Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.
DrugDrug NameDrug Indication
DB00518AlbendazoleFor the treatment of parenchymal neurocysticercosis due to active lesions caused by larval forms of the pork tapeworm, Taenia solium and for the treatment of cystic hydatid disease of the liver, lung, and peritoneum, caused by the larval form of the dog tapeworm, Echinococcus granulosus.
DB00592PiperazineUsed as alternative treatment for ascariasis caused by Ascaris lumbricoides (roundworm) and enterobiasis (oxyuriasis) caused by Enterobius vermicularis (pinworm). It is also used to treat partial intestinal obstruction by the common roundworm, a condition primarily occurring in children.
DB00643MebendazoleFor the treatment of Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ascaris lumbricoides (common roundworm), Ancylostoma duodenale (common hookworm), Necator americanus (American hookworm) in single or mixed infections.
DB00711DiethylcarbamazineUsed for the treatment of certain filarial diseases, including tropical pulmonary eosinophilia, loiasis, and lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori.
DB00730ThiabendazoleFor the treatment of strongyloidiasis (threadworm), cutaneous larva migrans (creeping eruption), visceral larva migrans, and trichinosis.
DB00848LevamisoleFor adjuvant treatment in combination with fluorouracil after surgical resection in patients with Dukes' stage C colon cancer. Also used to treat malignant melanoma and head/neck cancer.
DB01058PraziquantelFor the treatment of infections due to all species of schistosoma.
DB01096OxamniquineFor treatment of Schistosomiasis caused by Schistosoma mansoni
DB04813BithionolNot Available
DB06803NiclosamideFor the treatment of tapeworm and intestinal fluke infections: Taenia saginata (Beef Tapeworm), Taenia solium (Pork Tapeworm), Diphyllobothrium latum (Fish Tapeworm), Fasciolopsis buski (large intestinal fluke). Niclosamide is also used as a molluscicide in the control of schistosomiasis.
DB06816PyrviniumPyrvinium was once used in the treatment of pinworm infestations [T39].
DB08974FlubendazoleNot Available
DB11156PyrantelFor the treatment of enterobiasis including roundworm (ascariasis), pinworm (enterobius) and hookworm (strongyloides) and hookworm (ancylostoma) in the pyrantel pamoate form [L1893]. Pyrantel is available in various formulations for humans, dogs, and cats as the pamoate (US Pharmacopeia nomenclature) or embonate (European Pharmacopoeia nomenclature) salt, which contains 34.7% pyrantel base combined with pamoic acid [L1893]. [L1900], [A32283]. Pyrantel pamoate (embonate) ingested orally is effective for removal and control of ascarid and hookworm infections in puppies and dogs (adult Toxocara canis, Toxascaris leonina, Ancylostoma tubaeforme, An. braziliense, Uncinaria stenocephala), cats (adult Toxocara cati, Toxa. leonina, An. caninum, An. braziliense, U. stenocephala), horses and ponies (adult and immature Parascaris equorum, adult Strongylus vulgaris, S. edentatus, S. equinus, Cyathostomes (Triodontophorus spp., Cyathostomum spp., Cylicodontophorus spp., Cylicocyclus spp., Cylicostephanus spp., Poteriostomum spp.), Oxyuris equi, Anoplocephala perfoliata), swine (adult Ascaris suum, Oesophagostomum dentatum), and humans (adult A. lumbricoides, Enterobius vermicularis, An. duodenale, Necator americanus) [L1900].
DB11410FenbendazoleNot Available
DB11473MetrifonateNot Available
DB12245TriclabendazoleThis drug is indicated for the treatment of fascioliasis in patients aged 6 years old and above.[FDA label,L5452]
DB11396DichlorophenNot Available
DB13661NiridazoleNot Available
DB13670OxantelNot Available
DB04910OxibendazoleInvestigated for use/treatment in infectious and parasitic disease (unspecified) and pediatric indications.
