Quinolones

Name
Quinolones
Accession Number
DBCAT000903
Description

A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.

Drugs
DrugDrug Description
MoxifloxacinA fluoroquinolone antibiotic used to treat various bacterial infections.
CiprofloxacinA second generation fluoroquinolone used to treat various susceptible bacterial infections.
GatifloxacinA fourth generation fluoroquinolone used to treat a wide variety of infections in the body.
NorfloxacinA broad-spectrum fluoroquinolone antibiotic with variable activity against gram-positive and gram-negative bacteria. Typically reserved for the treatment of UTIs due to accumulation in the urine.
LevofloxacinA fluoroquinolone antibiotic used to treat infections caused by susceptible bacteria of the upper respiratory tract, skin and skin structures, urinary tract, and prostate, as well as for post-exposure treatment of inhaled anthrax and the plague.
OfloxacinAn antibacterial agent used for the treatment of bacterial infections in many parts of the body, including the respiratory tract, kidney, skin, soft tissue, and urinary tract.
GrepafloxacinA fluoroquinolone antibiotic used to treat various gram positive and gram negative bacterial infections.
EnoxacinFor the treatment of adults (≥18 years of age) with the following infections caused by susceptible strains of the designated microorganisms: (1) uncomplicated urethral or cervical gonorrhea due to Neisseria...
PefloxacinFor the treatment of uncomplicated gonococcal urethritis in males and for gram-negative-bacterial infections in the gastrointestinal system and the genitourinary tract.
CarteololA beta adrenergic antagonist used to treat arrhythmia, angina, hypertension, and glaucoma.
TrovafloxacinAn antibiotic used to treat gonorrhea and chlamydia.
NedocromilA pyrano quinoline used to treat allergic conjunctivitis.
Nalidixic acidA quinolone antibiotic used to treat urinary tract infections.
LomefloxacinA fluoroquinolone used to prevent and treat a wide variety of infections in the body.
SparfloxacinFor the treatment of adults with the following infections caused by susceptible strains microorganisms: community-acquired pneumonia (caused by Chlamydia pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, Mycoplasma pneumoniae, or Streptococcus...
AripiprazoleAn atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome.
TemafloxacinFor the treatment of lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections.
FleroxacinFleroxacin is a broad-spectrum antimicrobial fluoroquinolone.
Technetium Tc-99m ciprofloxacinInvestigated for use/treatment in infectious and parasitic disease (unspecified).
GarenoxacinInvestigated for use/treatment in bacterial infection.
FlumequineFlumequine is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class used to treat bacterial infections.
AlatrofloxacinA fluoroquinolone antibiotic used to treat a variety of bacterial infections.
DanofloxacinDanofloxacin is an antibiotic agent from the family of the fluoroquinolones used in veterinary.
EnrofloxacinEnrofloxacin is an antibiotic agent from the fluoroquinolone family produced by the Bayer Corporation. Enrofloxacin is approved by the FDA for its veterinary use. Due to the identification of fluoroquinolone-resistant...
MarbofloxacinMarbofloxacin is a carboxylic acid, part of the third generation of antibiotic fluoroquinolones. It is used in veterinary. A formulation of marbofloxacin combined with clotrimazole and dexamethasone is available under...
OrbifloxacinOrbifloxacin is a fluoroquinolone antibiotic. It is marketed by Schering-Plough Animal Health and approved for certain infections in dogs.
PradofloxacinPradofloxacin is a 3rd generation fluoroquinolone antibiotic developed by Bayer HealthCare AG, Animal Health GmBH. It was approved by the European Commission in April 2011 for bacterial infections in dogs...
SarafloxacinSarafloxacin is a quinolone antibiotic drug, which was discontinued by its manufacturer, Abbott Laboratories, before receiving approval for use in the US or Canada.
DifloxacinDifloxacin is a synthetic fluoroquinolone used in veterinary. As an antibacterial, it presents a broad bactericidal spectrum and its effects are dependent on its concentration. However, it presents a reduced...
