Adrenergic alpha-2 Receptor Agonists

Name
Adrenergic alpha-2 Receptor Agonists
Accession Number
DBCAT002651  (DBCAT000921)
Description

Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS.

Drugs
DrugDrug Description
MethyldopaA centrally-acting alpha-2 adrenergic agonist used to manage hypertension alone or in combination with hydrochlorothiazide, and to treat hypertensive crises.
AmitrazAmitraz is a non-systemic acaricide and insecticide. It was generated in 1969 by the Boots Co. in England. Amitraz presents insect repellent effects and hence, it can be used as...
MedetomidineMedetomidine is a synthetic compound used as a surgical anesthetic and analgesic. It is normally found as its hydrochloride salt, medetomidine hydrochloride. Medetomidine is an intravenously available alpha-2 adrenergic agonist....
RomifidineRomifidine is a veterinary drug utilized as a sedative primarily in large animals, most frequently horses. It is also used less commonly in a wide variety of other animal species....
DetomidineUsed as a large animal sedative, primarily in horses.
DipivefrinA prodrug of epinephrine used in ophthalmic solutions to reduce intraocular pressure in chronic open-angle glaucoma.
BrimonidineAn alpha-2 adrenergic agonist used to treat glaucoma and ocular hypertension, as well as facial erythema in rosacea.
ClonidineAn alpha-2 adrenergic agonist used to treat hypertension and severe cancer pain, among other conditions, and to treat withdrawal symptoms from various substances. It is also used to aid in the diagnosis of pheochromocytoma and to prevent migraines.
GuanabenzAn alpha-2 adrenergic agonist used to treat hypertension.
DexmedetomidineAn alpha-2 agonist used for sedation during various procedures.
TizanidineAn alpha-2 adrenergic agonist used for the short-term treatment of muscle spasticity.
ApraclonidineAn alpha adrenergic agonist used to treat raised intraocular pressure.
GuanfacineAn alpha-2A adrenergic receptor agonist used to treat ADHD.
PseudoephedrineAn alpha and beta adrenergic agonist used to treat nasal and sinus congestion, as well as allergic rhinitis.
OxymetazolineAn alpha-1A adrenoceptor agonist used to treat nasal congestion, allergic reactions of the eye, and facial erythema associated with rosacea.
NorepinephrineA sympathomimetic used in the control of blood pressure during various hypotensive states and as an adjunct treatment during cardiac arrest.
LofexidineA centrally acting alpha2-adrenergic agonist used for the symptomatic treatment of acute opioid withdrawal syndrome to facilitate abrupt opioid discontinuation in adults.
XylometazolineA direct-acting alpha-adrenergic agonist used for the symptomatic treatment of nasal congestion and minor inflammation due to allergies or colds.
PergolideA long-acting dopamine agonist that is uncommonly used for the management of Parkinson's disease, due to the risk for cardiac valvulopathy.
BromocriptineA dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome.
NaphazolineA sympathomimetic vasoconstrictor used for the symptomatic relief of redness and itching of the eye, and nasal congestion.
Ephedra sinica rootAn alpha and beta-adrenergic agonist used for the management of respiratory conditions related to bronchial asthma, such as wheezing, shortness of breath, and tightness of chest.
MetamfetamineA sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and exogenous obesity.
EpinephrineA hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma.
MoxonidineAn imidazoline/α-2 receptor agonist used to treat hypertension, especially in cases where ACE inhibitors, β-blockers, calcium channel blockers, and thiazides are not appropriate or provide inadequate blood pressure control.
RacepinephrineA bronchodilator used to treat intermittent asthma.
DL-MethylephedrineUsed as an antitussive and decongestant .
EtomidateA short-acting intravenous anesthetic indicated for the induction of anesthesia and supplementation of subpotent anesthesia during short operative procedures.
BethanidineFor the treatment of hypertension.
XylazineA non-opioid and clonidine analog with analgesic and muscle relaxant properties used as a tranquilizer used in veterinary medicine.
DroxidopaA medication used to treat symptomatic neurogenic orthostatic hypotension (nOH) caused by dopamine beta-hydroxylase deficiency, non-diabetic autonomic neuropathy and primary autonomic failure caused by conditions such as Parkinson's disease.
RilmenidineAn I1-imidazoline receptor agonist used to treat hypertension.
