Quinolones

A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.
DrugDrug NameDrug Indication
DB00218MoxifloxacinFor the treatment of sinus and lung infections such as sinusitis, pneumonia, and secondary infections in chronic bronchitis. Also for the treatment of bacterial conjunctivitis (pinkeye).
DB00537CiprofloxacinCiprofloxacin is only indicated in infections caused by susceptible bacteria.[L6469,L6472,L6475,L6478,L6481,L6484,L6487,L6490,L6493] Ciprofloxacin immediate release tablets, oral suspensions, and intravenous injections are indicated for the treatment of skin and skin structure infections, bone and joint infections, complicated intra-abdominal infections, nosocomial pneumonia, febrile neutropenia, adults who have inhaled anthrax, plague, chronic bacterial prostatitis, lower respiratory tract infections including acute exacerbations of chronic bronchitis, urinary tract infections, complicated urinary tract infections in pediatrics, complicated pyelonephritis in pediatrics, and acute sinusitis.[L6481,L6478] A ciprofloxacin otic solution and otic suspension with hydrocortisone are indicated for acute otitis externa.[L6469,L6484] Ciprofloxacin suspension with dexamethasone is indicated for acute otitis media in pediatric patients with tympanostomy tubes or acute otitis externa.[L6490] A ciprofloxacin intratympanic injection is indicated for pediatric patients with bilateral otitis media with effusion who are having tympanostomy tubes placed or pediatric patients 6 months or older with acute otitis externa.[L6493] A ciprofloxacin eye drop is indicated for bacterial corneal ulcers and conjunctivitis.[L6472] A ciprofloxacin eye ointment is indicated for bacterial conjunctivitis.[L6475] A ciprofloxacin extended release tablet is indicated for uncomplicated urinary tract infections, complicated urinary tract infections, and acute uncomplicated pyelonephritis.[L6487]
DB01044GatifloxacinFor the treatment of bronchitis, sinusitis, community-acquired pneumonia, and skin infections (abscesses, wounds) caused by S. pneumoniae, H. influenzae, S. aureus, M. pneumoniae, C. pneumoniae, L. pneumophila, S. pyogenes
DB01059NorfloxacinFor the treatment of urinary tract infection
DB01137LevofloxacinFor the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms: Corynebacterium species, Staphylococus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus (Groups C/F/G), Viridans group streptococci, Acinetobacter lwoffii, Haemophilus influenzae, Serratia marcescens.
DB01165OfloxacinFor the treatment of infections (respiratory tract, kidney, skin, soft tissue, UTI), urethral and cervical gonorrhoea.
DB00365GrepafloxacinFor treatment of adults with mild to moderate infections caused by susceptible strains of Haemophilus influenzae, Streptococcus pneumoniae, or Moraxella catarrhalis.
DB00467EnoxacinFor the treatment of adults (≥18 years of age) with the following infections caused by susceptible strains of the designated microorganisms: (1) uncomplicated urethral or cervical gonorrhea due to Neisseria gonorrhoeae, (2) uncomplicated urinary tract infections (cystitis) due to Escherichia coli, Staphylococcus epidermidis, or Staphylococcus saprophyticus, and (3) complicated urinary tract infections due to Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus epidermidis, or Enterobacter cloacae.
DB00487PefloxacinFor the treatment of uncomplicated gonococcal urethritis in males and for gram-negative-bacterial infections in the gastrointestinal system and the genitourinary tract.
DB00521CarteololFor the treatment of intraocular hypertension and chronic open-angle glaucoma
DB00685TrovafloxacinFor treatment of infections caused by susceptible strains of the designated microorganisms in uncomplicated urethral gonorrhea in males and endocervical and rectal gonorrhea in females caused by Neisseria gonorrhoeae as well as non gonoccocal urethritis and cervicitis due to Chlamydia trachomatis.
DB00716NedocromilFor the treatment of mild to moderate asthma
DB00779Nalidixic acidFor the treatment of urinary tract infections caused by susceptible gram-negative microorganisms, including the majority of E. Coli, Enterobacter species, Klebsiella species, and Proteus species.
DB00978LomefloxacinFor the treatment of bacterial infections of the respiratory tract (chronic bronchitis) and urinary tract, and as a pre-operative prophylactic to prevent urinary tract infection caused by: S.pneumoniae, H.influenzae, S.aureus, P.aeruginosa, E. cloacae, P. mirabilis, C. civersus, S. asprphyticus, E.coli, and K.pneumoniae.
