- Nicotinic Antagonists
- Accession Number
Drugs that bind to nicotinic cholinergic receptors (RECEPTORS, NICOTINIC) and block the actions of acetylcholine or cholinergic agonists. Nicotinic antagonists block synaptic transmission at autonomic ganglia, the skeletal neuromuscular junction, and at central nervous system nicotinic synapses.
Drug Drug Description Gallamine triethiodide A nondepolarizing nerve blocker used in addition to anesthesia to cause skeletal muscle relaxation. Mecamylamine A nicotine antagonist used to treat moderate to severe essential hypertension and uncomplicated malignant hypertension. Atracurium besylate A non-depolarizing neuromuscular blocker used to facilitate endotracheal intubation and relax skeletal muscles during surgery. Pentolinium Used to produce controlled hypotension during surgical procedures and in hypertensive crises. Trimethaphan For the controlled reduction of blood pressure during surgery and in the treatment of hypertensive emergencies. Tubocurarine A neuromuscular blocker used for the diagnosis of and facilitation of intubation after induction of anesthesia during surgical procedures. Pancuronium A neuromuscular blocker used as an adjunct to general anesthesia to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Pipecuronium A nondepolarizing neuromuscular blocking agent used to relax muscles during anesthesia and surgical procedures. Vecuronium A nondepolarizing neuromuscular blocking agent used to relax muscles or as an adjunct in general anesthesia during surgical procedures. Atracurium Not Annotated Gallamine Not Annotated Alcuronium A non-depolarizing skeletal muscle relaxant similar to tubocurarine. It is used as an anesthesia adjuvant. Methadone An opioid analgesic indicated for management of severe pain that is not responsive to alternative treatments. Also used to aid in detoxification and maintenance treatment of opioid addiction. Chloroprocaine A local anesthetic agent indicated for intrathecal injection in adults for the production of subarachnoid block, or spinal anesthesia. Metocurine iodide For use as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy. Rocuronium A vecuronium analog used to facilitate tracheal intubation and to relax skeletal muscles during surgery. Biperiden A muscarinic receptor antagonist used to treat parkinsonism and control extrapyramidal side effects of neuroleptic drugs. Doxacurium A nondepolarizing neuromuscular blocking agent used as an adjunct to general anesthesia to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgical procedures. Mivacurium A short-acting non-depolarizing neuromuscular blocking agent used to induce anesthesia during intubation and promote skeletal muscle relaxation during surgery or mechanical ventilation. Dextromethorphan An NMDA receptor antagonist used to treat cases of dry cough. Metocurine Metocurine is a muscle relaxant. Procaine A local anesthetic used for anesthesia, peripheral nerve block, and spinal nerve block. Amobarbital A barbiturate derivative used for the induction of sedation during procedures, short-term management of insomnia, and acute management of refractory tonic-clonic seizures. Pentobarbital A barbiturate drug used to induce sleep, cause sedation, and control certain types of seizures. Butabarbital A barbiturate drug used as a sedative and hypnotic. Butalbital A barbiturate drug used for symptomatic treatment of tension-type headache in various combinations with acetaminophen, aspirin, caffeine, and codeine. Talbutal For use as a sedative and hypnotic. Secobarbital A barbiturate used for the short-term treatment of insomnia. Metharbital Metharbital is used for the treatment of epilepsy. Thiopental A barbiturate used to induce general anesthesia, treat convulsions, and reduce intracranial pressure. Primidone An antiepileptic used to treat grand mal, psychomotor, and focal epileptic seizures. Methylphenobarbital For the relief of anxiety, tension, and apprehension, also used as an anticonvulsant for the treatment of epilepsy. Phenobarbital A long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures. Aprobarbital Aprobarbital is a barbiturate derivative synthesized in the 1920s by Ernst Preiswerk. It was determined that the substance was capable of demonstrating sedative, hypnotic, and anticonvulsant effects. A primary treatment... Butobarbital For the treatment of insomnia. Heptabarbital Used mainly for sedation and hypnosis. Hexobarbital For the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful... Barbital A long-acting barbiturate that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. Barbital is also used in veterinary practice... Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Not Available Levacetylmethadol For the treatment and management of opiate dependence. It is sometimes used to treat severe pain in terminal patients. Agmatine Agmatine is being studied experimentally for several indications such as cardioprotection, diabetes, decreased kidney function, neuroprotection (stroke, severe CNS injuries, epilepsy, glaucoma, and neuropathic pain), and psychiatric conditions (depression, anxiety,... Cisatracurium A skeletal muscle relaxant used to facilitate tracheal intubation, muscle relaxation in surgery, or mechanical ventilation. Gantacurium Investigated for use/treatment in anesthesia (unspecified). Hexamethonium A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been... Isoflurane An inhaled general anesthetic used in surgery. Amantadine A medication used to treat dyskinesia in Parkinson's patients receiving levodopa, as well as extrapyramidal side effects of medications. Fluoxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I. Hexafluronium Used as an adjunct with succinylcholine (or suxamethonium chloride) to prolong muscle relaxation and to prevent succinylcholine-induced muscle fasciculations.
- Drugs & Drug Targets