy Subjects.).
DB14857AvadomideAvadomide is under investigation in clinical trial NCT02031419 (Novel Combinations of CC-122, CC-223, CC-292, and Rituximab in Diffuse Large B-cell Lymphoma and Follicular Lymphoma).
DB00317GefitinibA tyrosine kinase inhibitor used as first-line therapy to treat non-small cell lung carcinoma (NSCLC) that meets certain genetic mutation criteria.
DB01259LapatinibAn antineoplastic agent and tyrosine kinase inhibitor used for the treatment of advanced or metastatic HER-negative breast cancer in patients who received prior chemotherapeutic treatments.
DB08916AfatinibAn antineoplastic agent used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) with non-resistant EGFR mutations or resistance to platinum-based chemotherapy.
DB12000ApabetaloneApabetalone has been investigated for the treatment of Diabetes, Atherosclerosis, and Coronary Artery Disease.
DrugDrug NameTargetType
DB00457PrazosinAlpha-1A adrenergic receptortarget
DB00457PrazosinAlpha-1B adrenergic receptortarget
DB00457PrazosinAlpha-1D adrenergic receptortarget
DB00457PrazosinPotassium voltage-gated channel subfamily H member 2target
DB00457PrazosinAlpha-1-acid glycoprotein 1carrier
DB00457PrazosinSolute carrier family 22 member 1transporter
DB00457PrazosinSolute carrier family 22 member 3transporter
DB00457PrazosinP-glycoprotein 1transporter
DB00457PrazosinATP-binding cassette sub-family G member 2transporter
DB00457PrazosinAlpha-2A adrenergic receptortarget
DB00457PrazosinAlpha-2B adrenergic receptortarget
DB00457PrazosinAlpha-1 adrenergic receptorstarget
DB00524MetolazoneSolute carrier family 12 member 3target
DB00530ErlotinibEpidermal growth factor receptortarget
DB00530ErlotinibCytochrome P450 3A4enzyme
DB00530ErlotinibATP-binding cassette sub-family G member 2transporter
DB00530ErlotinibP-glycoprotein 1transporter
DB00530ErlotinibNuclear receptor subfamily 1 group I member 2target
DB00530ErlotinibCytochrome P450 3A5enzyme
DB00530ErlotinibCytochrome P450 1A1enzyme
DB00530ErlotinibCytochrome P450 1A2enzyme
DB00530ErlotinibCytochrome P450 1B1enzyme
DB00530ErlotinibCytochrome P450 2D6enzyme
DB00530ErlotinibCytochrome P450 2C8enzyme
DB00530ErlotinibUDP-glucuronosyltransferase 1-1enzyme
DB00530ErlotinibSerum albumincarrier
DB00530ErlotinibAlpha-1-acid glycoprotein 1carrier
DB00530ErlotinibSolute carrier organic anion transporter family member 2B1transporter
DB00590DoxazosinAlpha-1A adrenergic receptortarget
DB00590DoxazosinAlpha-1D adrenergic receptortarget
DB00590DoxazosinHERG human cardiac K+ channeltarget
DB00590DoxazosinP-glycoprotein 1transporter
DB00590DoxazosinCytochrome P450 2C19enzyme
DB00590DoxazosinCytochrome P450 2D6enzyme
DB00590DoxazosinSolute carrier family 22 member 1transporter
DB00590DoxazosinCytochrome P450 3A4enzyme
DB00590DoxazosinAlpha-1B adrenergic receptortarget
DB00590DoxazosinCytochrome P450 2C9enzyme
DB01157TrimetrexateDihydrofolate reductasetarget
DB01162TerazosinAlpha-1A adrenergic receptortarget
DB01162TerazosinAlpha-1B adrenergic receptortarget
DB01162TerazosinAlpha-1D adrenergic receptortarget
DB01162TerazosinPotassium voltage-gated channel subfamily H member 2target
DB01162TerazosinPotassium voltage-gated channel subfamily H member 6target
DB01162TerazosinPotassium voltage-gated channel subfamily H member 7target
DB01162TerazosinP-glycoprotein 1transporter
