Agents counteracting or neutralizing the action of POISONS.
DrugDrug NameDrug Description
DB00733PralidoximeA cholinesterase reactivator used to treat organophosphate poisoning.
DB01205FlumazenilA benzodiazepine antagonist that is used for the complete or partial reversal of the sedative effects caused by benzodiazepines in various clinical settings, such as induced general anesthesia for diagnostic and therapeutic procedures.
DB01213FomepizoleAn inhibitor of alcohol dehydrogenase used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning.
DB06783Prussian blueA chelating agent used to reduce the extent of systemic contamination with radioactive cesium and/or radioactive or non-radioactive thallium.
DB06778Cupric sulfateA compound used as an intravenous copper supplement for Total Parenteral Nutrition (TPN).
DB135494-dimethylaminophenolNot Annotated
DB00650LeucovorinA folate analog used to treat the toxic effects of methotrexate and other folate antagonists, to treat megaloblastic anemia, and to provide palliative treatment of colorectal cancer.
DB00076Digoxin Immune Fab (Ovine)An antibody binding fragment which binds digoxin molecules which is used as an antidote to digoxin overdose.
DB06206SugammadexA modified gamma cyclodextrin used to reverse neuromuscular blockade induced by vecuronium bromide and rocuronium bromide which are agents used for anesthesia.
DB09112Nitrous acidAn iron binder used to reverse life-threatening acute cyanide poisoning.
DB00200HydroxocobalaminA synthetic form of vitamin B12 used to treat vitamin B12 associated disorders and cyanide poisoning.
DB06151AcetylcysteineA medication that can be used as a mucolytic in patients with certain lung conditions and as an antidote for acetaminophen overdose.
DB09499Thiosulfuric acidA sulfur donor used for sequential use with sodium nitrite for the reversal of acute cyanide poisoning that is judged to be life-threatening.
DB00466PicrotoxinUsed internally for relieving respiratory distress. Also for use as an antidote in poisoning by CNS depressants, especially barbiturates.
DB00566SuccimerA mercaptodicarboxylic acid heavy metal chelator used in the treatment of heavy metal poisoning.
DB00859PenicillamineA chelator used to treat Wilson's disease, cystinuria, and rheumatoid arthritis.
DB01010EdrophoniumA cholinesterase inhibitor used to diagnose and evaluate myasthenia gravis.
DB01574AttapulgiteA veterinary antidiarrheal agent used to treat non-infectious diarrhea in animals.
DB05779OglufanideInvestigated for use/treatment in hepatitis (viral, C).
DB08690UBIQUINONE-2Not Available
DB09278Activated charcoalA gastric decontamination agent used in emergency clinical settings as a antidote to treat poisonings following excessive oral ingestion of certain medications or poisons.
DB11306BentoniteNot Annotated
DB11596LevoleucovorinA folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer.
DB13654MontmorilloniteNot Annotated
DB14007Pentetic acidDTPA is widely used in industry and medicine. As a medical agent, it is approved for its use in medical imaging and for the decorporation of internally deposited radionuclides. It...
DB00134MethionineAn amino acid commonly found as a component in total parenteral nutrition.
DB00143GlutathioneFor nutritional supplementation, also for treating dietary shortage or imbalance
DB00981PhysostigmineA cholinesterase inhibitor used to treat glaucoma and anticholinergic toxicity.
DB01183NaloxoneAn opioid receptor antagonist used to rapidly reverse an opioid overdose. Also included in some drug formulations as an abuse deterrent to prevent injection.
DB01612Amyl NitriteA fast acting vasodilator used for rapid relief of angina pectoris.
DB06782DimercaprolA chelating agent used as an antidote to arsenic, gold, and mercury poisoning, as well as acute lead poisoning in combination with edetate calcium disodium.
DB09264IdarucizumabAn antibody that binds dabigatran for the reversal of anticoagulant effects of dabigatran.
DB11490NalorphineUsed to reverse opioid overdose.
