|DB00475||Chlordiazepoxide||For the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety.|
|DB01643||Thymidine monophosphate||Not Available|
|DB03041||UDP-alpha-D-glucuronic acid||Not Available|
|DB03668||1-(5'-Phospho-Beta-D-Ribofuranosyl)Barbituric Acid||Not Available|
|DB03800||Deoxyuridine monophosphate||Not Available|
|DB04672||Cyclic 3',5'-thymidine monophosphate||Not Available|
|DB04983||Denufosol||For use as an inhaled treatment for cystic fibrosis.|
|DB08934||Sofosbuvir||Sofosbuvir is used in combination therapy with other antiviral medications to treat chronic hepatitis C virus (HCV) infected patients with HCV genoptypes 1-6, and to treat HCV and HIV co-infected patients. Depending on the level of cirrhosis or decompensation, combination therapy can also include either ribavirin alone or ribavirin and peg-interferon alfa.
When used in combination with [DB09027] as the combination product Harvoni, sofosbuvir has the following indications: treatment of genotypes 1, 4, 5, or 6 infection without cirrhosis or with compensated cirrhosis; in combination with [DB00811] for genotype 1 infection with decompensated cirrhosis; or in combination with [DB00811] for the treatment of genotype 1 or 4 infection who are liver transplant recipients without cirrhosis or with compensated cirrhosis.
When used in combination with [DB11613] as the combination product Epclusa, sofosbuvir is indicated for the treatment of adult patients with chronic hepatitis C virus (HCV) genotypes 1, 2, 3, 4, 5, or 6 infection without cirrhosis or with compensated cirrhosis, or in combination with [DB00811] if associated with decompensated cirrhosis.
Resistance: Reduced susceptibility to sofosbuvir has been associated with the NS5B substitution mutation S282T [A19634].|
|DB01861||Uridine diphosphate glucose||Not Available|
|DB03258||2'-Deoxycytidine 5'-triphosphate||Not Available|
|DB03685||Uridine monophosphate||Not Available|
|DB04005||Uridine 5'-triphosphate||Not Available|