DB01208SparfloxacinFor the treatment of adults with the following infections caused by susceptible strains microorganisms: community-acquired pneumonia (caused by Chlamydia pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, Mycoplasma pneumoniae, or Streptococcus pneumoniae) and acute bacterial exacerbations of chronic bronchitis (caused by Chlamydia pneumoniae, Enterobacter cloacae, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Staphylococcus aureus, or Streptococcus pneumoniae).
DB01238AripiprazoleAripiprazole is indicated for manic and mixed episodes associated with bipolar I disorder, irritability associated with autism spectrum disorder, treatment of schizophrenia, treatment of Tourette's disorder, and as an adjunctive treatment of major depressive disorder[Label]. An injectable formulation of aripiprazole is indicated for agitation associated with schizophrenia or bipolar mania[Label].
DB01405TemafloxacinFor the treatment of lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections.
DB04576FleroxacinFleroxacin is a broad-spectrum antimicrobial fluoroquinolone.
DB05488Technetium Tc-99m ciprofloxacinInvestigated for use/treatment in infectious and parasitic disease (unspecified).
DB06160GarenoxacinInvestigated for use/treatment in bacterial infection.
DB08972FlumequineNot Available
DB09335AlatrofloxacinNot Available
DB11393DanofloxacinNot Available
DB11426MarbofloxacinNot Available
DB11443OrbifloxacinNot Available
DB11491SarafloxacinNot Available
DB11511DifloxacinNot Available
DB11774PazufloxacinNot Available
DB11892PrulifloxacinNot Available
DB11943DelafloxacinDelafloxacin is indicated for the treatment of acute bacterial skin and skin structure infections caused by the Gram-positive organisms Staphylococcus aureus (including methicillin-resistant and methicillin-susceptible isolates), Staphylococcus haemolyticus, Staphylococcus lugdunensis, Streptococcus agalactiae, Streptococcus anginosus Group (including Streptococcus anginosus, Streptococcus intermedius, and Streptococcus constellatus), Streptococcus pyogenes, and Enterococcus faecalis as well as the Gram-negative organisms Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae, and Pseudomonas aeruginosa [FDA Label].
DB12447NadifloxacinNot Available
DB12479ZabofloxacinNot Available
DB13261SitafloxacinNot Available
DB13627Oxolinic acidNot Available
DB13772RufloxacinNot Available
DB14025ClinafloxacinNot Available
DB14185Aripiprazole lauroxilAripiprazole lauroxil is indicated for the treatment of schizophrenia and related psychotic disorders.
DB01155GemifloxacinFor the treatment of bacterial infection caused by susceptible strains such as S. pneumoniae, H. influenzae, H. parainfluenzae, or M. catarrhalis, S. pneumoniae (including multi-drug resistant strains [MDRSP]), M. pneumoniae, C. pneumoniae, or K. pneumoniae.
DB06771BesifloxacinTreatment of bacterial conjunctivitis. Bacterial isolates that are susceptible to besifloxacin include: CDC coryneform group G; Corynebacterium pseudodiphtheriticum; Corynebacterium striatum; Haemophilus influenzae; Moraxella lacunata; Staphylococcus aureus; Staphylococcus epidermidis; Staphylococcus hominis; Staphylococcus lugdunensis; Streptococcus mitis group; Streptococcus oralis; Streptococcus pneumoniae; Streptococcus salivarius*
DB09047FinafloxacinFinafloxacin is indicated for the treatment of acute otitis externa (AOE) with or without an otowick, caused by susceptible strains of Pseudomonas aeruginosa and Staphylococcus aureus in patients age 1 year and older.
