Excitatory Amino Acid Antagonists

Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists.
DrugDrug NameDrug Description
DB00514DextromethorphanAn NMDA receptor antagonist used to treat cases of dry cough.
DB00740RiluzoleA glutamate antagonist used to treat amyotrophic lateral sclerosis.
DB01043MemantineAn NMDA receptor antagonist used to treat moderate to severe dementia in Alzheimer's.
DB01174PhenobarbitalA long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures.
DB01221KetamineA rapid-acting general anesthetic and NMDA receptor antagonist used for induction of anesthesia diagnostic and surgical procedures typically in combination with a muscle relaxant.
DB03575PhencyclidineA hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to ketamine in structure and in many of its effects. Like...
DB03759FG-9041Not Available
DB06444DexanabinolInvestigated for use/treatment in traumatic brain injuries and neurologic disorders.
DB06738KetobemidoneFor the treatment of all types of severe pain, such as postoperative, cancer, kidney stones and fractures.
DB06741GavestinelHighly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (Kd = 0.8 nM). Gavestinel displays > 1000-fold selectivity over NMDA, AMPA...
DB08954IfenprodilIfenprodil is a selective NMDA receptor (glutamate) antagonist.
DB11937Kynurenic AcidKynurenic Acid is under investigation in clinical trial NCT02340325 (FS2 Safety and Tolerability Study in Healthy Volunteers).
DB12869EliprodilEliprodil has been used in trials studying the treatment of Parkinson Disease and Movement Disorders.
DB13096GacyclidineGacyclidine has been used in trials studying the treatment of Tinnitus.
DB13835CaroverineNot Annotated
DB14682DextrorphanNot Annotated
DB00949FelbamateAn anticonvulsant used to treat severe epilepsy.
DB019315,7-Dichlorokynurenic acidNot Available
DrugDrug NameTargetType
DB00514DextromethorphanSigma non-opioid intracellular receptor 1target
DB00514DextromethorphanHCG20471, isoform CRA_ctarget
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-2target
DB00514DextromethorphanSodium-dependent serotonin transportertarget
DB00514DextromethorphanGlutamate receptor ionotropic, NMDA 3Atarget
DB00514DextromethorphanCytochrome P450 2D6enzyme
DB00514DextromethorphanCytochrome P450 3A4enzyme
DB00514DextromethorphanCytochrome P450 3A7enzyme
DB00514DextromethorphanCytochrome P450 2C9enzyme
DB00514DextromethorphanCytochrome P450 2B6enzyme
DB00514DextromethorphanCytochrome P450 2C19enzyme
DB00514DextromethorphanMembrane-associated progesterone receptor component 1target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-3target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-4target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit beta-4target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit beta-2target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-7target
DB00514DextromethorphanMu-type opioid receptortarget
DB00514DextromethorphanDelta-type opioid receptortarget
DB00514DextromethorphanKappa-type opioid receptortarget
DB00514DextromethorphanNADPH oxidasetarget
DB00514DextromethorphanSodium-dependent noradrenaline transportertarget
DB00740RiluzoleSodium channel protein type 5 subunit alphatarget
DB00740RiluzoleCytochrome P450 1A2enzyme
DB00740RiluzoleCystine/glutamate transportertarget
DB00740RiluzoleATP-binding cassette sub-family G member 2transporter
DB00740RiluzoleCytochrome P450 1A1enzyme
DB01043MemantineCytochrome P450 2B6enzyme
DB01043MemantineSolute carrier family 22 member 2transporter
DB01043Memantine5-hydroxytryptamine receptor 3Atarget
DB01043MemantineAlpha-7 nicotinic cholinergic receptor subunittarget
DB01043MemantineCytochrome P450 2A6enzyme
DB01043MemantineCytochrome P450 2C19enzyme
DB01043MemantineDopamine D2 receptortarget
DB01043MemantineGlutamate receptor ionotropic, NMDA 1target
DB01043MemantineSodium/hydrogen exchanger 1transporter
DB01043MemantineSolute carrier family 22 member 4transporter
DB01043MemantineMultidrug and toxin extrusion protein 1transporter
DB01043MemantineGlutamate (NMDA) receptortarget
DB01043MemantineGABA-A receptor (anion channel)target
DB01043MemantineGlycine receptorstarget
DB01174PhenobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
