Selective Cyclooxygenase 2 Inhibitors (NSAIDs)

Name
Selective Cyclooxygenase 2 Inhibitors (NSAIDs)
Accession Number
DBCAT000887  (DBCAT003694)
Description

A subclass of cyclooxygenase inhibitors with specificity for CYCLOOXYGENASE-2.

Drugs
DrugDrug Description
RofecoxibA COX-2 inhibitor NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, primary dysmenorrhea, and migraine attacks.
ValdecoxibA COX-2 inhibitor used to treat osteoarthritis and dysmenorrhoea.
LumiracoxibFor the acute and chronic treatment of the signs and symptoms of osteoarthritis of the knee in adults.
EtoricoxibFor the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout.
ParecoxibA selective COX-2 inhibitor and NSAID used for the short-term management of perioperative pain.
NabumetoneAn NSAID used to treat osteoarthritis and rheumatoid arthritis.
CelecoxibAn NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis.
EtodolacAn NSAID used to treat osteoarthritis and rheumatoid arthritis, as well as acute pain.
RobenacoxibRobenacoxib is a non-steroidal anti-inflammatory drug used in veterinary medicine for the relief of pain and inflammation in cats and dogs.
CarprofenFor use as a pain reliever in the treatment of joint pain and post-surgical pain.
MeloxicamAn NSAID used to treat osteoarthritis in adults, rheumatoid arthritis in adults, and juvenile rheumatoid arthritis in pediatrics.
BromfenacAn NSAID used to treat postoperative pain and inflammation of the eye.
NimesulideFor the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.
NepafenacAn ophthalmic NSAID used for the symptomatic treatment of pain and inflammation associated with cataract surgery.
Niflumic acidUsed in the treatment of rheumatoid arthritis.
CimicoxibInvestigated for use/treatment in depression.
AceclofenacAceclofenac is indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.
FirocoxibUsed for the treatment of pain inflammation and fever in horses and dogs.
TalniflumateTalnifumate is a phthalidyl ester of nifumic acid, which has potent analgesic and anti-inflammatory effects and is widely used to treat inflammatory disorders, such as rheumatoid arthritis and osteoarthritis ,...
PolmacoxibPolmacoxib has been used in trials studying the treatment of Osteoarthritis, Osteoarthritis, Hip, Osteoarthritis, Knee, Localized Primary Osteoarthritis of Hip, and Localized Primary Osteoarthritis of Knee.
Drugs & Drug Targets
DrugTargetType
RofecoxibProstaglandin G/H synthase 2target
RofecoxibElastintarget
RofecoxibCytochrome P450 3A4enzyme
RofecoxibCytochrome P450 1A2enzyme
RofecoxibMultidrug resistance-associated protein 4transporter
RofecoxibProstaglandin G/H synthase 1enzyme
RofecoxibCytochrome P450 2C8enzyme
RofecoxibCytochrome P450 2C9enzyme
ValdecoxibProstaglandin G/H synthase 2target
ValdecoxibCytochrome P450 2C9enzyme
ValdecoxibCytochrome P450 3A4enzyme
ValdecoxibUDP-glucuronosyltransferase 1-9enzyme
ValdecoxibCarbonic anhydrase 2target
ValdecoxibCarbonic anhydrase 3target
LumiracoxibProstaglandin G/H synthase 2target
LumiracoxibProstaglandin G/H synthase 1target
LumiracoxibCytochrome P450 2C9enzyme
LumiracoxibCytochrome P450 2C19enzyme
LumiracoxibUDP-glucuronosyltransferase 1-9enzyme
LumiracoxibCytochrome P450 1A2enzyme
EtoricoxibProstaglandin G/H synthase 2target
EtoricoxibCytochrome P450 3A4enzyme
EtoricoxibCytochrome P450 2C9enzyme
EtoricoxibCytochrome P450 2D6enzyme
EtoricoxibCytochrome P450 1A2enzyme
EtoricoxibCytochrome P450 2C19enzyme
EtoricoxibCytochrome P450 2E1enzyme