DrugDrug NameTargetType
DB00218MoxifloxacinDNA gyrase subunit Atarget
DB00218MoxifloxacinDNA topoisomerase 4 subunit Atarget
DB00218MoxifloxacinDNA topoisomerase 2-alphatarget
DB00218MoxifloxacinCytochrome P450 1A2enzyme
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 4 subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 2-alphatarget
DB00537CiprofloxacinCytochrome P450 1A2enzyme
DB00537CiprofloxacinCytochrome P450 3A4enzyme
DB00537CiprofloxacinCytochrome P450 3A5enzyme
DB00537CiprofloxacinCytochrome P450 3A7enzyme
DB00537CiprofloxacinMultidrug resistance protein 1transporter
DB00537CiprofloxacinPotassium voltage-gated channel subfamily H member 2target
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 4 subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 4 subunit Btarget
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinMultidrug resistance protein MdtKtarget
DB00537CiprofloxacinGyrase Atarget
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinMultidrug and toxin extrusion protein 1transporter
DB00537CiprofloxacinMultidrug and toxin extrusion protein 2transporter
DB00537CiprofloxacinSerum albumincarrier
DB01044GatifloxacinSerum albumincarrier
DB01044GatifloxacinDNA gyrase subunit Atarget
DB01044GatifloxacinDNA gyrase subunit Btarget
DB01044GatifloxacinDNA topoisomerase 4 subunit Atarget
DB01044GatifloxacinDNA topoisomerase 4 subunit Btarget
DB01044GatifloxacinCytochrome P450 1A2enzyme
DB01059NorfloxacinDNA gyrase subunit Atarget
DB01059NorfloxacinDNA topoisomerase 4 subunit Atarget
DB01059NorfloxacinDNA topoisomerase 2-alphatarget
DB01059NorfloxacinCytochrome P450 1A2enzyme
DB01059NorfloxacinCytochrome P450 3A4enzyme
DB01059NorfloxacinCytochrome P450 3A5enzyme
DB01059NorfloxacinCytochrome P450 3A7enzyme
DB01059NorfloxacinSolute carrier family 22 member 5transporter
DB01059NorfloxacinSolute carrier family 22 member 6transporter
DB01059NorfloxacinCytochrome P450 1A1enzyme
DB01137LevofloxacinDNA gyrase subunit Atarget
DB01137LevofloxacinDNA topoisomerase 4 subunit Atarget
DB01137LevofloxacinDNA topoisomerase 2-alphatarget
DB01137LevofloxacinCytochrome P450 1A2enzyme
DB01137LevofloxacinSolute carrier family 22 member 2transporter
DB01137LevofloxacinMultidrug resistance protein 1transporter
DB01137LevofloxacinSolute carrier family 22 member 4transporter
DB01137LevofloxacinSolute carrier family 22 member 6transporter
DB01137LevofloxacinCytochrome P450 3A4enzyme
DB01137LevofloxacinMultidrug and toxin extrusion protein 1transporter
DB01137LevofloxacinMultidrug and toxin extrusion protein 2transporter
DB01165OfloxacinDNA gyrase subunit Atarget
DB01165OfloxacinDNA topoisomerase 4 subunit Atarget
DB01165OfloxacinDNA topoisomerase 2-alphatarget
DB01165OfloxacinCytochrome P450 1A2enzyme
DB01165OfloxacinSolute carrier family 22 member 5transporter
DB01165OfloxacinMultidrug resistance-associated protein 1transporter
DB01165OfloxacinSolute carrier family 22 member 6transporter
DB01165OfloxacinCanalicular multispecific organic anion transporter 1transporter
DB01165OfloxacinSolute carrier family 22 member 4transporter
DB01165OfloxacinBile salt export pumptransporter
DB00365GrepafloxacinDNA gyrase subunit Atarget
DB00365GrepafloxacinDNA topoisomerase 4 subunit Atarget
DB00365GrepafloxacinCytochrome P450 3A4enzyme
DB00365GrepafloxacinCytochrome P450 1A2enzyme
DB00365GrepafloxacinSolute carrier family 22 member 2transporter
DB00365GrepafloxacinSolute carrier family 22 member 5transporter
DB00365GrepafloxacinCanalicular multispecific organic anion transporter 1transporter
DB00365GrepafloxacinMultidrug resistance protein 1transporter
DB00365GrepafloxacinMultidrug resistance-associated protein 1transporter
DB00365GrepafloxacinSolute carrier family 22 member 6transporter
DB00467EnoxacinDNA gyrase subunit Atarget
