Pyrimidine Nucleotides

Pyrimidines with a RIBOSE and phosphate attached that can polymerize to form DNA and RNA.
DrugDrug NameDrug Indication
DB00475ChlordiazepoxideFor the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety.
DB01643Thymidine monophosphateNot Available
DB03041UDP-alpha-D-glucuronic acidNot Available
DB03326deoxycytidylyl-3',5'-guanosineNot Available
DB03501Galactose-uridine-5'-diphosphateNot Available
DB036681-(5'-Phospho-Beta-D-Ribofuranosyl)Barbituric AcidNot Available
DB037186-Aza-UmpNot Available
DB03800Deoxyuridine monophosphateNot Available
DB04672Cyclic 3',5'-thymidine monophosphateNot Available
DB04983DenufosolFor use as an inhaled treatment for cystic fibrosis.
DB08934SofosbuvirSofosbuvir is used in combination therapy with other antiviral medications to treat chronic hepatitis C virus (HCV) infected patients with HCV genoptypes 1-6, and to treat HCV and HIV co-infected patients. Depending on the level of cirrhosis or decompensation, combination therapy can also include either ribavirin alone or ribavirin and peg-interferon alfa. When used in combination with [DB09027] as the combination product Harvoni, sofosbuvir has the following indications: treatment of genotypes 1, 4, 5, or 6 infection without cirrhosis or with compensated cirrhosis; in combination with [DB00811] for genotype 1 infection with decompensated cirrhosis; or in combination with [DB00811] for the treatment of genotype 1 or 4 infection who are liver transplant recipients without cirrhosis or with compensated cirrhosis. When used in combination with [DB11613] as the combination product Epclusa, sofosbuvir is indicated for the treatment of adult patients with chronic hepatitis C virus (HCV) genotypes 1, 2, 3, 4, 5, or 6 infection without cirrhosis or with compensated cirrhosis, or in combination with [DB00811] if associated with decompensated cirrhosis. Resistance: Reduced susceptibility to sofosbuvir has been associated with the NS5B substitution mutation S282T [A19634].
DB01861Uridine diphosphate glucoseNot Available
DB027143'-UridinemonophosphateNot Available
DB032582'-Deoxycytidine 5'-triphosphateNot Available
DB03403Cytidine-5'-MonophosphateNot Available
DB03685Uridine monophosphateNot Available
DB04005Uridine 5'-triphosphateNot Available
DB12153CiticolineNot Available
DB15057NUC-1031Not Available
DrugDrug NameTargetType
DB00475ChlordiazepoxideCytochrome P450 3A4enzyme
DB00475ChlordiazepoxideGABA-A receptor (anion channel)target
DB01643Thymidine monophosphateThymidylate kinasetarget
DB01643Thymidine monophosphateThymidylate kinasetarget
DB01643Thymidine monophosphateThymidine kinasetarget
DB01643Thymidine monophosphateThymidylate synthasetarget
DB01643Thymidine monophosphateDNA topoisomerase 1target
DB01643Thymidine monophosphateThymidylate synthasetarget
DB01643Thymidine monophosphatePCZA361.16target
DB01643Thymidine monophosphateDNA polymerase III subunit epsilontarget
DB01643Thymidine monophosphateGlucose-1-phosphate thymidylyltransferasetarget
DB03041UDP-alpha-D-glucuronic acidGalactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3target
DB03041UDP-alpha-D-glucuronic acidUDP-glucose 6-dehydrogenasetarget
DB03041UDP-alpha-D-glucuronic acidUDP-glucose 4-epimerasetarget
DB03326deoxycytidylyl-3',5'-guanosineRibonuclease pancreatictarget
DB03501Galactose-uridine-5'-diphosphateHisto-blood group ABO system transferasetarget
DB03501Galactose-uridine-5'-diphosphateUDP-glucose 4-epimerasetarget
DB03501Galactose-uridine-5'-diphosphateBeta-1,4-galactosyltransferase 1target
DB036681-(5'-Phospho-Beta-D-Ribofuranosyl)Barbituric AcidOrotidine 5'-phosphate decarboxylasetarget
DB03800Deoxyuridine monophosphateDeoxyuridine 5'-triphosphate nucleotidohydrolasetarget
DB03800Deoxyuridine monophosphateThymidylate synthasetarget