DB13700ProtamineNot Annotated
DB13750ObidoximeNot Annotated
DB09241Methylene blueAn oxidation-reduction agent used for the treatment of pediatric and adult patients with acquired methemoglobinemia.
DB00692PhentolamineAn alpha adrenergic antagonist used to reverse soft tissue anesthesia.
DB00860PrednisoloneA glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.
DB00898EthanolFor therapeutic neurolysis of nerves or ganglia for the relief of intractable chronic pain in such conditions as inoperable cancer and trigeminal neuralgia (tic douloureux), in patients for whom neurosurgical...
DB01069PromethazineA first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness.
DB06715Potassium IodideAn oral antithyroid agent used for the prevention of radioactive iodine uptake into the thyroid gland during a nuclear radiation emergency.
DB13293IpecacAn emetic agent used to induce vomiting in poisoning.
DB13831Potassium permanganateNot Annotated
DB14562Andexanet alfaA recombinant Factor Xa used to reverse anticoagulation caused by rivaroxaban and apixaban.
DrugDrug NameTargetType
DB00733PralidoximeAcetylcholinesterasetarget
DB00733PralidoximeCholinesterasetarget
DB01205FlumazenilGamma-aminobutyric acid receptor subunit alpha-1target
DB01205FlumazenilGamma-aminobutyric acid receptor subunit gamma-2target
DB01205FlumazenilGamma-aminobutyric acid receptor subunit alpha-5target
DB01205FlumazenilGABA-A receptor (anion channel)target
DB01213FomepizoleAlcohol dehydrogenase 1Atarget
DB01213FomepizoleAlcohol dehydrogenase 1Btarget
DB01213FomepizoleAlcohol dehydrogenase 1Ctarget
DB01213FomepizoleCatalasetarget
DB01213FomepizoleCytochrome P450 2E1enzyme
DB01213FomepizoleCytochrome P450 2A6enzyme
DB06778Cupric sulfateSerum albumintransporter
DB06778Cupric sulfateCeruloplasmintransporter
DB06778Cupric sulfatePhenylalanine-4-hydroxylaseenzyme
DB06778Cupric sulfateProtein-lysine 6-oxidaseenzyme
DB06778Cupric sulfateCytochrome c oxidase subunit 1enzyme
DB00650LeucovorinSolute carrier family 22 member 8transporter
DB00076Digoxin Immune Fab (Ovine)Digoxintarget
DB09112Nitrous acidHemoglobin subunit alphatarget
DB09112Nitrous acidHemoglobin subunit betatarget
DB09112Nitrous acidMyoglobintarget
DB00200HydroxocobalaminMethylmalonic aciduria type A protein, mitochondrialtarget
DB00200HydroxocobalaminProtein amnionlesstarget
DB00200HydroxocobalaminTranscobalamin-1target
DB00200HydroxocobalaminMethylmalonyl-CoA mutase, mitochondrialtarget
DB00200HydroxocobalaminMethionine synthase reductasetarget
DB00200HydroxocobalaminCob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrialtarget
DB00200HydroxocobalaminMethionine synthasetarget
DB00200HydroxocobalaminCubilintarget
DB00200HydroxocobalaminMethylmalonic aciduria and homocystinuria type C proteintarget
DB00200HydroxocobalaminTranscobalamin-2carrier
DB06151AcetylcysteineSolute carrier organic anion transporter family member 1B1transporter
DB06151AcetylcysteineNAPQI (N-acetyl-p-benzoquinone imine)target
DB06151AcetylcysteineSolute carrier family 22 member 6transporter
DB06151AcetylcysteineAminoacylase-1target
DB06151AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit alphatarget
DB06151AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB06151AcetylcysteineGlutathione synthetasetarget
DB06151AcetylcysteineCystine/glutamate transportertarget
