Neprilysin, antagonists & inhibitors

Name
Neprilysin, antagonists & inhibitors
Accession Number
DBCAT001007
Description
Not Available
Drugs
DrugDrug Description
CandoxatrilCandoxatril is the orally-active prodrug of candoxatrilat (UK-73967), a potent neutral endopeptidase (NEP) inhibitor.
DaglutrilInvestigated for use/treatment in congestive heart failure and hypertension.
SacubitrilA neprilysin inhibitor used in combination with valsartan as an adjunct to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction.
CandoxatrilatA dicarboxylic acid monoamide obtained by formal condensation between the amino group of cis-4-aminocyclohexanecarboxylic acid and the cyclopentanecarboxylic acid group of 1-[(2S)-2-carboxy-3-(2-methoxyethoxy)propyl]cyclopentanecarboxylic acid. A potent inhibitor of neutral endopeptidase (NEP,...
RacecadotrilRacecadotril has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.
Drugs & Drug Targets
DrugTargetType
CandoxatrilNeprilysintarget
CandoxatrilAngiotensin-converting enzymetarget
DaglutrilNeprilysintarget
SacubitrilNeprilysintarget
SacubitrilSolute carrier organic anion transporter family member 1B1transporter
SacubitrilSolute carrier organic anion transporter family member 1B3transporter
CandoxatrilatNeprilysintarget