DB03800Deoxyuridine monophosphateThymidylate synthasetarget
DB03800Deoxyuridine monophosphateThymidylate synthasetarget
DB03800Deoxyuridine monophosphateThymidylate synthase ThyXtarget
DB03800Deoxyuridine monophosphatePol polyproteintarget
DB03800Deoxyuridine monophosphateDeoxyuridine 5'-triphosphate nucleotidohydrolasetarget
DB03800Deoxyuridine monophosphateThymidylate synthasetarget
DB04672Cyclic 3',5'-thymidine monophosphate5'(3')-deoxyribonucleotidase, mitochondrialtarget
DB04983DenufosolP2Y purinoceptor 2target
DB08934SofosbuvirMultidrug resistance protein 1transporter
DB08934SofosbuvirATP-binding cassette sub-family G member 2transporter
DB08934SofosbuvirRNA-dependent RNA-polymerasetarget
DB08934SofosbuvirLysosomal protective proteinenzyme
DB08934SofosbuvirCarboxylesteraseenzyme
DB08934SofosbuvirHistidine triad nucleotide-binding protein 1enzyme
DB08934SofosbuvirUMP-CMP kinaseenzyme
DB08934SofosbuvirNucleoside diphosphate kinase Aenzyme
DB01861Uridine diphosphate glucoseGalactose-1-phosphate uridylyltransferasetarget
DB01861Uridine diphosphate glucoseUDP-glucose 4-epimerasetarget
DB01861Uridine diphosphate glucoseAlpha,alpha-trehalose-phosphate synthase [UDP-forming]target
DB01861Uridine diphosphate glucoseGlucose-1-phosphate thymidylyltransferasetarget
DB01861Uridine diphosphate glucoseUDP-glucose 4-epimerasetarget
DB01861Uridine diphosphate glucoseDNA beta-glucosyltransferasetarget
DB01861Uridine diphosphate glucoseGlycosyltransferase 6 domain-containing protein 1target
DB01861Uridine diphosphate glucoseWbpPtarget
DB01861Uridine diphosphate glucoseGlycogenin-1target
DB027143'-UridinemonophosphateRibonuclease pancreatictarget
DB032582'-Deoxycytidine 5'-triphosphateAnaerobic ribonucleoside-triphosphate reductasetarget
DB032582'-Deoxycytidine 5'-triphosphateDeoxycytidine triphosphate deaminasetarget
DB032582'-Deoxycytidine 5'-triphosphateDNA polymerase I, thermostabletarget
DB032582'-Deoxycytidine 5'-triphosphateRibonucleoside-diphosphate reductase 2 subunit alphatarget
DB03403Cytidine-5'-MonophosphateUridine-cytidine kinase 2target
DB03403Cytidine-5'-Monophosphate3-deoxy-manno-octulosonate cytidylyltransferasetarget
DB03403Cytidine-5'-Monophosphate2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthasetarget
DB03403Cytidine-5'-MonophosphateBifunctional enzyme IspD/IspFtarget
DB03403Cytidine-5'-MonophosphateUMP-CMP kinasetarget
DB03403Cytidine-5'-Monophosphate2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthasetarget
DB03403Cytidine-5'-MonophosphateCytidylate kinasetarget
DB03403Cytidine-5'-MonophosphateCoenzyme A biosynthesis bifunctional protein CoaBCtarget
DB03403Cytidine-5'-MonophosphateAlpha-2,3-/2,8-sialyltransferasetarget
DB03685Uridine monophosphateUridine-cytidine kinase-like 1target
DB03685Uridine monophosphateGalactose-1-phosphate uridylyltransferasetarget
DB03685Uridine monophosphateThymidylate synthasetarget
DB03685Uridine monophosphateGlycosyltransferase 6 domain-containing protein 1target
DB03685Uridine monophosphateU6 snRNA-associated Sm-like protein LSm6target
DB03685Uridine monophosphateUracil phosphoribosyltransferasetarget
DB03685Uridine monophosphateBeta-1,4-galactosyltransferase 1target
DB03685Uridine monophosphateInterferon-stimulated gene 20 kDa proteintarget
DB03685Uridine monophosphateOrotidine 5'-phosphate decarboxylasetarget
DB03685Uridine monophosphateBifunctional protein PyrRtarget
DB03685Uridine monophosphateUracil phosphoribosyltransferasetarget
DB03685Uridine monophosphateBifunctional polymyxin resistance protein ArnAtarget
DB03685Uridine monophosphateRibosomal small subunit pseudouridine synthase Atarget
DB04005Uridine 5'-triphosphateUridine-cytidine kinase 2target
DB04005Uridine 5'-triphosphateGenome polyproteintarget
DB04005Uridine 5'-triphosphateGenome polyproteintarget
DB12153CiticolineLicC proteintarget