Agents counteracting or neutralizing the action of POISONS.
DrugDrug NameDrug Indication
DB00733PralidoximeFor the treatment of poisoning due to those pesticides and chemicals of the organophosphate class which have anticholinesterase activity and in the control of overdosage by anticholinesterase drugs used in the treatment of myasthenia gravis.
DB01205FlumazenilFor the complete or partial reversal of the sedative effects of benzodiazepines in cases where general anesthesia has been induced and/or maintained with benzodiazepines, and where sedation has been produced with benzodiazepines for diagnostic and therapeutic procedures. Also for the management of benzodiazepine overdose as an adjunct for appropriate supportive and symptomatic measures.
DB01213FomepizoleAntizol is indicated as an antidote for ethylene glycol (such as antifreeze) or methanol poisoning, or for use in suspected ethylene glycol or methanol ingestion, either alone or in combination with hemodialysis
DB06783Prussian blueIndicated for treatment of patients with known or suspected internal contamination with radioactive cesium and/or radioactive or non-radioactive thallium to increase their rates of elimination.
DB06778Cupric sulfateNot Available
DB00650LeucovorinFor the treatment of osteosarcoma (after high dose methotrexate therapy). Used to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists, and to treat megaloblastic anemias due to folic acid deficiency. Also used in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer.
DB00076Digoxin Immune Fab (Ovine)For treatment of digitoxin overdose or digitalis glycoside toxicity.
DB06206SugammadexSugammadex is indicated for the reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide in adults undergoing surgery.
DB09112Sodium NitriteFor sequential use with sodium thiosulfate for the treatment of acute cyanide poisoning that is judged to be life-threatening [FDA Label].
DB00200HydroxocobalaminFor treatment of pernicious anemia and the prevention and treatment of vitamin B12 deficiency arising from alcoholism, malabsorption, tapeworm infestation, celiac, hyperthyroidism, hepatic-biliary tract disease, persistent diarrhea, ileal resection, pancreatic cancer, renal disease, prolonged stress, vegan diets, macrobiotic diets or other restrictive diets. Also for the treatment of known or suspected cyanide poisoning.
DB06151AcetylcysteineAcetylcysteine is used mainly as a mucolytic and in the management of paracetamol (acetaminophen) overdose.
DB09499Thiosulfuric acidAntidote: Sodium thiosulfate is indicated to counteract or neutralize actions of poisons, e.g. cyanide poisoning. Antineoplastic adjunct:
DB00466PicrotoxinUsed internally for relieving respiratory distress. Also for use as an antidote in poisoning by CNS depressants, especially barbiturates.
DB00566SuccimerFor the treatment of lead poisoning in pediatric patients with blood lead levels above 45 µg/dL. May also be used to treat mercury or arsenic poisoning.
DB00859PenicillamineFor treatment of Wilson's disease, cystinuria and active rheumatoid arthritis.
DB01010EdrophoniumFor the differential diagnosis of myasthenia gravis and as an adjunct in the evaluation of treatment requirements in this disease. It may also be used for evaluating emergency treatment in myasthenic crises.
DB01574AttapulgiteWhen used in medicine, it physically binds to acids and toxic substances in the stomach and digestive tract. For that reason, it has often been used in antidiarrheal medications. Attapulgite is an adsorbent.
DB05779OglufanideInvestigated for use/treatment in hepatitis (viral, C).
DB06805Pentetate calcium trisodiumNot Available
DB06806Pentetate zinc trisodiumNot Available
DB08690UBIQUINONE-2Not Available
DB09278Activated charcoalUsed as a antidote to treat poisonings following excessive oral ingestion of certain medications or poisons.
DB11596LevoleucovorinLevoleucovorin is indicated for use as rescue therapy following high-dose methotrexate in the treatment of osteosarcoma or for diminishing the toxicity associated with inadvertent overdosage of folic acid antagonists. Levoleucovorin, as the product Fusilev (FDA, dosed at one-half the usual dose of racemic d,l-leucovorin), has an additional indication for use in combination chemotherapy with 5-fluorouracil in the palliative treatment of patients with advanced metastatic colorectal cancer (although they should not be mixed in the same infusion as a precipitate may form).
DB00134L-MethionineUsed for protein synthesis including the formation of SAMe, L-homocysteine, L-cysteine, taurine, and sulfate.
DB00143GlutathioneFor nutritional supplementation, also for treating dietary shortage or imbalance
DB00981PhysostigmineFor the treatment of glaucoma, and in the treatment of severe anticholinergic toxicity.
DB01183NaloxoneFor the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids including natural and synthetic narcotics, propoxyphene, methadone and the narcotic-antagonist analgesics: nalbuphine, pentazocine and butorphanol. It is also indicated for the diagnosis of suspected acute opioid overdose. It may also be used as an adjunctive agent to increase blood pressure in the management of septic shock.