PazufloxacinPazufloxacin is under investigation in clinical trial NCT02592096 (Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol).
PrulifloxacinPrulifloxacin has been investigated for the treatment of Urinary Tract Infection.
DelafloxacinA fluoroquinolone antibiotic used to treat skin and skin structure infections.
NadifloxacinNadifloxacin has been used in trials studying the treatment of Acne Vulgaris.
ZabofloxacinZabofloxacin has been used in trials studying the treatment of Community Acquired Pneumonia and Chronic Obstructive Pulmonary Disease.
SitafloxacinNot Annotated
Oxolinic acidNot Annotated
RufloxacinRufloxacin is a quinolone antibiotic.
ClinafloxacinClinafloxacin is a fluoroquinolone antibacterial currently under research. It has been proven to present good antibiotic properties. However, its approval and release have been halted due to the presence of...
Aripiprazole lauroxilAn antipsychotic used to treat schizophrenia in adults.
GemifloxacinA quinolone antibacterial agent used for the treatment of acute bacterial exacerbation of chronic bronchitis and mild to moderate community-acquired pneumonia caused by susceptible bacteria.
BesifloxacinA fluoroquinolone antibiotic agent used for the treatment of bacterial conjunctivitis.
FinafloxacinFinafloxacin is indicated for the treatment of acute otitis externa (AOE) with or without an otowick, caused by susceptible strains of Pseudomonas aeruginosa and Staphylococcus aureus in patients age 1...
Piromidic acidNot Annotated
Drugs & Drug Targets
DrugTargetType
MoxifloxacinDNA gyrase subunit Atarget
MoxifloxacinDNA topoisomerase 4 subunit Atarget
MoxifloxacinDNA topoisomerase 2-alphatarget
MoxifloxacinCytochrome P450 1A2enzyme
CiprofloxacinDNA gyrase subunit Atarget
CiprofloxacinDNA topoisomerase 4 subunit Atarget
CiprofloxacinDNA topoisomerase 2-alphatarget
CiprofloxacinCytochrome P450 1A2enzyme
CiprofloxacinCytochrome P450 3A4enzyme
CiprofloxacinCytochrome P450 3A5enzyme
CiprofloxacinCytochrome P450 3A7enzyme
CiprofloxacinP-glycoprotein 1transporter
CiprofloxacinPotassium voltage-gated channel subfamily H member 2target
CiprofloxacinDNA gyrase subunit Atarget
CiprofloxacinDNA topoisomerase 4 subunit Atarget
CiprofloxacinDNA topoisomerase 4 subunit Btarget
CiprofloxacinDNA gyrase subunit Atarget
CiprofloxacinMultidrug resistance protein MdtKtarget
CiprofloxacinGyrase Atarget
CiprofloxacinDNA gyrase subunit Atarget
CiprofloxacinMultidrug and toxin extrusion protein 1transporter
CiprofloxacinMultidrug and toxin extrusion protein 2transporter
CiprofloxacinSerum albumincarrier
GatifloxacinSerum albumincarrier
GatifloxacinDNA gyrase subunit Atarget
GatifloxacinDNA gyrase subunit Btarget
GatifloxacinDNA topoisomerase 4 subunit Atarget
GatifloxacinDNA topoisomerase 4 subunit Btarget
GatifloxacinCytochrome P450 1A2enzyme
NorfloxacinDNA gyrase subunit Atarget
NorfloxacinDNA topoisomerase 4 subunit Atarget
NorfloxacinDNA topoisomerase 2-alphatarget
NorfloxacinCytochrome P450 1A2enzyme
NorfloxacinCytochrome P450 3A4enzyme
NorfloxacinSolute carrier family 22 member 5transporter
