Contraceptive Agents, Male

Chemical substances or agents with contraceptive activity in males. Use for male contraceptive agents in general or for which there is no specific heading.
DrugDrug NameDrug Description
DB00603Medroxyprogesterone acetateA progestin used as a contraceptive and in the treatment of secondary amenorrhea, abnormal uterine bleeding, pain from endometriosis, endometrial and renal carcinomas, paraphilia in males, and GnRH-dependent precocious puberty.
DB04066para-Coumaric AcidNot Available
DB04682Octylphenoxy polyethoxyethanolNot Available
DB04839Cyproterone acetateA steroid used in combination with ethinyl estradiol to treat women with severe acne and symptoms of androgenization. Also used alone at much higher doses for palliative treatment of patients with prostate cancer
DB06266LonidamineInvestigated for use/treatment in benign prostatic hyperplasia, prostate disorders, and cancer/tumors (unspecified).
DB06804Nonoxynol-9A vaginal spermicide used for the non-hormonal contraception in conjunction with other modes of contraception.
DB09123DienogestAn oral progestin used for the treatment of endometriosis as monotherapy or contraception in combination with ethinylestradiol.
DB09401IsosorbideA vasodilator used for the prevention and treatment of angina pectoris due to coronary artery disease.
DB12025TriptolideTriptolide has been used in trials studying the treatment of HIV, Crohn's Disease, Intestinal Diseases, Gastrointestinal Diseases, and Digestive System Diseases, among others.
DB13044GossypolGossypol has been used in trials studying the treatment of Non-small Cell Lung Cancer.
DB01115NifedipineA dihydropyridine calcium channel blocker indicated for the management of several subtypes of angina pectoris, and hypertension.
DB13944Testosterone enanthateAn androgen used to treat low or absent testosterone.
DB05830TrestoloneInvestigated for use/treatment in contraception and male hormonal deficiencies/abnormalities.
DB00255DiethylstilbestrolUsed in the treatment of prostate cancer. Previously used in the prevention of miscarriage or premature delivery in pregnant women prone to miscarriage or premature delivery.
DrugDrug NameTargetType
DB00603Medroxyprogesterone acetateProgesterone receptortarget
DB00603Medroxyprogesterone acetateEstrogen receptor alphatarget
DB00603Medroxyprogesterone acetateCytochrome P450 3A4enzyme
DB00603Medroxyprogesterone acetateCytochrome P450 2C8enzyme
DB00603Medroxyprogesterone acetate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
DB00603Medroxyprogesterone acetateCytochrome P450 2C9enzyme
DB00603Medroxyprogesterone acetateCytochrome P450 3A1enzyme
DB00603Medroxyprogesterone acetateSerum albumincarrier
DB00603Medroxyprogesterone acetateP-glycoprotein 1target
DB00603Medroxyprogesterone acetateGABA-A receptor (anion channel)target
DB04066para-Coumaric AcidPhotoactive yellow proteintarget
DB04066para-Coumaric AcidPPHtarget
DB04066para-Coumaric AcidProstaglandin reductase 1target
DB04066para-Coumaric AcidHistidine ammonia-lyasetarget
DB04682Octylphenoxy polyethoxyethanolTroponin C, skeletal muscletarget
DB04839Cyproterone acetateAndrogen receptortarget
DB04839Cyproterone acetateProstate-specific antigentarget
DB04839Cyproterone acetateCytochrome P450 3A4enzyme
DB04839Cyproterone acetateCytochrome P450 19A1enzyme
DB06266LonidamineCystic fibrosis transmembrane conductance regulatortarget
DB06266LonidamineHexokinase-1target
DB06804Nonoxynol-9Prostaglandin G/H synthase 2enzyme
DB09123DienogestCytochrome P450 3A4enzyme
DB09123DienogestProgesterone receptortarget
DB09123DienogestAndrogen receptortarget
DB09401IsosorbideApoptosis regulator Bcl-2target
DB09401IsosorbideBcl-2-like protein 1target
DB09401IsosorbideInduced myeloid leukemia cell differentiation protein Mcl-1target
DB13044GossypolBcl-2-like protein 1target
DB01115NifedipineVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB01115NifedipineCytochrome P450 3A4enzyme
DB01115NifedipineCytochrome P450 2E1enzyme
DB01115NifedipineCytochrome P450 2D6enzyme
DB01115NifedipineCalmodulintarget
