|DB00733||Pralidoxime||For the treatment of poisoning due to those pesticides and chemicals of the organophosphate class which have anticholinesterase activity and in the control of overdosage by anticholinesterase drugs used in the treatment of myasthenia gravis.|
|DB01205||Flumazenil||For the complete or partial reversal of the sedative effects of benzodiazepines in cases where general anesthesia has been induced and/or maintained with benzodiazepines, and where sedation has been produced with benzodiazepines for diagnostic and therapeutic procedures. Also for the management of benzodiazepine overdose as an adjunct for appropriate supportive and symptomatic measures.|
|DB01213||Fomepizole||Antizol is indicated as an antidote for ethylene glycol (such as antifreeze) or methanol poisoning, or for use in suspected ethylene glycol or methanol ingestion, either alone or in combination with hemodialysis|
|DB06783||Prussian blue||Indicated for treatment of patients with known or suspected internal contamination with radioactive cesium and/or radioactive or non-radioactive thallium to increase their rates of elimination. |
|DB06778||Cupric sulfate||Elemental use in copper deficiency [L1823]
Copper and copper containing compounds are broadly used in medical practice. Metallic copper is used already for many years in dental fillings and in copper intrauterine devices (IUD) for reversible contraception. Ointments containing copper, which release copper ions that are absorbed by the skin in the management of cramps, disturbances of renal function, peripheral, venous hypostatic circulatory disturbances, rheumatic disease and swelling associated with trauma. There are also cosmetic facial creams containing copper as their main active ingredient [L1828].|
|DB00650||Leucovorin||For the treatment of osteosarcoma (after high dose methotrexate therapy). Used to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists, and to treat megaloblastic anemias due to folic acid deficiency. Also used in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer.|
|DB00076||Digoxin Immune Fab (Ovine)||For treatment of digitoxin overdose or digitalis glycoside toxicity.|
|DB06206||Sugammadex||Sugammadex is indicated for the reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide in adults undergoing surgery.|
|DB09112||Nitrous acid||For sequential use with sodium thiosulfate for the treatment of acute cyanide poisoning that is judged to be life-threatening [FDA Label].|
|DB00200||Hydroxocobalamin||For treatment of pernicious anemia and the prevention and treatment of vitamin B12 deficiency arising from alcoholism, malabsorption, tapeworm infestation, celiac, hyperthyroidism, hepatic-biliary tract disease, persistent diarrhea, ileal resection, pancreatic cancer, renal disease, prolonged stress, vegan diets, macrobiotic diets or other restrictive diets. Also for the treatment of known or suspected cyanide poisoning.|
|DB06151||Acetylcysteine||Acetylcysteine is used mainly as a mucolytic and in the management of paracetamol (acetaminophen) overdose.|
|DB09499||Thiosulfuric acid||Antidote: Sodium thiosulfate is indicated to counteract or neutralize actions of poisons, e.g. cyanide poisoning.
Antineoplastic adjunct: |
|DB00466||Picrotoxin||Used internally for relieving respiratory distress. Also for use as an antidote in poisoning by CNS depressants, especially barbiturates.|
|DB00566||Succimer||For the treatment of lead poisoning in pediatric patients with blood lead levels above 45 µg/dL. May also be used to treat mercury or arsenic poisoning.|
|DB00859||Penicillamine||For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis.|
|DB01010||Edrophonium||For the differential diagnosis of myasthenia gravis and as an adjunct in the evaluation of treatment requirements in this disease. It may also be used for evaluating emergency treatment in myasthenic crises.|
|DB01574||Attapulgite||When used in medicine, it physically binds to acids and toxic substances in the stomach and digestive tract. For that reason, it has often been used in antidiarrheal medications. Attapulgite is an adsorbent. |
|DB05779||Oglufanide||Investigated for use/treatment in hepatitis (viral, C).|
|DB09278||Activated charcoal||Used as a antidote to treat poisonings following excessive oral ingestion of certain medications or poisons. |
|DB11596||Levoleucovorin||Levoleucovorin is indicated for use as rescue therapy following high-dose methotrexate in the treatment of osteosarcoma or for diminishing the toxicity associated with inadvertent overdosage of folic acid antagonists. Levoleucovorin, as the product Fusilev (FDA, dosed at one-half the usual dose of racemic d,l-leucovorin), has an additional indication for use in combination chemotherapy with 5-fluorouracil in the palliative treatment of patients with advanced metastatic colorectal cancer (although they should not be mixed in the same infusion as a precipitate may form).|