NorfloxacinSolute carrier family 22 member 6transporter
NorfloxacinCytochrome P450 1A1enzyme
LevofloxacinDNA gyrase subunit Atarget
LevofloxacinDNA topoisomerase 4 subunit Atarget
LevofloxacinCytochrome P450 1A2enzyme
LevofloxacinSolute carrier family 22 member 2transporter
LevofloxacinP-glycoprotein 1transporter
LevofloxacinSolute carrier family 22 member 4transporter
LevofloxacinMultidrug and toxin extrusion protein 1transporter
LevofloxacinMultidrug and toxin extrusion protein 2transporter
LevofloxacinCytochrome P450 2C9enzyme
LevofloxacinSerum albumincarrier
LevofloxacinSolute carrier organic anion transporter family member 4C1transporter
LevofloxacinSolute carrier family 22 member 1transporter
LevofloxacinSolute carrier organic anion transporter family member 1A2transporter
OfloxacinDNA gyrase subunit Atarget
OfloxacinDNA topoisomerase 4 subunit Atarget
OfloxacinDNA topoisomerase 2-alphatarget
OfloxacinCytochrome P450 1A2enzyme
OfloxacinSolute carrier family 22 member 5transporter
OfloxacinMultidrug resistance-associated protein 1transporter
OfloxacinSolute carrier family 22 member 6transporter
OfloxacinCanalicular multispecific organic anion transporter 1transporter
OfloxacinSolute carrier family 22 member 4transporter
OfloxacinBile salt export pumptransporter
GrepafloxacinDNA gyrase subunit Atarget
GrepafloxacinDNA topoisomerase 4 subunit Atarget
GrepafloxacinCytochrome P450 3A4enzyme
GrepafloxacinCytochrome P450 1A2enzyme
GrepafloxacinSolute carrier family 22 member 2transporter
GrepafloxacinSolute carrier family 22 member 5transporter
GrepafloxacinCanalicular multispecific organic anion transporter 1transporter
GrepafloxacinP-glycoprotein 1transporter
GrepafloxacinMultidrug resistance-associated protein 1transporter
GrepafloxacinSolute carrier family 22 member 6transporter
EnoxacinDNA gyrase subunit Atarget
EnoxacinDNA topoisomerase 4 subunit Atarget
EnoxacinDNA topoisomerase 2-alphatarget
EnoxacinCytochrome P450 1A2enzyme
PefloxacinDNA gyrase subunit Atarget
PefloxacinDNA topoisomerase 4 subunit Atarget
PefloxacinDNA topoisomerase 2-alphatarget
PefloxacinCytochrome P450 1A2enzyme
PefloxacinDNA topoisomerase 1target
CarteololBeta-2 adrenergic receptortarget
CarteololBeta-1 adrenergic receptortarget
CarteololCytochrome P450 2D6enzyme
TrovafloxacinDNA gyrase subunit Atarget
TrovafloxacinDNA topoisomerase 4 subunit Atarget
TrovafloxacinDNA topoisomerase 2-alphatarget
TrovafloxacinCytochrome P450 1A2enzyme
NedocromilCysteinyl leukotriene receptor 1target
NedocromilCysteinyl leukotriene receptor 2target
NedocromilProstaglandin D2 receptortarget
NedocromilfMet-Leu-Phe receptortarget
NedocromilHeat shock protein HSP 90-alphatarget
Nalidixic acidDNAtarget
Nalidixic acidSolute carrier family 22 member 6transporter
Nalidixic acidTryptophan 2,3-dioxygenaseenzyme
Nalidixic acidCytochrome P450 1A2enzyme
LomefloxacinDNA gyrase subunit Atarget
LomefloxacinDNA topoisomerase 4 subunit Atarget
LomefloxacinDNA topoisomerase 2-alphatarget
LomefloxacinCytochrome P450 1A2enzyme