DB01612Amyl NitriteFor the rapid relief of angina pectoris.
DB06782DimercaprolFor the treatment of arsenic, gold and mercury poisoning. Indicated in acute lead poisoning when used concomitantly with edetate calcium disodium (DB00974).
DB09264IdarucizumabFor use in patients treated with Dabigatran when reversal of the anticoagulant effects of dabigatran is needed for emergency surgery/urgent procedures and in life-threatening or uncontrolled bleeding.
DB01373CalciumCalcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. It is vital in cell signaling, muscular contractions, bone health, and signalling cascades.
DB09241Methylene blueMethylene blue has several indications in medicine: 1. found to improve the hypotension associated with various clinical states. 2. Antiseptic in urinary tract infections. 3. Improves hypoxia and hyper dynamic circulation in cirrhosis of liver and severe hepatopulmonary syndrome. 4. Results in transient and reproducible improvement in blood pressure and cardiac function in septic shock. 5. Investigated for the treatment of Alzheimer's disease. 6. Treatment of ifofosamide induced neurotoxicity.
DrugDrug NameTargetType
DB00733PralidoximeAcetylcholinesterasetarget
DB00733PralidoximeCholinesterasetarget
DB01205FlumazenilGamma-aminobutyric acid receptor subunit alpha-1target
DB01205FlumazenilGamma-aminobutyric acid receptor subunit gamma-2target
DB01205FlumazenilGamma-aminobutyric acid receptor subunit alpha-5target
DB01205FlumazenilGABA-A receptor (anion channel)target
DB01213FomepizoleAlcohol dehydrogenase 1Atarget
DB01213FomepizoleAlcohol dehydrogenase 1Btarget
DB01213FomepizoleAlcohol dehydrogenase 1Ctarget
DB01213FomepizoleCatalasetarget
DB01213FomepizoleCytochrome P450 2E1enzyme
DB01213FomepizoleCytochrome P450 2A6enzyme
DB00076Digoxin Immune Fab (Ovine)Digoxintarget
DB09112Sodium NitriteHemoglobin subunit alphatarget
DB09112Sodium NitriteHemoglobin subunit betatarget
DB09112Sodium NitriteMyoglobintarget
DB00200HydroxocobalaminMethylmalonic aciduria type A protein, mitochondrialtarget
DB00200HydroxocobalaminProtein amnionlesstarget
DB00200HydroxocobalaminTranscobalamin-1target
DB00200HydroxocobalaminMethylmalonyl-CoA mutase, mitochondrialtarget
DB00200HydroxocobalaminMethionine synthase reductasetarget
DB00200HydroxocobalaminCob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrialtarget
DB00200HydroxocobalaminMethionine synthasetarget
DB00200HydroxocobalaminCubilintarget
DB00200HydroxocobalaminMethylmalonic aciduria and homocystinuria type C proteintarget
DB00200HydroxocobalaminTranscobalamin-2carrier
DB06151AcetylcysteineSolute carrier organic anion transporter family member 1B1transporter
DB06151AcetylcysteineNAPQI (N-acetyl-p-benzoquinone imine)target
DB06151AcetylcysteineSolute carrier family 22 member 6transporter
DB06151AcetylcysteineAminoacylase-1target
DB06151AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit alphatarget
DB06151AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB06151AcetylcysteineGlutathione synthetasetarget
DB06151AcetylcysteineCystine/glutamate transportertarget
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 2Btarget
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 1target
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 2Atarget
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 2Dtarget
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 3Atarget
DB09499Thiosulfuric acidThiosulfate sulfurtransferaseenzyme
DB00466PicrotoxinGamma-aminobutyric acid receptor subunit rho-1target
DB00466PicrotoxinGamma-aminobutyric acid receptor subunit alpha-1target
DB00466PicrotoxinGlycine receptor subunit alpha-2target
DB00466PicrotoxinGlycine receptor subunit alpha-3target
DB00466PicrotoxinCytochrome P450 1A1enzyme
DB00466PicrotoxinGlutamine synthetaseenzyme
DB00466PicrotoxinGlycine receptor subunit alpha-1target
DB00566SuccimerLeadtarget
DB00566SuccimerMercurytarget
DB00566SuccimerCadmiumtarget
DB00566SuccimerArsenictarget
