Xanthine derivatives

A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP.
DrugDrug NameDrug Indication
DB01303OxtriphyllineUsed to treat the symptoms of asthma, bronchitis, COPD, and emphysema.
DB09273DoxofyllineIndicated for the treatment of chronic obstructive pulmonary disease (COPD), bronchial asthma and pulmonary disease with spastic bronchial component.
DB13203BamifyllineNot Available
DB01482FenethyllineNot Available
DB14018BromotheophyllineBromotheophylline is used as a diuretic and also, in combination with [DB00316], it is used for the relief of temporary water weight gain, bloating, swelling and full feeling associated with the premenstrual and menstrual periods.[L2737]
DB00806PentoxifyllineFor the treatment of patients with intermittent lameness or immobility arising from chronic occlusive arterial disease of the limbs.
DB016678-azaguanineNot Available
DB019787,9-DimethylguanineNot Available
DB02134XanthineNot Available
DB022457-DeazaguanineNot Available
DB02377GuanineNot Available
DB024899-MethylguanineNot Available
DB02568PeldesineNot Available
DB04076HypoxanthineNot Available
DB043569-DeazaguanineNot Available
DB06575ValomaciclovirInvestigated for use/treatment in herpes zoster infections and viral infection.
DB079543-isobutyl-1-methyl-7H-xanthineNot Available
DB08844Uric AcidAt present (August 2013), there is no approved indication for uric acid. The potential therapeutic use for uric acid is as an adjunct in acute ischemic stroke.
DB119196-O-benzylguanineNot Available
DB12406LisofyllineNot Available
DB12531LobucavirNot Available
DB12926CafedrineNot Available
DB12927TheodrenalineNot Available
DB14029FurafyllineNot Available
DB01412Theobrominetheobromine is used as a vasodilator, a diuretic, and heart stimulant. And similar to caffeine, it may be useful in management of fatigue and orthostatic hypotension.
DB06479PropentofyllineInvestigated for use/treatment in alzheimer's disease.
DB00201CaffeineFor management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants.
DB141328-chlorotheophyllineWhen used in combination with [DB01075] as the antiemetic [DB00985], 8-chlorotheophylline is indicated for the prevention and treatment of nausea, vomiting, or vertigo of motion sickness.
DB00277TheophyllineFor the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, such as emphysema and chronic bronchitis.
DB00651DyphyllineFor relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema.
DrugDrug NameTargetType
DB01303OxtriphyllineCytochrome P450 1A2enzyme
DB01303OxtriphyllinecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DB01303OxtriphyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB01303OxtriphyllineAdenosine receptor A2atarget
DB01303OxtriphyllineAdenosine receptor A1target
DB01303OxtriphyllineHistone deacetylase 2target
DB01303OxtriphyllineSolute carrier family 22 member 7transporter
DB09273DoxofyllineCytochrome P450 1A2enzyme
DB09273DoxofyllinePhosphodiesterase 2A, cGMP-stimulatedtarget
DB09273DoxofyllineAdenosine receptor A2atarget
DB09273DoxofyllineBeta-2 adrenergic receptortarget
DB13203BamifyllineCytochrome P450 1A2enzyme
DB01482FenethyllineCytochrome P450 1A2enzyme
DB14018BromotheophyllineCytochrome P450 1A2enzyme
DB00806PentoxifyllineCytochrome P450 1A2enzyme
DB00806PentoxifyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB00806PentoxifyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB00806Pentoxifylline5'-nucleotidasetarget
DB00806PentoxifyllinecGMP-specific 3',5'-cyclic phosphodiesterasetarget
DB00806PentoxifyllineAdenosine receptor A1target
DB00806PentoxifyllineAdenosine receptor A2atarget
DB016678-azaguanineCytochrome P450 1A2enzyme
DB016678-azaguaninePurine nucleoside phosphorylasetarget
DB019787,9-DimethylguanineCap-specific mRNA (nucleoside-2'-O-)-methyltransferasetarget
DB02134XanthineCytochrome P450 1A2enzyme
DB02134XanthinePurine nucleoside phosphorylase 2target
DB02134XanthineXanthine phosphoribosyltransferasetarget
DB02377GuaninePurine nucleoside phosphorylasetarget
DB02377GuaninePurine nucleoside phosphorylase 2target
DB02377GuanineXanthine phosphoribosyltransferasetarget
DB02377GuanineGTP cyclohydrolase 1target
DB02377GuaninePurine nucleoside phosphorylasetarget
DB024899-MethylguanineCytochrome P450 1A2enzyme
DB024899-MethylguanineDihydroneopterin aldolasetarget
DB02568PeldesinePurine nucleoside phosphorylasetarget
DB04076HypoxanthineCytochrome P450 1A2enzyme
DB04076HypoxanthinePurine nucleoside phosphorylasetarget