DB01115NifedipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB01115NifedipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB01115NifedipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB01115NifedipineVoltage-dependent L-type calcium channel subunit beta-2target
DB01115NifedipinePotassium voltage-gated channel subfamily A member 1target
DB01115NifedipineVoltage-dependent T-type calcium channel subunit alpha-1Htarget
DB01115NifedipineCytochrome P450 1A2enzyme
DB01115NifedipineCytochrome P450 2A6enzyme
DB01115NifedipineCytochrome P450 2C8enzyme
DB01115NifedipineCanalicular multispecific organic anion transporter 2transporter
DB01115NifedipineP-glycoprotein 1transporter
DB01115NifedipineCanalicular multispecific organic anion transporter 1transporter
DB01115NifedipineCytochrome P450 1A1enzyme
DB01115NifedipineCytochrome P450 2B6enzyme
DB01115NifedipineNuclear receptor subfamily 1 group I member 2target
DB01115NifedipineSolute carrier organic anion transporter family member 1B1transporter
DB01115NifedipineBile salt export pumptransporter
DB13944Testosterone enanthateAndrogen receptortarget
DB13944Testosterone enanthateCytochrome P450 3A4enzyme
DB13944Testosterone enanthateAmine oxidase [flavin-containing] Aenzyme
DB13944Testosterone enanthateCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB13944Testosterone enanthateSerum albumincarrier
DB13944Testosterone enanthateSex hormone-binding globulincarrier
DB13944Testosterone enanthateCytochrome P450 3A5enzyme
DB13944Testosterone enanthateCytochrome P450 3A7enzyme
DB13944Testosterone enanthateSolute carrier organic anion transporter family member 1A2transporter
DB13944Testosterone enanthateSolute carrier family 22 member 8transporter
DB13944Testosterone enanthateSolute carrier family 22 member 7transporter
DB13944Testosterone enanthateP-glycoprotein 1transporter
DB13944Testosterone enanthateSodium/bile acid cotransportertransporter
DB13944Testosterone enanthateSolute carrier family 22 member 3transporter
DB13944Testosterone enanthateSolute carrier family 22 member 4transporter
DB13944Testosterone enanthateATP-binding cassette sub-family G member 2transporter
DB13944Testosterone enanthateCytochrome P450 1A1enzyme
DB13944Testosterone enanthateCytochrome P450 2A13enzyme
DB13944Testosterone enanthateCytochrome P450 2B6enzyme
DB13944Testosterone enanthateCytochrome P450 2C19enzyme
DB13944Testosterone enanthateCytochrome P450 2C8enzyme
DB13944Testosterone enanthateCytochrome P450 2C9enzyme
DB13944Testosterone enanthateCytochrome P450 3A43enzyme
DB13944Testosterone enanthateEstrogen receptor alphatarget
DB13944Testosterone enanthateMineralocorticoid receptortarget
DB13944Testosterone enanthate3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
DB13944Testosterone enanthateCytochrome P450 19A1enzyme
DB00255DiethylstilbestrolEstrogen receptor alphatarget
DB00255DiethylstilbestrolEstrogen-related receptor gammatarget
DB00255DiethylstilbestrolTransthyretincarrier
DB00255DiethylstilbestrolCatechol O-methyltransferaseenzyme
DB00255DiethylstilbestrolCytochrome P450 19A1enzyme
DB00255DiethylstilbestrolATP-binding cassette sub-family G member 2transporter
DB00255DiethylstilbestrolP-glycoprotein 1transporter
DB00255DiethylstilbestrolEstrogen receptor betatarget
DB00255DiethylstilbestrolCytochrome P450 3A4enzyme
DB00255DiethylstilbestrolCytochrome P450 2C8enzyme
DB00255DiethylstilbestrolCytochrome P450 2C9enzyme
DB00255DiethylstilbestrolCytochrome P450 2E1enzyme
DB00255DiethylstilbestrolSteroid hormone receptor ERR1target
DB00255DiethylstilbestrolSteroid hormone receptor ERR2target
DB00255DiethylstilbestrolNuclear receptor coactivator 2target
DB00255DiethylstilbestrolNuclear receptor subfamily 1 group I member 2target
DB00255DiethylstilbestrolAndrogen receptortarget
DB00255DiethylstilbestrolSex hormone-binding globulintarget
DB00255DiethylstilbestrolSolute carrier organic anion transporter family member 1B1transporter
DB00255DiethylstilbestrolSolute carrier organic anion transporter family member 2B1transporter
DB00255DiethylstilbestrolBile salt export pumptransporter