Phenylpropionates

DrugDrug NameDrug Indication
DB00573FenoprofenFor relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis. Also for the relief of mild to moderate pain.
DB00870SuprofenUsed as eye drops to inhibit the miosis (pupil constriction) that may occur during ocular surgery.
DB01009KetoprofenFor symptomatic treatment of acute and chronic rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, primary dysmenorrhea and mild to moderate pain associated with musculotendinous trauma (sprains and strains), postoperative (including dental surgery) or postpartum pain.
DB01050IbuprofenIbuprofen is the most commonly used and prescribed NSAID. It is very common over the counter medication widely used as an analgesic, anti-inflammatory and antipyretic.[A39096] The use of ibuprofen and its enantiomer [DB09213] in a racemic mix is common for the management of mild to moderate pain related to dysmenorrhea, headache, migraine, postoperative dental pain, spondylitis, osteoarthritis, rheumatoid arthritis, and soft tissue disorder.[A39097] Due to its activity against prostaglandin and thromboxane synthesis, ibuprofen has been attributed to alteration of platelet function and prolongation of gestation and labor.[A39092] As ibuprofen is a widely used medication, the main therapeutic indications are: * Patent Ductus Arteriosus - it is a neonatal condition wherein the ductus arteriosus (blood vessel that connects the main pulmonary artery to the proximal descending aorta) fails to close after birth causing severe risk of heart failure. The prostaglandin inhibition of ibuprofen has been studied for the treatment of this condition as it is known that prostaglandin E2 is responsible for keeping the ductus arteriosus open.[A39100] * Rheumatoid- and osteo-arthritis - ibuprofen is very commonly used in the symptomatic treatment of inflammatory, musculoskeletal and rheumatic disorders.[A39176] * Cystic fibrosis - the use of high dosages of ibuprofen has been proven to decrease inflammation and decreasing polymorphonuclear cell influx in the lungs.[A39177] * Orthostatic hypotension - ibuprofen can induce sodium retention and antagonize the effect of diuretics which has been reported to be beneficial for patients with severe orthostatic hypotension.[A1651] * Dental pain - ibuprofen is used to manage acute and chronic orofacial pain.[A10901] * Minor pain - ibuprofen is widely used to reduce minor aches and pains as well as to reduce fever and manage dysmenorrhea. It is very commonly used for the relief of acute indications such as fever and tension headaches.[A39092] * Investigational uses - efforts have been put into developing ibuprofen for the prophylaxis of Alzheimer's disease, Parkinson disease, and breast cancer.[A39092]
DB05303OMS-103HPInvestigated for use/treatment in inflammatory disorders (unspecified), knee replacement, orthopedic surgery, and pain (acute or chronic).
DB08951IndoprofenNot Available
DB09213DexibuprofenFor more information, refer to [ibuprofen].
DrugDrug NameTargetType
DB00573FenoprofenProstaglandin G/H synthase 1target
DB00573FenoprofenProstaglandin G/H synthase 2target
DB00573FenoprofenSerum albumincarrier
DB00573FenoprofenPeroxisome proliferator-activated receptor alphatarget
DB00573FenoprofenPeroxisome proliferator-activated receptor gammatarget
DB00870SuprofenProstaglandin G/H synthase 1target
DB00870SuprofenProstaglandin G/H synthase 2target
DB00870SuprofenCytochrome P450 2C9enzyme
DB00870SuprofenUDP-glucuronosyltransferase 1-1enzyme
DB00870SuprofenUDP-glucuronosyltransferase 2B7enzyme
DB01009KetoprofenProstaglandin G/H synthase 1target
DB01009KetoprofenProstaglandin G/H synthase 2target
DB01009KetoprofenC-X-C chemokine receptor type 1target
DB01009KetoprofenSerum albumincarrier
DB01009KetoprofenMultidrug resistance-associated protein 4transporter
DB01009KetoprofenSolute carrier organic anion transporter family member 1A2transporter