DB01174PhenobarbitalCytochrome P450 2C19enzyme
DB01174PhenobarbitalCytochrome P450 2C9enzyme
DB01174PhenobarbitalCytochrome P450 2B6enzyme
DB01174PhenobarbitalCytochrome P450 2C8enzyme
DB01174PhenobarbitalCytochrome P450 1A2enzyme
DB01174PhenobarbitalCytochrome P450 3A4enzyme
DB01174PhenobarbitalCanalicular multispecific organic anion transporter 2transporter
DB01174PhenobarbitalBile salt export pumptransporter
DB01174PhenobarbitalP-glycoprotein 1transporter
DB01174PhenobarbitalMultidrug resistance-associated protein 1transporter
DB01174PhenobarbitalSolute carrier organic anion transporter family member 2A1transporter
DB01174PhenobarbitalCanalicular multispecific organic anion transporter 1transporter
DB01174PhenobarbitalNeuronal acetylcholine receptor subunit alpha-4target
DB01174PhenobarbitalNeuronal acetylcholine receptor subunit alpha-7target
DB01174PhenobarbitalGlutamate receptor 2target
DB01174PhenobarbitalGlutamate receptor ionotropic, kainate 2target
DB01174PhenobarbitalCytochrome P450 2A6enzyme
DB01174PhenobarbitalCytochrome P450 2E1enzyme
DB01174PhenobarbitalCytochrome P450 3A5enzyme
DB01174PhenobarbitalCytochrome P450 1A1enzyme
DB01174PhenobarbitalCytochrome P450 2C18enzyme
DB01174PhenobarbitalCytochrome P450 3A7enzyme
DB01174PhenobarbitalCytochrome P450 4B1enzyme
DB01174PhenobarbitalNMDA receptortarget
DB01174PhenobarbitalNuclear receptor subfamily 1 group I member 2target
DB01174PhenobarbitalUDP-glucuronosyltransferase 1-1enzyme
DB01174PhenobarbitalUDP-glucuronosyltransferase 2B7enzyme
DB01221KetamineGlutamate receptor ionotropic, NMDA 3Atarget
DB01221KetamineNeurokinin 1 receptortarget
DB01221KetamineCytochrome P450 2B6enzyme
DB01221KetamineCytochrome P450 2C9enzyme
DB01221KetamineCytochrome P450 3A4enzyme
DB01221KetamineDopamine D2 receptortarget
DB01221KetamineProstaglandin G/H synthase 1enzyme
DB01221KetamineCytochrome P450 2C8enzyme
DB01221KetamineDelta-type opioid receptortarget
DB01221KetamineSodium-dependent noradrenaline transportertarget
DB01221KetamineKappa-type opioid receptortarget
DB01221KetamineMu-type opioid receptortarget
DB01221KetamineMuscarinic acetylcholine receptortarget
DB01221Ketamine5-hydroxytryptamine receptor 2target
DB01221Ketamine5-hydroxytryptamine receptor 1target
DB01221Ketamine5-hydroxytryptamine receptor 3Atarget
DB01221KetamineAlpha-7 nicotinic cholinergic receptor subunittarget
DB01221KetamineCholinesterasetarget
DB01221KetamineNitric oxide synthase, braintarget
DB03575PhencyclidineGlutamate receptor ionotropic, NMDA 3Atarget
DB03575PhencyclidineSigma non-opioid intracellular receptor 1target
DB03575PhencyclidineCytochrome P450 2B6enzyme
DB03759FG-9041Glutamate receptor 2target
DB06444DexanabinolTumor necrosis factortarget
DB06738KetobemidoneProstaglandin G/H synthase 1enzyme
DB06738KetobemidoneCytochrome P450 2C9enzyme
DB06738KetobemidoneCytochrome P450 3A4enzyme
DB06738KetobemidoneUDP-glucuronosyltransferase 1-9enzyme
DB06738KetobemidoneCytochrome P450 2B6enzyme
DB06738KetobemidoneCytochrome P450 2C19enzyme
DB06738KetobemidoneCytochrome P450 2C8enzyme
DB06738KetobemidoneMu-type opioid receptortarget
DB06738KetobemidoneKappa-type opioid receptortarget
DB06738KetobemidoneDelta-type opioid receptortarget
DB06738KetobemidoneNMDA receptortarget
DB06741GavestinelUDP-glucuronosyltransferase 1-1enzyme
DB06741GavestinelUDP-glucuronosyltransferase 1-3enzyme
DB06741GavestinelUDP-glucuronosyltransferase 1-9enzyme
DB06741GavestinelUDP-glucuronosyltransferase 2B4enzyme
DB06741GavestinelGlutamate (NMDA) receptortarget
DB08954IfenprodilGlutamate receptor ionotropic, NMDA 1target
DB08954IfenprodilGlutamate receptor ionotropic, NMDA 2Btarget
DB11937Kynurenic AcidAryl hydrocarbon receptortarget
DB11937Kynurenic AcidG-protein coupled receptor 35target
DB13835CaroverineCytochrome P450 3A4enzyme
DB00949FelbamateGlutamate receptor ionotropic, NMDA 3Atarget
DB00949FelbamateGlutamate receptor ionotropic, NMDA 2Btarget
DB00949FelbamateGlutamate receptor ionotropic, NMDA 2Atarget
DB00949FelbamateCytochrome P450 2C19enzyme
DB00949FelbamateCytochrome P450 3A4enzyme
DB00949FelbamateCytochrome P450 2E1enzyme
DB00949FelbamateCytochrome P450 2C9enzyme
DB019315,7-Dichlorokynurenic acidGlutamate receptor ionotropic, NMDA 1target