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 2Btarget
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 1target
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 2Atarget
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 2Dtarget
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 3Atarget
DB09499Thiosulfuric acidThiosulfate sulfurtransferaseenzyme
DB00466PicrotoxinGamma-aminobutyric acid receptor subunit rho-1target
DB00466PicrotoxinGamma-aminobutyric acid receptor subunit alpha-1target
DB00466PicrotoxinGlycine receptor subunit alpha-2target
DB00466PicrotoxinGlycine receptor subunit alpha-3target
DB00466PicrotoxinCytochrome P450 1A1enzyme
DB00466PicrotoxinGlutamine synthetaseenzyme
DB00466PicrotoxinGlycine receptor subunit alpha-1target
DB00566SuccimerLeadtarget
DB00566SuccimerMercurytarget
DB00566SuccimerCadmiumtarget
DB00566SuccimerArsenictarget
DB00859PenicillamineSolute carrier organic anion transporter family member 1B1transporter
DB00859PenicillamineCoppertarget
DB01010EdrophoniumAcetylcholinesterasetarget
DB01010EdrophoniumCholinesterasetarget
DB08690UBIQUINONE-2Succinate dehydrogenase flavoprotein subunittarget
DB08690UBIQUINONE-2Succinate dehydrogenase iron-sulfur subunittarget
DB08690UBIQUINONE-2Succinate dehydrogenase cytochrome b556 subunittarget
DB08690UBIQUINONE-2Succinate dehydrogenase hydrophobic membrane anchor subunittarget
DB08690UBIQUINONE-2Cytochrome c1, heme protein, mitochondrialtarget
DB08690UBIQUINONE-2Cytochrome btarget
DB08690UBIQUINONE-2Cytochrome b-c1 complex subunit 1, mitochondrialtarget
DB08690UBIQUINONE-2Cytochrome b-c1 complex subunit 2, mitochondrialtarget
DB08690UBIQUINONE-2Cytochrome b-c1 complex subunit 6, mitochondrialtarget
DB08690UBIQUINONE-2Cytochrome b-c1 complex subunit 8target
DB08690UBIQUINONE-2Cytochrome b-c1 complex subunit Rieske, mitochondrialtarget
DB08690UBIQUINONE-2Cytochrome b-c1 complex subunit 10target
DB08690UBIQUINONE-2Cytochrome b-c1 complex subunit 7target
DB08690UBIQUINONE-2Cytochrome b-c1 complex subunit 9target
DB08690UBIQUINONE-2Photosynthetic reaction center cytochrome c subunittarget
DB08690UBIQUINONE-2Reaction center protein H chaintarget
DB08690UBIQUINONE-2Reaction center protein L chaintarget
DB08690UBIQUINONE-2Reaction center protein M chaintarget
DB08690UBIQUINONE-2Disulfide bond formation protein Btarget
DB08690UBIQUINONE-2Cytochrome btarget
DB08690UBIQUINONE-2Ubiquinol-cytochrome c reductase iron-sulfur subunittarget
DB08690UBIQUINONE-2Cytochrome c1target
DB08690UBIQUINONE-2Reaction center protein L chaintarget
DB08690UBIQUINONE-2Reaction center protein M chaintarget
DB08690UBIQUINONE-2Reaction center protein H chaintarget
DB11596LevoleucovorinSerine hydroxymethyltransferasetarget
DB11596LevoleucovorinDihydrofolate reductasetarget
DB14007Pentetic acidTransuranium elementstarget
DB14007Pentetic acidAlpha-1-antitrypsincarrier
DB00134MethionineMethionine synthase reductasetarget
DB00134MethionineMethionine synthasetarget
DB00134MethionineMethionine aminopeptidase 2target
DB00134MethionineBetaine--homocysteine S-methyltransferase 1target
DB00134MethionineS-methylmethionine--homocysteine S-methyltransferase BHMT2target
DB00134MethionineGlutamine synthetaseenzyme
DB00134MethionineMethylenetetrahydrofolate reductaseenzyme
DB00134MethionineMonocarboxylate transporter 10transporter
