Selective Cyclooxygenase 2 Inhibitors (NSAIDs)

A subclass of cyclooxygenase inhibitors with specificity for CYCLOOXYGENASE-2.
DrugDrug NameDrug Indication
DB00533RofecoxibFor the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras.
DB00580ValdecoxibFor the treatment of osteoarthritis and dysmenorrhoea
DB01283LumiracoxibFor the acute and chronic treatment of the signs and symptoms of osteoarthritis of the knee in adults.
DB01628EtoricoxibFor the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout.
DB08439ParecoxibUsed for short term perioperative pain control.
DB00461Nabumetone**Indicated** for:[label] 1) Symptomatic relief in rheumatoid arthritis. 2) Symptomatic relief in osteoarthritis.
DB00482CelecoxibFor the relief and management of osteoarthritis (OA), rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), ankylosing spondylitis, acute pain, primary dysmenorrhea and oral adjunct to usual care for patients with familial adenomatous polyposis [FDA label].
DB00749EtodolacFor acute and long-term management of signs and symptoms of osteoarthritis and rheumatoid arthritis, as well as for the management of pain.
DB11455RobenacoxibNot Available
DB00821CarprofenFor use as a pain reliever in the treatment of joint pain and post-surgical pain.
DB00814MeloxicamFor symptomatic treatment of arthritis and osteoarthritis.
DB00963BromfenacFor the treatment of postoperative inflammation in patients who have undergone cataract extraction.
DB04743NimesulideFor the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.
DB06802NepafenacFor the treatment of pain and inflammation associated with cataract surgery.
DB04552Niflumic acidUsed in the treatment of rheumatoid arthritis.
DB05095CimicoxibInvestigated for use/treatment in depression.
DB06736AceclofenacAceclofenac is indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.
DB09217FirocoxibUsed for the treatment of pain inflammation and fever in horses and dogs.
DB09295TalniflumateTalnifumate is a phthalidyl ester of nifumic acid, which has potent analgesic and anti-inflammatory effects and is widely used to treat inflammatory disorders, such as rheumatoid arthritis and osteoarthritis [L1409], and has also been studied for the management of cystic fibrosis [L1403].
DB12399PolmacoxibNot Available
DrugDrug NameTargetType
DB00533RofecoxibProstaglandin G/H synthase 2target
DB00533RofecoxibElastintarget
DB00533RofecoxibCytochrome P450 3A4enzyme
DB00533RofecoxibCytochrome P450 1A2enzyme
DB00533RofecoxibMultidrug resistance-associated protein 4transporter
DB00533RofecoxibProstaglandin G/H synthase 1enzyme
DB00533RofecoxibCytochrome P450 2C8enzyme
DB00533RofecoxibCytochrome P450 2C9enzyme
DB00580ValdecoxibProstaglandin G/H synthase 2target
DB00580ValdecoxibCytochrome P450 2C9enzyme
DB00580ValdecoxibCytochrome P450 3A4enzyme
DB00580ValdecoxibUDP-glucuronosyltransferase 1-9enzyme
DB00580ValdecoxibCarbonic anhydrase 2target
DB00580ValdecoxibCarbonic anhydrase 3target
DB01283LumiracoxibProstaglandin G/H synthase 2target
DB01283LumiracoxibProstaglandin G/H synthase 1target
DB01283LumiracoxibCytochrome P450 2C9enzyme
DB01283LumiracoxibCytochrome P450 2C19enzyme
DB01283LumiracoxibUDP-glucuronosyltransferase 1-9enzyme
DB01283LumiracoxibCytochrome P450 1A2enzyme
DB01628EtoricoxibProstaglandin G/H synthase 2target
DB01628EtoricoxibCytochrome P450 3A4enzyme
DB01628EtoricoxibCytochrome P450 2C9enzyme
DB01628EtoricoxibCytochrome P450 2D6enzyme
DB01628EtoricoxibCytochrome P450 1A2enzyme
DB01628EtoricoxibCytochrome P450 2C19enzyme
DB01628EtoricoxibCytochrome P450 2E1enzyme
DB08439ParecoxibLactotransferrintarget
DB08439ParecoxibProstaglandin G/H synthase 2target
DB08439ParecoxibCytochrome P450 3A4enzyme
DB08439ParecoxibCytochrome P450 2C9enzyme
DB00461NabumetoneProstaglandin G/H synthase 1target
