A group of compounds that are derivatives of oxo-pyrrolidines. A member of this group is 2-oxo pyrrolidine, which is an intermediate in the manufacture of polyvinylpyrrolidone. (From Merck Index, 11th ed)
DrugDrug NameDrug Description
DB00561DoxapramA short acting respiratory stimulant used to treat acute respiratory insufficiency in COPD patients.
DB00593EthosuximideAn anticonvulsant used to treat petit mal seizures.
DB00832PhensuximideFor the treatment of epilepsy.
DB01202LevetiracetamA novel anticonvulsant agent used as an adjunct medication to manage partial onset, myoclonic, and generalized tonic-clonic seizures in patients with epilepsy.
DB01954RolipramA phosphodiesterase inhibitor with antidepressant properties.
DB03088Pidolic acidThere is currently no clinically approved and/or marketed medicine that relies upon pidolic acid as an active ingredient for any formal therapeutic indication. Although pidolic acid may be sold in...
DB05246MethsuximideA succinimide anticonvulsant that increases the seizure threshold. Primarily used for childhood absence seizures. Functions by suppressing paroxysmal spike-and-wave patterns associated with lapses of consciousness in absence seizures.
DB06812Povidone-iodineA topical antiseptic agent used for the treatment and prevention of infection in wounds.
DB06817RaltegravirAn antiretroviral agent used for the treatment of HIV infections in conjunction with other antiretrovirals.
DB09210PiracetamIndicated in adult patients suffering from myoclonus of cortical origin, irrespective of aetiology, and should be used in combination with other anti-myoclonic therapies .
DB11061PovidoneWhen in complex with iodine, indicated for inducing antisepsis for prevention of infection in minor cuts, scrapes, and burns.
DB11364PidotimodFor use as immunostimulant therapy for treatment of cell-mediated immunosuppression with respiratory or urinary infections .
DB11868EtiracetamEtiracetam is under investigation in clinical trial NCT01137110 (Comparison of Short Duration Levetiracetam to Extended Course for Seizure Prophylaxis After Subarachnoid Hemorrhage (SAH)).
DB12224Oxothiazolidinecarboxylic acidProcysteine has been used in trials studying the treatment of HIV Infections.
DB13376SuccinimideNot Annotated
DrugDrug NameTargetType
DB00561DoxapramPotassium channel subfamily K member 3target
DB00561DoxapramPotassium channel subfamily K member 9target
DB00593EthosuximideVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
DB00593EthosuximideCytochrome P450 3A4enzyme
DB00593EthosuximideCytochrome P450 2E1enzyme
DB01202LevetiracetamSynaptic vesicle glycoprotein 2Atarget
DB01202LevetiracetamP-glycoprotein 1transporter
DB01202LevetiracetamVoltage-dependent N-type calcium channel subunit alpha-1Btarget
DB01954RolipramcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
DB01954RolipramcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB03088Pidolic acidAlpha-amylase 2Btarget
DB03088Pidolic acidAngiogenintarget
DB03088Pidolic acidChondroitinase-Btarget
DB03088Pidolic acidAlpha-amylase 1target
DB03088Pidolic acidVascular endothelial growth factor Atarget
DB03088Pidolic acidPancreatic alpha-amylasetarget
DB03088Pidolic acidIg lambda-1 chain C regionstarget
DB03088Pidolic acidIg lambda chain V-II region MGCtarget
DB03088Pidolic acidTrefoil factor 2target
DB03088Pidolic acidCytochrome c2target
DB03088Pidolic acidDisintegrin and metalloproteinase domain-containing protein 28target
DB03088Pidolic acidEndo-1,4-beta-xylanasetarget
DB03088Pidolic acidDissimilatory copper-containing nitrite reductasetarget
DB03088Pidolic acidKeratin-associated protein 5-2target
DB03088Pidolic acidOrexintarget
DB03088Pidolic acidC-C motif chemokine 8target
DB03088Pidolic acidCytochrome c'target
DB03088Pidolic acidPancreatic alpha-amylaseenzyme
DB05246MethsuximideCytochrome P450 2C19enzyme
DB05246MethsuximideVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
DB06817RaltegravirUDP-glucuronosyltransferase 1-1enzyme