QUINOLONES containing a 4-oxo (a carbonyl in the para position to the nitrogen). They inhibit the A subunit of DNA GYRASE and are used as antimicrobials. Second generation 4-quinolones are also substituted with a 1-piperazinyl group at the 7-position and a fluorine at the 6-position.
|Drug||Drug Name||Drug Indication|
|DB00716||Nedocromil||For the treatment of mild to moderate asthma|
|DB00779||Nalidixic acid||For the treatment of urinary tract infections caused by susceptible gram-negative microorganisms, including the majority of E. Coli, Enterobacter species, Klebsiella species, and Proteus species.|
|DB13627||Oxolinic acid||Not Available|