DB00461NabumetoneProstaglandin G/H synthase 2target
DB00461NabumetoneMyeloperoxidaseenzyme
DB00461NabumetoneCytochrome P450 1A2enzyme
DB00461NabumetoneCytochrome P450 2C9enzyme
DB00461NabumetoneCorticosteroid 11-beta-dehydrogenase isozyme 1enzyme
DB00461NabumetoneAldo-keto reductase family 1 member C1enzyme
DB00461NabumetoneAldo-keto reductase family 1 member C3enzyme
DB00461NabumetoneAldo-keto reductase family 1 member C4enzyme
DB00461NabumetoneSerum albumincarrier
DB00482CelecoxibProstaglandin G/H synthase 2target
DB00482Celecoxib3-phosphoinositide-dependent protein kinase 1target
DB00482CelecoxibCytochrome P450 2C9enzyme
DB00482CelecoxibCytochrome P450 2D6enzyme
DB00482CelecoxibMultidrug resistance-associated protein 4transporter
DB00482CelecoxibCytochrome P450 3A4enzyme
DB00482CelecoxibCytochrome P450 2C8enzyme
DB00482CelecoxibCarbonic anhydrase 2target
DB00482CelecoxibCarbonic anhydrase 3target
DB00482CelecoxibATP-binding cassette sub-family B member 5target
DB00482CelecoxibATP-binding cassette sub-family G member 2target
DB00482CelecoxibMultidrug resistance protein 1target
DB00482CelecoxibBile salt export pumptransporter
DB00749EtodolacProstaglandin G/H synthase 1target
DB00749EtodolacProstaglandin G/H synthase 2target
DB00749EtodolacCytochrome P450 2C9enzyme
DB00749EtodolacUDP-glucuronosyltransferase 1-9enzyme
DB00749EtodolacRetinoic acid receptor RXR-alphatarget
DB00749EtodolacSerum albumincarrier
DB00749EtodolacSolute carrier family 22 member 6transporter
DB00749EtodolacUDP-glucuronosyltransferase 1-3enzyme
DB00749EtodolacUDP-glucuronosyltransferase 1-10enzyme
DB00749EtodolacUDP-glucuronosyltransferase 2B7enzyme
DB11455RobenacoxibCyclooxygenase 2target
DB00821CarprofenProstaglandin G/H synthase 2target
DB00821CarprofenProstaglandin G/H synthase 1target
DB00821CarprofenSolute carrier family 22 member 6transporter
DB00814MeloxicamProstaglandin G/H synthase 2target
DB00814MeloxicamCytochrome P450 2C9enzyme
DB00814MeloxicamProstaglandin G/H synthase 1target
DB00814MeloxicamCytochrome P450 3A4enzyme
DB00814MeloxicamMultidrug resistance-associated protein 4transporter
DB00814Meloxicam6-phosphogluconate dehydrogenase, decarboxylatingenzyme
DB00814MeloxicamCytochrome P450 2C8enzyme
DB00963BromfenacProstaglandin G/H synthase 1target
DB00963BromfenacProstaglandin G/H synthase 2target
DB00963BromfenacProstaglandin G/H synthase 2enzyme
DB04743NimesulideProstaglandin G/H synthase 2target
DB04743NimesulideGroup IIE secretory phospholipase A2target
DB04743NimesulideLactotransferrintarget
DB04743NimesulideCytochrome P450 3A4enzyme
DB06802NepafenacProstaglandin G/H synthase 1target
DB06802NepafenacProstaglandin G/H synthase 2target
DB04552Niflumic acidPhospholipase A2target
DB04552Niflumic acidChloride channel protein ClC-Katarget
DB04552Niflumic acidMonocarboxylate transporter 2transporter
DB04552Niflumic acidMonocarboxylate transporter 1transporter
DB04552Niflumic acidProstaglandin G/H synthase 2target
DB04552Niflumic acidProstaglandin G/H synthase 1target
DB04552Niflumic acidCytosolic phospholipase A2target
DB04552Niflumic acidUDP-glucuronosyltransferase 1-9target
DB04552Niflumic acidUDP-glucuronosyltransferase 1-9enzyme
DB05095CimicoxibProstaglandin G/H synthase 2target
DB05095CimicoxibProstaglandin G/H synthase 2enzyme
DB06736AceclofenacCytochrome P450 2C9enzyme
DB06736AceclofenacProstaglandin G/H synthase 2target
DB06736AceclofenacProstaglandin G/H synthase 1target
DB09217FirocoxibProstaglandin G/H synthase 2target
DB09295TalniflumateProstaglandin G/H synthase 1target
DB09295TalniflumateProstaglandin G/H synthase 2target
DB09295TalniflumateChloride channel protein ClC-Katarget
DB09295TalniflumateProstaglandin G/H synthase 1enzyme
DB09295TalniflumateProstaglandin G/H synthase 2enzyme