DB11254HexylresorcinolHexylresorcinol is predominantly employed as the active ingredient in lotions, sprays, or lozenges indicated as a (a) topical antiseptic to help prevent skin infection in minor cuts, scrapes, or burns, or (b) as an antiseptic and local anesthetic for the relief of a sore throat and its associated pain [L2734, L2735]. In addition, hexylresorcinol is used as an active ingredient in various commercial cosmetic skincare products as an anti-aging cream [L2736] while other studies have looked into whether or not the compound could be used effectively as an anti-inflammatory agent or even as an anti-cancer therapy [L2736].
DB11380CambendazoleNot Available
DB11389ClorsulonNot Available
DB11390CoumaphosNot Available
DB11397DichlorvosNot Available
DB11400DoramectinNot Available
DB11405EprinomectinNot Available
DB11409FebantelNot Available
DB11431MoxidectinMoxidectin is indicated for the treatment of river blindness, also called onchocerciasis, in patients aged 12 years and older. River blindness is caused by a parasitic worm _Onchocerca volvulus_ and it is manifested as severe itching, disfiguring skin conditions and visual impairment caused by the worm's larvae.[L2971] The transmission of _Onchocerca volvulus_ is performed person to person by black flies that breed in fast-flowing rivers in sub-Saharan Africa, Yemen and South and Central America. The larvae released by the adult parasite invade skin and eyes where they can produce the severe disease manifestations.[L2971]
DB11446OxfendazoleNot Available
DB11520Hygromycin BNot Available
DB12539OltiprazNot Available
DB13009CarbendazimNot Available
DB13871Albendazole oxideNot Available
DB13236StibophenNot Available
DB13462BepheniumNot Available
DB13465CiclobendazoleNot Available
DB13567DesaspidinNot Available
DB00602IvermectinFor the treatment of intestinal (i.e., nondisseminated) strongyloidiasis due to the nematode parasite Strongyloides stercoralis. Also for the treatment of onchocerciasis (river blindness) due to the nematode parasite Onchocerca volvulus. Can be used to treat scabies caused by Sarcoptes scabiei.
DB04967LucanthoneIntended for use as a radiation sensitizer in the treatment of brain cancer.
DB02962BenzimidazoleNot Available
DB14061HycanthoneNot Available
DB09274ArtesunateFor the treatment of severe malaria caused by *Plasmodium falciparum* in adults and children [L891]
DrugDrug NameTargetType
DB00518AlbendazoleTubulin alpha-1A chaintarget
DB00518AlbendazoleTubulin beta-4B chaintarget
DB00518AlbendazoleCytochrome P450 3A4enzyme
DB00518AlbendazoleFumarate reductase flavoprotein subunittarget
DB00518AlbendazoleP-glycoprotein 1transporter
DB00518AlbendazoleCytochrome P450 1A1enzyme
DB00518AlbendazoleCytochrome P450 1A2enzyme
DB00518AlbendazoleTubulin beta-2 chaintarget
DB00518AlbendazoleCytochrome P450 2C19enzyme
DB00592PiperazineGamma-aminobutyric acid receptor subunit beta-3target
DB00592PiperazineCytochrome P450 2D6enzyme
DB00643MebendazoleTubulin alpha-1A chaintarget
DB00643MebendazoleTubulin beta-4B chaintarget
DB00643MebendazoleCytochrome P450 1A1enzyme
DB00711DiethylcarbamazineArachidonate 5-lipoxygenasetarget
DB00711DiethylcarbamazineProstaglandin G/H synthase 1target
DB00730ThiabendazoleFumarate reductase flavoprotein subunittarget