DB043569-DeazaguanineCytochrome P450 1A2enzyme
DB043569-DeazaguanineHypoxanthine-guanine phosphoribosyltransferasetarget
DB079543-isobutyl-1-methyl-7H-xanthinecGMP-specific 3',5'-cyclic phosphodiesterasetarget
DB079543-isobutyl-1-methyl-7H-xanthinecGMP-inhibited 3',5'-cyclic phosphodiesterase Btarget
DB079543-isobutyl-1-methyl-7H-xanthineHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7Atarget
DB079543-isobutyl-1-methyl-7H-xanthinecAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
DB079543-isobutyl-1-methyl-7H-xanthineHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9Atarget
DB079543-isobutyl-1-methyl-7H-xanthineHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8Atarget
DB079543-isobutyl-1-methyl-7H-xanthinecGMP-dependent 3',5'-cyclic phosphodiesterasetarget
DB079543-isobutyl-1-methyl-7H-xanthineRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammatarget
DB08844Uric AcidGlycogen phosphorylase, liver formtarget
DB08844Uric AcidSolute carrier family 22 member 6transporter
DB08844Uric AcidSolute carrier family 22 member 8transporter
DB08844Uric AcidSolute carrier family 2, facilitated glucose transporter member 9transporter
DB119196-O-benzylguanineCytochrome P450 3A4enzyme
DB12406LisofyllineCytochrome P450 1A2enzyme
DB14029FurafyllineCytochrome P450 1A2enzyme
DB01412TheobromineCytochrome P450 1A2enzyme
DB01412TheobromineCytochrome P450 2E1enzyme
DB01412TheobromineAdenosine receptor A1target
DB01412TheobromineAdenosine receptor A2atarget
DB01412TheobrominecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB06479PropentofyllineCytochrome P450 1A2enzyme
DB06479PropentofyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB00201CaffeineCytochrome P450 1A2enzyme
DB00201CaffeineCytochrome P450 3A4enzyme
DB00201CaffeineCytochrome P450 3A5enzyme
DB00201CaffeineCytochrome P450 3A7enzyme
DB00201CaffeineCytochrome P450 2E1enzyme
DB00201CaffeineCytochrome P450 2C8enzyme
DB00201CaffeineCytochrome P450 2C9enzyme
DB00201CaffeineCytochrome P450 1A1enzyme
DB00201CaffeineCytochrome P450 1B1enzyme
DB00201CaffeineCytochrome P450 2D6enzyme
DB00201CaffeineAdenosine receptor A1target
DB00201CaffeinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB00201CaffeineAdenosine receptor A2atarget
DB00201CaffeineRyanodine receptor 1target
DB00201CaffeineCyclic nucleotide phosphodiesterasetarget
DB00201CaffeineDNA-dependent protein kinase catalytic subunittarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformtarget
DB00201CaffeineInositol 1,4,5-trisphosphate receptortarget
DB00201CaffeineSerine-protein kinase ATMtarget
DB00201CaffeineMultidrug resistance protein 1transporter
DB141328-chlorotheophyllineCytochrome P450 1A2enzyme
DB141328-chlorotheophyllineAdenosine receptor A2atarget
DB00277TheophyllineCytochrome P450 1A2enzyme
DB00277TheophyllineAdenosine deaminaseenzyme
DB00277TheophyllineCytochrome P450 2E1enzyme
DB00277TheophyllineCytochrome P450 3A4enzyme
DB00277TheophyllineCytochrome P450 1A1enzyme
DB00277TheophyllineCytochrome P450 1B1enzyme
DB00277TheophyllineCytochrome P450 2C8enzyme
DB00277TheophyllineCytochrome P450 2D6enzyme
DB00277TheophyllinecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DB00277TheophyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB00277TheophyllineAdenosine receptor A2btarget
DB00277TheophyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB00277TheophyllinecGMP-specific 3',5'-cyclic phosphodiesterasetarget
DB00277TheophyllineAdenosine receptor A1target
DB00277TheophyllineAdenosine receptor A2atarget
DB00277TheophyllineHistone deacetylase 2target
DB00277TheophyllineCopine-1target
DB00277TheophyllineMinor histocompatibility antigen H13target
DB00277TheophyllineNodal modulator 1target
DB00277TheophyllinePoly [ADP-ribose] polymerase 1target
DB00277TheophyllineProtein RIC-3target
DB00277TheophyllineTubulin monoglycylase TTLL3target
DB00277TheophyllineSolute carrier family 22 member 7transporter
DB00651DyphyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB00651DyphyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB00651DyphyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Ctarget
DB00651DyphyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
DB00651DyphyllineHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7Atarget
DB00651DyphyllinecAMP-specific 3',5'-cyclic phosphodiesterase 7Btarget
DB00651DyphyllineAdenosine receptor A1target
DB00651DyphyllineAdenosine receptor A2atarget