Drugs & Drug Targets
DrugTargetType
MethyldopaAlpha-2A adrenergic receptortarget
MethyldopaCatechol O-methyltransferaseenzyme
MethyldopaSolute carrier family 15 member 1transporter
MethyldopaAromatic-L-amino-acid decarboxylasetarget
MethyldopaSerum albumincarrier
MethyldopaSulfotransferaseenzyme
MethyldopaDopamine beta-hydroxylaseenzyme
MethyldopaPhenylethanolamine N-methyltransferaseenzyme
MethyldopaAromatic-L-amino-acid decarboxylaseenzyme
DipivefrinAlpha-2A adrenergic receptortarget
DipivefrinCholinesterasetarget
DipivefrinBeta-2 adrenergic receptortarget
DipivefrinAlpha-1A adrenergic receptortarget
DipivefrinAcetylcholinesterasetarget
BrimonidineAlpha-2A adrenergic receptortarget
BrimonidineAlpha-2B adrenergic receptortarget
BrimonidineAlpha-2C adrenergic receptortarget
BrimonidineAldehyde oxidaseenzyme
ClonidineAlpha-2A adrenergic receptortarget
ClonidineCytochrome P450 2D6enzyme
ClonidineAlpha-2B adrenergic receptortarget
ClonidineAlpha-2C adrenergic receptortarget
ClonidineSolute carrier family 22 member 3transporter
ClonidineSolute carrier family 22 member 5transporter
ClonidineSolute carrier family 22 member 4transporter
ClonidineCytochrome P450 1A2enzyme
ClonidineCytochrome P450 3A4enzyme
ClonidineCytochrome P450 1A1enzyme
ClonidineCytochrome P450 3A5enzyme
ClonidineAlpha-1A adrenergic receptortarget
ClonidineAlpha-1B adrenergic receptortarget
ClonidineAlpha-1D adrenergic receptortarget
ClonidineSerum albumincarrier
GuanabenzAlpha-2A adrenergic receptortarget
GuanabenzCytochrome P450 1A2enzyme
GuanabenzAlpha-2B adrenergic receptortarget
DexmedetomidineAlpha-2A adrenergic receptortarget
DexmedetomidineCytochrome P450 2E1enzyme
DexmedetomidineCytochrome P450 1A2enzyme
DexmedetomidineCytochrome P450 1A1enzyme
DexmedetomidineCytochrome P450 2D6enzyme
TizanidineAlpha-2 adrenergic receptorstarget
TizanidineCytochrome P450 1A2enzyme
TizanidineNischarintarget
TizanidineAlpha-1 adrenergic receptorstarget
ApraclonidineAlpha-2A adrenergic receptortarget
ApraclonidineAlpha-1A adrenergic receptortarget
ApraclonidineAlpha-2B adrenergic receptortarget
GuanfacineAlpha-2A adrenergic receptortarget
GuanfacineCytochrome P450 2C19enzyme
GuanfacineCytochrome P450 3A4enzyme
GuanfacineAlpha-2B adrenergic receptortarget
GuanfacineMultidrug and toxin extrusion protein 1transporter
GuanfacineSolute carrier family 22 member 1transporter
GuanfacineSolute carrier family 22 member 2transporter
PseudoephedrineAlpha-1A adrenergic receptortarget
PseudoephedrineAlpha-2A adrenergic receptortarget
PseudoephedrineBeta-2 adrenergic receptortarget
PseudoephedrineAmine oxidase [flavin-containing] Aenzyme
PseudoephedrineBeta-1 adrenergic receptortarget
PseudoephedrineSodium-dependent dopamine transportertarget
PseudoephedrineSodium-dependent noradrenaline transportertarget
PseudoephedrineSodium-dependent serotonin transportertarget
PseudoephedrineNuclear factor of activated T-cells, cytoplasmic 1target
PseudoephedrineTumor necrosis factortarget
PseudoephedrineNuclear factor NF-kappa-B p105 subunittarget
Pseudoephedrineactivator protein 1target
PseudoephedrineInterleukin-2target
PseudoephedrineSerum albumincarrier
PseudoephedrineSodium-dependent noradrenaline transportertransporter
PseudoephedrineSodium-dependent dopamine transportertransporter
PseudoephedrineSodium-dependent serotonin transportertransporter
OxymetazolineAlpha-1A adrenergic receptortarget
OxymetazolineAlpha-2A adrenergic receptortarget
OxymetazolineAlpha-2C adrenergic receptortarget
OxymetazolineAlpha-2B adrenergic receptortarget
OxymetazolineAlpha-1B adrenergic receptortarget
OxymetazolineAlpha-1D adrenergic receptortarget
Oxymetazoline5-hydroxytryptamine receptor 1Atarget
Oxymetazoline5-hydroxytryptamine receptor 1Btarget
Oxymetazoline5-hydroxytryptamine receptor 1Dtarget