LomefloxacinSolute carrier family 22 member 5transporter
LomefloxacinCanalicular multispecific organic anion transporter 1transporter
SparfloxacinDNA gyrase subunit Atarget
SparfloxacinDNA topoisomerase 4 subunit Atarget
SparfloxacinDNA topoisomerase 2-alphatarget
SparfloxacinSolute carrier family 22 member 5transporter
SparfloxacinCanalicular multispecific organic anion transporter 1transporter
SparfloxacinP-glycoprotein 1transporter
SparfloxacinCytochrome P450 1A2enzyme
AripiprazoleDopamine D2 receptortarget
Aripiprazole5-hydroxytryptamine receptor 1Atarget
Aripiprazole5-hydroxytryptamine receptor 2Atarget
AripiprazoleCytochrome P450 3A4enzyme
AripiprazoleCytochrome P450 2D6enzyme
Aripiprazole5-hydroxytryptamine receptor 1Btarget
Aripiprazole5-hydroxytryptamine receptor 1Dtarget
Aripiprazole5-hydroxytryptamine receptor 1Etarget
AripiprazoleDopamine D1 receptortarget
AripiprazoleDopamine D5 receptortarget
AripiprazoleDopamine D3 receptortarget
AripiprazoleDopamine D4 receptortarget
Aripiprazole5-hydroxytryptamine receptor 2Ctarget
Aripiprazole5-hydroxytryptamine receptor 3Atarget
Aripiprazole5-hydroxytryptamine receptor 6target
Aripiprazole5-hydroxytryptamine receptor 7target
AripiprazoleHistamine H1 receptortarget
AripiprazoleAlpha-1A adrenergic receptortarget
AripiprazoleAlpha-1B adrenergic receptortarget
AripiprazoleAlpha-2A adrenergic receptortarget
AripiprazoleAlpha-2B adrenergic receptortarget
AripiprazoleAlpha-2C adrenergic receptortarget
AripiprazoleCytochrome P450 3A5enzyme
AripiprazoleCytochrome P450 3A7enzyme
AripiprazoleSerum albumincarrier
Aripiprazole5-hydroxytryptamine receptor 2Btarget
Aripiprazole5-hydroxytryptamine receptor 5Atarget
AripiprazoleBeta-1 adrenergic receptortarget
AripiprazoleBeta-2 adrenergic receptortarget
AripiprazoleHistamine H2 receptortarget
AripiprazoleHistamine H3 receptortarget
AripiprazoleHistamine H4 receptortarget
AripiprazoleMuscarinic acetylcholine receptor M1target
AripiprazoleMuscarinic acetylcholine receptor M2target
AripiprazoleMuscarinic acetylcholine receptor M3target
AripiprazoleMuscarinic acetylcholine receptor M4target
AripiprazoleMuscarinic acetylcholine receptor M5target
AripiprazoleKappa-type opioid receptortarget
AripiprazoleMu-type opioid receptortarget
AripiprazoleDelta-type opioid receptortarget
AripiprazoleGlutamate (NMDA) receptortarget
AripiprazoleSodium-dependent dopamine transportertarget
AripiprazoleSodium-dependent serotonin transportertarget
TemafloxacinDNA gyrase subunit Atarget
TemafloxacinDNA topoisomerase 4 subunit Atarget
TemafloxacinCytochrome P450 1A2enzyme
FleroxacinDNA topoisomerase 2-alphatarget
FleroxacinDNA gyrase subunit Atarget
FleroxacinDNA topoisomerase 4 subunit Atarget
Technetium Tc-99m ciprofloxacinDNA gyrase subunit Btarget
Technetium Tc-99m ciprofloxacinDNA topoisomerase 2-betatarget
Technetium Tc-99m ciprofloxacinCytochrome P450 1A2enzyme
GarenoxacinCytochrome P450 1A2enzyme
FlumequineCytochrome P450 1A2enzyme
EnrofloxacinCytochrome P450 1A2enzyme
OrbifloxacinCytochrome P450 1A2enzyme
SarafloxacinCytochrome P450 1A2enzyme