DB00730ThiabendazoleCytochrome P450 1A2enzyme
DB00730ThiabendazoleCytochrome P450 1A1enzyme
DB00848LevamisoleNeuronal acetylcholine receptor subunit alpha-3target
DB00848LevamisoleAlkaline phosphatase, placental-liketarget
DB00848LevamisoleAcetylcholine receptor subunit alpha-type unc-38target
DB00848LevamisoleAcetylcholine receptor subunit alpha-type unc-63target
DB00848LevamisoleAcetylcholine receptor subunit beta-type lev-1target
DB00848LevamisoleAcetylcholine receptor subunit beta-type unc-29target
DB01058PraziquantelSchistosome calcium ion (Ca2+) channelstarget
DB01058PraziquantelCytochrome P450 3A4enzyme
DB01058PraziquantelCytochrome P450 1A2enzyme
DB01058PraziquantelCytochrome P450 2C19enzyme
DB01058PraziquantelCytochrome P450 3A43enzyme
DB01058PraziquantelCytochrome P450 3A5enzyme
DB01058PraziquantelCytochrome P450 3A7enzyme
DB01096OxamniquineCytochrome P450 2D6enzyme
DB06803NiclosamideCytochrome P450 2C9enzyme
DB06803NiclosamideCytochrome P450 1A2enzyme
DB11156PyrantelG-protein coupled receptor 35target
DB11156PyrantelCytochrome P450 4A11enzyme
DB11156PyrantelMuscarinic acetylcholine receptor M1target
DB12245TriclabendazoleCytochrome P450 1A2enzyme
DB12245TriclabendazoleCytochrome P450 2C9enzyme
DB12245TriclabendazoleExcretory Secretory (ES) proteinstarget
DB12245TriclabendazoleCytochrome P450 3A4enzyme
DB12245TriclabendazoleCytochrome P450 1A1enzyme
DB12245TriclabendazoleCytochrome P450 1B1enzyme
DB12245TriclabendazoleCytochrome P450 2C19enzyme
DB12245TriclabendazoleCytochrome P450 2D6enzyme
DB12245TriclabendazoleCytochrome P450 2A6enzyme
DB12245TriclabendazoleCytochrome P450 2C8enzyme
DB12245TriclabendazoleCytochrome P450 2B6enzyme
DB04910OxibendazoleTubulin beta-4B chaintarget
DB11254HexylresorcinolDNA topoisomerase 1target
DB11254HexylresorcinolProtein-glutamine gamma-glutamyltransferase 2target
DB11397DichlorvosSerum albumincarrier
DB11400DoramectinCytochrome P450 3A4enzyme
DB11405EprinomectinCytochrome P450 3A4enzyme
DB11431MoxidectinCYP2B proteinenzyme
DB11431MoxidectinP-glycoprotein 1transporter
DB11431MoxidectinATP-binding cassette sub-family G member 2transporter
DB11431MoxidectinGlutamate-gated chloride channeltarget
DB11431MoxidectinGABA-A gated chloride channeltarget
DB11431MoxidectinABC transporterstarget
DB00602IvermectinGamma-aminobutyric acid receptor subunit beta-3target
DB00602IvermectinGlycine receptor subunit alpha-3target
DB00602IvermectinP-glycoprotein 1transporter
DB00602IvermectinMultidrug resistance-associated protein 1transporter
DB00602IvermectinCanalicular multispecific organic anion transporter 1transporter
DB00602IvermectinATP-binding cassette sub-family G member 2transporter
DB00602IvermectinCytochrome P450 3A4enzyme
DB00602IvermectinSolute carrier organic anion transporter family member 1B1transporter
DB00602IvermectinSolute carrier organic anion transporter family member 1B3transporter
DB04967LucanthoneDNA topoisomerase 2-alphatarget
DB04967LucanthoneDNA-(apurinic or apyrimidinic site) lyasetarget
DB04967LucanthoneDNA topoisomerase 1target
DB02962BenzimidazoleNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferasetarget
DB14061HycanthoneP-glycoprotein 1target
DB09274ArtesunateMalaria protein EXP-1target
DB09274ArtesunateCytochrome P450 2A6enzyme
DB09274ArtesunateCytochrome P450 3A4enzyme