Hypoxanthines

Purine bases related to hypoxanthine, an intermediate product of uric acid synthesis and a breakdown product of adenine catabolism.
DrugDrug NameDrug Indication
DB00299PenciclovirUsed to treat recurrent cold sores on the lips and face from various herpesvirus invections.
DB00442EntecavirFor the treatment of chronic hepatitis B virus infection in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.
DB00577ValaciclovirFor the treatment or suppression of cold sores (herpes labialis), herpes zoster (shingles), genital herpes in immunocompetent individuals, and recurrent genital herpes in HIV-infected individuals.
DB00642PemetrexedUsed in combination with cisplatin for the treatment of malignant pleural mesothelioma in adults whose disease is unresectable or who otherwise are not candidates for potentially curative surgery. Also used as a monotherapy for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) after prior chemotherapy
DB00787AcyclovirFor the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox.
DB01004GanciclovirFor induction and maintenance in the treatment of cytomegalovirus (CMV) retinitis in immunocompromised patients, including patients with acquired immunodeficiency syndrome (AIDS). Also used in the treatment of severe cytomegalovirus (CMV) disease, including CMV pneumonia, CMV gastrointestinal disease, and disseminated CMV infections, in immunocompromised patients.
DB01610ValganciclovirValganciclovir is an antiviral medication used for the treatment of cytomegalovirus infections.
DB016678-azaguanineNot Available
DB019787,9-DimethylguanineNot Available
DB022457-DeazaguanineNot Available
DB02377GuanineNot Available
DB024899-MethylguanineNot Available
DB02568PeldesineNot Available
DB04076HypoxanthineNot Available
DB043569-DeazaguanineNot Available
DB05402ME-609Investigated for use/treatment in herpes labialis infections (cold sores).
DB06575ValomaciclovirInvestigated for use/treatment in herpes zoster infections and viral infection.
DB119196-O-benzylguanineNot Available
DB12531LobucavirNot Available
DrugDrug NameTargetType
DB00299PenciclovirDNA polymerase catalytic subunittarget
DB00299PenciclovirThymidine kinasetarget
DB00442EntecavirDNAtarget
DB00577ValaciclovirThymidine kinasetarget
DB00577ValaciclovirDNA polymerase catalytic subunittarget
DB00577ValaciclovirSolute carrier family 15 member 1transporter
DB00577ValaciclovirSolute carrier family 15 member 2transporter
DB00577ValaciclovirSolute carrier family 22 member 8transporter
DB00577ValaciclovirSolute carrier family 22 member 6transporter
DB00577ValaciclovirSodium- and chloride-dependent neutral and basic amino acid transporter B(0+)transporter
DB00577ValaciclovirIleal sodium/bile acid cotransportertransporter
DB00577ValaciclovirCytochrome P450 1A2enzyme
DB00642PemetrexedThymidylate synthasetarget
DB00642PemetrexedDihydrofolate reductasetarget
DB00642PemetrexedTrifunctional purine biosynthetic protein adenosine-3target
DB00642PemetrexedDeoxycytidine kinaseenzyme
DB00642PemetrexedBifunctional purine biosynthesis protein PURHtarget
DB00642PemetrexedEquilibrative nucleoside transporter 1enzyme
DB00787AcyclovirDNA polymerase catalytic subunittarget
DB00787AcyclovirDNA polymerase catalytic subunittarget
DB00787AcyclovirThymidine kinasetarget
DB00787AcyclovirSolute carrier family 22 member 1transporter
DB00787AcyclovirSolute carrier family 22 member 6transporter
DB00787AcyclovirSolute carrier family 22 member 8transporter
DB00787AcyclovirIleal sodium/bile acid cotransportertransporter
DB00787AcyclovirMultidrug and toxin extrusion protein 1transporter
DB00787AcyclovirMultidrug and toxin extrusion protein 2transporter
DB00787AcyclovirCytochrome P450 1A2enzyme
DB01004GanciclovirDNA polymerase catalytic subunittarget
DB01004GanciclovirThymidine kinasetarget
DB01004GanciclovirSolute carrier family 22 member 1transporter
DB01004GanciclovirSolute carrier family 22 member 6transporter
DB01004GanciclovirSolute carrier family 22 member 8transporter
DB01004GanciclovirSolute carrier family 22 member 7transporter
DB01004GanciclovirDNAtarget
DB01610ValganciclovirDNAtarget
DB01610ValganciclovirSolute carrier family 15 member 1transporter
DB01610ValganciclovirSolute carrier family 15 member 2transporter
DB01610ValganciclovirSodium- and chloride-dependent neutral and basic amino acid transporter B(0+)transporter
DB016678-azaguaninePurine nucleoside phosphorylasetarget
DB019787,9-DimethylguanineCap-specific mRNA (nucleoside-2'-O-)-methyltransferasetarget
DB02377GuaninePurine nucleoside phosphorylasetarget
DB02377GuaninePurine nucleoside phosphorylase 2target
DB02377GuanineXanthine phosphoribosyltransferasetarget
DB02377GuanineGTP cyclohydrolase 1target
DB02377GuaninePurine nucleoside phosphorylasetarget
DB024899-MethylguanineDihydroneopterin aldolasetarget
DB02568PeldesinePurine nucleoside phosphorylasetarget
DB04076HypoxanthinePurine nucleoside phosphorylasetarget
DB043569-DeazaguanineHypoxanthine-guanine phosphoribosyltransferasetarget