Oxymetazoline5-hydroxytryptamine receptor 1Ctarget
OxymetazolineUDP-glucuronosyltransferase 1-9enzyme
OxymetazolineCytochrome P450 2C19enzyme
NorepinephrinePhenylalanine-4-hydroxylasetarget
NorepinephrineAlpha-1A adrenergic receptortarget
NorepinephrineAlpha-1B adrenergic receptortarget
NorepinephrineAlpha-1D adrenergic receptortarget
NorepinephrineAlpha-2A adrenergic receptortarget
NorepinephrineAlpha-2B adrenergic receptortarget
NorepinephrineAlpha-2C adrenergic receptortarget
NorepinephrineBeta-1 adrenergic receptortarget
NorepinephrineBeta-2 adrenergic receptortarget
NorepinephrineBeta-3 adrenergic receptortarget
NorepinephrineSolute carrier family 22 member 2transporter
NorepinephrineSolute carrier family 22 member 3transporter
NorepinephrineSolute carrier family 22 member 5transporter
NorepinephrineSolute carrier family 22 member 1transporter
NorepinephrinePOU domain, class 5, transcription factor 1transporter
NorepinephrineSodium-dependent noradrenaline transportertransporter
NorepinephrineSynaptic vesicular amine transportertarget
NorepinephrineChromaffin granule amine transportertarget
LofexidineAlpha-2A adrenergic receptortarget
LofexidineAlpha-1A adrenergic receptortarget
Lofexidine5-hydroxytryptamine receptor 1Atarget
Lofexidine5-hydroxytryptamine receptor 7target
Lofexidine5-hydroxytryptamine receptor 2Ctarget
Lofexidine5-hydroxytryptamine receptor 1Dtarget
LofexidineCytochrome P450 2D6enzyme
LofexidineCytochrome P450 1A2enzyme
LofexidineCytochrome P450 2C19enzyme
LofexidineATP-binding cassette sub-family B member 5transporter
LofexidineMultidrug and toxin extrusion protein 1transporter
XylometazolineAlpha-2A adrenergic receptortarget
XylometazolineAlpha-1A adrenergic receptortarget
XylometazolineAlpha-1B adrenergic receptortarget
XylometazolineAlpha-1D adrenergic receptortarget
XylometazolineAlpha-2B adrenergic receptortarget
XylometazolineAlpha-2C adrenergic receptortarget
PergolideDopamine D2 receptortarget
PergolideDopamine D1 receptortarget
PergolideDopamine D3 receptortarget
Pergolide5-hydroxytryptamine receptor 1Atarget
PergolideAlpha-1A adrenergic receptortarget
PergolideAlpha-2 adrenergic receptorstarget
PergolideAlpha-1B adrenergic receptortarget
PergolideAlpha-1D adrenergic receptortarget
PergolideDopamine D4 receptortarget
PergolideDopamine D5 receptortarget
Pergolide5-hydroxytryptamine receptor 1Btarget
Pergolide5-hydroxytryptamine receptor 1Dtarget
Pergolide5-hydroxytryptamine receptor 2Atarget
Pergolide5-hydroxytryptamine receptor 2Btarget
Pergolide5-hydroxytryptamine receptor 2Ctarget
PergolideCytochrome P450 3A4enzyme
BromocriptineDopamine D2 receptortarget
BromocriptineCytochrome P450 3A4enzyme
Bromocriptine5-hydroxytryptamine receptor 1Dtarget
BromocriptineAlpha-2A adrenergic receptortarget
BromocriptineDopamine D3 receptortarget
Bromocriptine5-hydroxytryptamine receptor 1Atarget
BromocriptineAlpha-2C adrenergic receptortarget
BromocriptineAlpha-2B adrenergic receptortarget
Bromocriptine5-hydroxytryptamine receptor 2Btarget
BromocriptineDopamine D4 receptortarget
Bromocriptine5-hydroxytryptamine receptor 2Atarget
Bromocriptine5-hydroxytryptamine receptor 1Btarget
Bromocriptine5-hydroxytryptamine receptor 2Ctarget
BromocriptineDopamine D5 receptortarget
BromocriptineDopamine D1 receptortarget
BromocriptineAlpha-1A adrenergic receptortarget
BromocriptineAlpha-1B adrenergic receptortarget
BromocriptineAlpha-1D adrenergic receptortarget
Bromocriptine5-hydroxytryptamine receptor 7target
BromocriptineP-glycoprotein 1transporter
NaphazolineAlpha-1A adrenergic receptortarget
NaphazolineAlpha-2A adrenergic receptortarget
Ephedra sinica rootSodium-dependent dopamine transportertarget
Ephedra sinica rootSynaptic vesicular amine transportertarget
Ephedra sinica rootChromaffin granule amine transportertarget