DB00859PenicillamineSolute carrier organic anion transporter family member 1B1transporter
DB00859PenicillamineCoppertarget
DB01010EdrophoniumAcetylcholinesterasetarget
DB01010EdrophoniumCholinesterasetarget
DB08690UBIQUINONE-2Succinate dehydrogenase flavoprotein subunittarget
DB08690UBIQUINONE-2Succinate dehydrogenase iron-sulfur subunittarget
DB08690UBIQUINONE-2Succinate dehydrogenase cytochrome b556 subunittarget
DB08690UBIQUINONE-2Succinate dehydrogenase hydrophobic membrane anchor subunittarget
DB08690UBIQUINONE-2Cytochrome c1, heme protein, mitochondrialtarget
DB08690UBIQUINONE-2Cytochrome btarget
DB08690UBIQUINONE-2Cytochrome b-c1 complex subunit 1, mitochondrialtarget
DB08690UBIQUINONE-2Cytochrome b-c1 complex subunit 2, mitochondrialtarget
DB08690UBIQUINONE-2Cytochrome b-c1 complex subunit 6, mitochondrialtarget
DB08690UBIQUINONE-2Cytochrome b-c1 complex subunit 8target
DB08690UBIQUINONE-2Cytochrome b-c1 complex subunit Rieske, mitochondrialtarget
DB08690UBIQUINONE-2Cytochrome b-c1 complex subunit 10target
DB08690UBIQUINONE-2Cytochrome b-c1 complex subunit 7target
DB08690UBIQUINONE-2Cytochrome b-c1 complex subunit 9target
DB08690UBIQUINONE-2Photosynthetic reaction center cytochrome c subunittarget
DB08690UBIQUINONE-2Reaction center protein H chaintarget
DB08690UBIQUINONE-2Reaction center protein L chaintarget
DB08690UBIQUINONE-2Reaction center protein M chaintarget
DB08690UBIQUINONE-2Disulfide bond formation protein Btarget
DB08690UBIQUINONE-2Cytochrome btarget
DB08690UBIQUINONE-2Ubiquinol-cytochrome c reductase iron-sulfur subunittarget
DB08690UBIQUINONE-2Cytochrome c1target
DB08690UBIQUINONE-2Reaction center protein L chaintarget
DB08690UBIQUINONE-2Reaction center protein M chaintarget
DB08690UBIQUINONE-2Reaction center protein H chaintarget
DB11596LevoleucovorinSerine hydroxymethyltransferasetarget
DB11596LevoleucovorinDihydrofolate reductasetarget
DB00134L-MethionineMethionine synthase reductasetarget
DB00134L-MethionineMethionine synthasetarget
DB00134L-MethionineMethionine aminopeptidase 2target
DB00134L-MethionineBetaine--homocysteine S-methyltransferase 1target
DB00134L-MethionineS-methylmethionine--homocysteine S-methyltransferase BHMT2target
DB00134L-MethionineGlutamine synthetaseenzyme
DB00134L-MethionineMethylenetetrahydrofolate reductaseenzyme
DB00134L-MethionineMonocarboxylate transporter 10transporter
DB00134L-MethionineS-adenosylmethionine synthase isoform type-2enzyme
DB00134L-MethionineMethionine-R-sulfoxide reductase B2, mitochondrialenzyme
DB00134L-MethionineS-adenosylmethionine synthase isoform type-1enzyme
DB00134L-MethionineMethionine-R-sulfoxide reductase B1enzyme
DB00134L-MethionineMitochondrial peptide methionine sulfoxide reductaseenzyme
DB00134L-MethionineMethionine--tRNA ligase, cytoplasmicenzyme
DB00134L-MethionineMethionine--tRNA ligase, mitochondrialenzyme
DB00134L-MethionineMethionine adenosyltransferase 2 subunit betaenzyme
DB00143GlutathioneGlutathione reductase, mitochondrialtarget
DB00143GlutathioneGlutathione synthetasetarget
DB00143GlutathioneGlutathione S-transferase Mu 1target
DB00143GlutathioneGlutathione S-transferase kappa 1target
DB00143GlutathioneGlutathione S-transferase A3target
DB00143GlutathioneGlutathione S-transferase Mu 3target
DB00143GlutathioneGlutathione S-transferase A4target
DB00143GlutathioneGlutathione S-transferase Mu 4target
DB00143GlutathioneGlutathione S-transferase A5target
DB00143GlutathioneGlutathione S-transferase Ptarget
DB00143GlutathioneGlutathione S-transferase omega-1target
DB00143GlutathioneGlutathione peroxidase 1target
DB00143GlutathioneGlutathione peroxidase 2target
DB00143GlutathioneGlutathione S-transferase theta-1target
DB00143GlutathioneMaleylacetoacetate isomerasetarget
DB00143GlutathioneEpididymal secretory glutathione peroxidasetarget
DB00143GlutathioneGlutathione peroxidase 3target
DB00143GlutathioneLactoylglutathione lyasetarget
DB00143GlutathioneLeukotriene C4 synthasetarget