DifloxacinCytochrome P450 1A2enzyme
DifloxacinCytochrome P450 1A1enzyme
PazufloxacinCytochrome P450 1A2enzyme
PrulifloxacinCytochrome P450 1A2enzyme
DelafloxacinUDP-glucuronosyltransferase 1-1enzyme
DelafloxacinUDP-glucuronosyltransferase 1-3enzyme
DelafloxacinUDP-glucuronosyltransferase 2B15enzyme
DelafloxacinDNA topoisomerase 4 subunit Atarget
DelafloxacinDNA gyrase subunit Atarget
DelafloxacinCytochrome P450 2E1enzyme
DelafloxacinCytochrome P450 2C9enzyme
DelafloxacinCytochrome P450 3A4enzyme
DelafloxacinATP-binding cassette sub-family B member 5transporter
DelafloxacinATP-binding cassette sub-family G member 2transporter
DelafloxacinSerum albumincarrier
SitafloxacinCytochrome P450 1A2enzyme
Oxolinic acidCytochrome P450 1A2enzyme
RufloxacinCytochrome P450 1A2enzyme
ClinafloxacinCytochrome P450 1A2enzyme
ClinafloxacinCytochrome P450 2C19enzyme
ClinafloxacinCytochrome P450 2D6enzyme
ClinafloxacinCytochrome P450 2C9enzyme
Aripiprazole lauroxilDopamine D2 receptortarget
Aripiprazole lauroxil5-hydroxytryptamine receptor 1Atarget
Aripiprazole lauroxil5-hydroxytryptamine receptor 2Atarget
Aripiprazole lauroxilCytochrome P450 3A4enzyme
Aripiprazole lauroxilCytochrome P450 2D6enzyme
Aripiprazole lauroxil5-hydroxytryptamine receptor 1Btarget
Aripiprazole lauroxil5-hydroxytryptamine receptor 1Dtarget
Aripiprazole lauroxil5-hydroxytryptamine receptor 1Etarget
Aripiprazole lauroxilDopamine D1 receptortarget
Aripiprazole lauroxilDopamine D5 receptortarget
Aripiprazole lauroxilDopamine D3 receptortarget
Aripiprazole lauroxilDopamine D4 receptortarget
Aripiprazole lauroxil5-hydroxytryptamine receptor 2Ctarget
Aripiprazole lauroxil5-hydroxytryptamine receptor 3Atarget
Aripiprazole lauroxil5-hydroxytryptamine receptor 6target
Aripiprazole lauroxil5-hydroxytryptamine receptor 7target
Aripiprazole lauroxilHistamine H1 receptortarget
Aripiprazole lauroxilAlpha-1A adrenergic receptortarget
Aripiprazole lauroxilAlpha-1B adrenergic receptortarget
Aripiprazole lauroxilAlpha-2A adrenergic receptortarget
Aripiprazole lauroxilAlpha-2B adrenergic receptortarget
Aripiprazole lauroxilAlpha-2C adrenergic receptortarget
Aripiprazole lauroxilMuscarinic acetylcholine receptor M1target
Aripiprazole lauroxilMuscarinic acetylcholine receptor M2target
Aripiprazole lauroxilMuscarinic acetylcholine receptor M3target
Aripiprazole lauroxilMuscarinic acetylcholine receptor M4target
Aripiprazole lauroxilMuscarinic acetylcholine receptor M5target
Aripiprazole lauroxilCytochrome P450 3A5enzyme
Aripiprazole lauroxilCytochrome P450 3A7enzyme
Aripiprazole lauroxilSerum albumincarrier
GemifloxacinDNA gyrase subunit Atarget
GemifloxacinDNA topoisomerase 4 subunit Atarget
GemifloxacinCytochrome P450 1A2enzyme
BesifloxacinDNA topoisomerase 4 subunit Atarget
BesifloxacinDNA topoisomerase 4 subunit Atarget
BesifloxacinDNA gyrase subunit Atarget
BesifloxacinDNA gyrase subunit Atarget
BesifloxacinCytochrome P450 1A2enzyme
FinafloxacinDNA gyrase subunit Atarget
FinafloxacinDNA topoisomerase 4 subunit Atarget
FinafloxacinDNA topoisomerase 2-alphatarget