DB01009KetoprofenSolute carrier family 22 member 6transporter
DB01009KetoprofenSolute carrier family 22 member 8transporter
DB01009KetoprofenSolute carrier family 22 member 11transporter
DB01009KetoprofenSolute carrier family 22 member 7transporter
DB01009KetoprofenCytochrome P450 2C9enzyme
DB01009KetoprofenCytochrome P450 2C8enzyme
DB01009KetoprofenUDP-glucuronosyltransferase 1-1enzyme
DB01050IbuprofenProstaglandin G/H synthase 1target
DB01050IbuprofenProstaglandin G/H synthase 2target
DB01050IbuprofenCytochrome P450 2C9enzyme
DB01050IbuprofenSerum albumincarrier
DB01050IbuprofenMultidrug resistance-associated protein 4transporter
DB01050IbuprofenMultidrug resistance-associated protein 1transporter
DB01050IbuprofenSolute carrier organic anion transporter family member 1A2transporter
DB01050IbuprofenSolute carrier family 22 member 6transporter
DB01050IbuprofenSolute carrier family 22 member 8transporter
DB01050IbuprofenSolute carrier family 22 member 11transporter
DB01050IbuprofenSolute carrier organic anion transporter family member 2B1transporter
DB01050IbuprofenMultidrug resistance protein 1transporter
DB01050IbuprofenUDP-glucuronosyltransferase 1-3enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 1-9enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 2B4enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 2B7enzyme
DB01050IbuprofenCytochrome P450 2C8enzyme
DB01050IbuprofenCytochrome P450 2C19enzyme
DB01050IbuprofenApoptosis regulator Bcl-2target
DB01050IbuprofenThrombomodulintarget
DB01050IbuprofenFatty acid-binding protein, intestinaltarget
DB01050IbuprofenPeroxisome proliferator-activated receptor gammatarget
DB01050IbuprofenCystic fibrosis transmembrane conductance regulatortarget
DB01050IbuprofenPeroxisome proliferator-activated receptor alphatarget
DB01050IbuprofenPlatelet glycoprotein Ib alpha chaintarget
DB01050IbuprofenProtein S100-A7target
DB01050IbuprofenAlpha-methylacyl-CoA racemaseenzyme
DB05303OMS-103HPTumor necrosis factortarget
DB05303OMS-103HPInterleukin-1 receptor type 1target
DB09213DexibuprofenProstaglandin G/H synthase 1target
DB09213DexibuprofenProstaglandin G/H synthase 2target
DB09213DexibuprofenApoptosis regulator Bcl-2target
DB09213DexibuprofenThrombomodulintarget
DB09213DexibuprofenTissue-type plasminogen activatortarget
DB09213DexibuprofenFatty acid-binding protein, intestinaltarget
DB09213DexibuprofenPeroxisome proliferator-activated receptor gammatarget
DB09213DexibuprofenCystic fibrosis transmembrane conductance regulatortarget
DB09213DexibuprofenCytochrome P450 2C9enzyme
DB09213DexibuprofenSerum albumincarrier
DB09213DexibuprofenMultidrug resistance-associated protein 4transporter
DB09213DexibuprofenMultidrug resistance-associated protein 1transporter
DB09213DexibuprofenSolute carrier organic anion transporter family member 1A2transporter
DB09213DexibuprofenSolute carrier family 22 member 6transporter
DB09213DexibuprofenSolute carrier family 22 member 8transporter
DB09213DexibuprofenSolute carrier family 22 member 11transporter
DB09213DexibuprofenSolute carrier organic anion transporter family member 2B1transporter
DB09213DexibuprofenMultidrug resistance protein 1transporter
DB09213DexibuprofenUDP-glucuronosyltransferase 1-1enzyme
DB09213DexibuprofenUDP-glucuronosyltransferase 1-3enzyme
DB09213DexibuprofenUDP-glucuronosyltransferase 1-9enzyme
DB09213DexibuprofenUDP-glucuronosyltransferase 2B4enzyme
DB09213DexibuprofenUDP-glucuronosyltransferase 2B7enzyme
DB09213DexibuprofenCytochrome P450 2C8enzyme
DB09213DexibuprofenCytochrome P450 2C19enzyme
DB09213DexibuprofenSolute carrier family 15 member 1target
DB09213DexibuprofenPeroxisome proliferator-activated receptor alphatarget
DB09213DexibuprofenPlatelet glycoprotein Ib alpha chaintarget
DB09213DexibuprofenProtein S100-A7target
DB09213DexibuprofenAlpha-methylacyl-CoA racemaseenzyme