Ephedra sinica rootSodium-dependent noradrenaline transportertarget
Ephedra sinica rootAmine oxidase [flavin-containing] Atarget
Ephedra sinica rootAmine oxidase [flavin-containing] Btarget
Ephedra sinica rootSodium-dependent serotonin transportertarget
Ephedra sinica rootAlpha-2A adrenergic receptortarget
Ephedra sinica rootAlpha-2B adrenergic receptortarget
Ephedra sinica rootAlpha-2C adrenergic receptortarget
Ephedra sinica rootBeta-1 adrenergic receptortarget
Ephedra sinica rootBeta-2 adrenergic receptortarget
Ephedra sinica rootBeta-3 adrenergic receptortarget
MetamfetamineCytochrome P450 2D6enzyme
MetamfetamineSolute carrier family 22 member 3transporter
MetamfetamineSolute carrier family 22 member 5transporter
MetamfetamineSodium-dependent dopamine transportertarget
MetamfetamineSynaptic vesicular amine transportertarget
MetamfetamineTrace amine-associated receptor 1target
MetamfetamineSodium-dependent serotonin transportertarget
MetamfetamineSodium-dependent noradrenaline transportertarget
MetamfetamineChromaffin granule amine transportertarget
MetamfetamineAmine oxidase [flavin-containing] Atarget
MetamfetamineAmine oxidase [flavin-containing] Btarget
MetamfetamineAlpha-2A adrenergic receptortarget
MetamfetamineAlpha-2B adrenergic receptortarget
MetamfetamineAlpha-2C adrenergic receptortarget
EpinephrineAlpha-1A adrenergic receptortarget
EpinephrineBeta-1 adrenergic receptortarget
EpinephrineBeta-2 adrenergic receptortarget
EpinephrineSolute carrier family 22 member 2transporter
EpinephrineSolute carrier family 22 member 1transporter
EpinephrineCytochrome P450 2C9enzyme
EpinephrineCytochrome P450 3A4enzyme
EpinephrineAlpha-1B adrenergic receptortarget
EpinephrineAlpha-1D adrenergic receptortarget
EpinephrineAlpha-2A adrenergic receptortarget
EpinephrineAlpha-2B adrenergic receptortarget
EpinephrineTumor necrosis factortarget
EpinephrineCatechol O-methyltransferaseenzyme
EpinephrineMonoamine oxidaseenzyme
MoxonidineNischarintarget
MoxonidineAlpha-2A adrenergic receptortarget
RacepinephrineAlpha-1A adrenergic receptortarget
RacepinephrineAlpha-1B adrenergic receptortarget
RacepinephrineAlpha-2A adrenergic receptortarget
RacepinephrineAlpha-2B adrenergic receptortarget
RacepinephrineAlpha-2C adrenergic receptortarget
RacepinephrineBeta-1 adrenergic receptortarget
RacepinephrineBeta-2 adrenergic receptortarget
RacepinephrineAlpha-1D adrenergic receptortarget
RacepinephrineBeta-3 adrenergic receptortarget
DL-MethylephedrineBeta-1 adrenergic receptortarget
DL-MethylephedrineAlpha-2A adrenergic receptortarget
DL-MethylephedrineAlpha adrenergic receptortarget
DL-MethylephedrineBeta adrenergic receptortarget
EtomidateGamma-aminobutyric acid receptor subunit alpha-1target
EtomidateAlpha-2B adrenergic receptortarget
EtomidateSolute carrier family 2, facilitated glucose transporter member 1carrier
EtomidateCytochrome P450 11B1, mitochondrialenzyme
EtomidateCytochrome P450 11B2, mitochondrialenzyme
EtomidateGABA(A) Receptortarget
BethanidineAlpha-2 adrenergic receptorstarget
BethanidineATP-sensitive inward rectifier potassium channel 1target
BethanidineBeta adrenergic receptortarget
XylazineAlpha-2 adrenergic receptorstarget
DroxidopaPhenylalanine-4-hydroxylasetarget
DroxidopaAlpha-1A adrenergic receptortarget
DroxidopaAlpha-1B adrenergic receptortarget
DroxidopaAlpha-1D adrenergic receptortarget
DroxidopaAlpha-2A adrenergic receptortarget
DroxidopaAlpha-2B adrenergic receptortarget
DroxidopaAlpha-2C adrenergic receptortarget
DroxidopaBeta-1 adrenergic receptortarget
DroxidopaBeta-2 adrenergic receptortarget
DroxidopaBeta-3 adrenergic receptortarget
DroxidopaAromatic-L-amino-acid decarboxylaseenzyme
DroxidopaMonocarboxylate transporter 10transporter
DroxidopaSodium-dependent noradrenaline transportertransporter
RilmenidineAlpha-2A adrenergic receptortarget