DB00467EnoxacinDNA topoisomerase 4 subunit Atarget
DB00467EnoxacinDNA topoisomerase 2-alphatarget
DB00467EnoxacinCytochrome P450 1A2enzyme
DB00487PefloxacinDNA gyrase subunit Atarget
DB00487PefloxacinDNA topoisomerase 4 subunit Atarget
DB00487PefloxacinDNA topoisomerase 2-alphatarget
DB00487PefloxacinCytochrome P450 1A2enzyme
DB00487PefloxacinDNA topoisomerase 1target
DB00521CarteololBeta-2 adrenergic receptortarget
DB00521CarteololBeta-1 adrenergic receptortarget
DB00521CarteololCytochrome P450 2D6enzyme
DB00685TrovafloxacinDNA gyrase subunit Atarget
DB00685TrovafloxacinDNA topoisomerase 4 subunit Atarget
DB00685TrovafloxacinDNA topoisomerase 2-alphatarget
DB00685TrovafloxacinCytochrome P450 1A2enzyme
DB00716NedocromilCysteinyl leukotriene receptor 1target
DB00716NedocromilCysteinyl leukotriene receptor 2target
DB00716NedocromilProstaglandin D2 receptortarget
DB00716NedocromilfMet-Leu-Phe receptortarget
DB00716NedocromilHeat shock protein HSP 90-alphatarget
DB00779Nalidixic acidDNAtarget
DB00779Nalidixic acidSolute carrier family 22 member 6transporter
DB00779Nalidixic acidTryptophan 2,3-dioxygenaseenzyme
DB00978LomefloxacinDNA gyrase subunit Atarget
DB00978LomefloxacinDNA topoisomerase 4 subunit Atarget
DB00978LomefloxacinDNA topoisomerase 2-alphatarget
DB00978LomefloxacinCytochrome P450 1A2enzyme
DB00978LomefloxacinSolute carrier family 22 member 5transporter
DB00978LomefloxacinCanalicular multispecific organic anion transporter 1transporter
DB01208SparfloxacinDNA gyrase subunit Atarget
DB01208SparfloxacinDNA topoisomerase 4 subunit Atarget
DB01208SparfloxacinDNA topoisomerase 2-alphatarget
DB01208SparfloxacinSolute carrier family 22 member 5transporter
DB01208SparfloxacinCanalicular multispecific organic anion transporter 1transporter
DB01208SparfloxacinMultidrug resistance protein 1transporter
DB01208SparfloxacinCytochrome P450 1A2enzyme
DB01238AripiprazoleD(2) dopamine receptortarget
DB01238Aripiprazole5-hydroxytryptamine receptor 1Atarget
DB01238Aripiprazole5-hydroxytryptamine receptor 2Atarget
DB01238AripiprazoleCytochrome P450 3A4enzyme
DB01238AripiprazoleCytochrome P450 2D6enzyme
DB01238Aripiprazole5-hydroxytryptamine receptor 1Btarget
DB01238Aripiprazole5-hydroxytryptamine receptor 1Dtarget
DB01238Aripiprazole5-hydroxytryptamine receptor 1Etarget
DB01238AripiprazoleD(1A) dopamine receptortarget
DB01238AripiprazoleD(1B) dopamine receptortarget
DB01238AripiprazoleD(3) dopamine receptortarget
DB01238AripiprazoleD(4) dopamine receptortarget
DB01238Aripiprazole5-hydroxytryptamine receptor 2Ctarget
DB01238Aripiprazole5-hydroxytryptamine receptor 3Atarget
DB01238Aripiprazole5-hydroxytryptamine receptor 6target
DB01238Aripiprazole5-hydroxytryptamine receptor 7target
DB01238AripiprazoleHistamine H1 receptortarget
DB01238AripiprazoleAlpha-1A adrenergic receptortarget
DB01238AripiprazoleAlpha-1B adrenergic receptortarget
DB01238AripiprazoleAlpha-2A adrenergic receptortarget
DB01238AripiprazoleAlpha-2B adrenergic receptortarget
DB01238AripiprazoleAlpha-2C adrenergic receptortarget
DB01238AripiprazoleMuscarinic acetylcholine receptor M1target
DB01238AripiprazoleMuscarinic acetylcholine receptor M2target
DB01238AripiprazoleMuscarinic acetylcholine receptor M3target
DB01238AripiprazoleMuscarinic acetylcholine receptor M4target
DB01238AripiprazoleMuscarinic acetylcholine receptor M5target
DB01238AripiprazoleCytochrome P450 3A5enzyme
DB01238AripiprazoleCytochrome P450 3A7enzyme
DB01238AripiprazoleSerum albumincarrier
DB01405TemafloxacinDNA gyrase subunit Atarget
DB01405TemafloxacinDNA topoisomerase 4 subunit Atarget
DB01405TemafloxacinCytochrome P450 1A2enzyme
DB04576FleroxacinDNA topoisomerase 2-alphatarget
DB04576FleroxacinDNA gyrase subunit Atarget
DB04576FleroxacinDNA topoisomerase 4 subunit Atarget
DB04576FleroxacinCytochrome P450 1A2enzyme