DB00134MethionineS-adenosylmethionine synthase isoform type-2enzyme
DB00134MethionineMethionine-R-sulfoxide reductase B2, mitochondrialenzyme
DB00134MethionineS-adenosylmethionine synthase isoform type-1enzyme
DB00134MethionineMethionine-R-sulfoxide reductase B1enzyme
DB00134MethionineMitochondrial peptide methionine sulfoxide reductaseenzyme
DB00134MethionineMethionine--tRNA ligase, cytoplasmicenzyme
DB00134MethionineMethionine--tRNA ligase, mitochondrialenzyme
DB00134MethionineMethionine adenosyltransferase 2 subunit betaenzyme
DB00143GlutathioneGlutathione reductase, mitochondrialtarget
DB00143GlutathioneGlutathione synthetasetarget
DB00143GlutathioneGlutathione S-transferase Mu 1target
DB00143GlutathioneGlutathione S-transferase kappa 1target
DB00143GlutathioneGlutathione S-transferase A3target
DB00143GlutathioneGlutathione S-transferase Mu 3target
DB00143GlutathioneGlutathione S-transferase A4target
DB00143GlutathioneGlutathione S-transferase Mu 4target
DB00143GlutathioneGlutathione S-transferase A5target
DB00143GlutathioneGlutathione S-transferase Ptarget
DB00143GlutathioneGlutathione S-transferase omega-1target
DB00143GlutathioneGlutathione peroxidase 1target
DB00143GlutathioneGlutathione peroxidase 2target
DB00143GlutathioneGlutathione S-transferase theta-1target
DB00143GlutathioneMaleylacetoacetate isomerasetarget
DB00143GlutathioneEpididymal secretory glutathione peroxidasetarget
DB00143GlutathioneGlutathione peroxidase 3target
DB00143GlutathioneLactoylglutathione lyasetarget
DB00143GlutathioneLeukotriene C4 synthasetarget
DB00143GlutathioneMicrosomal glutathione S-transferase 3target
DB00143GlutathioneHematopoietic prostaglandin D synthasetarget
DB00143GlutathioneThioredoxin domain-containing protein 12target
DB00143GlutathioneGlutathione S-transferase A1target
DB00143GlutathioneGlutathione S-transferase A2target
DB00143GlutathioneMicrosomal glutathione S-transferase 1target
DB00143GlutathioneS-formylglutathione hydrolasetarget
DB00143GlutathioneGamma-glutamyltranspeptidase 1target
DB00143GlutathioneGlutathione S-transferase Mu 2target
DB00143GlutathioneGlutaredoxin-1target
DB00143GlutathionePhospholipid hydroperoxide glutathione peroxidase, mitochondrialtarget
DB00143GlutathioneGlutathione S-transferase Mu 5target
DB00143GlutathioneGlutathione peroxidase 6target
DB00143GlutathioneHydroxyacylglutathione hydrolase, mitochondrialtarget
DB00143GlutathioneGlutathione peroxidasetarget
DB00143GlutathioneProbable glutathione peroxidase 8target
DB00143GlutathioneGlutathione peroxidase 7target
DB00143GlutathioneMicrosomal glutathione S-transferase 2target
DB00143GlutathioneGlutathione S-transferase omega-2target
DB00143GlutathioneGlutaredoxin-2, mitochondrialtarget
DB00143GlutathioneGlutathione S-transferase A2enzyme
DB00143GlutathioneGlutathione S-transferase A1enzyme
DB00143GlutathioneMultidrug resistance-associated protein 1transporter
DB00143GlutathioneCanalicular multispecific organic anion transporter 1transporter
DB00143GlutathioneCanalicular multispecific organic anion transporter 2transporter
DB00143GlutathioneMultidrug resistance-associated protein 4transporter
DB00143GlutathioneMultidrug resistance-associated protein 5transporter
DB00143GlutathioneAldose reductasetarget
DB00143GlutathioneMatrix metalloproteinase-9target
DB00143GlutathioneCytochrome P450 3A4target
DB00981PhysostigmineAcetylcholinesterasetarget
