4-Quinolones

Name
4-Quinolones
Accession Number
DBCAT001093
Description

QUINOLONES containing a 4-oxo (a carbonyl in the para position to the nitrogen). They inhibit the A subunit of DNA GYRASE and are used as antimicrobials. Second generation 4-quinolones are also substituted with a 1-piperazinyl group at the 7-position and a fluorine at the 6-position.

Drugs
DrugDrug Description
NedocromilA pyrano quinoline used to treat allergic conjunctivitis.
Nalidixic acidA quinolone antibiotic used to treat urinary tract infections.
Oxolinic acidNot Annotated
Drugs & Drug Targets
DrugTargetType
NedocromilCysteinyl leukotriene receptor 1target
NedocromilCysteinyl leukotriene receptor 2target
NedocromilProstaglandin D2 receptortarget
NedocromilfMet-Leu-Phe receptortarget
NedocromilHeat shock protein HSP 90-alphatarget
Nalidixic acidDNAtarget
Nalidixic acidSolute carrier family 22 member 6transporter
Nalidixic acidTryptophan 2,3-dioxygenaseenzyme
Nalidixic acidCytochrome P450 1A2enzyme
Oxolinic acidCytochrome P450 1A2enzyme