|DB14007||Pentetic acid||DTPA is widely used in industry and medicine. As a medical agent, it is approved for its use in medical imaging and for the decorporation of internally deposited radionuclides.[A32501] It is FDA approved for the treatment of individuals with known or suspected internal contamination with plutonium, americium or curium to increase the rates of elimination.[L2243]
Due to the pharmacokinetic elimination by the kidneys, pentetic acid conjugated with technetium Tc-99m is being used clinically to estimate physiological parameters such as glomerular filtration rat and effective renal plasma flow.[T168]|
|DB00134||Methionine||Used for protein synthesis including the formation of SAMe, L-homocysteine, L-cysteine, taurine, and sulfate.|
|DB00143||Glutathione||For nutritional supplementation, also for treating dietary shortage or imbalance|
|DB00981||Physostigmine||For the treatment of glaucoma, and in the treatment of severe anticholinergic toxicity.|
|DB01183||Naloxone||For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids including natural and synthetic narcotics, propoxyphene, methadone and the narcotic-antagonist analgesics: nalbuphine, pentazocine and butorphanol. It is also indicated for the diagnosis of suspected acute opioid overdose. It may also be used as an adjunctive agent to increase blood pressure in the management of septic shock.|
|DB01612||Amyl Nitrite||For the rapid relief of angina pectoris.|
|DB06782||Dimercaprol||For the treatment of arsenic, gold and mercury poisoning. Indicated in acute lead poisoning when used concomitantly with edetate calcium disodium (DB00974).|
|DB09264||Idarucizumab||For use in patients treated with Dabigatran when reversal of the anticoagulant effects of dabigatran is needed for emergency surgery/urgent procedures and in life-threatening or uncontrolled bleeding.|
|DB11490||Nalorphine||Used to reverse opioid overdose.|
|DB09241||Methylene blue||Methylene blue has several indications in medicine:
1. found to improve the hypotension associated with various clinical states.
2. Antiseptic in urinary tract infections.
3. Improves hypoxia and hyper dynamic circulation in cirrhosis of liver and severe hepatopulmonary syndrome.
4. Results in transient and reproducible improvement in blood pressure and cardiac function in septic shock.
5. Investigated for the treatment of Alzheimer's disease.
6. Treatment of ifofosamide induced neurotoxicity.|
|DB00692||Phentolamine||Used as an aid for the diagnosis of pheochromocytoma, and may be administered immediately prior to or during pheochromocytomectomy to prevent or control paroxysmal hypertension resulting from anesthesia, stress, or operative manipulation of the tumor. Phentolamine has also been used to treat hypertensive crisis caused by sympathomimetic amines or catecholamine excess by certain foods or drugs in patients taking MAO inhibitors, or by clonidine withdrawal syndrome. Other indications include the prevention of dermal necrosis and sloughing following IV administration or extravasation of norepinephrine, decrease in impedance to left ventricular ejection and the infarct size in patients with MI associated with left ventricular failure, treatment of erectile dysfunction through self-injection of small doses combined with papaverine hydrochloride into the corpus cavernosum, and as an adjunct to the management of cocaine overdose to reverse coronary vasoconstriction following use of oxygen, benzodiazepines,and nitroglycerin. |
|DB00860||Prednisolone||For the treatment of primary or secondary adrenocortical insufficiency, such as congenital adrenal hyperplasia, thyroiditis. Also used to treat psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, bursitis, acute gouty arthritis and epicondylitis. Also indicated for treatment of systemic lupus erythematosus, pemphigus and acute rhematic carditis. Can be used in the treatment of leukemias, lymphomas, thrombocytopenia purpura and autoimmune hemolytic anemia. Can be used to treat celiac disease, insulin resistance, ulcerative colitis and liver disorders.|
|DB00898||Ethanol||For therapeutic neurolysis of nerves or ganglia for the relief of intractable chronic pain in such conditions as inoperable cancer and trigeminal neuralgia (tic douloureux), in patients for whom neurosurgical procedures are contraindicated.|
|DB01069||Promethazine||For the treatment of allergic disorders, and nausea/vomiting.|
|DB06715||Potassium Iodide||Potassium Iodide is oral antithyroid agent. Potassium Iodide is used as an adjunct to other antithyroid agents in the treatment of hyperthyroidism and thyrotoxicosis and preoperatively to induce thyroid involution.|
|DB13293||Ipecac||Ipecac is indicated as an emetic agent for the induction of vomiting in poisoning victims who ingested systemic poison in order to prevent absorption of the chemicals through the gastrointestinal tract. In low doses, ipecac was also used as an expectorant.[L2753]
Reports have suggested that ipecac was vastly used in patients with eating disorders to produce vomiting.[T49]|
|DB13831||Potassium permanganate||Not Available|
|DB14089||Dimercaptosuccinic acid||Not Available|