DB00981PhysostigmineNeuronal acetylcholine receptor subunit alpha-4target
DB00981PhysostigmineNeuronal acetylcholine receptor subunit beta-2target
DB01183NaloxoneMu-type opioid receptortarget
DB01183NaloxoneEstrogen receptor alphatarget
DB01183NaloxoneCyclic AMP-responsive element-binding protein 1target
DB01183NaloxoneDelta-type opioid receptortarget
DB01183NaloxoneSolute carrier organic anion transporter family member 1A2transporter
DB01183NaloxoneP-glycoprotein 1transporter
DB01183NaloxoneKappa-type opioid receptortarget
DB01183NaloxoneCytochrome P450 3A4enzyme
DB01183NaloxoneSerum albumincarrier
DB01183NaloxoneToll-like receptor 4target
DB01183NaloxoneLiver carboxylesterase 1target
DB01183NaloxoneUDP-glucuronosyltransferase 1-1enzyme
DB01612Amyl NitriteAtrial natriuretic peptide receptor 1target
DB01612Amyl NitriteAldehyde dehydrogenase, mitochondrialenzyme
DB06782DimercaprolArsenictarget
DB06782DimercaprolCadmiumtarget
DB06782DimercaprolMercurytarget
DB06782DimercaprolAmyloid beta A4 proteintarget
DB09241Methylene blueGuanylate cyclase soluble subunit alpha-2target
DB09241Methylene blueNitric oxide synthase, braintarget
DB00692PhentolamineAlpha-2A adrenergic receptortarget
DB00692PhentolamineAlpha-1A adrenergic receptortarget
DB00692PhentolamineAlpha-1B adrenergic receptortarget
DB00692PhentolamineAlpha-1D adrenergic receptortarget
DB00860PrednisoloneCorticosteroid-binding globulincarrier
DB00860PrednisoloneCytochrome P450 3A4enzyme
DB00860PrednisoloneGlucocorticoid receptortarget
DB00860PrednisoloneSolute carrier organic anion transporter family member 1A2transporter
DB00860PrednisoloneP-glycoprotein 1transporter
DB00860PrednisoloneSerum albumincarrier
DB00898EthanolGamma-aminobutyric acid receptor subunit alpha-1target
DB00898EthanolGlutamate receptor ionotropic, NMDA 3Atarget
DB00898EthanolGlycine receptor subunit alpha-1target
DB00898EthanolGlycine receptor subunit alpha-2target
DB00898EthanolCytochrome P450 2E1enzyme
DB00898EthanolCytochrome P450 1A1enzyme
DB00898EthanolCytochrome P450 1A2enzyme
DB00898EthanolCytochrome P450 2B6enzyme
DB00898EthanolCytochrome P450 2C19enzyme
DB00898EthanolCytochrome P450 2C9enzyme
DB00898EthanolCytochrome P450 3A4enzyme
DB00898EthanolCytochrome P450 4A11enzyme
DB00898EthanolAlcohol dehydrogenase 1Aenzyme
DB00898EthanolAlcohol dehydrogenase 1Benzyme
DB00898EthanolAlcohol dehydrogenase 1Cenzyme
DB00898EthanolAlcohol dehydrogenase class-3enzyme
DB00898EthanolVoltage-dependent L-type calcium channel subunit beta-1target
DB00898Ethanol5-hydroxytryptamine receptor 3Atarget
DB00898EthanolAlcohol dehydrogenase 4enzyme
DB00898EthanolGamma-aminobutyric acid receptor subunit alpha-2target
DB00898EthanolNeuronal acetylcholine receptor subunit alpha-10target
DB00898EthanolVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00898EthanolGamma-aminobutyric acid receptor subunit alpha-5target
DB00898EthanolGamma-aminobutyric acid receptor subunit alpha-4target
DB00898EthanolAlcohol dehydrogenase class 4 mu/sigma chainenzyme
DB00898EthanolGamma-aminobutyric acid receptor subunit alpha-3target
DB00898EthanolGlutamate receptor 1target
DB00898EthanolVoltage-dependent calcium channel gamma-1 subunittarget
DB00898EthanolNeuronal acetylcholine receptor subunit alpha-2target
DB00898EthanolGamma-aminobutyric acid receptor subunit alpha-6target
