Androstanols

Androstanes and androstane derivatives which are substituted in any position with one or more hydroxyl groups.
DrugDrug NameDrug Indication
DB00621OxandroloneUse to promote weight gain after weight loss following extensive surgery.
DB01108TrilostaneUsed in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible.
DB01337PancuroniumUsed as a muscle relaxant during anesthesia and surgical procedures.
DB01339VecuroniumVecuronium is a muscle relaxing agent and is used as an adjunct in general anesthesia.
DB02901StanoloneNot Available
DB04834RapacuroniumUsed in anaesthesia, to aid and enable endotracheal intubation.
DB0510716-BromoepiandrosteroneInvestigated for use/treatment in cystic fibrosis, HIV infection, hepatitis (viral, B), and malaria.
DB06157IstaroximeInvestigated for use/treatment in heart disease.
DB06412OxymetholoneIndicated in the treatment of anemias caused by deficient red cell production. Acquired aplastic anemia, congenital aplastic anemia, myelofibrosis and the hypoplastic anemias due to the administration of myelotoxic drugs often respond. Oxymetholone should not replace other supportive measures such as transfusion, correction of iron, folic acid, vitamin B12 or pyridoxine deficiency, antibacterial therapy and the appropriate use of corticosteroids.
DB06718StanozololStanozolol is a synthetic anabolic steroid with therapeutic uses in treating C1-inhibitor deficient hereditary angioedema. C1-inhibitor is a protease that inhibits the complement system (part of the innate immune system), a biochemical chain of reactions which assists the body in removing pathogens from the body. Stanozolol may help control attacks of hereditary angioedema. Stanozolol can be administered orally or intramuscularly.
DB13587MesteroloneNot Available
DB00728RocuroniumFor inpatients and outpatients as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
DrugDrug NameTargetType
DB00621OxandroloneAndrogen receptortarget
DB00621OxandroloneCytochrome P450 2C9enzyme
DB01108Trilostane3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB01108Trilostane3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2target
DB01108TrilostaneEstrogen receptor betatarget
DB01108TrilostaneEstrogen receptor alphatarget
DB01108TrilostaneCytochrome P450 3A4enzyme
DB01337PancuroniumNeuronal acetylcholine receptor subunit alpha-2target
DB01337PancuroniumCholinesteraseenzyme
DB01337PancuroniumMuscarinic acetylcholine receptor M2target
DB01337PancuroniumMuscarinic acetylcholine receptor M3target
DB01337PancuroniumSolute carrier family 22 member 1transporter
DB01337PancuroniumSolute carrier family 22 member 2transporter
DB01339VecuroniumMultidrug resistance protein 1transporter
DB01339VecuroniumNeuronal acetylcholine receptor subunit alpha-2target
DB02901StanoloneSex hormone-binding globulincarrier
DB02901StanoloneAndrogen receptortarget
DB02901StanoloneEstradiol 17-beta-dehydrogenase 1target
DB02901StanoloneMultidrug resistance protein 1transporter
DB02901StanoloneCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB02901StanoloneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DB02901StanoloneCytochrome P450 19A1enzyme
DB02901StanoloneEstrogen receptor alphatarget
DB02901StanoloneMineralocorticoid receptortarget
DB04834RapacuroniumMuscarinic acetylcholine receptor M2target
DB0510716-BromoepiandrosteroneGlucose-6-phosphate 1-dehydrogenasetarget
DB06157IstaroximeSarcoplasmic/endoplasmic reticulum calcium ATPase 2target
DB06157IstaroximeSodium/potassium-transporting ATPase subunit alpha-1target
DB06412OxymetholoneAndrogen receptortarget
DB06412OxymetholoneSerum albumincarrier
DB06412OxymetholoneSex hormone-binding globulincarrier
DB06412OxymetholoneNatriuretic peptides Btarget
DB06412OxymetholoneAmine oxidase [flavin-containing] Aenzyme
DB06412OxymetholoneCytochrome P450 2D6enzyme
DB06412Oxymetholone3-oxo-5-alpha-steroid 4-dehydrogenase 1enzyme
DB06412OxymetholoneCytochrome P450 3A4enzyme
DB06412OxymetholoneCytochrome P450 3A5enzyme
DB06412OxymetholoneCytochrome P450 3A7enzyme
DB06412OxymetholoneCytochrome P450 3A43enzyme
DB06718StanozololStanozolol Binding Protein (STBP)target
DB06718StanozololLow-affinity glucocorticoid-binding protein (LAGS)target
DB00728RocuroniumNeuronal acetylcholine receptor subunit alpha-2target
DB00728RocuroniumMuscarinic acetylcholine receptor M2target
DB00728Rocuronium5-hydroxytryptamine receptor 3Atarget
DB00728RocuroniumSolute carrier family 22 member 1transporter
DB00728RocuroniumSolute carrier organic anion transporter family member 1A2transporter