DB01162TerazosinTransforming growth factor beta-1target
DB04833MethaqualoneCytochrome P450 3A4enzyme
DB04866HalofuginoneCollagen alpha-1(I) chaintarget
DB04866Halofuginone72 kDa type IV collagenasetarget
DB05232TetrodotoxinSodium channel protein type 1 subunit alphatarget
DB05232TetrodotoxinSodium channel protein type 2 subunit alphatarget
DB05232TetrodotoxinSodium channel protein type 3 subunit alphatarget
DB05232TetrodotoxinSodium channel protein type 8 subunit alphatarget
DB06350ElinogrelP2Y purinoceptor 12target
DB08882LinagliptinDipeptidyl peptidase 4target
DB08882LinagliptinCytochrome P450 3A4enzyme
DB08882LinagliptinP-glycoprotein 1transporter
DB08882LinagliptinSolute carrier family 22 member 1transporter
DB08882LinagliptinSolute carrier family 22 member 2transporter
DB08882LinagliptinSolute carrier family 22 member 3transporter
DB09054IdelalisibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
DB09054IdelalisibATP-binding cassette sub-family G member 2transporter
DB09054IdelalisibP-glycoprotein 1transporter
DB09054IdelalisibAldehyde oxidaseenzyme
DB09054IdelalisibUDP-glucuronosyltransferase 1-4enzyme
DB09054IdelalisibUDP-glucuronosyltransferase 1-4enzyme
DB09054IdelalisibCytochrome P450 2C8enzyme
DB09054IdelalisibCytochrome P450 2C19enzyme
DB09054IdelalisibCytochrome P450 2B6enzyme
DB09054IdelalisibCytochrome P450 3A4enzyme
DB09054IdelalisibSolute carrier organic anion transporter family member 1B1transporter
DB09054IdelalisibSolute carrier organic anion transporter family member 1B3transporter
DB09054IdelalisibCytochrome P450 3A5enzyme
DB09054IdelalisibCytochrome P450 3A43enzyme
DB09054IdelalisibCytochrome P450 3A7enzyme
DB11963DacomitinibCytochrome P450 2D6enzyme
DB11963DacomitinibSerum albumincarrier
DB11963DacomitinibCytochrome P450 3A4enzyme
DB11963DacomitinibCytochrome P450 2C9enzyme
DB11963DacomitinibUDP-glucuronosyltransferase 1-1enzyme
DB11963DacomitinibP-glycoprotein 1transporter
DB11963DacomitinibATP-binding cassette sub-family G member 2transporter
DB11963DacomitinibSolute carrier family 22 member 1transporter
DB11963DacomitinibEpidermal growth factor receptortarget
DB12465Ketanserin5-hydroxytryptamine receptor 2Atarget
DB00317GefitinibEpidermal growth factor receptortarget
DB00317GefitinibCytochrome P450 3A4enzyme
DB00317GefitinibCytochrome P450 2D6enzyme
DB00317GefitinibP-glycoprotein 1transporter
DB00317GefitinibATP-binding cassette sub-family G member 2transporter
DB00317GefitinibCytochrome P450 3A5enzyme
DB00317GefitinibCytochrome P450 1A1enzyme
DB00317GefitinibCytochrome P450 2C9enzyme
DB00317GefitinibCytochrome P450 2C19enzyme
DB00317GefitinibSerum albumincarrier
DB00317GefitinibAlpha-1-acid glycoprotein 1carrier
DB01259LapatinibEpidermal growth factor receptortarget
DB01259LapatinibReceptor tyrosine-protein kinase erbB-2target
DB01259LapatinibCytochrome P450 3A4enzyme
DB01259LapatinibCytochrome P450 2C8enzyme
DB01259LapatinibP-glycoprotein 1transporter
DB01259LapatinibAntigen peptide transporter 1transporter
DB01259LapatinibCytochrome P450 3A5enzyme
DB01259LapatinibCytochrome P450 2C19enzyme
DB08916AfatinibEpidermal growth factor receptortarget
DB08916AfatinibReceptor tyrosine-protein kinase erbB-2target
DB08916AfatinibReceptor tyrosine-protein kinase erbB-4target
DB08916AfatinibP-glycoprotein 1transporter
DB08916AfatinibATP-binding cassette sub-family G member 2transporter