DB00898EthanolGlutamate receptor 2target
DB00898EthanolGlutamate receptor 4target
DB00898EthanolGlutamate receptor 3target
DB00898EthanolNeuronal acetylcholine receptor subunit alpha-4target
DB00898EthanolNeuronal acetylcholine receptor subunit beta-2target
DB00898EthanolG protein-activated inward rectifier potassium channel 1target
DB00898EthanolG protein-activated inward rectifier potassium channel 2target
DB00898EthanolVascular cell adhesion protein 1target
DB00898EthanolEquilibrative nucleoside transporter 1target
DB00898EthanolG protein-activated inward rectifier potassium channel 4target
DB00898EthanolNeuronal acetylcholine receptor subunit alpha-7target
DB00898EthanolNeuronal acetylcholine receptor subunit alpha-9target
DB00898EthanolGamma-aminobutyric acid receptor subunit beta-1target
DB00898EthanolGamma-aminobutyric acid receptor subunit beta-3target
DB00898EthanolGamma-aminobutyric acid receptor subunit beta-2target
DB00898EthanolVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB00898EthanolVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB00898EthanolAlcohol dehydrogenase 6enzyme
DB00898EthanolNeuronal acetylcholine receptor subunit beta-4target
DB00898EthanolNeuronal acetylcholine receptor subunit alpha-3target
DB00898EthanolNeuronal acetylcholine receptor subunit alpha-5target
DB00898EthanolNeuronal acetylcholine receptor subunit alpha-6target
DB00898EthanolNeuronal acetylcholine receptor subunit beta-3target
DB00898EthanolGamma-aminobutyric acid receptor subunit gamma-1target
DB00898EthanolGamma-aminobutyric acid receptor subunit gamma-3target
DB00898EthanolGamma-aminobutyric acid receptor subunit epsilontarget
DB00898EthanolGamma-aminobutyric acid receptor subunit pitarget
DB00898EthanolGamma-aminobutyric acid receptor subunit thetatarget
DB00898EthanolGamma-aminobutyric acid receptor subunit deltatarget
DB00898EthanolAlcohol dehydrogenase [NADP(+)]enzyme
DB00898EthanolEquilibrative nucleoside transporter 2target
DB00898Ethanol5-hydroxytryptamine receptor 3Etarget
DB00898Ethanol5-hydroxytryptamine receptor 3Btarget
DB00898Ethanol5-hydroxytryptamine receptor 3Dtarget
DB00898Ethanol5-hydroxytryptamine receptor 3Ctarget
DB00898EthanolVoltage-dependent calcium channel gamma-2 subunittarget
DB00898EthanolG protein-activated inward rectifier potassium channel 3target
DB00898EthanolNeural cell adhesion molecule L1target
DB01069PromethazineDopamine D2 receptortarget
DB01069PromethazineHistamine H1 receptortarget
DB01069PromethazineMuscarinic acetylcholine receptor M4target
DB01069PromethazineMuscarinic acetylcholine receptor M1target
DB01069PromethazineMuscarinic acetylcholine receptor M5target
DB01069PromethazineAlpha-1A adrenergic receptortarget
DB01069Promethazine5-hydroxytryptamine receptor 2Atarget
DB01069PromethazineMuscarinic acetylcholine receptor M2target
DB01069PromethazineMuscarinic acetylcholine receptor M3target
DB01069PromethazineCalmodulintarget
DB01069PromethazineCytochrome P450 2D6enzyme
DB01069PromethazineCytochrome P450 2B6enzyme
DB01069PromethazineP-glycoprotein 1transporter
DB01069PromethazineCytochrome P450 2C9enzyme
DB01069PromethazineHistamine H2 receptortarget
DB06715Potassium IodideTyrosinetarget
DB13293IpecacCytochrome P450 2D6enzyme
DB13293IpecacCytochrome P450 3A4enzyme
DB14562Andexanet alfaTissue factor pathway inhibitortarget