ParecoxibLactotransferrintarget
ParecoxibProstaglandin G/H synthase 2target
ParecoxibCytochrome P450 3A4enzyme
ParecoxibCytochrome P450 2C9enzyme
NabumetoneProstaglandin G/H synthase 1target
NabumetoneProstaglandin G/H synthase 2target
NabumetoneMyeloperoxidaseenzyme
NabumetoneCytochrome P450 1A2enzyme
NabumetoneCytochrome P450 2C9enzyme
NabumetoneCorticosteroid 11-beta-dehydrogenase isozyme 1enzyme
NabumetoneAldo-keto reductase family 1 member C1enzyme
NabumetoneAldo-keto reductase family 1 member C2enzyme
NabumetoneAldo-keto reductase family 1 member C4enzyme
NabumetoneSerum albumincarrier
CelecoxibProstaglandin G/H synthase 2target
Celecoxib3-phosphoinositide-dependent protein kinase 1target
CelecoxibCytochrome P450 2C9enzyme
CelecoxibCytochrome P450 2D6enzyme
CelecoxibMultidrug resistance-associated protein 4transporter
CelecoxibCytochrome P450 3A4enzyme
CelecoxibCytochrome P450 2C8enzyme
CelecoxibCarbonic anhydrase 2target
CelecoxibCarbonic anhydrase 3target
CelecoxibBile salt export pumptransporter
CelecoxibCadherin-11target
CelecoxibP-glycoprotein 1transporter
CelecoxibATP-binding cassette sub-family G member 2transporter
EtodolacProstaglandin G/H synthase 1target
EtodolacProstaglandin G/H synthase 2target
EtodolacCytochrome P450 2C9enzyme
EtodolacUDP-glucuronosyltransferase 1-9enzyme
EtodolacRetinoic acid receptor RXR-alphatarget
EtodolacSerum albumincarrier
EtodolacSolute carrier family 22 member 6transporter
EtodolacUDP-glucuronosyltransferase 1-3enzyme
EtodolacUDP-glucuronosyltransferase 1-10enzyme
EtodolacUDP-glucuronosyltransferase 2B7enzyme
RobenacoxibCyclooxygenase 2target
CarprofenProstaglandin G/H synthase 2target
CarprofenProstaglandin G/H synthase 1target
CarprofenSolute carrier family 22 member 6transporter
MeloxicamProstaglandin G/H synthase 2target
MeloxicamCytochrome P450 2C9enzyme
MeloxicamProstaglandin G/H synthase 1target
MeloxicamCytochrome P450 3A4enzyme
MeloxicamMultidrug resistance-associated protein 4transporter
Meloxicam6-phosphogluconate dehydrogenase, decarboxylatingenzyme
MeloxicamCytochrome P450 2C8enzyme
MeloxicamSerum albumincarrier
MeloxicamHuman vesicular glutamate transporterstransporter
BromfenacProstaglandin G/H synthase 1target
BromfenacProstaglandin G/H synthase 2target
BromfenacProstaglandin G/H synthase 2enzyme
NimesulideProstaglandin G/H synthase 2target
NimesulideGroup IIE secretory phospholipase A2target
NimesulideLactotransferrintarget
NimesulideCytochrome P450 3A4enzyme
NepafenacProstaglandin G/H synthase 1target
NepafenacProstaglandin G/H synthase 2target
Niflumic acidPhospholipase A2target
Niflumic acidChloride channel protein ClC-Katarget
Niflumic acidMonocarboxylate transporter 2transporter
Niflumic acidMonocarboxylate transporter 1transporter
Niflumic acidProstaglandin G/H synthase 2target
Niflumic acidProstaglandin G/H synthase 1target
Niflumic acidCytosolic phospholipase A2target
Niflumic acidUDP-glucuronosyltransferase 1-9target
Niflumic acidUDP-glucuronosyltransferase 1-9enzyme
CimicoxibProstaglandin G/H synthase 2target
CimicoxibProstaglandin G/H synthase 2enzyme
AceclofenacCytochrome P450 2C9enzyme
AceclofenacProstaglandin G/H synthase 2target
AceclofenacProstaglandin G/H synthase 1target
FirocoxibProstaglandin G/H synthase 2target
TalniflumateProstaglandin G/H synthase 1target
TalniflumateProstaglandin G/H synthase 2target
TalniflumateChloride channel protein ClC-Katarget
TalniflumateProstaglandin G/H synthase 1enzyme
TalniflumateProstaglandin G/H synthase 2enzyme