DB05488Technetium Tc-99m ciprofloxacinDNA gyrase subunit Btarget
DB05488Technetium Tc-99m ciprofloxacinDNA topoisomerase 2-betatarget
DB05488Technetium Tc-99m ciprofloxacinCytochrome P450 1A2enzyme
DB06160GarenoxacinCytochrome P450 1A2enzyme
DB08972FlumequineCytochrome P450 1A2enzyme
DB11443OrbifloxacinCytochrome P450 1A2enzyme
DB11491SarafloxacinCytochrome P450 1A2enzyme
DB11511DifloxacinCytochrome P450 1A2enzyme
DB11774PazufloxacinCytochrome P450 1A2enzyme
DB11892PrulifloxacinCytochrome P450 1A2enzyme
DB11943DelafloxacinUDP-glucuronosyltransferase 1-1enzyme
DB11943DelafloxacinUDP-glucuronosyltransferase 1-3enzyme
DB11943DelafloxacinUDP-glucuronosyltransferase 2B15enzyme
DB11943DelafloxacinDNA topoisomerase 4 subunit Atarget
DB11943DelafloxacinDNA gyrase subunit Atarget
DB11943DelafloxacinCytochrome P450 2E1enzyme
DB11943DelafloxacinCytochrome P450 2C9enzyme
DB11943DelafloxacinCytochrome P450 3A4enzyme
DB11943DelafloxacinATP-binding cassette sub-family B member 5transporter
DB11943DelafloxacinATP-binding cassette sub-family G member 2transporter
DB11943DelafloxacinSerum albumincarrier
DB13261SitafloxacinCytochrome P450 1A2enzyme
DB13627Oxolinic acidCytochrome P450 1A2enzyme
DB13772RufloxacinCytochrome P450 1A2enzyme
DB14025ClinafloxacinCytochrome P450 1A2enzyme
DB14025ClinafloxacinCytochrome P450 2C19enzyme
DB14025ClinafloxacinCytochrome P450 2D6enzyme
DB14025ClinafloxacinCytochrome P450 2C9enzyme
DB14185Aripiprazole lauroxilD(2) dopamine receptortarget
DB14185Aripiprazole lauroxil5-hydroxytryptamine receptor 1Atarget
DB14185Aripiprazole lauroxil5-hydroxytryptamine receptor 2Atarget
DB14185Aripiprazole lauroxilCytochrome P450 3A4enzyme
DB14185Aripiprazole lauroxilCytochrome P450 2D6enzyme
DB14185Aripiprazole lauroxil5-hydroxytryptamine receptor 1Btarget
DB14185Aripiprazole lauroxil5-hydroxytryptamine receptor 1Dtarget
DB14185Aripiprazole lauroxil5-hydroxytryptamine receptor 1Etarget
DB14185Aripiprazole lauroxilD(1A) dopamine receptortarget
DB14185Aripiprazole lauroxilD(1B) dopamine receptortarget
DB14185Aripiprazole lauroxilD(3) dopamine receptortarget
DB14185Aripiprazole lauroxilD(4) dopamine receptortarget
DB14185Aripiprazole lauroxil5-hydroxytryptamine receptor 2Ctarget
DB14185Aripiprazole lauroxil5-hydroxytryptamine receptor 3Atarget
DB14185Aripiprazole lauroxil5-hydroxytryptamine receptor 6target
DB14185Aripiprazole lauroxil5-hydroxytryptamine receptor 7target
DB14185Aripiprazole lauroxilHistamine H1 receptortarget
DB14185Aripiprazole lauroxilAlpha-1A adrenergic receptortarget
DB14185Aripiprazole lauroxilAlpha-1B adrenergic receptortarget
DB14185Aripiprazole lauroxilAlpha-2A adrenergic receptortarget
DB14185Aripiprazole lauroxilAlpha-2B adrenergic receptortarget
DB14185Aripiprazole lauroxilAlpha-2C adrenergic receptortarget
DB14185Aripiprazole lauroxilMuscarinic acetylcholine receptor M1target
DB14185Aripiprazole lauroxilMuscarinic acetylcholine receptor M2target
DB14185Aripiprazole lauroxilMuscarinic acetylcholine receptor M3target
DB14185Aripiprazole lauroxilMuscarinic acetylcholine receptor M4target
DB14185Aripiprazole lauroxilMuscarinic acetylcholine receptor M5target
DB14185Aripiprazole lauroxilCytochrome P450 3A5enzyme
DB14185Aripiprazole lauroxilCytochrome P450 3A7enzyme
DB14185Aripiprazole lauroxilSerum albumincarrier
DB01155GemifloxacinDNA gyrase subunit Atarget
DB01155GemifloxacinDNA topoisomerase 4 subunit Atarget
DB01155GemifloxacinCytochrome P450 1A2enzyme
DB06771BesifloxacinDNA topoisomerase 4 subunit Atarget
DB06771BesifloxacinDNA topoisomerase 4 subunit Atarget
DB06771BesifloxacinDNA gyrase subunit Atarget
DB06771BesifloxacinDNA gyrase subunit Atarget
DB06771BesifloxacinCytochrome P450 1A2enzyme
DB09047FinafloxacinDNA gyrase subunit Atarget
DB09047FinafloxacinDNA topoisomerase 4 subunit Atarget
DB09047FinafloxacinDNA topoisomerase 2-alphatarget