DB00143GlutathioneMicrosomal glutathione S-transferase 3target
DB00143GlutathioneHematopoietic prostaglandin D synthasetarget
DB00143GlutathioneThioredoxin domain-containing protein 12target
DB00143GlutathioneGlutathione S-transferase A1target
DB00143GlutathioneGlutathione S-transferase A2target
DB00143GlutathioneMicrosomal glutathione S-transferase 1target
DB00143GlutathioneS-formylglutathione hydrolasetarget
DB00143GlutathioneGamma-glutamyltranspeptidase 1target
DB00143GlutathioneGlutathione S-transferase Mu 2target
DB00143GlutathioneGlutaredoxin-1target
DB00143GlutathionePhospholipid hydroperoxide glutathione peroxidase, mitochondrialtarget
DB00143GlutathioneGlutathione S-transferase Mu 5target
DB00143GlutathioneGlutathione peroxidase 6target
DB00143GlutathioneHydroxyacylglutathione hydrolase, mitochondrialtarget
DB00143GlutathioneGlutathione peroxidasetarget
DB00143GlutathioneProbable glutathione peroxidase 8target
DB00143GlutathioneGlutathione peroxidase 7target
DB00143GlutathioneMicrosomal glutathione S-transferase 2target
DB00143GlutathioneGlutathione S-transferase omega-2target
DB00143GlutathioneGlutaredoxin-2, mitochondrialtarget
DB00143GlutathioneGlutathione S-transferase A2enzyme
DB00143GlutathioneGlutathione S-transferase A1enzyme
DB00143GlutathioneMultidrug resistance-associated protein 1transporter
DB00143GlutathioneCanalicular multispecific organic anion transporter 1transporter
DB00143GlutathioneCanalicular multispecific organic anion transporter 2transporter
DB00143GlutathioneMultidrug resistance-associated protein 4transporter
DB00143GlutathioneMultidrug resistance-associated protein 5transporter
DB00143GlutathioneAldose reductasetarget
DB00143GlutathioneMatrix metalloproteinase-9target
DB00143GlutathioneCytochrome P450 3A4target
DB00981PhysostigmineAcetylcholinesterasetarget
DB00981PhysostigmineNeuronal acetylcholine receptor subunit alpha-4target
DB00981PhysostigmineNeuronal acetylcholine receptor subunit beta-2target
DB01183NaloxoneMu-type opioid receptortarget
DB01183NaloxoneEstrogen receptor alphatarget
DB01183NaloxoneCyclic AMP-responsive element-binding protein 1target
DB01183NaloxoneDelta-type opioid receptortarget
DB01183NaloxoneSolute carrier organic anion transporter family member 1A2transporter
DB01183NaloxoneMultidrug resistance protein 1transporter
DB01183NaloxoneKappa-type opioid receptortarget
DB01183NaloxoneCytochrome P450 2C8enzyme
DB01183NaloxoneCytochrome P450 3A4enzyme
DB01183NaloxoneSerum albumincarrier
DB01183NaloxoneToll-like receptor 4target
DB01183NaloxoneLiver carboxylesterase 1target
DB01612Amyl NitriteAtrial natriuretic peptide receptor 1target
DB01612Amyl NitriteAldehyde dehydrogenase, mitochondrialenzyme
DB06782DimercaprolArsenictarget
DB06782DimercaprolCadmiumtarget
DB06782DimercaprolMercurytarget
DB06782DimercaprolAmyloid beta A4 proteintarget
DB09264IdarucizumabDabigatran etexilatetarget
DB01373CalciumProtein S100-Btarget
DB01373CalciumCalpastatintarget
DB01373CalciumCartilage oligomeric matrix proteintarget
DB01373CalciumCalmodulintarget
DB01373CalciumSpectrin beta chain, non-erythrocytic 1target
DB01373CalciumVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB01373CalciumTroponin C, skeletal muscletarget
DB01373CalciumTroponin C, slow skeletal and cardiac musclestarget
DB01373CalciumCalcium-transporting ATPase type 2C member 1target
DB01373CalciumAmiloride-sensitive amine oxidase [copper-containing]target
DB01373CalciumProtein S100-A13target
DB01373CalciumAlkaline phosphatase, placental typetarget
DB01373CalciumProtein S100-A8target
DB01373CalciumProtein S100-A9target
DB01373CalciumProtein S100-A2target
DB01373CalciumCeruloplasmintarget
DB01373CalciumBone morphogenetic protein 4target
DB01373CalciumMatrix Gla proteintarget
DB01373CalciumProtocadherin-19target
DB01373CalciumProgrammed cell death protein 6target
DB09241Methylene blueGuanylate cyclase soluble subunit alpha-2target
DB09241Methylene blueNitric oxide synthase, braintarget