Drug Delivery Systems

Name
Drug Delivery Systems
Accession Number
DBCAT001055
Description

Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.

Drugs
DrugDrug Description
Amphotericin BAn antifungal used to treat fungal infections in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis.
CarbetocinAn oxytocin agent used to control postpartum hemorrhage and bleeding after giving birth.
Propylene glycolA clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
TromethamineA proton acceptor used for the prevention and correction of metabolic acidosis associated with various clinical conditions, such as cardiac bypass surgery.
AP5280Investigated for use/treatment in solid tumors.
TragacanthAn extract from Tragacanth used in allergy testing.
Polysorbate 80It is used as a solubilizer, antimicrobial preservative and disinfectant .
Polysorbate 20Polysorbate 20 is a polysorbate-type nonionic surfactant used in many commercial, household and pharmaceutical products. It is composed of 20 repeated units of polyethylene glycol via ethoxylation. Polysorbate 20 is...
Poloxamer 407Poloxamer 407 is a polyoxyethylene polymer and hydrophilic non-ionic surfactant. It consists of a central hydrophobic block of polypropylene glycol that is flanked on each side by polyethylene glycol blocks,...
Poloxamer 188A medication used to clean wounds.
AstodrimerAstodrimer has been used in trials studying the treatment and prevention of Bacterial Vaginosis. It is a lysine-based dendrimer with naphthalene disulfonic acid surface groups.
TricaprylinTricaprilin has been used in trials studying the supportive care and treatment of Alzheimer's Disease.
Microcrystalline celluloseA polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material,...
Poly(lactic acid)Poly(lactic acid) is under investigation in clinical trial NCT00126308 (Facial Lipoatrophy Trial: Immediate Versus Deferred Injections of Poly-L-Lactic Acid for HIV Facial Lipoatrophy).
Hydroxypropyl betadexHydroxypropyl betadex is under investigation in clinical trial NCT03471143 (Study of IV VTS-270 for Infantile Liver Disease Associated With Niemann-Pick Disease, Type C).
Polyethylene glycolA laxative used to treat constipation and used for bowel preparation before colonoscopies and other procedures.
TriethylhexanoinNot Annotated
Drugs & Drug Targets
DrugTargetType
Amphotericin BErgosteroltarget
Amphotericin BCytochrome P450 3A4enzyme
CarbetocinOxytocin receptortarget
Propylene glycolCoagulation factor XIII A chaintarget
Propylene glycolHaloalkane dehalogenasetarget
Propylene glycolClavaminate synthase 1target
Propylene glycolLactaldehyde reductasetarget
Propylene glycolB12-independent glycerol dehydratasetarget
TromethamineCholera enterotoxin subunit Btarget
TromethamineS-adenosylmethionine decarboxylase proenzymetarget
TromethamineBiotin synthasetarget
TromethamineVascular endothelial growth factor Atarget
Tromethamine6-phosphogluconolactonasetarget
TromethamineDecorintarget
TromethamineAutolysintarget
TromethamineCytochrome c4target
TromethamineSoluble calcium-activated nucleotidase 1target
TromethamineLipoprotein NlpItarget
TromethamineDNA protection during starvation proteintarget
TromethaminePutative glucose-6-phosphate 1-epimerasetarget
TromethamineEndonuclease 8-like 1target
AstodrimerEnvelope glycoprotein gp160target
Polyethylene glycolP-glycoprotein 1transporter